Modulating lung immune cells by pulmonary delivery of antigen-specific nanoparticles to treat autoimmune disease

Antigen-specific therapeutic approaches for autoimmunity

(2019) Pau Serra et al.   NATURE BIOTECHNOLOGY

Design of biodegradable nanoparticles to modulate phenotypes of antigen-presenting cells for antigen-specific treatment of autoimmune disease

(2019) Eiji Saito et al.   BIOMATERIALS

Pulmonary Administration of Soluble Antigen Arrays Is Superior to Antigen in Treatment of Experimental Autoimmune Encephalomyelitis

(2017) Christopher Kuehl et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance

(2017) Robert Kuo et al.   MOLECULAR THERAPY

Interaction of biomedical nanoparticles with the pulmonary immune system

(2017) Fabian Blank et al.   JOURNAL OF NANOBIOTECHNOLOGY

The formulation of nanomedicines for treating tuberculosis

(2016) Ana Costa et al.   ADVANCED DRUG DELIVERY REVIEWS

Lung inflammation stalls Th17-cell migrationen routeto the central nervous system during the development of experimental autoimmune encephalomyelitis

(2016) Masashi Kanayama et al.   INTERNATIONAL IMMUNOLOGY

Nanoparticle surface charge impacts distribution, uptake and lymph node trafficking by pulmonary antigen-presenting cells

(2016) Catherine A. Fromen et al.   Nanomedicine-Nanotechnology Biology and Medicine

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

(2016) Lisa H. Tostanoski et al.   Cell Reports

Tolerogenic nanoparticles inhibit T cell–mediated autoimmunity through SOCS2

(2016) Ada Yeste et al.   Science Signaling

Nano- and micro-based inhaled drug delivery systems for targeting alveolar macrophages

(2015) Wing-Hin Lee et al.   Expert Opinion on Drug Delivery

Nanotechnology approaches for inhalation treatment of lung diseases

(2015) Andriy Kuzmov et al.   JOURNAL OF CONTROLLED RELEASE

Comparedin vivotoxicity in mice of lung delivered biodegradable and non-biodegradable nanoparticles

(2015) Letícia Aragao-Santiago et al.   Nanotoxicology

Principles of nanoparticle design for overcoming biological barriers to drug delivery

(2015) Elvin Blanco et al.   NATURE BIOTECHNOLOGY

Multiple sclerosis—a quiet revolution

(2015) Richard M. Ransohoff et al.   Nature Reviews Neurology

Harnessing nanoparticles for immune modulation

(2015) Daniel R. Getts et al.   TRENDS IN IMMUNOLOGY

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Delivery strategies for sustained drug release in the lungs

(2014) Cristina Loira-Pastoriza et al.   ADVANCED DRUG DELIVERY REVIEWS

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Alveolar Macrophages Contribute to Respiratory Tolerance by Inducing FoxP3 Expression in Naive T Cells

(2013) Michelle M. Coleman et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Distribution and deposition of respirable PLGA microspheres in lung alveoli

(2013) Keiji Hirota et al.   COLLOIDS AND SURFACES B-BIOINTERFACES

Generation of Effector Memory T Cell-Based Mucosal and Systemic Immunity with Pulmonary Nanoparticle Vaccination

(2013) A. V. Li et al.   Science Translational Medicine

Doxorubicin-loaded highly porous large PLGA microparticles as a sustained- release inhalation system for the treatment of metastatic lung cancer

(2012) Insoo Kim et al.   BIOMATERIALS

Airway delivery of peptides and proteins using nanoparticles

(2012) Christophe Y. Dombu et al.   BIOMATERIALS

PLGA-based nanoparticles: An overview of biomedical applications

(2012) Fabienne Danhier et al.   JOURNAL OF CONTROLLED RELEASE

T cells become licensed in the lung to enter the central nervous system

(2012) Francesca Odoardi et al.   NATURE

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

(2012) A. Yeste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

IL-17- and IFN- -Secreting Foxp3+ T Cells Infiltrate the Target Tissue in Experimental Autoimmunity

(2010) M. Esposito et al.   JOURNAL OF IMMUNOLOGY

Delivery of rifampicin–PLGA microspheres into alveolar macrophages is promising for treatment of tuberculosis

(2009) Keiji Hirota et al.   JOURNAL OF CONTROLLED RELEASE

Alveolar Macrophages Transport Pathogens to Lung Draining Lymph Nodes

(2009) A. C. Kirby et al.   JOURNAL OF IMMUNOLOGY

Intracellular Time Course, Pharmacokinetics, and Biodistribution of Isoniazid and Rifabutin following Pulmonary Delivery of Inhalable Microparticles to Mice

(2008) R. K. Verma et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Intense immunosuppression in patients with rapidly worsening multiple sclerosis: treatment guidelines for the clinician

(2008) Aaron Boster et al.   LANCET NEUROLOGY