Therapeutic Importance of Kaempferol in the Treatment of Cancer through the Modulation of Cell Signalling Pathways

Kaempferol Regresses Carcinogenesis through a Molecular Cross Talk Involved in Proliferation, Apoptosis and Inflammation on Human Cervical Cancer Cells, HeLa

(2022) Nazia Afroze et al.   Applied Sciences-Basel

Using green biosynthesized kaempferol-coated sliver nanoparticles to inhibit cancer cells growth: an in vitro study using hepatocellular carcinoma (HepG2)

(2022) Nouf M. Alyami et al.   Cancer Nanotechnology

Kaempferol Reverses Aerobic Glycolysis via miR-339-5p-Mediated PKM Alternative Splicing in Colon Cancer Cells

(2021) Haili Wu et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Formulation and Evaluation of Kaempferol Loaded Nanoparticles against Experimentally Induced Hepatocellular Carcinoma: In Vitro and In Vivo Studies

(2021) Imran Kazmi et al.   Pharmaceutics

Dietary flavonols and risk of Alzheimer dementia

(2020) Thomas M. Holland et al.   NEUROLOGY

The Phenolic compound Kaempferol overcomes 5-fluorouracil resistance in human resistant LS174 colon cancer cells

(2019) Ichrak Riahi-Chebbi et al.   Scientific Reports

Kaempferol: A Key Emphasis to Its Anticancer Potential

(2019) Muhammad Imran et al.   MOLECULES

Fisetin and Quercetin: Promising Flavonoids with Chemopreventive Potential

(2019) Dharambir Kashyap et al.   Biomolecules

Progress in Research on the Role of Flavonoids in Lung Cancer

(2019) Oana Zanoaga et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Dietary Quercetin and Kaempferol: Bioavailability and Potential Cardiovascular-Related Bioactivity in Humans

(2019) Wijdan M. Dabeek et al.   Nutrients

Treatment with Phytoestrogens Reversed Triclosan and Bisphenol A-Induced Anti-Apoptosis in Breast Cancer Cells

(2018) Geum-A Lee et al.   Biomolecules & Therapeutics

Kaempferol-loaded mucoadhesive nanoemulsion for intranasal administration reduces glioma growth in vitro

(2018) Mariana Colombo et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Fisetin: A bioactive phytochemical with potential for cancer prevention and pharmacotherapy

(2018) Dharambir Kashyap et al.   LIFE SCIENCES

Programmed Cell Death, from a Cancer Perspective: An Overview

(2018) Abhay P. Mishra et al.   Molecular Diagnosis & Therapy

Kaempferol Induces G2/M Cell Cycle Arrest via Checkpoint Kinase 2 and Promotes Apoptosis via Death Receptors in Human Ovarian Carcinoma A2780/CP70 Cells

(2018) Ying Gao et al.   MOLECULES

Antiulcer Agents: From Plant Extracts to Phytochemicals in Healing Promotion

(2018) Mehdi Sharifi-Rad et al.   MOLECULES

Selective Cytotoxicity of Luteolin and Kaempferol on Cancerous Hepatocytes Obtained from Rat Model of Hepatocellular Carcinoma: Involvement of ROS-Mediated Mitochondrial Targeting

(2018) Enayatollah Seydi et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Kaempferol suppresses proliferation and induces cell cycle arrest, apoptosis, and DNA damage in breast cancer cells

(2018) Li Zhu et al.   ONCOLOGY RESEARCH

Enhancing the anti-ovarian cancer activity of quercetin using a self-assembling micelle and thermosensitive hydrogel drug delivery system

(2018) Guangya Xu et al.   RSC Advances

A Novel Flavonoid Composition Targets Androgen Receptor Signaling and Inhibits Prostate Cancer Growth in Preclinical Models

(2018) Kenza Mamouni et al.   NEOPLASIA

Kaempferol suppresses proliferation but increases apoptosis and autophagy by up-regulating microRNA-340 in human lung cancer cells

(2018) Xue Han et al.   BIOMEDICINE & PHARMACOTHERAPY

Association between inflammatory potential of diet and risk of lung cancer among smokers in a prospective study in Singapore

(2018) Nitin Shivappa et al.   EUROPEAN JOURNAL OF NUTRITION

Reactive Oxygen Species and p53 Mediated Activation of p38 and Caspases is Critically Involved in Kaempferol Induced Apoptosis in Colorectal Cancer Cells

