mTORC2 regulates renal tubule sodium uptake by promoting ENaC activity

mTORC1 maintains renal tubular homeostasis and is essential in response to ischemic stress

(2014) Florian Grahammer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated SGK1 predicts resistance of breast cancer cells to Akt inhibitors

(2013) Eeva M. Sommer et al.   BIOCHEMICAL JOURNAL

AGC protein kinases: From structural mechanism of regulation to allosteric drug development for the treatment of human diseases

(2013) José M. Arencibia et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Hepatic mTORC2 Activates Glycolysis and Lipogenesis through Akt, Glucokinase, and SREBP1c

(2012) Asami Hagiwara et al.   Cell Metabolism

SGK regulation of renal sodium transport

(2012) Alan C. Pao   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Epithelial Na+ channel regulation by cytoplasmic and extracellular factors

(2012) Ossama B. Kashlan et al.   EXPERIMENTAL CELL RESEARCH

Regulation of ion channels by the serum- and glucocorticoid-inducible kinase SGK1

(2012) Florian Lang et al.   FASEB JOURNAL

Significant Reduction of ATP Production in PHA-Activated CD4+ Cells in 1-Day-Old Blood from Transplant Patients

(2012) Elina Suviolahti et al.   TRANSPLANTATION

mSIN1 Protein Mediates SGK1 Protein Interaction with mTORC2 Protein Complex and Is Required for Selective Activation of the Epithelial Sodium Channel

(2011) Ming Lu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nedd4-2 Modulates Renal Na+-Cl- Cotransporter via the Aldosterone-SGK1-Nedd4-2 Pathway

(2011) J. P. Arroyo et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Epithelial Na+Channel (ENaC), Hormones, and Hypertension

(2010) James K. Bubien   JOURNAL OF BIOLOGICAL CHEMISTRY

mTOR Complex-2 Activates ENaC by Phosphorylating SGK1

(2010) M. Lu et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Hypertension in the Developing World: Challenges and Opportunities

(2009) Bharati V. Mittal et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

AZD8055 Is a Potent, Selective, and Orally Bioavailable ATP-Competitive Mammalian Target of Rapamycin Kinase Inhibitor with In vitro and In vivo Antitumor Activity

(2009) C. M. Chresta et al.   CANCER RESEARCH

mTOR signaling at a glance

(2009) M. Laplante et al.   JOURNAL OF CELL SCIENCE

Responses to Diuretic Treatment in Gene-Targeted Mice Lacking Serum- and Glucocorticoid-Inducible Kinase 1

(2009) Ferruh Artunc et al.   KIDNEY & BLOOD PRESSURE RESEARCH

The nuts and bolts of AGC protein kinases

(2009) Laura R. Pearce et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Regulated sodium transport in the renal connecting tubule (CNT) via the epithelial sodium channel (ENaC)

(2009) Johannes Loffing et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

(2009) Morris E Feldman et al.   PLOS BIOLOGY

mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)

(2008) Juan M. García-Martínez et al.   BIOCHEMICAL JOURNAL

Epithelial Sodium Channel

(2008) Bernard C. Rossier et al.   HYPERTENSION