Arrest in the Progression of Type 1 Diabetes at the Mid-Stage of Insulitic Autoimmunity Using an Autoantigen-Decorated All-trans Retinoic Acid and Transforming Growth Factor Beta-1 Single Microparticle Formulation

Dual-sized microparticle system generates suppressive dendritic cells, and prevents and reverses type 1 diabetes in the non-obese diabetic mouse

(2019) Jamal S Lewis et al.   ACS Biomaterials-Science & Engineering

Regulatory T cells sense effector T‐cell activation through synchronized JunB expression

(2019) Jingxia Wu et al.   FEBS LETTERS

Nanoparticles Containing an Insulin–ChgA Hybrid Peptide Protect from Transfer of Autoimmune Diabetes by Shifting the Balance between Effector T Cells and Regulatory T Cells

(2019) Braxton L. Jamison et al.   JOURNAL OF IMMUNOLOGY

Three Types of Functional Regulatory T Cells Control T Cell Responses at the Human Maternal-Fetal Interface

(2019) Maria Salvany-Celades et al.   Cell Reports

Neutrophils and type 1 diabetes

(2019) Manuela Battaglia et al.   Current Opinion in Endocrinology Diabetes and Obesity

Introducing the Endotype Concept to Address the Challenge of Disease Heterogeneity in Type 1 Diabetes

(2019) Manuela Battaglia et al.   DIABETES CARE

Orally delivered all-trans-retinoic acid- and transforming growth factor-β-loaded microparticles ameliorate type 1 diabetes in mice

(2019) Ivan Koprivica et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

The Role of NOD Mice in Type 1 Diabetes Research: Lessons from the Past and Recommendations for the Future

(2018) Yi-Guang Chen et al.   Frontiers in Endocrinology

Therapies to Suppress β Cell Autoimmunity in Type 1 Diabetes

(2018) Charles J. Kroger et al.   Frontiers in Immunology

Transforming Growth Factor-β Signaling in Regulatory T Cells Controls T Helper-17 Cells and Tissue-Specific Immune Responses

(2017) Joanne E. Konkel et al.   IMMUNITY

Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance

(2017) Robert Kuo et al.   MOLECULAR THERAPY

An antigen-encapsulating nanoparticle platform for TH1/17 immune tolerance therapy

(2017) Derrick P. McCarthy et al.   Nanomedicine-Nanotechnology Biology and Medicine

Foxp3-independent mechanism by which TGF-β controls peripheral T cell tolerance

(2017) Soyoung A. Oh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune Tolerance for Autoimmune Disease and Cell Transplantation

(2016) Xunrong Luo et al.   Annual Review of Biomedical Engineering

Antithymocyte Globulin Plus G-CSF Combination Therapy Leads to Sustained Immunomodulatory and Metabolic Effects in a Subset of Responders With Established Type 1 Diabetes

(2016) Michael J. Haller et al.   DIABETES

The importance of the Non Obese Diabetic (NOD) mouse model in autoimmune diabetes

(2016) James A. Pearson et al.   JOURNAL OF AUTOIMMUNITY

TGF-β–Induced Regulatory T Cells Directly Suppress B Cell Responses through a Noncytotoxic Mechanism

(2016) Anping Xu et al.   JOURNAL OF IMMUNOLOGY

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

(2016) Achille Broggi et al.   Jove-Journal of Visualized Experiments

Paracrine co-delivery of TGF-β and IL-2 using CD4-targeted nanoparticles for induction and maintenance of regulatory T cells

(2015) Michael D. McHugh et al.   BIOMATERIALS

A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice

(2015) Jamal S. Lewis et al.   CLINICAL IMMUNOLOGY

Cellular and molecular targeting for nanotherapeutics in transplantation tolerance

(2015) Kelan A. Hlavaty et al.   CLINICAL IMMUNOLOGY

Generation of antigen-specific Foxp3+ regulatory T-cells in vivo following administration of diabetes-reversing tolerogenic microspheres does not require provision of antigen in the formulation

