PEGylation enables subcutaneously administered nanoparticles to induce antigen-specific immune tolerance

Natural IgM dominates in vivo performance of liposomes

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Regulatory T Cells Induced by Single-Peptide Liposome Immunotherapy Suppress Islet-Specific T Cell Responses to Multiple Antigens and Protect from Autoimmune Diabetes

(2020) Anne-Sophie Bergot et al.   JOURNAL OF IMMUNOLOGY

Engineering long-circulating nanomaterial delivery systems

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Exploiting PLGA-Based Biocompatible Nanoparticles for Next-Generation Tolerogenic Vaccines against Autoimmune Disease

(2019) Giuseppe Cappellano et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dual-sized microparticle system generates suppressive dendritic cells, and prevents and reverses type 1 diabetes in the non-obese diabetic mouse

(2019) Jamal S Lewis et al.   ACS Biomaterials-Science & Engineering

Regulation of T cell expansion by antigen presentation dynamics

(2019) Andreas Mayer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

An injectable bone marrow–like scaffold enhances T cell immunity after hematopoietic stem cell transplantation

(2019) Nisarg J. Shah et al.   NATURE BIOTECHNOLOGY

Use of Polymeric Nanoparticle Platform Targeting the Liver To Induce Treg-Mediated Antigen-Specific Immune Tolerance in a Pulmonary Allergen Sensitization Model

(2019) Qi Liu et al.   ACS Nano

Complement therapeutics meets nanomedicine: overcoming human complement activation and leukocyte uptake of nanomedicines with soluble domains of CD55

(2019) Geoffrey Gifford et al.   JOURNAL OF CONTROLLED RELEASE

Macroscale biomaterials strategies for local immunomodulation

(2019) Maxence O. Dellacherie et al.   Nature Reviews Materials

Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes

(2019) D. Scott Wilson et al.   Nature Biomedical Engineering

Design of biodegradable nanoparticles to modulate phenotypes of antigen-presenting cells for antigen-specific treatment of autoimmune disease

(2019) Eiji Saito et al.   BIOMATERIALS

Atomic force microscopy measurements of anionic liposomes reveal the effect of liposomal rigidity on antigen-specific regulatory T cell responses

(2019) Naomi Benne et al.   JOURNAL OF CONTROLLED RELEASE

Cell membrane coating for reducing nanoparticle-induced inflammatory responses to scaffold constructs

(2018) Zhiyuan Fan et al.   Nano Research

Mechanisms of Tolerance Induction by Dendritic Cells In Vivo

(2018) Hitoshi Hasegawa et al.   Frontiers in Immunology

Dense and Dynamic Polyethylene Glycol Shells Cloak Nanoparticles from Uptake by Liver Endothelial Cells for Long Blood Circulation

(2018) Hao Zhou et al.   ACS Nano

Interferon-α Up-Regulates the Expression of PD-L1 Molecules on Immune Cells Through STAT3 and p38 Signaling

(2018) Alexandr V. Bazhin et al.   Frontiers in Immunology

Co-delivery of autoantigen and dexamethasone in incomplete Freund's adjuvant ameliorates experimental autoimmune encephalomyelitis

(2017) Laura Northrup et al.   JOURNAL OF CONTROLLED RELEASE

Targeted delivery of glucocorticoids to macrophages in a mouse model of multiple sclerosis using inorganic-organic hybrid nanoparticles

(2017) Elena Montes-Cobos et al.   JOURNAL OF CONTROLLED RELEASE

In vivo induction of regulatory T cells promotes allergen tolerance and suppresses allergic contact dermatitis

(2017) Stephen C. Balmert et al.   JOURNAL OF CONTROLLED RELEASE

Antigen-capturing nanoparticles improve the abscopal effect and cancer immunotherapy

(2017) Yuanzeng Min et al.   Nature Nanotechnology

Engineered erythrocytes covalently linked to antigenic peptides can protect against autoimmune disease

(2017) Novalia Pishesha et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tolerance through Education: How Tolerogenic Dendritic Cells Shape Immunity

(2017) Matthias P. Domogalla et al.   Frontiers in Immunology

Design of Polyelectrolyte Multilayers to Promote Immunological Tolerance

(2016) Lisa H. Tostanoski et al.   ACS Nano

PEGylation as a strategy for improving nanoparticle-based drug and gene delivery

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Impact of PEG and PEG- b -PAGE modified PLGA on nanoparticle formation, protein loading and release

(2016) René Rietscher et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Expanding antigen-specific regulatory networks to treat autoimmunity

(2016) Xavier Clemente-Casares et al.   NATURE

Improving the efficacy and safety of biologic drugs with tolerogenic nanoparticles

(2016) Takashi K. Kishimoto et al.   Nature Nanotechnology

Complement proteins bind to nanoparticle protein corona and undergo dynamic exchange in vivo

(2016) Fangfang Chen et al.   Nature Nanotechnology

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

(2016) Lisa H. Tostanoski et al.   Cell Reports

Controlled delivery of a metabolic modulator promotes regulatory T cells and restrains autoimmunity

(2015) Joshua M. Gammon et al.   JOURNAL OF CONTROLLED RELEASE

Nanoparticle-based autoantigen delivery to Treg-inducing liver sinusoidal endothelial cells enables control of autoimmunity in mice

(2015) Antonella Carambia et al.   JOURNAL OF HEPATOLOGY

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Treatment of Experimental Autoimmune Encephalomyelitis by Codelivery of Disease Associated Peptide and Dexamethasone in Acetalated Dextran Microparticles

(2014) Kevin J. Peine et al.   MOLECULAR PHARMACEUTICS

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcutaneous inverse vaccination with PLGA particles loaded with a MOG peptide and IL-10 decreases the severity of experimental autoimmune encephalomyelitis

(2014) Giuseppe Cappellano et al.   VACCINE

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Gene-expression profiles and transcriptional regulatory pathways that underlie the identity and diversity of mouse tissue macrophages

(2012) Emmanuel L Gautier et al.   NATURE IMMUNOLOGY

Biomolecular coronas provide the biological identity of nanosized materials

(2012) Marco P. Monopoli et al.   Nature Nanotechnology

Engineering antigens for in situ erythrocyte binding induces T-cell deletion

(2012) S. Kontos et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

(2012) A. Yeste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treating Human Autoimmunity: Current Practice and Future Prospects

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Antigen-Specific Suppression of Inflammatory Arthritis Using Liposomes

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TLR3-Stimulated Dendritic Cells Up-regulate B7-H1 Expression and Influence the Magnitude of CD8 T Cell Responses to Tumor Vaccination

(2009) V. Pulko et al.   JOURNAL OF IMMUNOLOGY

The role of CD40 and CD154/CD40L in dendritic cells

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Induction and effector functions of TH17 cells

(2008) Estelle Bettelli et al.   NATURE

Demyelination arrest and remyelination induced by glatiramer acetate treatment of experimental autoimmune encephalomyelitis

(2008) R. Aharoni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antigen kinetics determines immune reactivity

(2008) Pål Johansen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA