Sex differences regulate immune responses in experimental autoimmune encephalomyelitis and multiple sclerosis

Interleukin-17A Serves a Priming Role in Autoimmunity by Recruiting IL-1β-Producing Myeloid Cells that Promote Pathogenic T Cells

(2020) Aoife M. McGinley et al.   IMMUNITY

A population of proinflammatory T cells coexpresses αβ and γδ T cell receptors in mice and humans

(2020) Sarah C. Edwards et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The effect of sex on multiple sclerosis risk and disease progression

(2020) Rhonda R Voskuhl   Multiple Sclerosis Journal

Sex Differences in EAE Reveal Common and Distinct Cellular and Molecular Components

(2020) Jack Wiedrick et al.   CELLULAR IMMUNOLOGY

Sex differences in immune responses that underlie COVID-19 disease outcomes

(2020) Takehiro Takahashi et al.   NATURE

Female and male mouse lung group 2 innate lymphoid cells differ in gene expression profiles and cytokine production

(2019) Laura Mathä et al.   PLoS One

Dimethyl fumarate-induced IL-17low IFN-γlow IL-4+ Th cells protect mice from severe encephalomyelitis

(2018) Jürgen Brück et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Effectiveness and safety of Rituximab in multiple sclerosis: an observational study from Southern Switzerland

(2018) Barbara Scotti et al.   PLoS One

Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

(2018) Imran Mohammad et al.   Science Signaling

Estrogen receptor α contributes to T cell–mediated autoimmune inflammation by promoting T cell activation and proliferation

(2018) Imran Mohammad et al.   Science Signaling

Glucocorticoids, Sex Hormones, and Immunity

(2018) Oxana Bereshchenko et al.   Frontiers in Immunology

The role of B cells in multiple sclerosis: Current and future therapies

(2018) Austin Negron et al.   CELLULAR IMMUNOLOGY

Estrogen Signaling in Bystander Foxp3neg CD4+ T Cells Suppresses Cognate Th17 Differentiation in Trans and Protects from Central Nervous System Autoimmunity

(2018) Laure Garnier et al.   JOURNAL OF IMMUNOLOGY

Androgen signaling negatively controls group 2 innate lymphoid cells

(2017) Sophie Laffont et al.   JOURNAL OF EXPERIMENTAL MEDICINE

TLR7 Signaling Regulates Th17 Cells and Autoimmunity: Novel Potential for Autoimmune Therapy

(2017) Jian Ye et al.   JOURNAL OF IMMUNOLOGY

Glucocorticoid receptor in T cells mediates protection from autoimmunity in pregnancy

(2017) Jan Broder Engler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Testosterone Attenuates Group 2 Innate Lymphoid Cell-Mediated Airway Inflammation

(2017) Jacqueline-Yvonne Cephus et al.   Cell Reports

Sex differences in outcomes of disease-modifying treatments for multiple sclerosis: A systematic review

(2017) Rui Li et al.   Multiple Sclerosis and Related Disorders

Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study

(2016) Eva Havrdová et al.   JOURNAL OF NEUROLOGY

The importance of studying sex differences in disease: The example of multiple sclerosis

(2016) Lisa C. Golden et al.   JOURNAL OF NEUROSCIENCE RESEARCH

IL-12-polarized Th1 cells produce GM-CSF and induce EAE independent of IL-23

(2015) Heather M. Grifka-Walk et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Cutting Edge: c-Kit Signaling Differentially Regulates Type 2 Innate Lymphoid Cell Accumulation and Susceptibility to Central Nervous System Demyelination in Male and Female SJL Mice

(2015) Abigail E. Russi et al.   JOURNAL OF IMMUNOLOGY

Sex Differences in Plasmacytoid Dendritic Cell Levels of IRF5 Drive Higher IFN-  Production in Women

(2015) M. Griesbeck et al.   JOURNAL OF IMMUNOLOGY

Androgen receptor modulates Foxp3 expression in CD4+CD25+Foxp3+ regulatory T-cells

(2015) Magdalena Walecki et al.   MOLECULAR BIOLOGY OF THE CELL

Male Sex Is Independently Associated with Faster Disability Accumulation in Relapse-Onset MS but Not in Primary Progressive MS

(2015) Karen Ann Ribbons et al.   PLoS One

Innate IFN-γ promotes development of experimental autoimmune encephalomyelitis: A role for NK cells and M1 macrophages

(2014) Lara S. Dungan et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GATA binding protein 3+ group 2 innate lymphoid cells are present in cord blood and in higher proportions in male than in female neonates

(2014) Anna Forsberg et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility

(2014) Lillian Cruz-Orengo et al.   JOURNAL OF CLINICAL INVESTIGATION

Cutting Edge: Th1 Cells Facilitate the Entry of Th17 Cells to the Central Nervous System during Experimental Autoimmune Encephalomyelitis

(2014) R. A. O'Connor et al.   JOURNAL OF IMMUNOLOGY

XY sex chromosome complement, compared with XX, in the CNS confers greater neurodegeneration during experimental autoimmune encephalomyelitis

(2014) S. Du et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex differences in a mouse model of multiple sclerosis: neuropathic pain behavior in females but not males and protection from neurological deficits during proestrus

(2014) Elizabeth J Rahn et al.   Biology of Sex Differences

Gender difference in tumor necrosis factor-α production in human neutrophils stimulated by lipopolysaccharide and interferon-γ

