Exploiting Rational Assembly to Map Distinct Roles of Regulatory Cues during Autoimmune Therapy

MAFG-driven astrocytes promote CNS inflammation

(2020) Michael A. Wheeler et al.   NATURE

Engineered immunological niches to monitor disease activity and treatment efficacy in relapsing multiple sclerosis

(2020) Aaron H. Morris et al.   Nature Communications

Single-cell profiling identifies myeloid cell subsets with distinct fates during neuroinflammation

(2019) Marta Joana Costa Jordão et al.   SCIENCE

The prevalence of MS in the United States

(2019) Mitchell T. Wallin et al.   NEUROLOGY

Antigen-specific therapeutic approaches for autoimmunity

(2019) Pau Serra et al.   NATURE BIOTECHNOLOGY

Depletion of PD-1-positive cells ameliorates autoimmune disease

(2019) Peng Zhao et al.   Nature Biomedical Engineering

Gene expression in oligodendrocytes during remyelination reveals cholesterol homeostasis as a therapeutic target in multiple sclerosis

(2019) Rhonda R. Voskuhl et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Immune tolerance in multiple sclerosis and neuromyelitis optica with peptide-loaded tolerogenic dendritic cells in a phase 1b trial

(2019) Irati Zubizarreta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Material design for lymph node drug delivery

(2019) Alex Schudel et al.   Nature Reviews Materials

Synthetically glycosylated antigens induce antigen-specific tolerance and prevent the onset of diabetes

(2019) D. Scott Wilson et al.   Nature Biomedical Engineering

Pharmacological modulation of nucleic acid sensors — therapeutic potential and persisting obstacles

(2019) Claire Vanpouille-Box et al.   NATURE REVIEWS DRUG DISCOVERY

Metastatic conditioning of myeloid cells at a subcutaneous synthetic niche reflects disease progression and predicts therapeutic outcomes

(2019) Robert S Oakes et al.   CANCER RESEARCH

Caspase-1 inhibition prevents glial inflammasome activation and pyroptosis in models of multiple sclerosis

(2018) Brienne A. McKenzie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phase 2 Trial of Ibudilast in Progressive Multiple Sclerosis

(2018) Robert J. Fox et al.   NEW ENGLAND JOURNAL OF MEDICINE

Evolving concepts in the treatment of relapsing multiple sclerosis

(2017) Giancarlo Comi et al.   LANCET

Peptide-Conjugated Nanoparticles Reduce Positive Co-stimulatory Expression and T Cell Activity to Induce Tolerance

(2017) Robert Kuo et al.   MOLECULAR THERAPY

Controlled Delivery of Single or Multiple Antigens in Tolerogenic Nanoparticles Using Peptide-Polymer Bioconjugates

(2017) Ryan M. Pearson et al.   MOLECULAR THERAPY

Ocrelizumab versus Placebo in Primary Progressive Multiple Sclerosis

(2017) Xavier Montalban et al.   NEW ENGLAND JOURNAL OF MEDICINE

Classifying PML risk with disease modifying therapies

(2017) Joseph R. Berger   Multiple Sclerosis and Related Disorders

Design of Polyelectrolyte Multilayers to Promote Immunological Tolerance

(2016) Lisa H. Tostanoski et al.   ACS Nano

Disease-modifying therapies and infectious risks in multiple sclerosis

(2016) Alexander Winkelmann et al.   Nature Reviews Neurology

Reprogramming the Local Lymph Node Microenvironment Promotes Tolerance that Is Systemic and Antigen Specific

(2016) Lisa H. Tostanoski et al.   Cell Reports

Modular Vaccine Design Using Carrier-Free Capsules Assembled from Polyionic Immune Signals

(2015) Yu-Chieh Chiu et al.   ACS Biomaterials-Science & Engineering

Modular Vaccine Design Using Carrier-Free Capsules Assembled from Polyionic Immune Signals

(2015) Yu-Chieh Chiu et al.   ACS Biomaterials Science & Engineering

The effect of combined IL10 siRNA and CpG ODN as pathogen-mimicking microparticles on Th1/Th2 cytokine balance in dendritic cells and protective immunity against B cell lymphoma

(2014) Pallab Pradhan et al.   BIOMATERIALS

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interferon-dependent IL-10 production by Tregs limits tumor Th17 inflammation

(2013) C. Andrew Stewart et al.   JOURNAL OF CLINICAL INVESTIGATION

Antigen-Specific Tolerance by Autologous Myelin Peptide-Coupled Cells: A Phase 1 Trial in Multiple Sclerosis

(2013) A. Lutterotti et al.   Science Translational Medicine

High doses of CpG oligodeoxynucleotides stimulate a tolerogenic TLR9–TRIF pathway

(2013) Claudia Volpi et al.   Nature Communications

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

Nanoparticle-mediated codelivery of myelin antigen and a tolerogenic small molecule suppresses experimental autoimmune encephalomyelitis

(2012) A. Yeste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tumor vaccine composed of CpG ODN class C and irradiated tumor cells up-regulates the expression of genes characteristic of mature dendritic cells and of memory cells

(2011) Srdjan Novakovic   INTERNATIONAL JOURNAL OF ONCOLOGY

Cytosolic RIG-I–like helicases act as negative regulators of sterile inflammation in the CNS

(2011) Angela Dann et al.   NATURE NEUROSCIENCE

Treatment with a Toll-like receptor inhibitory GpG oligonucleotide delays and attenuates lupus nephritis in NZB/W mice

(2010) Kareem L. Graham et al.   AUTOIMMUNITY

Opportunistic infections and other risks with newer multiple sclerosis therapies

(2009) Joseph R. Berger et al.   ANNALS OF NEUROLOGY

Th1, Th17, and Th9 Effector Cells Induce Experimental Autoimmune Encephalomyelitis with Different Pathological Phenotypes

(2009) A. Jager et al.   JOURNAL OF IMMUNOLOGY

Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE

(2009) Mauricio F Farez et al.   NATURE IMMUNOLOGY

Reversal of axonal loss and disability in a mouse model of progressive multiple sclerosis

(2008) Alexandre S. Basso et al.   JOURNAL OF CLINICAL INVESTIGATION

Intense immunosuppression in patients with rapidly worsening multiple sclerosis: treatment guidelines for the clinician

(2008) Aaron Boster et al.   LANCET NEUROLOGY