Genetic and drug-induced hypomagnesemia: different cause, same mechanism

Magnesium and Calcium Homeostasis Depend on KCTD1 Function in the Distal Nephron

(2021) Alexander G. Marneros   Cell Reports

The phenotypic and genetic spectrum of patients with heterozygous mutations in cyclin M2 (CNNM2)

(2021) Gijs A. C. Franken et al.   HUMAN MUTATION

Mechanisms coupling sodium and magnesium reabsorption in the distal convoluted tubule of the kidney

(2020) Gijs A. C. Franken et al.   Acta Physiologica

Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function

(2020) Zhi-Guo Zou et al.   CLINICAL SCIENCE

AP-2β/KCTD1 Control Distal Nephron Differentiation and Protect against Renal Fibrosis

(2020) Alexander G. Marneros   DEVELOPMENTAL CELL

Prevalence and risk factors of long-term proton pump inhibitors-associated hypomagnesemia: a cross-sectional study in hospitalized patients

(2020) Delfina Ana Recart et al.   Internal and Emergency Medicine

Magnesium Absorption in Intestinal Cells: Evidence of Cross-Talk between EGF and TRPM6 and Novel Implications for Cetuximab Therapy

(2020) Giuseppe Pietropaolo et al.   Nutrients

Low gut microbiota diversity and dietary magnesium intake are associated with the development of PPI-induced hypomagnesemia

(2019) Lisanne M. M. Gommers et al.   FASEB JOURNAL

CNNM2 homozygous mutations cause severe refractory hypomagnesemia, epileptic encephalopathy and brain malformations

(2018) Andrea Accogli et al.   European Journal of Medical Genetics

The influence of long-term use of proton pump inhibitors on the gut microbiota: an age-sex-matched case-control study

(2018) Tomohisa Takagi et al.   JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION

Mutations in plasmalemma vesicle-associated protein cause severe syndromic protein-losing enteropathy

(2018) Ilse Julia Broekaert et al.   JOURNAL OF MEDICAL GENETICS

CrossTalk proposal: CNNM proteins are Na+ /Mg2+ exchangers playing a central role in transepithelial Mg2+ (re)absorption

(2018) Yosuke Funato et al.   JOURNAL OF PHYSIOLOGY-LONDON

CrossTalk opposing view: CNNM proteins are not Na+ /Mg2+ exchangers but Mg2+ transport regulators playing a central role in transepithelial Mg2+ (re)absorption

(2018) Francisco J. Arjona et al.   JOURNAL OF PHYSIOLOGY-LONDON

TRPM6 is Essential for Magnesium Uptake and Epithelial Cell Function in the Colon

(2018) Francesca Luongo et al.   Nutrients

Thiazide but not loop diuretics is associated with hypomagnesaemia in the general population

(2018) Brenda C.T. Kieboom et al.   PHARMACOEPIDEMIOLOGY AND DRUG SAFETY

Germline De Novo Mutations in ATP1A1 Cause Renal Hypomagnesemia, Refractory Seizures, and Intellectual Disability

(2018) Karl P. Schlingmann et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Increased NEFA levels reduce blood Mg2+ in hypertriacylglycerolaemic states via direct binding of NEFA to Mg2+

(2018) Steef Kurstjens et al.   DIABETOLOGIA

Constitutively Active SPAK Causes Hyperkalemia by Activating NCC and Remodeling Distal Tubules

(2017) P. Richard Grimm et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Loss of transcriptional activation of the potassium channel Kir5.1 by HNF1β drives autosomal dominant tubulointerstitial kidney disease

(2017) Andreas Kompatscher et al.   KIDNEY INTERNATIONAL

Proton-pump inhibitors: understanding the complications and risks

(2017) Peter Malfertheiner et al.   Nature Reviews Gastroenterology & Hepatology

Adverse kidney effects of epidermal growth factor receptor inhibitors

(2017) Hassan Izzedine et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Common single nucleotide polymorphisms in transient receptor potential melastatin type 6 increase the risk for proton pump inhibitor-induced hypomagnesemia

(2017) Mark W. Hess et al.   Pharmacogenetics and Genomics

TRPM6 and TRPM7 differentially contribute to the relief of heteromeric TRPM6/7 channels from inhibition by cytosolic Mg2+ and Mg·ATP

(2017) Silvia Ferioli et al.   Scientific Reports

Inulin significantly improves serum magnesium levels in proton pump inhibitor-induced hypomagnesaemia

(2016) M. W. Hess et al.   ALIMENTARY PHARMACOLOGY & THERAPEUTICS

Determinants of hypomagnesemia in patients with type 2 diabetes mellitus

(2016) Steef Kurstjens et al.   EUROPEAN JOURNAL OF ENDOCRINOLOGY

Epithelial magnesium transport by TRPM6 is essential for prenatal development and adult survival

(2016) Vladimir Chubanov et al.   eLife

The Calcium-Sensing Receptor and the Parathyroid: Past, Present, Future

(2016) Arthur D. Conigrave   Frontiers in Physiology

Proton Pump Inhibitors and Hypomagnesemia in the General Population: A Population-Based Cohort Study

(2015) Brenda C.T. Kieboom et al.   AMERICAN JOURNAL OF KIDNEY DISEASES

Hypomagnesemia as First Clinical Manifestation of ADTKD-HNF1B: A Case Series and Literature Review

(2015) Cas I. van der Made et al.   AMERICAN JOURNAL OF NEPHROLOGY

Proton Pump Inhibitors Alter Specific Taxa in the Human Gastrointestinal Microbiome: A Crossover Trial

(2015) Daniel E. Freedberg et al.   GASTROENTEROLOGY

EGFR-TKI, Erlotinib, Causes Hypomagnesemia, Oxidative Stress, and Cardiac Dysfunction

(2015) I. Tong Mak et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

Recurrent FXYD2 p.Gly41Arg mutation in patients with isolated dominant hypomagnesaemia

(2015) J. H. F. de Baaij et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Magnesium in Man: Implications for Health and Disease

(2015) Jeroen H. F. de Baaij et al.   PHYSIOLOGICAL REVIEWS

Influence of Proton-Pump Inhibitors on the Luminal Microbiota in the Gastrointestinal Tract

(2015) Ayumi Tsuda et al.   Clinical and Translational Gastroenterology

Calcium-sensing receptor 20 years later

(2014) Tariq I. Alfadda et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Mechanisms and Regulation of Renal Magnesium Transport

(2014) Pascal Houillier   Annual Review of Physiology

Mg2+-dependent Interactions of ATP with the Cystathionine-β-Synthase (CBS) Domains of a Magnesium Transporter

(2014) Yusuke Hirata et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Epithelial Inflammation Resulting from an Inherited Loss-of-Function Mutation in EGFR

(2014) Patrick Campbell et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

The Effect of WNK4 on the Na+-Cl- Cotransporter Is Modulated by Intracellular Chloride

(2014) S. Bazua-Valenti et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proton-pump inhibitor use is associated with lower urinary magnesium excretion

(2014) Jeffrey H. William et al.   NEPHROLOGY

KCNJ10 determines the expression of the apical Na-Cl cotransporter (NCC) in the early distal convoluted tubule (DCT1)

(2014) C. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Chloride Sensing by WNK1 Involves Inhibition of Autophosphorylation

(2014) A. T. Piala et al.   Science Signaling

CNNM2 Mutations Cause Impaired Brain Development and Seizures in Patients with Hypomagnesemia

(2014) Francisco J. Arjona et al.   PLoS Genetics

Proton Pump Inhibitors and Hospitalization with Hypomagnesemia: A Population-Based Case-Control Study

(2014) Jonathan Zipursky et al.   PLOS MEDICINE

Hypomagnesaemia associated with long-term use of proton pump inhibitors

(2014) James Wei Tatt Toh et al.   Gastroenterology Report

Mother-to-daughter transmission of Kenny-Caffey syndrome associated with the recurrent, dominantFAM111Amutation p.Arg569His

(2013) S.M. Nikkel et al.   CLINICAL GENETICS

A recurrent de novoFAM111Amutation causes kenny-caffey syndrome type 2

(2013) Tsuyoshi Isojima et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Functional Activities of Mutant Calcium-Sensing Receptors Determine Clinical Presentations in Patients With Autosomal Dominant Hypocalcemia

(2013) Yuka Kinoshita et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Mutations in PCBD1 Cause Hypomagnesemia and Renal Magnesium Wasting

(2013) S. Ferre et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Proton-pump inhibitor use is associated with low serum magnesium concentrations

(2013) John Danziger et al.   KIDNEY INTERNATIONAL

The quest to overcome resistance to EGFR-targeted therapies in cancer

(2013) Curtis R Chong et al.   NATURE MEDICINE

Magnesium loss in cyclosporine-treated patients is related to renal epidermal growth factor downregulation

(2013) K. J. Ledeganck et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Inulin modifies the bifidobacteria population, fecal lactate concentration, and fecal pH but does not influence iron absorption in women with low iron status

(2012) Nicolai Petry et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Claudin-14 regulates renal Ca++transport in response to CaSR signalling via a novel microRNA pathway

(2012) Yongfeng Gong et al.   EMBO JOURNAL

Transient receptor potential melastatin-related 7 channel is overexpressed in human pancreatic ductal adenocarcinomas and regulates human pancreatic cancer cell migration

(2012) Pierre Rybarczyk et al.   INTERNATIONAL JOURNAL OF CANCER

Deficiency of the Calcium-Sensing Receptor in the Kidney Causes Parathyroid Hormone-Independent Hypocalciuria

(2012) H. R. Toka et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Mutations in the Mitochondrial Seryl-tRNA Synthetase Cause Hyperuricemia, Pulmonary Hypertension, Renal Failure in Infancy and Alkalosis, HUPRA Syndrome

(2011) Ruth Belostotsky et al.   AMERICAN JOURNAL OF HUMAN GENETICS

CNNM2, Encoding a Basolateral Protein Required for Renal Mg2+ Handling, Is Mutated in Dominant Hypomagnesemia

(2011) Marchel Stuiver et al.   AMERICAN JOURNAL OF HUMAN GENETICS

EGF enhances the migration of cancer cells by up-regulation of TRPM7

(2011) Haixia Gao et al.   CELL CALCIUM

The Mg2+transporter MagT1 partially rescues cell growth and Mg2+uptake in cells lacking the channel-kinase TRPM7

(2011) Francina Deason-Towne et al.   FEBS LETTERS

Novel DNA mutation in the GATA3 gene in an Emirati boy with HDR syndrome and hypomagnesemia

(2011) Amar Al-Shibli et al.   PEDIATRIC NEPHROLOGY

The salt-wasting phenotype of EAST syndrome, a disease with multifaceted symptoms linked to the KCNJ10 K+ channel

(2011) Sascha Bandulik et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

HNF-1B specifically regulates the transcription of the γa-subunit of the Na+/K+-ATPase

(2010) Silvia Ferrè et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

TRPM7 regulates quiescent/proliferative metabolic transitions in lymphocytes

(2010) Jaya Sahni et al.   CELL CYCLE

Transient receptor potential ion channel Trpm7 regulates exocrine pancreatic epithelial proliferation by Mg2+-sensitive Socs3a signaling in development and cancer

(2010) N. S. Yee et al.   Disease Models & Mechanisms

Effects of the EGFR Inhibitor Erlotinib on Magnesium Handling

(2010) H. Dimke et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Posttransplantation Hypomagnesemia and Its Relation with Immunosuppression as Predictors of New-Onset Diabetes after Transplantation

(2009) S. Van Laecke et al.   AMERICAN JOURNAL OF TRANSPLANTATION

Calcineurin Inhibitor Nephrotoxicity

(2009) M. Naesens et al.   Clinical Journal of the American Society of Nephrology

HNF1B Mutations Associate with Hypomagnesemia and Renal Magnesium Wasting

(2009) S. Adalat et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

FATAL CONGENITAL MYOPATHY AND GASTROINTESTINAL PSEUDO-OBSTRUCTION DUE TO POLG1 MUTATIONS

(2009) C. Giordano et al.   NEUROLOGY

Epilepsy, Ataxia, Sensorineural Deafness, Tubulopathy, andKCNJ10Mutations

(2009) Detlef Bockenhauer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Seizures, sensorineural deafness, ataxia, mental retardation, and electrolyte imbalance (SeSAME syndrome) caused by mutations in KCNJ10

(2009) U. I. Scholl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impact of Cyclosporine A on Magnesium Homeostasis: Clinical Observation in Lung Transplant Recipients and Experimental Study in Mice

(2009) Fadi Sabbagh et al.   TRANSPLANTATION

Severe hypomagnesaemia in long-term users of proton-pump inhibitors

(2008) T. Cundy et al.   CLINICAL ENDOCRINOLOGY

EGF Increases TRPM6 Activity and Surface Expression

(2008) S. Thebault et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Cisplatin nephrotoxicity: Mechanisms and renoprotective strategies

(2008) N. Pabla et al.   KIDNEY INTERNATIONAL

Gitelman syndrome

(2008) Nine V.A.M. Knoers et al.   Orphanet Journal of Rare Diseases

Thick ascending limb: the Na+:K+:2Cl− co-transporter, NKCC2, and the calcium-sensing receptor, CaSR

(2008) Gerardo Gamba et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY