The Multiple Sclerosis (MS) Genetic Risk Factors Indicate both Acquired and Innate Immune Cell Subsets Contribute to MS Pathogenesis and Identify Novel Therapeutic Opportunities

The autoimmune risk gene ZMIZ1 is a vitamin D responsive marker of a molecular phenotype of multiple sclerosis

(2017) N.L. Fewings et al.   JOURNAL OF AUTOIMMUNITY

B-Cell Depletion — A Frontier in Monoclonal Antibodies for Multiple Sclerosis

(2017) Peter A. Calabresi   NEW ENGLAND JOURNAL OF MEDICINE

Ocrelizumab versus Interferon Beta-1a in Relapsing Multiple Sclerosis

(2017) Stephen L. Hauser et al.   NEW ENGLAND JOURNAL OF MEDICINE

Narrowband UVB Phototherapy for Clinically Isolated Syndrome: A Trial to Deliver the Benefits of Vitamin D and Other UVB-Induced Molecules

(2017) Prue H. Hart et al.   Frontiers in Immunology

The low EOMES/TBX21 molecular phenotype in multiple sclerosis reflects CD56+ cell dysregulation and is affected by immunomodulatory therapies

(2016) Fiona C. McKay et al.   CLINICAL IMMUNOLOGY

Cistromic and genetic evidence that the vitamin D receptor mediates susceptibility to latitude-dependent autoimmune diseases

(2016) D R Booth et al.   GENES AND IMMUNITY

Dimethyl Fumarate Treatment Mediates an Anti-Inflammatory Shift in B Cell Subsets of Patients with Multiple Sclerosis

(2016) Rui Li et al.   JOURNAL OF IMMUNOLOGY

Genetic loci for Epstein-Barr virus nuclear antigen-1 are associated with risk of multiple sclerosis

(2016) Yuan Zhou et al.   Multiple Sclerosis Journal

Interactions between genetic, lifestyle and environmental risk factors for multiple sclerosis

(2016) Tomas Olsson et al.   Nature Reviews Neurology

Identifying Patient-Specific Epstein-Barr Nuclear Antigen-1 Genetic Variation and Potential Autoreactive Targets Relevant to Multiple Sclerosis Pathogenesis

(2016) Monika Tschochner et al.   PLoS One

Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation

(2016) Catharina C. Gross et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Resolving TYK2 locus genotype-to-phenotype differences in autoimmunity

(2016) C. A. Dendrou et al.   Science Translational Medicine

Association of HLA Genetic Risk Burden With Disease Phenotypes in Multiple Sclerosis

(2016) Noriko Isobe et al.   JAMA Neurology

Genetic loci for Epstein-Barr virus nuclear antigen-1 are associated with risk of multiple sclerosis

(2016) Yuan Zhou et al.   Multiple Sclerosis Journal

The Genetic Architecture of the Human Immune System: A Bioresource for Autoimmunity and Disease Pathogenesis

(2015) Mario Roederer et al.   CELL

Variation in the Human Immune System Is Largely Driven by Non-Heritable Influences

(2015) Petter Brodin et al.   CELL

Twin studies in multiple sclerosis: A meta-estimation of heritability and environmentality

(2015) Corrado Fagnani et al.   Multiple Sclerosis Journal

The role of epidemiology in MS research: Past successes, current challenges and future potential

(2015) Steve Simpson et al.   Multiple Sclerosis Journal

Class II HLA interactions modulate genetic risk for multiple sclerosis

(2015) Loukas Moutsianas et al.   NATURE GENETICS

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli

(2015) William J. Housley et al.   Science Translational Medicine

Proinflammatory GM-CSF–producing B cells in multiple sclerosis and B cell depletion therapy

(2015) Rui Li et al.   Science Translational Medicine

Twin studies in multiple sclerosis: A meta-estimation of heritability and environmentality

(2015) Corrado Fagnani et al.   Multiple Sclerosis Journal

The role of epidemiology in MS research: Past successes, current challenges and future potential

(2015) Steve Simpson et al.   Multiple Sclerosis Journal

Leflunomide and teriflunomide: altering the metabolism of pyrimidines for the treatment of autoimmune diseases

(2015) Yara Dadalti Fragoso et al.   Expert Review of Clinical Pharmacology

Peripheral Blood T Cell Dynamics Predict Relapse in Multiple Sclerosis Patients on Fingolimod

(2015) Zi-Ye Song et al.   PLoS One

Modest familial risks for multiple sclerosis: a registry-based study of the population of Sweden

(2014) Helga Westerlind et al.   BRAIN

Mode of action and clinical studies with alemtuzumab

(2014) Joanne L. Jones et al.   EXPERIMENTAL NEUROLOGY

The influence of interleukin-7 receptorα-chain haplotypes on outcome after allogeneic hematopoietic cell transplantation

(2014) B. Broux et al.   International Journal of Immunogenetics

Common Genetic Variants Modulate Pathogen-Sensing Responses in Human Dendritic Cells

(2014) M. N. Lee et al.   SCIENCE

Multiple sclerosis-associated IL2RA polymorphism controls GM-CSF production in human TH cells

(2014) Felix J. Hartmann et al.   Nature Communications

Cost-effectiveness of natalizumab vs fingolimod for the treatment of relapsing-remitting multiple sclerosis: analyses in Sweden

(2014) Ken O’Day et al.   JOURNAL OF MEDICAL ECONOMICS

Immune cells after prolonged Natalizumab therapy: implications for effectiveness and safety

(2013) S. Marousi et al.   ACTA NEUROLOGICA SCANDINAVICA

Genetic Variants Regulating Immune Cell Levels in Health and Disease

(2013) Valeria Orrù et al.   CELL

Genetic burden in multiple sclerosis families

(2013) N Isobe et al.   GENES AND IMMUNITY

The CYP27B1 variant associated with an increased risk of autoimmune disease is underexpressed in tolerizing dendritic cells

(2013) Fernando Shahijanian et al.   HUMAN MOLECULAR GENETICS

Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis

(2013) Ashley H Beecham et al.   NATURE GENETICS

Structural and Dynamical Insights on HLA-DR2 Complexes That Confer Susceptibility to Multiple Sclerosis in Sardinia: A Molecular Dynamics Simulation Study

(2013) Amit Kumar et al.   PLoS One

IL7Rα Expression and Upregulation by IFNβ in Dendritic Cell Subsets Is Haplotype-Dependent

(2013) Fiona C. McKay et al.   PLoS One

Heritability versus the role of the environment in autoimmunity

(2012) Carlo Selmi et al.   JOURNAL OF AUTOIMMUNITY

TNF receptor 1 genetic risk mirrors outcome of anti-TNF therapy in multiple sclerosis

(2012) Adam P. Gregory et al.   NATURE

Tyrosine kinase 2 variant influences T lymphocyte polarization and multiple sclerosis susceptibility

(2011) N. Couturier et al.   BRAIN

Fingolimod for Multiple Sclerosis: Mechanism of Action, Clinical Outcomes, and Future Directions

(2011) Matthias Mehling et al.   Current Neurology and Neuroscience Reports

Genetic risk and a primary role for cell-mediated immune mechanisms in multiple sclerosis

(2011) Stephen Sawcer et al.   NATURE

The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis

(2010) Kaushal S. Gandhi et al.   HUMAN MOLECULAR GENETICS

Biological Determinants of Immune Reconstitution in HIV‐Infected Patients Receiving Antiretroviral Therapy: The Role of Interleukin 7 and Interleukin 7 Receptor α and Microbial Translocation

(2010) Reena Rajasuriar et al.   JOURNAL OF INFECTIOUS DISEASES

Multiple sclerosis

(2008) Alastair Compston et al.   LANCET