Article
Plant Sciences
Sujan Balami, Martina Vasutova, Vijay Kumar Chaudhary, Pavel Cudlin
Summary: The succession of root fungi in abandoned agricultural land in central Nepal differs among native tree species. The AM fungal community shows rapid changes and resembles that of regenerated forests in long-term abandoned land, while the total fungal community is similar in abandoned land types but significantly different from regenerated forests. The ECM community of A. nepalensis does not significantly differ among land use types, possibly due to low species diversity, while specific ECM species prefer different stages of succession. Our results suggest that AM fungal succession reaches the stage of regenerated forest relatively fast for both tree species, while the transition of total fungi is delayed in abandoned land due to hyperdiversity and specialization to various environments and substrates.
Article
Pharmacology & Pharmacy
Deepjyoti Dev, Bishnupada Roy
Summary: Scientists have found that the leaves of Schima wallichii, a traditional medicinal plant in Assam, India, have the potential to accelerate wound healing. Experimental results on Swiss albino mice showed that the extract from the leaves can reduce epithelialization time, promote faster closure of wounds, enhance protein synthesis and cellular proliferation, indicating its efficacy in wound healing.
INDIAN JOURNAL OF PHARMACEUTICAL SCIENCES
(2023)
Review
Chemistry, Multidisciplinary
Fan Yang, Sahana N. Bettadapura, Mark S. Smeltzer, Hua Zhu, Shanzhi Wang
Summary: This review discusses the roles of the gasdermin protein family in anti-cancer functions and various antitumor drugs that could activate the pyroptosis pathways.
ACTA PHARMACOLOGICA SINICA
(2022)
Article
Multidisciplinary Sciences
Asal Moradi, Mohammadreza Abdihaji, Sara Barari Kouchaksaraie, Tabarek Abdulrazaq Alkinani, Aida Mahmoudi, Arash Davoudi, William Dashtmiani, Somayeh Mikaeili Ghezeljeh, Shahrzad Aghajani, Reza Ghasemian, Somayeh Maghsoomi Taramsari, Amitis Majlesi, Zahra Mahdavi Niyaki, Ali Salehzadeh
Summary: The study aimed to fabricate Bi2O3/Gln-TSC nanoparticles and investigate their anticancer mechanism. The results showed that Bi2O3/Gln-TSC had significant cytotoxicity against prostate cancer cells and induced apoptosis.
SCIENTIFIC REPORTS
(2022)
Article
Medicine, General & Internal
Aleksandra Mielczarek-Palacz, Sylwia Jasinska, Anna Strzelec
Summary: Ovarian cancer is a major issue in gynecological oncology, and research on diagnostic markers like caspase-3, -8, and -9 is ongoing. This study found significantly decreased levels of these caspases in ovarian cancer patients compared to healthy controls, suggesting a link to immune system disturbances and potential for future diagnostic use, pending further research.
Review
Oncology
Mingxia Jiang, Ling Qi, Lisha Li, Yiming Wu, Dongfeng Song, Yanjing Li
Summary: Caspase-8 is a key player in cancer, involved in multiple programmed cell death modes and closely associated with tumor growth, invasion, therapeutic resistance, etc.
INTERNATIONAL JOURNAL OF CANCER
(2021)
Article
Environmental Sciences
Cheng-Hsun Lin, Kuang-Hsuan Lin, Hsiang-Ju Ku, Kun-Ching Lee, Song-Shei Lin, Fei-Ting Hsu
Summary: Amentoflavone has been found to inhibit the progression of colorectal cancer through mechanisms such as triggering G1 arrest, DNA damage, and apoptosis, making it a potential treatment option.
ENVIRONMENTAL TOXICOLOGY
(2023)
Article
Chemistry, Inorganic & Nuclear
Fatemeh Mehraban, Fariba Heidari Esfahani, Zahra Mosayebi Dorcheh, Erfaneh Heidari Esfahani, Mansoureh Azadeh, Ali Salehzadeh
Summary: This study evaluated the cytotoxic effect of GaFe2O4@Ag nanocomposite biosynthesized by Spirulina platensis on breast cancer cell line and investigated its influence on apoptosis pathways. The results showed that the nanocomposite exhibited high cytotoxicity against breast cancer cells and induced apoptosis through activation of apoptosis pathways.
INORGANIC CHEMISTRY COMMUNICATIONS
(2023)
Article
Materials Science, Biomaterials
Jingbo Lin, Jiaxin Zhang, Kuang Wang, Shengdi Guo, Wuli Yang
Summary: Ferroptosis, an alternative form of cell death, holds great promise for non-apoptotic cancer treatment. This study focused on the use of iron-based nanomaterials coated with zwitterionic polymers to enhance the effect of ferroptosis in colon cancer treatment. The results showed good biocompatibility and excellent tumor inhibitory effect in vivo.
JOURNAL OF MATERIALS CHEMISTRY B
(2022)
Review
Biochemistry & Molecular Biology
Caitlin Hounsell, Yun Fan
Summary: Caspases play a crucial role in apoptosis initiation and are also involved in non-apoptotic functions like proliferation and differentiation. Altered caspase function in cancer can have both preventive and promoting effects on tumor formation, impacting cancer treatment strategies. A comprehensive understanding of the dual role of caspases is essential for the development of successful cancer therapeutic approaches.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2021)
Article
Biochemistry & Molecular Biology
Hee-Yun Kim, Dongkyun Han, Jungeun Kim, Min-Sun Yoo, Jin-Soo Lee, Hyunyong Kim, Hyung-Min Kim, Hyun-Ja Jeong
Summary: Bamboo salt has demonstrated significant anti-cancer effects by reducing tumor growth, increasing survival rates, enhancing immune mediators, and inducing apoptosis signaling pathways. These findings suggest the potential use of bamboo salt for cancer therapy, highlighting its beneficial effects for various cancer diseases such as melanoma skin cancer.
JOURNAL OF FOOD BIOCHEMISTRY
(2021)
Review
Biochemistry & Molecular Biology
Kakali Bhadra
Summary: This article reviews the alternative pathways of cancer cell death targeted by anticancer drug molecules, providing a molecular basis for new strategies in cancer treatment. Many drugs can effectively induce cell death through targeting the caspase-independent cell death pathway, which is significant for cancer therapy.
Review
Biochemistry & Molecular Biology
Trinh Hua, Melanie Robitaille, Sarah J. Roberts-Thomson, Gregory R. Monteith
Summary: Apoptosis is a complex and regulated cell death pathway, and calcium signaling plays a crucial role in its regulation. The initiation and execution of apoptosis are controlled by different groups of cysteine proteases, including caspases, calpains, and cathepsins. Evading apoptosis is a hallmark of cancer cells, which can be achieved through deregulation of cysteine proteases and remodeling of calcium signaling. This review explores the involvement of calcium in the regulation of cysteine protease activity and its impact on intracellular calcium handling during apoptosis.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH
(2023)
Article
Chemistry, Medicinal
Mirian Leticia Carmo Bastos, Joao Victor Silva-Silva, Jorddy Neves Cruz, Amanda Roberta Palheta da Silva, Alexandre Augusto Bentaberry-Rosa, Gisele de Costa Ramos, Jose Edson de Sousa Siqueira, Marlia Regina Coelho-Ferreira, Sandro Percario, Patricia Santana Barbosa Marinho, Andrey Moacir do Rosario Marinho, Marcelo de Oliveira Bahia, Maria Fani Dolabela
Summary: This study found that the extract and fractions of Geissospermum sericeum have antitumor activity on human gastric adenocarcinoma cells and induce cell death. The alkaloid fraction and geissoschizoline N4-methylchlorine showed significant inhibitory effects on the ACP02 cell line, making them potential candidates for gastric cancer treatment.
Review
Neurosciences
Aziz Unnisa, Nigel H. H. Greig, Mohammad Amjad Kamal
Summary: Traumatic brain injury (TBI) is a major cause of death and morbidity, and is the focus of translational research. Apoptosis is important in the pathophysiology of TBI, and inhibiting it may improve functional recovery. Caspases, such as Caspase-3 and Caspase-9, are key mediators of cell death due to apoptosis in TBI. Understanding these apoptotic pathways and finding ways to inhibit Caspases may have significant treatment implications for TBI.
CURRENT NEUROPHARMACOLOGY
(2023)
Article
Immunology
Auliya A. Suwantika, Febby V. Purwadi, Neily Zakiyah, Irma M. Puspitasari, Rizky Abdulah, Ajeng Diantini, Cornelis Boersma, Maarten J. Postma
Summary: This study used multi-criteria decision analysis to prioritize the introduction of new vaccines in Indonesia. The results showed that PCV, rotavirus, HPV, and JE ranked as the top four vaccines in terms of priority, with PCV, rotavirus, and HPV vaccines being more prioritized than JE vaccine. This ranking aligns with the WHO's priority list, demonstrating the validity and usefulness of the MCDA approach.
EXPERT REVIEW OF VACCINES
(2021)
Review
Endocrinology & Metabolism
D. P. Destiani, S. Naja, S. Dewi, A. R. Rahmadi, S. A. S. Sulaiman, R. Abdulah
Summary: Methotrexate (MTX) remains commonly used for the management of rheumatoid arthritis (RA) despite the development of new drugs. A systematic review of MTX effectiveness in reducing bone erosion risk was presented in this article, with key factors such as gene polymorphism influencing treatment response. Future investigations are needed to clarify the exact mechanism of MTX in preventing bone erosion.
OSTEOPOROSIS INTERNATIONAL
(2021)
Article
Chemistry, Medicinal
Yuni Elsa Hadisaputri, Rheza Andika, Iyan Sopyan, Ade Zuhrotun, Rani Maharani, Rachmaniar Rachmat, Rizky Abdulah
Summary: The compounds in CA extract possess the ability to induce apoptotic cell death in A549 cells, making it a promising candidate for future anticancer therapy.
DRUG DESIGN DEVELOPMENT AND THERAPY
(2021)
Article
Chemistry, Medicinal
Melisa Intan Barliana, Ajeng Diantini, Anas Subarnas, Rizky Abdulah
Summary: This study investigated the antiproliferative mechanism of the active compound kaempferol-3-O-rhamnoside from Indonesian herbal medicine Schima wallichii against Jurkat cells. The results showed that kaempferol-3-O-rhamnoside had antiproliferative activity and inhibited Jurkat cell proliferation through the stimulation of phosphorylated Jun amino-terminal kinase.
NATURAL PRODUCTS JOURNAL
(2022)
Review
Health Care Sciences & Services
Abdurahman Ridho, Sofa D. Alfian, Job F. M. van Boven, Jutti Levita, Esin Aki Yalcin, Ly Le, Jan-Willem Alffenaar, Eelko Hak, Rizky Abdulah, Ivan S. Pradipta
Summary: Digital health technology interventions show promise in improving medication adherence and treatment outcomes in patients with tuberculosis. However, the effects of different interventions vary in terms of direction and extent of improvement.
JOURNAL OF MEDICAL INTERNET RESEARCH
(2022)
Article
Public, Environmental & Occupational Health
Auliya A. Suwantika, Inge Dhamanti, Yulianto Suharto, Fredrick D. Purba, Rizky Abdulah
Summary: The study shows that social distancing measures through school closures, workforce, and community contact reductions are cost-saving, and extending the duration of social distancing tends to increase both the savings and the number of averted deaths.
TRAVEL MEDICINE AND INFECTIOUS DISEASE
(2022)
Review
Health Care Sciences & Services
Gabriella J. Caren, Deni Iskandar, Dian A. E. Pitaloka, Rizky Abdulah, Auliya A. Suwantika
Summary: The COVID-19 pandemic has disrupted TB treatment in Indonesia, leading to a potential decrease in funding, interruptions in TB services, lower quality of care, and impacts on monitoring activities. Lessons from other countries, such as combining COVID-19 and TB screening and utilizing telemedicine, can provide useful strategies for managing TB during the pandemic.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2022)
Review
Infectious Diseases
Dian Ayu Eka Pitaloka, Mas Rizky Anggun A. A. Syamsunarno, Rizky Abdulah, Lidya Chaidir
Summary: Poor sensitivity of sputum conversion for monitoring TB treatment has led to the urgent need for identifying a non-sputum-based biomarker. Recent studies on omics-related research have contributed to the identification of surrogate markers and prediction of future reactivation risk in pulmonary TB. However, proper validation through longitudinal studies is crucial before utilizing these biomarkers in clinical practice.
INFECTION AND DRUG RESISTANCE
(2022)
Review
Oncology
Alistia Ilmiah Fahira, Riezki Amalia, Melisa Intan Barliana, Vesara Ardhe Gatera, Rizky Abdulah
Summary: Cancer is a leading cause of morbidity and mortality worldwide, and different types of cancer require different treatments. Polyethyleneimine (PEI) shows promise as a co-delivery system for anticancer therapy, but its clinical safety needs further evaluation.
BREAST CANCER-TARGETS AND THERAPY
(2022)
Review
Health Care Sciences & Services
Pungki Afifah Asyraf, Ivanna Fauziyah Kusnadi, Jonathan Stefanus, Miski Aghnia Khairinisa, Rizky Abdulah
Summary: Drug hypersensitivity is an inflammatory or immune reaction caused by drugs, which can have severe consequences if not properly treated. Sulfonamide drugs have a broad spectrum antimicrobial effect, but they can also cause adverse reactions in some individuals. This review identifies the symptoms, associated genes, and different allergic reactions that can be caused by sulfonamide hypersensitivity.
DRUG HEALTHCARE AND PATIENT SAFETY
(2022)
Article
Health Care Sciences & Services
Ivanny O. Y. Sinaga, Melisa Barliana, Ivan Surya Pradipta, Aulia Iskandarsyah, Rizky Abdulah, Sofa D. Alfian
Summary: This study found a positive association between depression and the incidence of multimorbidity in the general population in Indonesia, with higher prevalence of depression with increasing age. Respondents with depressive symptoms were more likely to report multimorbidity.
JOURNAL OF MULTIDISCIPLINARY HEALTHCARE
(2022)
Article
Pharmacology & Pharmacy
Rudi Hendra, Rohimatul Khodijah, Muhammad Almurdani, Yuli Haryani, Ari Satia Nugraha, Neni Frimayanti, Hilwan Yuda Teruna, Rizky Abdulah
Summary: This study investigated the activity of Stenochlaena palustris, a traditional medicinal plant. The results showed that the ethyl acetate extract of this plant exhibited potential free radical scavenging and antiplasmodial activities, without toxicity.
ADVANCES IN PHARMACOLOGICAL AND PHARMACEUTICAL SCIENCES
(2022)
Review
Biochemistry & Molecular Biology
Felix Zulhendri, Ronny Lesmana, Steven Tandean, Andreas Christoper, Kavita Chandrasekaran, Ilham Irsyam, Auliya A. Suwantika, Rizky Abdulah, Nasrul Wathoni
Summary: Recent research has shown that propolis has potential as a raw material for pharmaceuticals and nutraceuticals due to its anti-inflammatory properties. This review examines the latest experimental evidence on the anti-inflammatory properties of propolis from 2017 to 2022. The evidence suggests that propolis possesses various mechanisms to regulate inflammation and create an anti-inflammatory environment. It inhibits and downregulates pro-inflammatory cytokines and associated signaling pathways, and also reduces the migration of immune cells.
Article
Cardiac & Cardiovascular Systems
Qisty A. Khoiry, Sofa D. Alfian, Rizky Abdulah
Summary: Main factors associated with low awareness of hypertension treatment are modifiable, such as older age, irregular blood pressure control, depressive symptoms, insomnia, and low satisfaction with health care. Surprisingly, individuals with high religiosity are more likely to have low awareness of hypertension treatment.
Article
Public, Environmental & Occupational Health
Auliya A. Suwantika, Neily Zakiyah, Rizky Abdulah, Vensya Sitohang, Gertrudis Tandy, Atiek Anartati, Tetrawindu Hidayatullah, Putri Herliana, Sri R. Hadinegoro
Summary: The study found that implementing pneumococcal vaccination in Indonesia would reduce cases of pneumococcal disease, with PCV13 being more cost-effective than PCV10, especially when using the UNICEF price.
JOURNAL OF ENVIRONMENTAL AND PUBLIC HEALTH
(2021)