(2018) Jhin-Baek Choi et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Apigenin: A natural bioactive flavone-type molecule with promising therapeutic function

(2018) Dharambir Kashyap et al.   Journal of Functional Foods

Kaempferol induces autophagic cell death via IRE1-JNK-CHOP pathway and inhibition of G9a in gastric cancer cells

(2018) Tae Woo Kim et al.   Cell Death & Disease

Kaempferol Attenuates ROS-Induced Hemolysis and the Molecular Mechanism of Its Induction of Apoptosis on Bladder Cancer

(2018) Ping Wu et al.   MOLECULES

Chemo-preventive and therapeutic effect of the dietary flavonoid kaempferol: A comprehensive review

(2018) Muhammad Imran et al.   PHYTOTHERAPY RESEARCH

Kaempferol, a phytoestrogen, suppressed triclosan-induced epithelial-mesenchymal transition and metastatic-related behaviors of MCF-7 breast cancer cells

(2017) Geum-A Lee et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Kaempferol Inhibits the Invasion and Migration of Renal Cancer Cells through the Downregulation of AKT and FAK Pathways

(2017) Tung-Wei Hung et al.   International Journal of Medical Sciences

One-Pot Synthesis of Hyperoside by a Three-Enzyme Cascade Using a UDP-Galactose Regeneration System

(2017) Jianjun Pei et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Kaempferol increases apoptosis in human acute promyelocytic leukemia cells and inhibits multidrug resistance genes

(2017) Maliheh Moradzadeh et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

6-Hydroxy-3- O -methyl-kaempferol 6- O -glucopyranoside potentiates the anti-proliferative effect of interferon α/β by promoting activation of the JAK/STAT signaling by inhibiting SOCS3 in hepatocellular carcinoma cells

(2017) Orawan Wonganan et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Low dose of kaempferol suppresses the migration and invasion of triple-negative breast cancer cells by downregulating the activities of RhoA and Rac1

(2017) Shoushan Li et al.   OncoTargets and Therapy

Kaempferol – A dietary anticancer molecule with multiple mechanisms of action: Recent trends and advancements

(2017) Dharambir Kashyap et al.   Journal of Functional Foods

Kaempherol and Luteolin Decrease Claudin-2 Expression Mediated by Inhibition of STAT3 in Lung Adenocarcinoma A549 Cells

(2017) Hiroyuki Sonoki et al.   Nutrients

PGC1α induced by reactive oxygen species contributes to chemoresistance of ovarian cancer cells

(2017) Boyun Kim et al.   Oncotarget

In Vivo Exposure of Kaempferol Is Driven by Phase II Metabolic Enzymes and Efflux Transporters

(2016) Liang Zheng et al.   AAPS Journal

Kaempferol inhibits the growth and metastasis of cholangiocarcinomain vitroandin vivo

(2016) Youyou Qin et al.   ACTA BIOCHIMICA ET BIOPHYSICA SINICA

KAEMPFEROL, A FLAVONOID COMPOUND FROM GYNURA MEDICA INDUCED APOPTOSIS AND GROWTH INHIBITION IN MCF-7 BREAST CANCER CELL

(2016) Xiaofang Yi et al.   African Journal of Traditional Complementary and Alternative Medicines

Protective effects of kaempferol against reactive oxygen species-induced hemolysis and its antiproliferative activity on human cancer cells

(2016) Wenzhen Liao et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Kaempferol Activates G2-Checkpoint of the Cell Cycle Resulting in G2-Arrest and Mitochondria-Dependent Apoptosis in Human Acute Leukemia Jurkat T Cells

(2016) Ki Yun Kim et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Treatment with kaempferol suppresses breast cancer cell growth caused by estrogen and triclosan in cellular and xenograft breast cancer models

(2016) Seung-Hee Kim et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The mechanism of kaempferol induced apoptosis and inhibited proliferation in human cervical cancer SiHa cell: From macro to nano

(2016) Lv-Ying Tu et al.   SCANNING

Cancer prevention and therapy through the modulation of transcription factors by bioactive natural compounds

(2016) Muthu K Shanmugam et al.   SEMINARS IN CANCER BIOLOGY

Kaempferol inhibits cell proliferation and glycolysis in esophagus squamous cell carcinoma via targeting EGFR signaling pathway

(2016) Shihua Yao et al.   TUMOR BIOLOGY

Molecular targets of gambogic acid in cancer: recent trends and advancements

(2016) Dharambir Kashyap et al.   TUMOR BIOLOGY

Kaempferol Inhibits Pancreatic Cancer Cell Growth and Migration through the Blockade of EGFR-Related Pathway In Vitro

(2016) Jungwhoi Lee et al.   PLoS One

Kaempferol Induces DNA Damage and Inhibits DNA Repair Associated Protein Expressions in Human Promyelocytic Leukemia HL-60 Cells

(2015) Lung-Yuan Wu et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Hepatoprotective Effect of Kaempferol Against Alcoholic Liver Injury in Mice

(2015) Meng Wang et al.   AMERICAN JOURNAL OF CHINESE MEDICINE

Challenges and advances in quantum dot fluorescent probes to detect reactive oxygen and nitrogen species: A review

(2015) Oluwasesan Adegoke et al.   ANALYTICA CHIMICA ACTA

Inhibitory effects of kaempferol on the invasion of human breast carcinoma cells by downregulating the expression and activity of matrix metalloproteinase-9

(2015) Chenglin Li et al.   Biochemistry and Cell Biology

Winery by-products: Extraction optimization, phenolic composition and cytotoxic evaluation to act as a new source of scavenging of reactive oxygen species

(2015) Priscilla Siqueira Melo et al.   FOOD CHEMISTRY

Kaempferol enhances the suppressive function of Treg cells by inhibiting FOXP3 phosphorylation

(2015) Fang Lin et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Soy Leaf Extract Containing Kaempferol Glycosides and Pheophorbides Improves Glucose Homeostasis by Enhancing Pancreatic β-Cell Function and Suppressing Hepatic Lipid Accumulation in db/db Mice

(2015) Hua Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Hepatoprotective effects of kaempferol 3-O-rutinoside and kaempferol 3-O-glucoside from Carthamus tinctorius L. on CCl4-induced oxidative liver injury in mice

(2015) Yu Wang et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

Global surveillance of cancer survival 1995–2009: analysis of individual data for 25 676 887 patients from 279 population-based registries in 67 countries (CONCORD-2)

(2015) Claudia Allemani et al.   LANCET

Molecular aspects of metal oxide nanoparticle (MO-NPs) mediated pharmacological effects

(2015) Hardeep Singh Tuli et al.   LIFE SCIENCES

Molecular aspects of melatonin (MLT)-mediated therapeutic effects

(2015) Hardeep Singh Tuli et al.   LIFE SCIENCES

The Dietary Flavonoid Kaempferol Mediates Anti-Inflammatory Responses via the Src, Syk, IRAK1, and IRAK4 Molecular Targets

(2015) Shi Hyoung Kim et al.   MEDIATORS OF INFLAMMATION

Kaempferol inhibits vascular smooth muscle cell migration by modulating BMP-mediated miR-21 expression

(2015) Kwangho Kim et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Anticarcinogenic action of quercetin by downregulation of phosphatidylinositol 3-kinase (PI3K) and protein kinase C (PKC) via induction of p53 in hepatocellular carcinoma (HepG2) cell line

(2015) Akhilendra Kumar Maurya et al.   MOLECULAR BIOLOGY REPORTS

Abstract A07: Decline in the growth of murine T-cell lymphoma via modulation of PI3K signaling pathway: Key role of quercetin and PI-103

(2015) Akhilendra Kumar Maurya et al.   MOLECULAR CANCER THERAPEUTICS

CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States in 2008-2012

(2015) Quinn T. Ostrom et al.   NEURO-ONCOLOGY

The Chemopreventive Effect of the Dietary Compound Kaempferol on the MCF-7 Human Breast Cancer Cell Line Is Dependent on Inhibition of Glucose Cellular Uptake

(2015) Cláudia Azevedo et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Quercetin Regresses Dalton's Lymphoma Growth via Suppression of PI3K/AKT Signaling Leading to Upregulation of p53 and Decrease in Energy Metabolism

(2015) Akhilendra Kumar Maurya et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Natural products induce a G protein-mediated calcium pathway activating p53 in cancer cells

(2015) Paul R. van Ginkel et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Kaempferol Suppresses Transforming Growth Factor-β1–Induced Epithelial-to-Mesenchymal Transition and Migration of A549 Lung Cancer Cells by Inhibiting Akt1-Mediated Phosphorylation of Smad3 at Threonine-179

(2015) Eunji Jo et al.   NEOPLASIA

Kaempferol, a potential cytostatic and cure for inflammatory disorders

(2014) Peramaiyan Rajendran et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

The berry constituents quercetin, kaempferol, and pterostilbene synergistically attenuate reactive oxygen species: Involvement of the Nrf2-ARE signaling pathway

(2014) Constance Lay Lay Saw et al.   FOOD AND CHEMICAL TOXICOLOGY

Mechanisms Underlying Apoptosis-Inducing Effects of Kaempferol in HT-29 Human Colon Cancer Cells

(2014) Hyun Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Microbial pigments as natural color sources: current trends and future perspectives

(2014) Hardeep S. Tuli et al.   JOURNAL OF FOOD SCIENCE AND TECHNOLOGY-MYSORE

Kaempferol suppresses bladder cancer tumor growth by inhibiting cell proliferation and inducing apoptosis

(2014) Qiang Dang et al.   MOLECULAR CARCINOGENESIS

Kaempferol inhibits gastric cancer tumor growth: An in vitro and in vivo study

(2014) HAIBIN SONG et al.   ONCOLOGY REPORTS

Kaempferol induces cell cycle arrest and apoptosis in renal cell carcinoma through EGFR/p38 signaling

(2014) WENBIN SONG et al.   ONCOLOGY REPORTS

Posttranslational regulation of Akt in human cancer

(2014) Chia-Hsin Chan et al.   Cell and Bioscience

Drug Resistance in Cancer: An Overview

(2014) Genevieve Housman et al.   Cancers

Anti-inflammatory properties of kaempferol via its inhibition of aldosterone signaling and aldosterone-induced gene expression

(2013) Zi-Kui Liu et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Kaempferol Promotes Apoptosis in Human Bladder Cancer Cells by Inducing the Tumor Suppressor, PTEN

(2013) Feng Xie et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Kaempferol induces autophagy through AMPK and AKT signaling molecules and causes G2/M arrest via downregulation of CDK1/cyclin B in SK-HEP-1 human hepatic cancer cells

(2013) WEN-WEN HUANG et al.   INTERNATIONAL JOURNAL OF ONCOLOGY

The anti-inflammatory effect of kaempferol on early atherosclerosis in high cholesterol fed rabbits

(2013) Lingxi Kong et al.   Lipids in Health and Disease

Antioxidant RichMorus albaleaf Extract Induces Apoptosis in Human Colon and Breast Cancer Cells by the Downregulation of Nitric Oxide Produced by Inducible Nitric Oxide Synthase

(2013) Mundekkad Deepa et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Kaempferol suppresses cell metastasis via inhibition of the ERK-p38-JNK and AP-1 signaling pathways in U-2 OS human osteosarcoma cells

(2013) HUI-JYE CHEN et al.   ONCOLOGY REPORTS

Kaempferol Reduces Matrix Metalloproteinase-2 Expression by Down-Regulating ERK1/2 and the Activator Protein-1 Signaling Pathways in Oral Cancer Cells

(2013) Chiao-Wen Lin et al.   PLoS One

Flavonoids, a ubiquitous dietary phenolic subclass, exert extensive in vitro anti-invasive and in vivo anti-metastatic activities

(2012) Chia-Jui Weng et al.   CANCER AND METASTASIS REVIEWS

Quercetin abrogates IL-6/STAT3 signaling and inhibits glioblastoma cell line growth and migration

(2012) Jonathan Michaud-Levesque et al.   EXPERIMENTAL CELL RESEARCH

A review of the dietary flavonoid, kaempferol on human health and cancer chemoprevention

(2012) Allen Y. Chen et al.   FOOD CHEMISTRY

The Antioxidant and Anti-inflammatory Effects of Phenolic Compounds Isolated from the Root of Rhodiola sachalinensis A. BOR

(2012) Kang In Choe et al.   MOLECULES

Kaempferol-3-O-rhamnoside isolated from the leaves of Schima wallichii Korth. inhibits MCF-7 breast cancer cell proliferation through activation of the caspase cascade pathway

