Prevention of Type 1 Diabetes with Acetalated Dextran Microparticles Containing Rapamycin and Pancreatic Peptide P31

Degradation of acetalated dextran can be broadly tuned based on cyclic acetal coverage and molecular weight

(2016) Naihan Chen et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Metabolomics in diabetic complications

(2016) Laura A. Filla et al.   Molecular BioSystems

Towards a commercial process for the manufacture of genetically modified T cells for therapy

(2015) A D Kaiser et al.   CANCER GENE THERAPY

A combination dual-sized microparticle system modulates dendritic cells and prevents type 1 diabetes in prediabetic NOD mice

(2015) Jamal S. Lewis et al.   CLINICAL IMMUNOLOGY

A combination hydrogel microparticle-based vaccine prevents type 1 diabetes in non-obese diabetic mice

(2015) Young Mee Yoon et al.   Scientific Reports

A Biodegradable Nanoparticle Platform for the Induction of Antigen-Specific Immune Tolerance for Treatment of Autoimmune Disease

(2014) Zoe Hunter et al.   ACS Nano

Nanoparticle delivery of donor antigens for transplant tolerance in allogeneic islet transplantation

(2014) Jane Bryant et al.   BIOMATERIALS

Treatment of Experimental Autoimmune Encephalomyelitis by Codelivery of Disease Associated Peptide and Dexamethasone in Acetalated Dextran Microparticles

(2014) Kevin J. Peine et al.   MOLECULAR PHARMACEUTICS

Polymeric synthetic nanoparticles for the induction of antigen-specific immunological tolerance

(2014) Roberto A. Maldonado et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Subcutaneous inverse vaccination with PLGA particles loaded with a MOG peptide and IL-10 decreases the severity of experimental autoimmune encephalomyelitis

(2014) Giuseppe Cappellano et al.   VACCINE

Inflammatory Cytokines Presented from Polymer Matrices Differentially Generate and Activate DCs In Situ

(2013) Omar A. Ali et al.   ADVANCED FUNCTIONAL MATERIALS

PD-1, but Not PD-L1, Expressed by Islet-Reactive CD4 + T Cells Suppresses Infiltration of the Pancreas During Type 1 Diabetes

(2013) Kristen E. Pauken et al.   DIABETES

Synthesis and Characterization of Acetalated Dextran Polymer and Microparticles with Ethanol as a Degradation Product

(2012) Kevin J. Kauffman et al.   ACS Applied Materials & Interfaces

Enhanced stability of horseradish peroxidase encapsulated in acetalated dextran microparticles stored outside cold chain conditions

(2012) Naveen Kanthamneni et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Pathogenesis of NOD diabetes is initiated by reactivity to the insulin B chain 9-23 epitope and involves functional epitope spreading

(2012) Suchitra Prasad et al.   JOURNAL OF AUTOIMMUNITY

Microparticles bearing encephalitogenic peptides induce T-cell tolerance and ameliorate experimental autoimmune encephalomyelitis

(2012) Daniel R Getts et al.   NATURE BIOTECHNOLOGY

IL-10-conditioned dendritic cells prevent autoimmune diabetes in NOD and humanized HLA-DQ8/RIP-B7.1 mice

(2011) Ningwen Tai et al.   CLINICAL IMMUNOLOGY

Prevention of "Humanized" Diabetogenic CD8 T-Cell Responses in HLA-Transgenic NOD Mice by a Multipeptide Coupled-Cell Approach

(2011) M. Niens et al.   DIABETES

Optimization of rapamycin-loaded acetalated dextran microparticles for immunosuppression

(2011) Kevin J. Kauffman et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Antigen-based therapy with glutamic acid decarboxylase (GAD) vaccine in patients with recent-onset type 1 diabetes: a randomised double-blind trial

(2011) Diane K Wherrett et al.   LANCET

PLGA, PLGA-TMC and TMC-TPP Nanoparticles Differentially Modulate the Outcome of Nasal Vaccination by Inducing Tolerance or Enhancing Humoral Immunity

(2011) Chantal Keijzer et al.   PLoS One

MR Contrast in Mouse Lymph Nodes with Subcutaneous Administration of Iron Oxide Particles: Size Dependency

(2011) Yuki MORI et al.   Magnetic Resonance in Medical Sciences

Dendritic cells pulsed with antigen-specific apoptotic bodies prevent experimental type 1 diabetes

(2010) S. Marin-Gallen et al.   CLINICAL AND EXPERIMENTAL IMMUNOLOGY

IL-10/TGF-β-Treated Dendritic Cells, Pulsed with Insulin, Specifically Reduce the Response to Insulin of CD4+ Effector/Memory T Cells from Type 1 Diabetic Individuals

(2010) Honorio Torres-Aguilar et al.   JOURNAL OF CLINICAL IMMUNOLOGY

Treatment of patients with new onset Type 1 diabetes with a single course of anti-CD3 mAb teplizumab preserves insulin production for up to 5 years

(2009) Kevan C. Herold et al.   CLINICAL IMMUNOLOGY

Induction of Treg by monocyte-derived DC modulated by vitamin D3or dexamethasone: Differential role for PD-L1

(2009) Wendy W. J. Unger et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Acetalated dextran is a chemically and biologically tunable material for particulate immunotherapy

(2009) K. E. Broaders et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Microsphere-Based Vaccine Prevents and Reverses New-Onset Autoimmune Diabetes

(2008) B. Phillips et al.   DIABETES

Nanoparticles target distinct dendritic cell populations according to their size

(2008) Vania Manolova et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Acetal-Derivatized Dextran: An Acid-Responsive Biodegradable Material for Therapeutic Applications

(2008) Eric M. Bachelder et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides

(2008) R. Juliano et al.   NUCLEIC ACIDS RESEARCH

Role of Particle Size in Phagocytosis of Polymeric Microspheres

(2008) Julie A. Champion et al.   PHARMACEUTICAL RESEARCH