Rheb1 protects against cisplatin-induced tubular cell death and acute kidney injury via maintaining mitochondrial homeostasis

Fibroblast mTOR/PPARγ/HGF axis protects against tubular cell death and acute kidney injury

(2019) Yuan Gui et al.   CELL DEATH AND DIFFERENTIATION

Acute kidney injury overview: From basic findings to new prevention and therapy strategies

(2019) Sabrina Ribeiro Gonsalez et al.   PHARMACOLOGY & THERAPEUTICS

Silencing of RHEB inhibits cell proliferation and promotes apoptosis in colorectal cancer cells via inhibition of the mTOR signaling pathway

(2019) Yuxi Tian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Myo-inositol oxygenase expression profile modulates pathogenic ferroptosis in the renal proximal tubule

(2019) Fei Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

Renal tubule injury: a driving force toward chronic kidney disease

(2018) Bi-Cheng Liu et al.   KIDNEY INTERNATIONAL

The Role of Peroxisome Proliferator-Activated Receptor γ Coactivator 1α (PGC-1α) in Kidney Disease

(2018) Szu-Yuan Li et al.   SEMINARS IN NEPHROLOGY

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(2018) Eric A. J. Hoste et al.   Nature Reviews Nephrology

UCP2-dependent improvement of mitochondrial dynamics protects against acute kidney injury

(2018) Nan Qin et al.   JOURNAL OF PATHOLOGY

Pharmacologic Approaches to Improve Mitochondrial Function in AKI and CKD

(2017) Hazel H. Szeto   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondrial energetics in the kidney

(2017) Pallavi Bhargava et al.   Nature Reviews Nephrology

Inactivation of Tsc2 in Mesoderm-Derived Cells Causes Polycystic Kidney Lesions and Impairs Lung Alveolarization

(2016) Siying Ren et al.   AMERICAN JOURNAL OF PATHOLOGY

Mitochondrial Biogenesis as a Pharmacological Target: A New Approach to Acute and Chronic Diseases

(2016) Ryan M. Whitaker et al.   Annual Review of Pharmacology and Toxicology

Rheb1 promotes tumor progression through mTORC1 in MLL-AF9-initiated murine acute myeloid leukemia

(2016) Yanan Gao et al.   Journal of Hematology & Oncology

A Role for Tubular Necroptosis in Cisplatin-Induced AKI

(2015) Y. Xu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

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(2015) M. A. Venkatachalam et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mitochondria: a therapeutic target in acute kidney injury

(2015) Yu Ishimoto et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Recent progress in the study of the Rheb family GTPases

(2014) Jeffrey J. Heard et al.   CELLULAR SIGNALLING

Regulated Cell Death in AKI

(2014) A. Linkermann et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Rictor/mTORC2 protects against cisplatin-induced tubular cell death and acute kidney injury

(2014) Jianzhong Li et al.   KIDNEY INTERNATIONAL

A Vascular Model of Tsc1 Deficiency Accelerates Renal Tumor Formation with Accompanying Hemangiosarcomas

(2014) Jarrett D. Leech et al.   MOLECULAR CANCER RESEARCH

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

(2014) Florian Grahammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Defective mitophagy driven by dysregulation of rheb and KIF5B contributes to mitochondrial reactive oxygen species (ROS)-induced nod-like receptor 3 (NLRP3) dependent proinflammatory response and aggravates lipotoxicity

(2014) Sijun Yang et al.   Redox Biology

Genetic and Pharmacological Inhibition of Rheb1-mTORC1 Signaling Exerts Cardioprotection against Adverse Cardiac Remodeling in Mice

(2013) Xiangqi Wu et al.   AMERICAN JOURNAL OF PATHOLOGY

Rheb Regulates Mitophagy Induced by Mitochondrial Energetic Status

(2013) Su Melser et al.   Cell Metabolism

Therapeutic targeting of the mitochondrial dysfunction in septic acute kidney injury

(2013) Samir M. Parikh   Current Opinion in Critical Care

Cardiac Ablation of Rheb1 Induces Impaired Heart Growth, Endoplasmic Reticulum-Associated Apoptosis and Heart Failure in Infant Mice

(2013) Yunshan Cao et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Rheb/mTORC1 Signaling Promotes Kidney Fibroblast Activation and Fibrosis

(2013) L. Jiang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of mTORC1 in Collecting Ducts Causes Hyperkalemia

(2013) Z. Chen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury

(2013) Dong Zhou et al.   KIDNEY INTERNATIONAL

Acute kidney injury: an increasing global concern

(2013) Norbert H Lameire et al.   LANCET

Rheb and mammalian target of rapamycin in mitochondrial homoeostasis

(2013) M. J. Groenewoud et al.   Open Biology

Regulation of TOR by small GTPases

(2012) Raúl V Durán et al.   EMBO REPORTS

Transcriptional integration of mitochondrial biogenesis

(2012) Richard C. Scarpulla et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Programmed Cell Death in Animal Development and Disease

(2011) Yaron Fuchs et al.   CELL

Rheb1 Is Required for mTORC1 and Myelination in Postnatal Brain Development

(2011) Jia Zou et al.   DEVELOPMENTAL CELL

PGC-1α promotes recovery after acute kidney injury during systemic inflammation in mice

(2011) Mei Tran et al.   JOURNAL OF CLINICAL INVESTIGATION

Rheb GTPase Controls Apoptosis by Regulating Interaction of FKBP38 with Bcl-2 and Bcl-XL

(2010) Dongzhu Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Ras Homolog Enriched in Brain (Rheb) Enhances Apoptotic Signaling

(2010) Sascha Karassek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1

(2009) Jing Zhou et al.   HUMAN MOLECULAR GENETICS

The biology of PGC-1α and its therapeutic potential

(2009) Christoph Handschin   TRENDS IN PHARMACOLOGICAL SCIENCES

The Switch I Region of Rheb Is Critical for Its Interaction with FKBP38

(2008) Dongzhu Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL