Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney

Renal Tubule Nedd4-2 Deficiency Stimulates Kir4.1/Kir5.1 and Thiazide-Sensitive NaCl Cotransporter in Distal Convoluted Tubule

(2020) Peng Wu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Resistance to Insulin in Patients with Gitelman Syndrome and a Subtle Intermediate Phenotype in Heterozygous Carriers: A Cross-Sectional Study

(2019) Anne Blanchard et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of sodium chloride co-transporter impairs the outgrowth of the renal distal convoluted tubule during renal development

(2019) Christina Schnoz et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Patient-iPSC-Derived Kidney Organoids Show Functional Validation of a Ciliopathic Renal Phenotype and Reveal Underlying Pathogenetic Mechanisms

(2018) Thomas A. Forbes et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Distal tubule basolateral potassium channels

(2018) Oleg Palygin et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

CNNM2 homozygous mutations cause severe refractory hypomagnesemia, epileptic encephalopathy and brain malformations

(2018) Andrea Accogli et al.   European Journal of Medical Genetics

Rebuttal from Francisco J. Arjona and Jeroen H. F. de Baaij

(2018) Francisco J. Arjona et al.   JOURNAL OF PHYSIOLOGY-LONDON

Rebuttal from Yosuke Funato, Kazuharu Furutani, Yoshihisa Kurachi and Hiroaki Miki

(2018) Yosuke Funato et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk opposing view: CNNM proteins are not Na+ /Mg2+ exchangers but Mg2+ transport regulators playing a central role in transepithelial Mg2+ (re)absorption

(2018) Francisco J. Arjona et al.   JOURNAL OF PHYSIOLOGY-LONDON

Potassium intake modulates the thiazide-sensitive sodium-chloride cotransporter (NCC) activity via the Kir4.1 potassium channel

(2018) Ming-Xiao Wang et al.   KIDNEY INTERNATIONAL

TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon

(2018) Francesca Luongo et al.   Nutrients

A Simple Bioreactor-Based Method to Generate Kidney Organoids from Pluripotent Stem Cells

(2018) Aneta Przepiorski et al.   Stem Cell Reports

Thiazide but not loop diuretics is associated with hypomagnesaemia in the general population

(2018) Brenda C.T. Kieboom et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability

(2018) Karl P. Schlingmann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

SLC41A1 is essential for magnesium homeostasis in vivo

(2018) Francisco J. Arjona et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Optical Clearing in the Kidney Reveals Potassium-Mediated Tubule Remodeling

(2018) Turgay Saritas et al.   Cell Reports

Potassium Sensing by Renal Distal Tubules Requires Kir4.1

(2017) Catherina A. Cuevas et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules

(2017) P. Richard Grimm et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease

(2017) Andreas Kompatscher et al.   KIDNEY INTERNATIONAL

Organoid cystogenesis reveals a critical role of microenvironment in human polycystic kidney disease

(2017) Nelly M. Cruz et al.   NATURE MATERIALS

Overexpression of Na+/Mg2+ exchanger SLC41A1 attenuates pro-survival signaling

(2017) Gerhard Sponder et al.   Oncotarget

Glucose tolerance and insulin responsiveness in Gitelman syndrome patients

(2017) Tao Yuan et al.   Endocrine Connections

TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP

(2017) Silvia Ferioli et al.   Scientific Reports

Final results and outcomes by prior bevacizumab exposure, skin toxicity, and hypomagnesaemia from ASPECCT: randomized phase 3 non-inferiority study of panitumumab versus cetuximab in chemorefractory wild-type KRAS exon 2 metastatic colorectal cancer

(2016) Timothy Price et al.   EUROPEAN JOURNAL OF CANCER

Aldosterone Upregulates Transient Receptor Potential Melastatin 7 (TRPM7)

(2016) William C. Valinsky et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Genetic causes of hypomagnesemia, a clinical overview

(2016) Daan H. H. M Viering et al.   PEDIATRIC NEPHROLOGY

Potassium Modulates Electrolyte Balance and Blood Pressure through Effects on Distal Cell Voltage and Chloride

(2015) Andrew S. Terker et al.   Cell Metabolism

Regulation of blood pressure and renal function by NCC and ENaC: lessons from genetically engineered mice

(2015) Sophia N Verouti et al.   CURRENT OPINION IN PHARMACOLOGY

Differential diagnosis of Bartter syndrome, Gitelman syndrome and pseudo–Bartter/Gitelman syndrome based on clinical characteristics

(2015) Natsuki Matsunoshita et al.   GENETICS IN MEDICINE

Integrated compensatory network is activated in the absence of NCC phosphorylation

(2015) P. Richard Grimm et al.   JOURNAL OF CLINICAL INVESTIGATION

1A.01

(2015) H. Louis Dit Picard et al.   JOURNAL OF HYPERTENSION

Direct and Indirect Mineralocorticoid Effects Determine Distal Salt Transport

(2015) A. S. Terker et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia

(2015) J. H. F. de Baaij et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

TRPM6 kinase activity regulates TRPM7 trafficking and inhibits cellular growth under hypomagnesic conditions

(2014) Katherine Brandao et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Hyperkalemic hypertension–associated cullin 3 promotes WNK signaling by degrading KLHL3

(2014) James A. McCormick et al.   JOURNAL OF CLINICAL INVESTIGATION

Differential expression of the Kv1 voltage-gated potassium channel family in the rat nephron

(2014) Rolando Carrisoza-Gaytán et al.   JOURNAL OF MOLECULAR HISTOLOGY

Functional coupling of renal K+and Na+handling causes high blood pressure in Na+replete mice

(2014) Helga Vitzthum et al.   JOURNAL OF PHYSIOLOGY-LONDON

KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1)

(2014) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with Hypomagnesemia

(2014) Francisco J. Arjona et al.   PLoS Genetics

Abnormal Glucose Metabolism and Insulin Sensitivity in Chinese Patients with Gitelman Syndrome

(2013) Hong Ren et al.   AMERICAN JOURNAL OF NEPHROLOGY

The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction

(2013) Akihito Ohta et al.   BIOCHEMICAL JOURNAL

Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain

(2013) Alvaro Yogi et al.   CELLULAR SIGNALLING

Mutation of the Mg2+ Transporter SLC41A1 Results in a Nephronophthisis-Like Phenotype

(2013) T. W. Hurd et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Pharmacological approaches to restore mitochondrial function

(2013) Pénélope A. Andreux et al.   NATURE REVIEWS DRUG DISCOVERY

Membrane Topology and Intracellular Processing of Cyclin M2 (CNNM2)

(2012) Jeroen H. F. de Baaij et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mutations in kelch-like 3 and cullin 3 cause hypertension and electrolyte abnormalities

(2012) Lynn M. Boyden et al.   NATURE

KLHL3 mutations cause familial hyperkalemic hypertension by impairing ion transport in the distal nephron

(2012) Hélène Louis-Dit-Picard et al.   NATURE GENETICS

Aldosterone does not require angiotensin II to activate NCC through a WNK4–SPAK–dependent pathway

(2012) Nils van der Lubbe et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Loss of insulin-induced activation of TRPM6 magnesium channels results in impaired glucose tolerance during pregnancy

(2012) A. V. Nair et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CNNM2, Encoding a Basolateral Protein Required for Renal Mg2+ Handling, Is Mutated in Dominant Hypomagnesemia

(2011) Marchel Stuiver et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Human gene SLC41A1 encodes for the Na+/Mg2+ exchanger

(2011) Martin Kolisek et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Cellular magnesium homeostasis

(2011) Andrea M.P. Romani   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

A SPAK Isoform Switch Modulates Renal Salt Transport and Blood Pressure

(2011) James A. McCormick et al.   Cell Metabolism

Dysregulation of renal transient receptor potential melastatin 6/7 but not paracellin-1 in aldosterone-induced hypertension and kidney damage in a model of hereditary hypomagnesemia

(2011) Alvaro Yogi et al.   JOURNAL OF HYPERTENSION

Nedd4-2 Modulates Renal Na+-Cl- Cotransporter via the Aldosterone-SGK1-Nedd4-2 Pathway

(2011) J. P. Arroyo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Acute Insulin Stimulation Induces Phosphorylation of the Na-Cl Cotransporter in Cultured Distal mpkDCT Cells and Mouse Kidney

(2011) Eisei Sohara et al.   PLoS One

Generation and analysis of the thiazide-sensitive Na+-Cl− cotransporter (Ncc/Slc12a3) Ser707X knockin mouse as a model of Gitelman syndrome

(2010) Sung-Sen Yang et al.   HUMAN MUTATION

Methionine Sulfoxide Reductase B1 (MsrB1) Recovers TRPM6 Channel Activity during Oxidative Stress

(2010) Gang Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling

(2010) H. Dimke et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mechanisms of Type I and Type II Pseudohypoaldosteronism

(2010) S. B. Furgeson et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

SPAK-Knockout Mice Manifest Gitelman Syndrome and Impaired Vasoconstriction

(2010) S.-S. Yang et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Molecular Basis of Decreased Kir4.1 Function in SeSAME/EAST Syndrome

(2010) D. M. Williams et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Angiotensin II diminishes the effect of SGK1 on the WNK4-mediated inhibition of ROMK1 channels

(2010) Peng Yue et al.   KIDNEY INTERNATIONAL

Posttransplantation Hypomagnesemia and Its Relation with Immunosuppression as Predictors of New-Onset Diabetes after Transplantation

(2009) S. Van Laecke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

ATP and magnesium drive conformational changes of the Na+/K+-ATPase cytoplasmic headpiece

(2009) Lenka Grycova et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Functional Analysis of the Kv1.1 N255D Mutation Associated with Autosomal Dominant Hypomagnesemia

(2009) Jenny van der Wijst et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of the Epithelial Mg2+Channel TRPM6 by Estrogen and the Associated Repressor Protein of Estrogen Receptor Activity (REA)

(2009) Gang Cao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A missense mutation in the Kv1.1 voltage-gated potassium channel–encoding gene KCNA1 is linked to human autosomal dominant hypomagnesemia

(2009) Bob Glaudemans et al.   JOURNAL OF CLINICAL INVESTIGATION

Epilepsy, Ataxia, Sensorineural Deafness, Tubulopathy, andKCNJ10Mutations

(2009) Detlef Bockenhauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10

(2009) U. I. Scholl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Downregulation of Renal TRPM7 and Increased Inflammation and Fibrosis in Aldosterone-Infused Mice

(2008) Bruno Sontia et al.   HYPERTENSION

SLC41A1 Is a Novel Mammalian Mg2+Carrier

(2008) Martin Kolisek et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Activation of the thiazide-sensitive Na+-Cl- cotransporter by the WNK-regulated kinases SPAK and OSR1

(2008) C. Richardson et al.   JOURNAL OF CELL SCIENCE

EGF Increases TRPM6 Activity and Surface Expression

(2008) S. Thebault et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Dietary salt regulates the phosphorylation of OSR1/SPAK kinases and the sodium chloride cotransporter through aldosterone

(2008) Motoko Chiga et al.   KIDNEY INTERNATIONAL

Gitelman syndrome

(2008) Nine V.A.M. Knoers et al.   Orphanet Journal of Rare Diseases