Bacterial origins of cyclic nucleotide-activated antiviral immune signaling

CBASS phage defense and evolution of antiviral nucleotide signaling

(2022) Brianna Duncan-Lowey et al.   CURRENT OPINION IN IMMUNOLOGY

Alternative functions of CRISPR–Cas systems in the evolutionary arms race

(2022) Prarthana Mohanraju et al.   NATURE REVIEWS MICROBIOLOGY

Bacterial gasdermins reveal an ancient mechanism of cell death

(2022) Alex G. Johnson et al.   SCIENCE

Crystal structure and functional implication of bacterial STING

(2022) Tzu-Ping Ko et al.   Nature Communications

Evolutionary plasticity and functional versatility of CRISPR systems

(2022) Eugene V. Koonin et al.   PLOS BIOLOGY

TIR domains of plant immune receptors are 2′,3′-cAMP/cGMP synthetases mediating cell death

(2022) Dongli Yu et al.   CELL

Structural principles of CRISPR-Cas enzymes used in nucleic acid detection

(2022) Anuska Das et al.   JOURNAL OF STRUCTURAL BIOLOGY

Phage anti-CBASS and anti-Pycsar nucleases subvert bacterial immunity

(2022) Samuel J. Hobbs et al.   NATURE

Structural biology of CRISPR–Cas immunity and genome editing enzymes

(2022) Joy Y. Wang et al.   NATURE REVIEWS MICROBIOLOGY

Cyclic Nucleotide Signaling in Phage Defense and Counter-Defense

(2022) Januka S. Athukoralage et al.   Annual Review of Virology

Cyclic nucleotide-induced helical structure activates a TIR immune effector

(2022) Gaëlle Hogrel et al.   NATURE

Cryo-EM structure of an active bacterial TIR–STING filament complex

(2022) Benjamin R. Morehouse et al.   NATURE

Shared TIR enzymatic functions regulate cell death and immunity across the tree of life

(2022) Kow Essuman et al.   SCIENCE

TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

(2022) Aolin Jia et al.   SCIENCE

Identification and receptor mechanism of TIR-catalyzed small molecules in plant immunity

(2022) Shijia Huang et al.   SCIENCE

Prokaryotic innate immunity through pattern recognition of conserved viral proteins

(2022) Linyi Alex Gao et al.   SCIENCE

Viruses inhibit TIR gcADPR signalling to overcome bacterial defence

(2022) Azita Leavitt et al.   NATURE

Cyclic ADP ribose isomers: Production, chemical structures, and immune signaling

(2022) Mohammad K. Manik et al.   SCIENCE

The Card1 nuclease provides defence during type-III CRISPR immunity

(2021) Jakob T. Rostøl et al.   NATURE

The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

(2021) Wenlong Zhu et al.   NUCLEIC ACIDS RESEARCH

Molecular mechanisms of assembly and TRIP13-mediated remodeling of the human Shieldin complex

(2021) Wei Xie et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic oligoadenylate signalling and regulation by ring nucleases during type III CRISPR defence

(2021) Januka S Athukoralage et al.   RNA

Structure-based functional mechanisms and biotechnology applications of anti-CRISPR proteins

(2021) Ning Jia et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Molecular basis of CD-NTase nucleotide selection in CBASS anti-phage defense

(2021) Apurva A. Govande et al.   Cell Reports

Cyclic CMP and cyclic UMP mediate bacterial immunity against phages

(2021) Nitzan Tal et al.   CELL

Effector-mediated membrane disruption controls cell death in CBASS antiphage defense

(2021) Brianna Duncan-Lowey et al.   MOLECULAR CELL

Antiviral activity of bacterial TIR domains via immune signalling molecules

(2021) Gal Ofir et al.   NATURE

Specificity and sensitivity of an RNA targeting type III CRISPR complex coupled with a NucC endonuclease effector

(2021) Sabine Grüschow et al.   NUCLEIC ACIDS RESEARCH

Structural basis of cyclic oligoadenylate degradation by ancillary Type III CRISPR-Cas ring nucleases

(2021) Rafael Molina et al.   NUCLEIC ACIDS RESEARCH

Molecular mechanisms of the CdnG-Cap5 antiphage defense system employing 3′,2′-cGAMP as the second messenger

(2021) Shirin Fatma et al.   Nature Communications

Structure and Mechanism of a Cyclic Trinucleotide-Activated Bacterial Endonuclease Mediating Bacteriophage Immunity

(2020) Rebecca K. Lau et al.   MOLECULAR CELL

HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity

(2020) Qiaozhen Ye et al.   MOLECULAR CELL

An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity

(2020) Januka S. Athukoralage et al.   NATURE

Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

(2020) Stephen A. McMahon et al.   Nature Communications

Anti-CRISPRs: Protein Inhibitors of CRISPR-Cas Systems

(2020) Alan R. Davidson et al.   Annual Review of Biochemistry

Cyclic dinucleotides at the forefront of innate immunity

(2020) Shivam A. Zaver et al.   CURRENT OPINION IN CELL BIOLOGY

Regulation of the RNA and DNA nuclease activities required for Pyrococcus furiosus Type III-B CRISPR–Cas immunity

(2020) Kawanda Foster et al.   NUCLEIC ACIDS RESEARCH

Activation and self-inactivation mechanisms of the cyclic oligoadenylate-dependent CRISPR ribonuclease Csm6

(2020) Carmela Garcia-Doval et al.   Nature Communications

CBASS Immunity Uses CARF-Related Effectors to Sense 3′–5′- and 2′–5′-Linked Cyclic Oligonucleotide Signals and Protect Bacteria from Phage Infection

(2020) Brianna Lowey et al.   CELL

Structures of the Cmr-β Complex Reveal the Regulation of the Immunity Mechanism of Type III-B CRISPR-Cas

(2020) Nicholas Sofos et al.   MOLECULAR CELL

Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense

(2020) Kira S Makarova et al.   NUCLEIC ACIDS RESEARCH

Type III-A CRISPR-associated protein Csm6 degrades cyclic hexa-adenylate activator using both CARF and HEPN domains

(2020) Dalia Smalakyte et al.   NUCLEIC ACIDS RESEARCH

Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation

(2020) Donghyun Ka et al.   Nature Communications

Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

(2020) Januka S Athukoralage et al.   eLife

Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

(2020) Anna Lopatina et al.   Annual Review of Virology

STING cyclic dinucleotide sensing originated in bacteria

(2020) Benjamin R. Morehouse et al.   NATURE

Prokaryotic viperins produce diverse antiviral molecules

(2020) Aude Bernheim et al.   NATURE

Diversity and classification of cyclic-oligonucleotide-based anti-phage signalling systems

(2020) Adi Millman et al.   Nature Microbiology

Non-specific degradation of transcripts promotes plasmid clearance during type III-A CRISPR–Cas immunity

(2019) Jakob T. Rostøl et al.   Nature Microbiology

Bacterial cGAS-like enzymes synthesize diverse nucleotide signals

(2019) Aaron T. Whiteley et al.   NATURE

Cryo-EM structures of STING reveal its mechanism of activation by cyclic GMP–AMP

(2019) Guijun Shang et al.   NATURE

A Type III CRISPR Ancillary Ribonuclease Degrades Its Cyclic Oligoadenylate Activator

(2019) Januka S. Athukoralage et al.   JOURNAL OF MOLECULAR BIOLOGY

CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity

(2019) Ning Jia et al.   MOLECULAR CELL

Second Messenger cA4 Formation within the Composite Csm1 Palm Pocket of Type III-A CRISPR-Cas Csm Complex and Its Release Path

(2019) Ning Jia et al.   MOLECULAR CELL

Cyclic GMP–AMP signalling protects bacteria against viral infection

(2019) Daniel Cohen et al.   NATURE

Structure of Csx1-cOA4 complex reveals the basis of RNA decay in Type III-B CRISPR-Cas

(2019) Rafael Molina et al.   Nature Communications

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

Direct activation of a phospholipase by cyclic GMP-AMP in El TorVibrio cholerae

(2018) Geoffrey B. Severin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic discovery of antiphage defense systems in the microbial pangenome

(2018) Shany Doron et al.   SCIENCE

Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate

(2018) Januka S. Athukoralage et al.   NATURE

Mechanism for remodelling of the cell cycle checkpoint protein MAD2 by the ATPase TRIP13

(2018) Claudio Alfieri et al.   NATURE

Structure Studies of the CRISPR-Csm Complex Reveal Mechanism of Co-transcriptional Interference

(2018) Lilan You et al.   CELL

Type III-A CRISPR-Cas Csm Complexes: Assembly, Periodic RNA Cleavage, DNase Activity Regulation, and Autoimmunity

(2018) Ning Jia et al.   MOLECULAR CELL

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

(2017) Ole Niewoehner et al.   NATURE

A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems

(2017) Migle Kazlauskiene et al.   SCIENCE

Type III CRISPR-Cas Immunity: Major Differences Brushed Aside

(2017) Gintautas Tamulaitis et al.   TRENDS IN MICROBIOLOGY

Regulation and function of the cGAS–STING pathway of cytosolic DNA sensing

(2016) Qi Chen et al.   NATURE IMMUNOLOGY

Structural basis for the endoribonuclease activity of the type III-A CRISPR-associated protein Csm6

(2016) Ole Niewoehner et al.   RNA

Crystal Structure of the CRISPR-Cas RNA Silencing Cmr Complex Bound to a Target Analog

(2015) Takuo Osawa et al.   MOLECULAR CELL

Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling

(2015) A. Maxwell Burroughs et al.   NUCLEIC ACIDS RESEARCH

Structures of the CRISPR-Cmr complex reveal mode of RNA target positioning

(2015) D. W. Taylor et al.   SCIENCE

Structure, mechanism, and regulation of soluble adenylyl cyclases — similarities and differences to transmembrane adenylyl cyclases

(2014) Clemens Steegborn   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Structure-Guided Reprogramming of Human cGAS Dinucleotide Linkage Specificity

(2014) Philip J. Kranzusch et al.   CELL

Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus

(2014) Gintautas Tamulaitis et al.   MOLECULAR CELL

DNA-guided DNA interference by a prokaryotic Argonaute

(2014) Daan C. Swarts et al.   NATURE

Structure-Function Analysis of STING Activation by c[G(2′,5′)pA(3′,5′)p] and Targeting by Antiviral DMXAA

(2013) Pu Gao et al.   CELL

Cyclic [G(2′,5′)pA(3′,5′)p] Is the Metazoan Second Messenger Produced by DNA-Activated Cyclic GMP-AMP Synthase

(2013) Pu Gao et al.   CELL

Cyclic GMP-AMP Containing Mixed Phosphodiester Linkages Is An Endogenous High-Affinity Ligand for STING

(2013) Xu Zhang et al.   MOLECULAR CELL

cGAS produces a 2′-5′-linked cyclic dinucleotide second messenger that activates STING

(2013) Andrea Ablasser et al.   NATURE

The Innate Immune DNA Sensor cGAS Produces a Noncanonical Cyclic Dinucleotide that Activates Human STING

(2013) Elie J. Diner et al.   Cell Reports

Cyclic GMP-AMP Is an Endogenous Second Messenger in Innate Immune Signaling by Cytosolic DNA

(2012) J. Wu et al.   SCIENCE

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

(2012) L. Sun et al.   SCIENCE

The Oligoadenylate Synthetase Family: An Ancient Protein Family with Multiple Antiviral Activities

(2010) Helle Kristiansen et al.   JOURNAL OF INTERFERON AND CYTOKINE RESEARCH

RNA-Guided RNA Cleavage by a CRISPR RNA-Cas Protein Complex

(2009) Caryn R. Hale et al.   CELL