(2013) Megumi Aomatsu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Estradiol Promotes Functional Responses in Inflammatory and Steady-State Dendritic Cells through Differential Requirement for Activation Function-1 of Estrogen Receptor  

(2013) C. Seillet et al.   JOURNAL OF IMMUNOLOGY

Targeting estrogen receptor β in microglia and T cells to treat experimental autoimmune encephalomyelitis

(2013) Wan-fu Wu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systems analysis of sex differences reveals an immunosuppressive role for testosterone in the response to influenza vaccination

(2013) D. Furman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sex differences matter in the gut: effect on mucosal immune activation and inflammation

(2013) Sumathi Sankaran-Walters et al.   Biology of Sex Differences

A gender-related action of IFNbeta-therapy was found in multiple sclerosis

(2012) Ida Contasta et al.   Journal of Translational Medicine

Sex Differences in the Response to Viral Infections: TLR8 and TLR9 Ligand Stimulation Induce Higher IL10 Production in Males

(2012) Maria Gabriella Torcia et al.   PLoS One

IL-27 mediates the response to IFN-β therapy in multiple sclerosis patients by inhibiting Th17 cells

(2011) Cheryl M. Sweeney et al.   BRAIN BEHAVIOR AND IMMUNITY

Gender effect on in vitro lymphocyte subset levels of healthy individuals

(2011) Maha Abdullah et al.   CELLULAR IMMUNOLOGY

Beta-interferon for multiple sclerosis

(2011) Richard A. Rudick et al.   EXPERIMENTAL CELL RESEARCH

Progesterone Promotes Differentiation of Human Cord Blood Fetal T Cells into T Regulatory Cells but Suppresses Their Differentiation into Th17 Cells

(2011) J. H. Lee et al.   JOURNAL OF IMMUNOLOGY

Estrogen Receptor   Signaling in T Lymphocytes Is Required for Estradiol-Mediated Inhibition of Th1 and Th17 Cell Differentiation and Protection against Experimental Autoimmune Encephalomyelitis

(2011) K. Lelu et al.   JOURNAL OF IMMUNOLOGY

High nationwide prevalence of multiple sclerosis in Sweden

(2011) C Ahlgren et al.   Multiple Sclerosis Journal

RORγt drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation

(2011) Laura Codarri et al.   NATURE IMMUNOLOGY

T cells in multiple sclerosis and experimental autoimmune encephalomyelitis

(2010) J. M. Fletcher et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

Endogenous estrogens, through estrogen receptor α, constrain autoimmune inflammation in female mice by limiting CD4+ T-cell homing into the CNS

(2010) Karine Lélu et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Loxoribine, a selective Toll-like receptor 7 agonist, induces maturation of human monocyte-derived dendritic cells and stimulates their Th-1- and Th-17-polarizing capability

(2010) Tanja Dzopalic et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

The natural history of secondary progressive multiple sclerosis

(2010) M. Koch et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Sex bias in neuroscience and biomedical research

(2010) Annaliese K. Beery et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Stronger inflammatory/cytotoxic T-cell response in women identified by microarray analysis

(2009) A Hewagama et al.   GENES AND IMMUNITY

Interleukin-1 and IL-23 Induce Innate IL-17 Production from γδ T Cells, Amplifying Th17 Responses and Autoimmunity

(2009) Caroline E. Sutton et al.   IMMUNITY

Human Plasmacytoid Dendritic Cells Support Th17 Cell Effector Function in Response to TLR7 Ligation

(2009) C.-F. Yu et al.   JOURNAL OF IMMUNOLOGY

CD39+Foxp3+ Regulatory T Cells Suppress Pathogenic Th17 Cells and Are Impaired in Multiple Sclerosis

(2009) J. M. Fletcher et al.   JOURNAL OF IMMUNOLOGY

Effect of immigration on multiple sclerosis sex ratio in Canada: the Canadian Collaborative Study

(2009) S-M Orton et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Regulatory T cells exert checks and balances on self tolerance and autoimmunity

(2009) Kajsa Wing et al.   NATURE IMMUNOLOGY

IL17 and IFNγ production by peripheral blood mononuclear cells from clinically isolated syndrome to secondary progressive multiple sclerosis

(2008) Giovanni Frisullo et al.   CYTOKINE

What does the “four core genotypes” mouse model tell us about sex differences in the brain and other tissues?

(2008) Arthur P. Arnold et al.   FRONTIERS IN NEUROENDOCRINOLOGY

Oestrogen modulates experimental autoimmune encephalomyelitis and interleukin-17 production via programmed death 1

(2008) Chunhe Wang et al.   IMMUNOLOGY

A role for sex chromosome complement in the female bias in autoimmune disease

(2008) Deborah L. Smith-Bouvier et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Factors associated with the risk of secondary progression in multiple sclerosis

(2008) M Koch et al.   Multiple Sclerosis Journal

Testosterone Reduces Macrophage Expression in the Mouse of Toll-Like Receptor 4, a Trigger for Inflammation and Innate Immunity

(2007) Jennifer A. Rettew et al.   BIOLOGY OF REPRODUCTION

Sex differences in the recognition of and innate antiviral responses to Seoul virus in Norway rats

(2007) Michele F. Hannah et al.   BRAIN BEHAVIOR AND IMMUNITY