Mitigating permeability-mediated risks in drug discovery

Comprehensive Assessment of ADMET Risks in Drug Discovery

(2009) Jianling Wang   CURRENT PHARMACEUTICAL DESIGN

Determination of permeability and lipophilicity of pyrazolo-pyrimidine tyrosine kinase inhibitors and correlation with biological data

(2009) Elena Dreassi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

QSAR application for the prediction of compound permeability with in silico descriptors in practical use

(2009) Kazuya Nakao et al.   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Increased Understanding of Intestinal Drug Permeability Determined by the LOC-I-GUT Approach Using Multislice Computed Tomography

(2009) T. Knutson et al.   MOLECULAR PHARMACEUTICS

Permeability evaluation of peptidic HCV protease inhibitors in Caco-2 cells-correlation with in vivo absorption predicted in humans

(2008) Cheng Li et al.   BIOCHEMICAL PHARMACOLOGY

Recent Advances in High Throughput Screening for ADME Properties

(2008) Timothy Carlson et al.   COMBINATORIAL CHEMISTRY & HIGH THROUGHPUT SCREENING

Artificial Membrane Assays to Assess Permeability

(2008) Bernard Faller   CURRENT DRUG METABOLISM

Permeability for Intestinal Absorption: Caco-2 Assay and Related Issues

(2008) Barry Press et al.   CURRENT DRUG METABOLISM

Strategies to assess blood–brain barrier penetration

(2008) Li Di et al.   Expert Opinion on Drug Discovery

Use of simulated intestinal fluid for Caco-2 permeability assay of lipophilic drugs

(2008) Lina Fossati et al.   INTERNATIONAL JOURNAL OF PHARMACEUTICS

Generation of a Set of Simple, Interpretable ADMET Rules of Thumb

(2008) M. Paul Gleeson   JOURNAL OF MEDICINAL CHEMISTRY

Comparison of blood–brain barrier permeability assays: in situ brain perfusion, MDR1-MDCKII and PAMPA-BBB

(2008) Li Di et al.   JOURNAL OF PHARMACEUTICAL SCIENCES

Biopharmaceutics Classification System: Validation and Learnings of an in Vitro Permeability Assay

(2008) Victoria E. Thiel-Demby et al.   MOLECULAR PHARMACEUTICS

Segmental Dependent Transport of Low Permeability Compounds along the Small Intestine Due to P-Glycoprotein: The Role of Efflux Transport in the Oral Absorption of BCS Class III Drugs

(2008) Arik Dahan et al.   MOLECULAR PHARMACEUTICS

Optimisation of the Caco-2 Permeability Assay Using Experimental Design Methodology

(2008) Mark Lakeram et al.   PHARMACEUTICAL RESEARCH

A modified fast (4 day) 96-well plate Caco-2 permeability assay

(2008) Masashi Uchida et al.   JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS

Variability in Caco-2 and MDCK Cell-Based Intestinal Permeability Assays

(2007) Donna A. Volpe   JOURNAL OF PHARMACEUTICAL SCIENCES