Biophysical Properties of Self-Assembled Immune Signals Impact Signal Processing and the Nature of Regulatory Immune Function

Peptide–TLR-7/8a conjugate vaccines chemically programmed for nanoparticle self-assembly enhance CD8 T-cell immunity to tumor antigens

(2020) Geoffrey M. Lynn et al.   NATURE BIOTECHNOLOGY

Enabling sublingual peptide immunization with molecular self-assemblies

(2020) Sean H. Kelly et al.   BIOMATERIALS

Endosomal Organization of CpG Constructs Correlates with Enhanced Immune Activation

(2020) Kwahun Lee et al.   NANO LETTERS

Self-Assembly as a Molecular Strategy to Improve Immunotherapy

(2020) Eugene Froimchuk et al.   ACCOUNTS OF CHEMICAL RESEARCH

Designing natural and synthetic immune tissues

(2018) Emily A. Gosselin et al.   NATURE MATERIALS

Improving Vaccine and Immunotherapy Design Using Biomaterials

(2018) Michelle L. Bookstaver et al.   TRENDS IN IMMUNOLOGY

Polyplex interaction strength as a driver of potency during cancer immunotherapy

(2018) Shannon J. Tsai et al.   Nano Research

Peptide–MHC-based nanomedicines for autoimmunity function as T-cell receptor microclustering devices

(2017) Santiswarup Singha et al.   Nature Nanotechnology

Bypassing adverse injection reactions to nanoparticles through shape modification and attachment to erythrocytes

(2017) Peter Popp Wibroe et al.   Nature Nanotechnology

Inhibition of Toll-Like Receptor Signaling as a Promising Therapy for Inflammatory Diseases: A Journey from Molecular to Nano Therapeutics

(2017) Wei Gao et al.   Frontiers in Physiology

Major Histocompatibility Complex (MHC) Class I and MHC Class II Proteins: Conformational Plasticity in Antigen Presentation

(2017) Marek Wieczorek et al.   Frontiers in Immunology

Association of Therapy for Autoimmune Disease With Myelodysplastic Syndromes and Acute Myeloid Leukemia

(2017) Natalie Ertz-Archambault et al.   JAMA Oncology

Design of Polyelectrolyte Multilayers to Promote Immunological Tolerance

(2016) Lisa H. Tostanoski et al.   ACS Nano

Switching the Immunogenicity of Peptide Assemblies Using Surface Properties

(2016) Yi Wen et al.   ACS Nano

Shape-Dependent Activation of Cytokine Secretion by Polymer Capsules in Human Monocyte-Derived Macrophages

(2016) Xi Chen et al.   BIOMACROMOLECULES

Shape and size-dependent immune response to antigen-carrying nanoparticles

(2015) Sunny Kumar et al.   JOURNAL OF CONTROLLED RELEASE

Biodegradable Nanoellipsoidal Artificial Antigen Presenting Cells for Antigen Specific T-Cell Activation

(2015) Randall A. Meyer et al.   Small

The study of polyplex formation and stability by time-resolved fluorescence spectroscopy of SYBR Green I-stained DNA

(2014) Cosimo D'Andrea et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Titrating T-Cell Epitopes within Self-Assembled Vaccines Optimizes CD4+ Helper T Cell and Antibody Outputs

(2014) Rebecca R. Pompano et al.   Advanced Healthcare Materials

Toll-Like Receptor Signaling Pathways

(2014) Takumi Kawasaki et al.   Frontiers in Immunology

Particle shape dependence of CD8+ T cell activation by artificial antigen presenting cells

(2013) Joel C. Sunshine et al.   BIOMATERIALS

Regulatory T cell phenotype and function 4 years after GAD-alum treatment in children with type 1 diabetes

(2013) M. Pihl et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Differential Uptake of Nanoparticles and Microparticles by Pulmonary APC Subsets Induces Discrete Immunological Imprints

(2013) C. L. Hardy et al.   JOURNAL OF IMMUNOLOGY

The Different Interactions of Lysine and Arginine Side Chains with Lipid Membranes

(2013) Libo Li et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Engineering synthetic vaccines using cues from natural immunity

(2013) Darrell J. Irvine et al.   NATURE MATERIALS

Gold Nanoparticle Delivery of Modified CpG Stimulates Macrophages and Inhibits Tumor Growth for Enhanced Immunotherapy

(2013) Adam Yuh Lin et al.   PLoS One

Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

(2013) A. Lutterotti et al.   Science Translational Medicine

Self-Assembly of Poly-Adenine-Tailed CpG Oligonucleotide-Gold Nanoparticle Nanoconjugates with Immunostimulatory Activity

(2013) Nan Chen et al.   Small

Engineering Nano- and Microparticles to Tune Immunity

(2012) James J. Moon et al.   ADVANCED MATERIALS

The role of surface charge in cellular uptake and cytotoxicity of medical nanoparticles

(2012) Eleonore Fröhlich   International Journal of Nanomedicine

How the TCR balances sensitivity and specificity for the recognition of self and pathogens

(2012) Gerald P Morris et al.   NATURE IMMUNOLOGY

A Study on the Effect of Surface Lysine to Arginine Mutagenesis on Protein Stability and Structure Using Green Fluorescent Protein

(2012) Sriram Sokalingam et al.   PLoS One

Treating Human Autoimmunity: Current Practice and Future Prospects

(2012) M. D. Rosenblum et al.   Science Translational Medicine

Register shifting of an insulin peptide–MHC complex allows diabetogenic T cells to escape thymic deletion

(2011) James F. Mohan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Strength of TCR-Peptide/MHC Interactions and In Vivo T Cell Responses

(2011) E. Corse et al.   JOURNAL OF IMMUNOLOGY

Targeting Toll-like receptors: Emerging therapeutics for multiple sclerosis management

(2011) M. Gambuzza et al.   JOURNAL OF NEUROIMMUNOLOGY

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

(2011) Diane K Wherrett et al.   LANCET

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Diabetogenic T cells recognize insulin bound to IAg7 in an unexpected, weakly binding register

(2010) B. D. Stadinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

T-cell receptor binding affinities and kinetics: impact on T-cell activity and specificity

(2008) Jennifer D. Stone et al.   IMMUNOLOGY

GAD Treatment and Insulin Secretion in Recent-Onset Type 1 Diabetes

(2008) Johnny Ludvigsson et al.   NEW ENGLAND JOURNAL OF MEDICINE