Article
Medicine, Research & Experimental
Anastasia Chilla, Cecilia Anceschi, Elena Frediani, Francesca Scavone, Tommaso Del Rosso, Giuseppe Pelagio, Antonio Tufaro, Giuseppe De Palma, Mario Del Rosso, Gabriella Fibbi, Paola Chiarugi, Anna Laurenzana, Francesca Margheri
Summary: Studies have found that inhibitors of matrix metalloproteinase (MMPs) as anti-tumoral drugs have been disappointing. Recent research shows that endothelial cells and endothelial colony forming cells (ECFCs) can switch invasion modes and perform amoeboid angiogenesis in the absence of protease activity. TIMP1, TIMP2, and TIMP3 have been identified as high-powered protease inhibitors that can induce amoeboid invasion of ECFCs, while Marimastat promotes ECFC invasion and tubular formation. It is important to consider the amoeboid mechanism of invasion in developing new cancer drugs.
JOURNAL OF TRANSLATIONAL MEDICINE
(2023)
Article
Pharmacology & Pharmacy
Chen Zhao, Hio-Tong Kam, Yan Chen, Guiyi Gong, Maggie Pui-Man Hoi, Krystyna Skalicka-Wozniak, Alberto Carlos Pires Dias, Simon Ming-Yuen Lee
Summary: The study revealed that crocetin was more effective than crocin in inhibiting angiogenesis by regulating the VEGF/VEGFR2 signaling pathway.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Chemistry, Medicinal
Donghwa Kim, Sang Won Choi, Jihee Cho, Jae-Hui Been, Kyoungsun Choi, Wenzhe Jiang, Jaeho Han, Jedo Oh, Changmin Park, Soongyu Choi, Songyi Seo, Koung Li Kim, Wonhee Suh, Sang Kook Lee, Sanghee Kim
Summary: Diabetic retinopathy is a leading cause of blindness associated with excessive angiogenesis. Researchers have developed a novel antiangiogenesis agent by modifying the structure of wondonin marine natural products, resulting in improved bioactivity and selectivity. This compound, 31, shows potential as a lead for developing small-molecule drugs to treat diabetic retinopathy and to uncover new mechanisms of angiogenesis.
JOURNAL OF MEDICINAL CHEMISTRY
(2021)
Article
Biochemistry & Molecular Biology
Tur-Fu Huang, Shih-Wei Wang, Yu-Wei Lai, Shih-Chia Liu, Yu-Jen Chen, Thomas Y. Hsueh, Chih-Chung Lin, Chun-Hsuan Lin, Ching-Hu Chung
Summary: The compound 4-acetylantroquinonol B (4AAQB) has shown inhibitory effects on cancer growth and angiogenesis, making it a potential candidate for prostate cancer therapy.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemistry & Molecular Biology
Ruyang Yu, Jia Zhong, Qilyu Zhou, Wei Ren, Zhongjie Liu, Yifei Bian
Summary: In this study, the protective effect of kaempferol on the damage to the gutvascular barrier caused by LPS and TNF-alpha was investigated. Our results showed that kaempferol exhibited significant anti-inflammatory effects and prevented intestinal angiogenesis by regulating tube formation and migration of RIMVECs and suppressing the expression of angiogenesis-related signals.
CHEMICO-BIOLOGICAL INTERACTIONS
(2022)
Article
Biochemistry & Molecular Biology
Junhui Shen, Franco Aparecido Rossato, Issahy Cano, Yin Shan Eric Ng
Summary: The study evaluates the cellular effects of engineered VEGF variants tethering VEGF121 to the cell membrane, activating VEGFR2 in endothelial cells in a sustained manner. The membrane-tethered variants induce pro-angiogenic activities such as cell proliferation, increased endothelial permeability, tube network formation, and elongated filopodia formation, through activation of VEGFR2, MAPK/ERK, and Rho GTPase mediators CDC42 and ROCK.
Article
Biochemistry & Molecular Biology
Balaji Kyathegowdanadoddi Srinivas, Madhu Chakkere Shivamadhu, Shankar Jayarama
Summary: This study aimed to purify lectin from the sap of Musa acuminate pseudostem and investigate its apoptotic and angiogenic mechanisms in both in-vitro and in-vivo models. The findings suggest that the lectin possesses significant anticancer potential by inducing apoptosis and suppressing neoangiogenesis in cancer cells and animal models.
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
(2021)
Article
Medicine, Research & Experimental
Gowtham Kumar Subbaraj, Tariq Masoodi, Santhosh Kumar Yasam, Kirubhanand Chandrashekar, Langeswaran Kulanthaivel, Noor Ahmad Shaik, Sheema Hashem, Ammira S. Alshabeeb Akil, Ajaz A. Bhat
Summary: The study evaluated the efficacy of nano-formulated water-soluble kaempferol and combretastatin in inhibiting angiogenesis. The combination of nano-formulated kaempferol and combretastatin showed better anti-angiogenic activity compared to individual treatments. The findings suggest that nano-formulated kaempferol and combretastatin suppress angiogenesis by inhibiting endothelial cell activation and angiogenic factors.
BIOMEDICINE & PHARMACOTHERAPY
(2023)
Article
Developmental Biology
Guangzhuang Jing, Jianling Yao, Yuhui Dang, Weitao Liang, Li'ao Xie, Jia Chen, Zhilan Li
Summary: The study reveals that decreased production of beta-hCG in early pregnancy can down-regulate the expression of the VEGF-MEK/ERK signaling pathway, leading to reduced angiogenesis and abnormal villous angiogenesis, which may be an important mechanism of missed abortion.
Article
Plant Sciences
Rui Cao, Chun Cao, Xiaojie Hu, Kang Du, Jingrong Zhang, Mengxue Li, Bowen Li, Huimin Lin, Anqi Zhang, Yangyang Li, Li Wu, Yan Huang
Summary: This study found that kaempferol has significant effects against hepatic fibrosis and explored its molecular mechanisms. Kaempferol can regulate the ASIC1a-eIF2α-ATF-4 signaling pathway, inhibiting the activation of HSCs and the release of VEGF.
Article
Food Science & Technology
Ruyang Yu, Qilyu Zhou, Tianlong Liu, Ping Liu, Hong Li, Yifei Bian, Zhongjie Liu
Summary: This study investigated the effects of kaempferol on intestinal angiogenesis and microflora in mice with chronic colitis. The results showed that kaempferol could alleviate the symptoms of chronic colitis, modulate inflammatory factors and regulatory proteins, and regulate colonic microflora. Therefore, kaempferol may have potential as a preventive strategy for chronic colitis.
JOURNAL OF FUNCTIONAL FOODS
(2023)
Article
Multidisciplinary Sciences
Shiho Hashiguchi, Tomoko Tanaka, Ryosuke Mano, Seiji Kondo, Shohta Kodama
Summary: CCN2 promotes lymphangiogenesis by enhancing integrin alpha v beta 5-mediated phosphorylation of ERK, and DUSP6 is a negative regulator of excessive lymphangiogenesis by CCN2.
SCIENTIFIC REPORTS
(2022)
Article
Cell Biology
Marina Katsman, Aviva Azriel, Guy Horev, Yitzhak Reizel, Ben-Zion Levi
Summary: The study reveals the crucial role of N-VEGF as an autoregulatory arm of VEGF-A in angiogenesis and cell survival under hypoxic conditions.
Review
Oncology
Domenico Ribatti, Antonio Giovanni Solimando, Francesco Pezzella
Summary: Several anti-angiogenic drugs are approved for cancer treatment, but resistance and adverse effects may occur. Combining multiple anti-angiogenic molecules or using them in combination with other treatment regimens is indicated as alternative therapeutic strategies to overcome resistance. Comprehensive omics profiling is crucial for increasing clinical benefits and overcoming resistance to anti-angiogenic therapies.
Article
Biochemistry & Molecular Biology
Yi-Fan Chou, Yu-Hsuan Lan, Jun-Han Hsiao, Chiao-Yun Chen, Pei-Yu Chou, Ming-Jyh Sheu
Summary: Curcumin and demethoxycurcumin demonstrated antiangiogenic activity via the inhibition of endoglin/Smad1 signaling. Combination treatment with curcuminoids and semaxanib is expected to reverse semaxanib resistance.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Biochemical Research Methods
Jie Lin, Jing Wei, Donald Adjeroh, Bing-Hua Jiang, Yue Jiang
BMC BIOINFORMATICS
(2018)
Article
Biochemistry & Molecular Biology
Cheng-Fei Jiang, Zhu-Mei Shi, Dong-Mei Li, Ying-Chen Qian, Yi Ren, Xiao-Ming Bai, Yun-Xia Xie, Lin Wang, Xin Ge, Wei-Tao Liu, Lin-Lin Zhen, Ling-Zhi Liu, Bing-Hua Jiang
Article
Biochemistry & Molecular Biology
Ryan Kolb, Paige Kluz, Zhen Wei Tan, Nicholas Borcherding, Nicholas Bormann, Ajaykumar Vishwakarma, Louis Balcziak, Pengcheng Zhu, Brandon S. J. Davies, Francoise Gourronc, Ling-Zhi Liu, Xin Ge, Bing-Hua Jiang, Katherine Gibson-Corley, Aloysius Klingelhutz, Nguan Soon Tan, Yuwen Zhu, Fayyaz S. Sutterwala, Xian Shen, Weizhou Zhang
Article
Cell Biology
Xin Ge, Min-Hong Pan, Lin Wang, Wei Li, Chengfei Jiang, Jun He, Khaled Abouzid, Ling-Zhi Liu, Zhumei Shi, Bing-Hua Jiang
CELL DEATH & DISEASE
(2018)
Article
Pharmacology & Pharmacy
Lin Wang, Jian-Ge Qiu, Jun He, Wen-Jing Liu, Xin Ge, Feng-Mei Zhou, Ying-Xue Huang, Bing-Hua Jiang, Ling-Zhi Liu
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Article
Oncology
Jing Jie Yu, Thomas Hogan, Chad Morley, Chad Crigger, Shunchang Jiao, Dorian J. Williams, Mohamad W. Salkini, Xuqing Yang, Xiaobing Liang, Bingxue Yan, Courtney Cecil, Ava C. Winn, Jenny Zheng, Yi Guo, Bing-Hua Jiang, Ida M. Washington
ANTICANCER RESEARCH
(2019)
Article
Biochemistry & Molecular Biology
Xu Qian, Xinjian Li, Zhumei Shi, Yan Xia, Qingsong Cai, Daqian Xu, Lin Tan, Linyong Du, Yanhua Zheng, Dan Zhao, Chuanbao Zhang, Philip L. Lorenzi, Yongping You, Bing-Hua Jiang, Tao Jiang, Haitao Li, Zhimin Lu
Article
Pharmacology & Pharmacy
Jun He, Weitao Liu, Xin Ge, Gao-Chan Wang, Vilas Desai, Shaomin Wang, Wei Mu, Vikas Bhardwaj, Erin Seifert, Ling-Zhi Liu, Alok Bhushan, Stephen C. Peiper, Bing-Hua Jiang
TOXICOLOGY AND APPLIED PHARMACOLOGY
(2019)
Article
Pharmacology & Pharmacy
Jian-Ge Qiu, Lin Wang, Wen-Jing Liu, Ju-Feng Wang, Er-Jiang Zhao, Feng-Mei Zhou, Xiang-Bo Ji, Li-Hong Wang, Zhong-Kun Xia, Wei Wang, Marie Chia-mi Lin, Ling-Zhi Liu, Ying-Xue Huang, Bing-Hua Jiang
FRONTIERS IN PHARMACOLOGY
(2019)
Article
Oncology
Wei Li, Lin Wang, Xiang-Bo Ji, Li-Hong Wang, Xin Ge, Wei-Tao Liu, Ling Chen, Zhong Zheng, Zhu-Mei Shi, Ling-Zhi Liu, Marie C. Lin, Jie-Yu Chen, Bing-Hua Jiang
FRONTIERS IN ONCOLOGY
(2019)
Article
Cell Biology
Wen-Jing Liu, Ying-Xue Huang, Wei Wang, Ye Zhang, Bing-Jie Liu, Jian-Ge Qiu, Bing-Hua Jiang, Ling-Zhi Liu
Summary: High NOX4 levels are detected in human ovarian cancer samples, induced by HIF-1 alpha and IGF-1, playing a crucial role in chemotherapy and radiotherapy resistance. Knockdown of NOX4 increases sensitivity to targeted therapy and radiotherapy by reducing expression of HER3 and NF-kappa B p65, revealing a new pathway for overcoming therapeutic resistance in ovarian cancer.
Article
Biochemistry & Molecular Biology
Bing-Jie Liu, Fang-Fang Li, Yun-Xia Xie, Chong-Yuan Fan, Wen-Jing Liu, Jian-Ge Qiu, Bing-Hua Jiang
Summary: This study identified the critical role of miR-196a in the development of resistance to TKI therapy in lung cancer cells. The NRF2/miR-196a/GLTP pathway was found to mediate TKI resistance and lung tumor development, suggesting its potential as a biomarker or therapeutic target for TKI resistance in the future.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
David C. Stieg, Yifang Wang, Ling-Zhi Liu, Bing-Hua Jiang
Summary: Recent research has revealed the diverse cellular mechanisms underlying certain types of cancer, leading to more effective treatment options. Ovarian cancer (OC) is particularly challenging to treat, with limited options available, especially for late-stage patients. Dysregulation of miRNAs and ROS in OC plays significant roles in tumorigenesis and affects the therapeutic outcomes through their involvement in angiogenesis regulation.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Statistics & Probability
Jie Lin, Donald A. Adjeroh, Bing-Hua Jiang, Yue Jiang
COMPUTATIONAL STATISTICS
(2018)
Article
Biochemical Research Methods
Jie Lin, Donald A. Adjeroh, Bing-Hua Jiang, Yue Jiang
Article
Chemistry, Applied
M. Graca Dias, Elsa Vasco, Francisco Ravasco, Lufsa Oliveira
Summary: This study estimated the vitamin D intake of "adults" and "elderly" populations in Portugal using the TDS methodology. The results showed that the majority of people had inadequate vitamin D intake, well below the Dietary Reference Values.
Article
Chemistry, Applied
Yanan Wang, Jiachen Shi, Yong-Jiang Xu, Chin-Ping Tan, Yuanfa Liu
Summary: This study investigates the variations in lipid digestion profiles among individuals of different ages using in vitro digestion models. The findings suggest that adults have a more comprehensive lipid digestion compared to infants, and infants tend to release shorter chain length and more saturated free fatty acids during digestion. Additionally, the particle sizes in the stomach of the elderly were consistently larger. This study enhances our understanding of how lipids with different degrees of unsaturation undergo digestion in diverse age groups.
Article
Chemistry, Applied
Hyunjong Yu, Huisu Kim, Pahn-Shick Chang
Summary: Chitosan-pectin emulsion-filled hydrogel (EFH) was developed to enhance the bioaccessibility of lipophilic bioactive compounds through intestinal delivery. The EFH, prepared without crosslinking agents, demonstrated improved mechanical strength and compactness with higher pectin concentration. It retained the emulsion at pH 2.0 and released it at pH 7.4, resulting in enhanced release of free fatty acids and improved bioaccessibility of curcumin.
Article
Chemistry, Applied
Tongze Zhang, Siqi Hong, Jia-Rong Zhang, Pin-He Liu, Siyi Li, Zixian Wen, Jianwei Xiao, Guirong Zhang, Olivier Habimana, Nagendra P. Shah, Zhongquan Sui, Harold Corke
Summary: Lactic acid fermentation significantly affects the morphology and physicochemical properties of proso millet starch, including the formation of surface indentations and small pores, decrease in gelatinization temperatures, and changes in hardness and adhesiveness.
Article
Chemistry, Applied
Liqin Kong, Feng Hong, Peng Luan, Yiping Chen, Yaoze Feng, Ming Zhu
Summary: This study presents a novel impedance biosensor using composite nanomaterials and T1R1 as a signal probe, which can competitively and ultra-sensitively detect umami intensity. The biosensor exhibits exceptional analytical performance and is suitable for food flavor evaluation.
Article
Chemistry, Applied
Kunying Lv, Yixin Yang, Qilong Li, Ran Chen, Liang Deng, Yiwei Zhang, Ning Jiang
Summary: Horse's milk, with its high nutritional value and low allergenic proteins, could be a substitute for cow's milk in infant consumption. A proteomic method was used to identify and compare milk fat globule membrane (MFGM) and whey proteins from different horse breeds. The study found differences in protein composition and functionality, which could support the development of formulas more suitable for human infants.
Article
Chemistry, Applied
Enrique Jacobo Diaz-Montana, Helene Brignot, Ramon Aparicio-Ruiz, Thierry Thomas- Danguin, Maria Teresa Morales
Summary: Sensory perception of virgin olive oil is influenced by phenols and volatiles, which are affected by the composition of the oil and biological factors. This study investigated the effect of saliva and phenols on the release of volatiles, and found that the presence of phenols decreased the release of saturated volatiles.
Article
Chemistry, Applied
Wei Zhou, Rui Zhang, Zhen Cai, Fangfang Wu, Yong Hu, Chao Huang, Kun Hu, Yun Chen
Summary: Environmentally friendly and outstanding pH-responsive cationic starch nanoparticles (CSNP) were prepared from pH-sensitive starch. CSNP exhibited nanosize and regular sphere, highly free-flowing molecular chains, and demonstrated excellent pH responsiveness through multiple emulsion/demulsification transitions.
Article
Chemistry, Applied
Andrea Koo, Vinayak Ghate, Weibiao Zhou
Summary: This study suggests that direct seeding may negatively affect the nutritional quality of crops, causing a decrease in ascorbic acid, vitamin K, and total glucosinolate content.
Article
Chemistry, Applied
Tonghao Du, Yazhou Xu, Xiaoyan Xu, Shijin Xiong, Linli Zhang, Biao Dong, Jinqing Huang, Tao Huang, Muyan Xiao, Tao Xiong, Mingyong Xie
Summary: This study successfully improved the ACE inhibitory activity of black sesame seeds by fermenting them with Lactobacillus Plantarum NCU116 and hydrolyzing them using acid protease. The RF-PSO model was used to predict the ACE inhibitory activity during the hydrolysis process. Eight peptides with ACE inhibitory activity were identified from fermented black sesame seed hydrolysates after separation and screening.
Article
Chemistry, Applied
Yao Liu, Songyi Lin, Kexin Liu, Shan Wang, Qiaozhen Liu, Na Sun
Summary: This study analyzed the structural changes of shrimp proteins during digestion, predicted the immunodominant epitopes, and validated their allergenicity. The results showed that shrimp proteins were degraded into peptides during digestion, but still carried IgE epitopes that trigger allergic reactions.
Article
Chemistry, Applied
Tiantian Fu, Hongwei Cao, Yu Zhang, Xiao Guan
Summary: This study investigates the impact of milling on the active components in rice, with a focus on the stability and bioaccessibility of phenols, VB1, and alpha-GABA during cooking and digestion. The findings show that milling exacerbates the instability of gamma-GABA during cooking and VB1 during digestion, and it affects the bioaccessibility of these active compounds.
Article
Chemistry, Applied
Zhihao Yang, Yanru Hou, Min Zhang, Puxin Hou, Chang Liu, Lu Dou, Xiaoyu Chen, Lihua Zhao, Lin Su, Ye Jin
Summary: This study investigated the molecular mechanism of feeding regimes on lamb flavor by using TMT labeling combined with MS. The results showed that pasture-fed groups had higher levels of amino acids and volatile flavor substances compared to concentrate-fed groups. Additionally, several differentially abundant proteins associated with lamb flavor were identified.
Article
Chemistry, Applied
Zixuan Xie, De Zhang, Junyu Zhu, Qianqian Luo, Jun Liu, Jingtao Zhou, Xiaoyong Wang, Yuqiong Chen, Zhi Yu, Dejiang Ni
Summary: This study investigated the acidification of aroma-enhanced black tea during storage. Analysis of non-volatile substances and organic acids using UPLC-Q-TOF/MS and HPLC revealed a decrease in soluble sugars and amino acids, while an increase in organic acids such as oxalic acid, malic acid, and quinic acid. In vitro experiments further demonstrated that the acidification is a result of the decomposition of sugars and amino acids by heating, as well as the oxidation of aromatic aldehydes. Additionally, the study showed that the taste composition of tea infusion is altered, with reduced amino acids, catechins, soluble sugars, and flavonoids. This research provides a theoretical basis for improving the quality of black tea.
Article
Chemistry, Applied
Lin Wang, Falai Ma, Zihan Li, Yan Zhang
Summary: This study developed time-temperature integrators based on amyloglucosidase@Cu3(PO4)2 nanoflowers for monitoring the freshness of chilled pork. The results showed that the integrators were highly reliable and accurate in predicting the quality of chilled pork.