(2012) AJENG DIANTINI et al.   Oncology Letters

Kaempferol induces apoptosis in ovarian cancer cells through activating p53 in the intrinsic pathway

(2011) Haitao Luo et al.   FOOD CHEMISTRY

Kaempferol inhibits VEGF expression and in vitro angiogenesis through a novel ERK-NFκB-cMyc-p21 pathway

(2011) Haitao Luo et al.   FOOD CHEMISTRY

A Review on the Dietary Flavonoid Kaempferol

(2011) J. M. Calderon-Montano et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

Targeting Cell Signaling and Apoptotic Pathways by Dietary Agents: Role in the Prevention and Treatment of Cancer

(2011) Muthu Shanmugam et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

The dietary flavonoid kaempferol effectively inhibits HIF-1 activity and hepatoma cancer cell viability under hypoxic conditions

(2010) Ilias Mylonis et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Kaempferol inhibits UVB-induced COX-2 expression by suppressing Src kinase activity

(2010) Kyung Mi Lee et al.   BIOCHEMICAL PHARMACOLOGY

Sustained ERK activation is involved in the kaempferol-induced apoptosis of breast cancer cells and is more evident under 3-D culture condition

(2010) Bong-Woo Kim et al.   CANCER BIOLOGY & THERAPY

Kaempferol enhances cisplatin's effect on ovarian cancer cells through promoting apoptosis caused by down regulation of cMyc

(2010) Haitao Luo et al.   Cancer Cell International

Interleukin-6 as a Potential Indicator for Prevention of High-Risk Adenoma Recurrence by Dietary Flavonols in the Polyp Prevention Trial

(2010) G. Bobe et al.   Cancer Prevention Research

The Bioflavonoid Kaempferol Is an Abcg2 Substrate and Inhibits Abcg2-Mediated Quercetin Efflux

(2010) G. An et al.   DRUG METABOLISM AND DISPOSITION

Effect of kaempferol on lipid peroxidation and antioxidant status in 1,2-dimethyl hydrazine induced colorectal carcinoma in rats

(2010) Parthasarathy Nirmala et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Mitigating permeability-mediated risks in drug discovery

(2010) Jianling Wang et al.   Expert Opinion on Drug Metabolism & Toxicology

IL-6 promotion of glioblastoma cell invasion and angiogenesis in U251 and T98G cell lines

(2010) Qinglin Liu et al.   JOURNAL OF NEURO-ONCOLOGY

Simultaneous determination of the flavonoids robinin and kaempferol in human breast cancer cells by liquid chromatography-tandem mass spectrometry

(2010) Lia Tsiklauri et al.   JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS

Kaempferol induced apoptosis via endoplasmic reticulum stress and mitochondria-dependent pathway in human osteosarcoma U-2 OS cells

(2010) Wen-Wen Huang et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Environmental causes of cancer: endocrine disruptors as carcinogens

(2010) Ana M. Soto et al.   Nature Reviews Endocrinology

The emerging mechanisms of isoform-specific PI3K signalling

(2010) Bart Vanhaesebroeck et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Dietary intake of selected flavonols, flavones, and flavonoid-rich foods and risk of cancer in middle-aged and older women

(2009) Lu Wang et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Enhanced bioavailability of etoposide after oral or intravenous administration of etoposide with kaempferol in rats

(2009) Cheng Li et al.   ARCHIVES OF PHARMACAL RESEARCH

Metabolism, oral bioavailability and pharmacokinetics of chemopreventive kaempferol in rats

(2009) Avantika Barve et al.   BIOPHARMACEUTICS & DRUG DISPOSITION

A Molecular Link between AKT Regulation and Chemotherapeutic Response

(2009) Christian C. Dibble et al.   CANCER CELL

A Regulatory Mechanism for RSK2 NH2-Terminal Kinase Activity

(2009) Y.-Y. Cho et al.   CANCER RESEARCH

Structures of New Flavonoids and Benzofuran-Type Stilbene and Degranulation Inhibitors of Rat Basophilic Leukemia Cells from the Brazilian Herbal Medicine Cissus sicyoides

(2009) Fengming Xu et al.   CHEMICAL & PHARMACEUTICAL BULLETIN

Lipid – An emerging platform for oral delivery of drugs with poor bioavailability