(2015) Carl Engman et al.   CLINICAL IMMUNOLOGY

Abnormalities of the Exocrine Pancreas in Type 1 Diabetes

(2015) Martha Campbell-Thompson et al.   Current Diabetes Reports

The Streetlight Effect in Type 1 Diabetes

(2015) Manuela Battaglia et al.   DIABETES

Staging Presymptomatic Type 1 Diabetes: A Scientific Statement of JDRF, the Endocrine Society, and the American Diabetes Association

(2015) Richard A. Insel et al.   DIABETES CARE

Thinking bedside at the bench: the NOD mouse model of T1DM

(2015) James C. Reed et al.   Nature Reviews Endocrinology

Type 1 diabetes immunotherapy using polyclonal regulatory T cells

(2015) Jeffrey A. Bluestone et al.   Science Translational Medicine

A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice

(2015) Young Mee Yoon et al.   Scientific Reports

The Environment of Regulatory T Cell Biology: Cytokines, Metabolites, and the Microbiome

(2015) Romy E. Hoeppli et al.   Frontiers in Immunology

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Therapy of type 1 diabetes with CD4+CD25highCD127-regulatory T cells prolongs survival of pancreatic islets — Results of one year follow-up

(2014) Natalia Marek-Trzonkowska et al.   CLINICAL IMMUNOLOGY

Control of tissue-localized immune responses by human regulatory T cells

(2014) Anne M. Pesenacker et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Treg functional stability and its responsiveness to the microenvironment

(2014) Joseph Barbi et al.   IMMUNOLOGICAL REVIEWS

Anti-thymocyte globulin/G-CSF treatment preserves β cell function in patients with established type 1 diabetes

(2014) Michael J. Haller et al.   JOURNAL OF CLINICAL INVESTIGATION

Real-time immune cell interactions in target tissue during autoimmune-induced damage and graft tolerance

(2014) Jason Miska et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Retinoic Acid Increases Foxp3+ Regulatory T Cells and Inhibits Development of Th17 Cells by Enhancing TGF- -Driven Smad3 Signaling and Inhibiting IL-6 and IL-23 Receptor Expression

(2014) S. Xiao et al.   JOURNAL OF IMMUNOLOGY

Involvement of Suppressive B-Lymphocytes in the Mechanism of Tolerogenic Dendritic Cell Reversal of Type 1 Diabetes in NOD Mice

(2014) Valentina Di Caro et al.   PLoS One

Retinoic acid-producing,ex vivo-generated human tolerogenic dendritic cells induce the proliferation of immunosuppressive B-lymphocytes

(2013) Valentina Di Caro et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Reduction of Circulating Neutrophils Precedes and Accompanies Type 1 Diabetes

(2013) A. Valle et al.   DIABETES

DEC-205-mediated antigen targeting to steady-state dendritic cells induces deletion of diabetogenic CD8+ T cells independently of PD-1 and PD-L1

(2013) Gayatri Mukherjee et al.   INTERNATIONAL IMMUNOLOGY

Impact of culture medium on CD4+ CD25highCD127lo/neg Treg expansion for the purpose of clinical application

(2013) Karolina Gołąb et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Control of inflammation by integration of environmental cues by regulatory T cells

(2013) Ashutosh Chaudhry et al.   JOURNAL OF CLINICAL INVESTIGATION

PLGA nanoparticles enhance the expression of retinaldehyde dehydrogenase enzymes in dendritic cells and induce FoxP3+ T-cells in vitro

(2013) Chantal Keijzer et al.   JOURNAL OF CONTROLLED RELEASE

Type 1 diabetes

(2013) Mark A Atkinson et al.   LANCET

Clinical application of regulatory T cells in type 1 diabetes

(2013) Natalia Marek-Trzonkowska et al.   PEDIATRIC DIABETES

The Pathogenesis and Natural History of Type 1 Diabetes

(2013) M. A. Atkinson   Cold Spring Harbor Perspectives in Medicine

Combinatorial delivery of immunosuppressive factors to dendritic cells using dual-sized microspheres

(2013) Jamal S. Lewis et al.   Journal of Materials Chemistry B

Autologous Regulatory T Cells for the Treatment of Type 1 Diabetes

(2012) James A. Thompson et al.   Current Diabetes Reports

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Expansion of Th17 Cells and Functional Defects in T Regulatory Cells Are Key Features of the Pancreatic Lymph Nodes in Patients With Type 1 Diabetes

(2011) Alessandra Ferraro et al.   DIABETES

Multifunctional dendritic cell-targeting polymeric microparticles

(2011) Benjamin G. Keselowsky et al.   Human vaccines & immunotherapeutics

The Role of Retinoic Acid in Tolerance and Immunity

(2011) Jason A. Hall et al.   IMMUNITY

Teplizumab for treatment of type 1 diabetes (Protégé study): 1-year results from a randomised, placebo-controlled trial

(2011) Nicole Sherry et al.   LANCET

All-Trans Retinoic Acid Promotes TGF-β-Induced Tregs via Histone Modification but Not DNA Demethylation on Foxp3 Gene Locus

(2011) Ling Lu et al.   PLoS One

TGF-β: the sword, the wand, and the shield of FOXP3+ regulatory T cells

(2011) Dat Q. Tran   Journal of Molecular Cell Biology

A peptide-based material platform for displaying antibodies to engage T cells

(2010) Ying Zheng et al.   BIOMATERIALS

A Short Pulse of IL-4 Delivered by DCs Electroporated With Modified mRNA Can Both Prevent and Treat Autoimmune Diabetes in NOD Mice

(2010) Rémi J Creusot et al.   MOLECULAR THERAPY

Inhibition of Th17 Cells Regulates Autoimmune Diabetes in NOD Mice

(2009) J. A. Emamaullee et al.   DIABETES

Natural and Adaptive Foxp3+ Regulatory T Cells: More of the Same or a Division of Labor?

(2009) Maria A. Curotto de Lafaille et al.   IMMUNITY

C-Peptide Levels and Insulin Independence Following Autologous Nonmyeloablative Hematopoietic Stem Cell Transplantation in Newly Diagnosed Type 1 Diabetes Mellitus

(2009) Carlos E. B. Couri   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Characterization of Nickel-Decorated PLGA Particles Anchored with a His-tagged Polycation

(2009) Jeffrey R. Kovacs et al.   JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION

The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

(2009) K. Yanaba et al.   JOURNAL OF IMMUNOLOGY

All-trans retinoic acid down-regulates inflammatory responses by shifting the Treg/Th17 profile in human ulcerative and murine colitis

(2009) Aiping Bai et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Retinoids differentially regulate the progression of autoimmune diabetes in three preclinical models in mice

(2009) Stanislava Stošić-Grujičić et al.   MOLECULAR IMMUNOLOGY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

Rituximab, B-Lymphocyte Depletion, and Preservation of Beta-Cell Function

(2009) Mark D. Pescovitz et al.   NEW ENGLAND JOURNAL OF MEDICINE

A Microsphere-Based Vaccine Prevents and Reverses New-Onset Autoimmune Diabetes

(2008) B. Phillips et al.   DIABETES

A Regulatory B Cell Subset with a Unique CD1dhiCD5+ Phenotype Controls T Cell-Dependent Inflammatory Responses

(2008) Koichi Yanaba et al.   IMMUNITY

Regulatory B cells as inhibitors of immune responses and inflammation

(2008) Jean-David Bouaziz et al.   IMMUNOLOGICAL REVIEWS

Innocuous IFNγ induced by adjuvant-free antigen restores normoglycemia in NOD mice through inhibition of IL-17 production

(2008) Renu Jain et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Selective delivery of   cell antigen to dendritic cells in vivo leads to deletion and tolerance of autoreactive CD8+ T cells in NOD mice

(2008) A. Mukhopadhaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Expansion of Foxp3-expressing regulatory T cells in vitro by dendritic cells modified with polymeric particles carrying a plasmid encoding interleukin-10

(2007) Liang Jia et al.   BIOMATERIALS