(2009) Subhashis Chakraborty et al.   EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS

Downregulation of PLK-1 expression in kaempferol-induced apoptosis of MCF-7 cells

(2009) Gum-Yong Kang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Kaempferol induces apoptosis in two different cell lines via Akt inactivation, Bax and SIRT3 activation, and mitochondrial dysfunction

(2009) Gabriella Marfe et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Targeting the phosphoinositide 3-kinase pathway in cancer

(2009) Pixu Liu et al.   NATURE REVIEWS DRUG DISCOVERY

Kaempferol Inhibits Angiogenesis and VEGF Expression Through Both HIF Dependent and Independent Pathways in Human Ovarian Cancer Cells

(2009) Haitao Luo et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Kaempferol induced the apoptosis via cell cycle arrest in human breast cancer MDA-MB-453 cells

(2009) Eun Jeong Choi et al.   Nutrition Research and Practice

Kaempferol and quercetin, components of Ginkgo biloba extract (EGb 761), induce caspase-3-dependent apoptosis in oral cavity cancer cells

(2009) Ju Wan Kang et al.   PHYTOTHERAPY RESEARCH

Regulation of heme oxygenase-1 expression and MAPK pathways in response to kaempferol and rhamnocitrin in PC12 cells

(2009) Jing-Ting Hong et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Regulation of phosphoinositide 3-kinase expression in health and disease

(2009) Klaartje Kok et al.   TRENDS IN BIOCHEMICAL SCIENCES

A food pattern that is predictive of flavonol intake and risk of pancreatic cancer

(2008) Ute Nöthlings et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Kaempferol sensitizes colon cancer cells to TRAIL-induced apoptosis

(2008) Tatsushi Yoshida et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Flavonoid Intake and Risk of Pancreatic Cancer in Male Smokers (Finland)

(2008) G. Bobe et al.   CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION

Kaempferol-7-O-β-d-glucoside (KG) isolated from Smilax china L. rhizome induces G2/M phase arrest and apoptosis on HeLa cells in a p53-independent manner

(2008) Wen Xu et al.   CANCER LETTERS

Kaempferol induces apoptosis in human HCT116 colon cancer cells via the Ataxia-Telangiectasia Mutated-p53 pathway with the involvement of p53 Upregulated Modulator of Apoptosis

(2008) Wei Li et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Substrates and Inhibitors of Human Multidrug Resistance Associated Proteins and the Implications in Drug Development

(2008) Shu-Feng Zhou et al.   CURRENT MEDICINAL CHEMISTRY

Flavonoid intake and ovarian cancer risk in a population-based case-control study

(2008) Margaret A. Gates et al.   INTERNATIONAL JOURNAL OF CANCER

Quercetin May Suppress Rat Aberrant Crypt Foci Formation by Suppressing Inflammatory Mediators That Influence Proliferation and Apoptosis

(2008) Cynthia A. Warren et al.   JOURNAL OF NUTRITION

Ginkgo biloba Extract Kaempferol Inhibits Cell Proliferation and Induces Apoptosis in Pancreatic Cancer Cells

(2008) Yuqing Zhang et al.   JOURNAL OF SURGICAL RESEARCH

Kaempferol and quercetin stimulate granulocyte-macrophage colony-stimulating factor secretion in human prostate cancer cells

(2008) Sanghamitra Bandyopadhyay et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

The flavonoid kaempferol sensitizes human glioma cells to TRAIL-mediated apoptosis by proteasomal degradation of survivin

(2008) M. D. Siegelin et al.   MOLECULAR CANCER THERAPEUTICS

Kaempferol Induces Cell Death Through ERK and Akt-Dependent Down-Regulation of XIAP and Survivin in Human Glioma Cells

(2008) Ji Cheon Jeong et al.   NEUROCHEMICAL RESEARCH

Lung Cancer

(2008) Roy S. Herbst et al.   NEW ENGLAND JOURNAL OF MEDICINE

AP4 encodes a c-MYC-inducible repressor of p21

(2008) P. Jung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting phosphoinositide 3-kinase—Moving towards therapy

(2007) Romina Marone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Cell cycle control as a basis for cancer chemoprevention through dietary agents

(2007) Syed Musthapa Meeran   Frontiers in Bioscience-Landmark