Alternative functions of CRISPR–Cas systems in the evolutionary arms race

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

(2021) Rachael E. Workman et al.   CELL

The Card1 nuclease provides defence during type-III CRISPR immunity

(2021) Jakob T. Rostøl et al.   NATURE

Anti-CRISPR AcrIF9 functions by inducing the CRISPR–Cas complex to bind DNA non-specifically

(2021) Wang-Ting Lu et al.   NUCLEIC ACIDS RESEARCH

Structure of a type IV CRISPR-Cas ribonucleoprotein complex

(2021) Yi Zhou et al.   iScience

Dual modes of CRISPR-associated transposon homing

(2021) Makoto Saito et al.   CELL

Type III-A CRISPR immunity promotes mutagenesis of staphylococci

(2021) Charlie Y. Mo et al.   NATURE

Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems

(2021) Ming Li et al.   SCIENCE

Noncanonical crRNAs derived from host transcripts enable multiplexable RNA detection by Cas9

(2021) Chunlei Jiao et al.   SCIENCE

The gRAMP CRISPR-Cas effector is an RNA endonuclease complexed with a caspase-like peptidase

(2021) Sam P. B. van Beljouw et al.   SCIENCE

Structure of the mini-RNA-guided endonuclease CRISPR-Cas12j3

(2021) Arturo Carabias et al.   Nature Communications

SCOPE enables type III CRISPR-Cas diagnostics using flexible targeting and stringent CARF ribonuclease activation

(2021) Jurre A. Steens et al.   Nature Communications

Clades of huge phages from across Earth’s ecosystems

(2020) Basem Al-Shayeb et al.   NATURE

An anti-CRISPR viral ring nuclease subverts type III CRISPR immunity

(2020) Januka S. Athukoralage et al.   NATURE

Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

(2020) Stephen A. McMahon et al.   Nature Communications

CRISPR-cas3 of Salmonella Upregulates Bacterial Biofilm Formation and Virulence to Host Cells by Targeting Quorum-Sensing Systems

(2020) Luqing Cui et al.   Pathogens

Critical Anti-CRISPR Locus Repression by a Bi-functional Cas9 Inhibitor

(2020) Beatriz A. Osuna et al.   Cell Host & Microbe

Listeria Phages Induce Cas9 Degradation to Protect Lysogenic Genomes

(2020) Beatriz A. Osuna et al.   Cell Host & Microbe

PAM recognition by miniature CRISPR–Cas12f nucleases triggers programmable double-stranded DNA target cleavage

(2020) Tautvydas Karvelis et al.   NUCLEIC ACIDS RESEARCH

AcrIF9 tethers non-sequence specific dsDNA to the CRISPR RNA-guided surveillance complex

(2020) Marscha Hirschi et al.   Nature Communications

Structures and Strategies of Anti-CRISPR-Mediated Immune Suppression

(2020) Tanner Wiegand et al.   Annual Review of Microbiology

A scoutRNA Is Required for Some Type V CRISPR-Cas Systems

(2020) Lucas B. Harrington et al.   MOLECULAR CELL

Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense

(2020) Kira S Makarova et al.   NUCLEIC ACIDS RESEARCH

Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

(2020) Anna Lopatina et al.   Annual Review of Virology

Guide-free Cas9 from pathogenic Campylobacter jejuni bacteria causes severe damage to DNA

(2020) Chinmoy Saha et al.   Science Advances

Virulence of the Pathogen Porphyromonas gingivalis Is Controlled by the CRISPR-Cas Protein Cas3

(2020) Jose Solbiati et al.   mSystems

Guide RNA Categorization Enables Target Site Choice in Tn7-CRISPR-Cas Transposons

(2020) Michael T. Petassi et al.   CELL

Mechanistic Insights into the cis- and trans-Acting DNase Activities of Cas12a

(2019) Daan C. Swarts et al.   MOLECULAR CELL

Non-specific degradation of transcripts promotes plasmid clearance during type III-A CRISPR–Cas immunity

(2019) Jakob T. Rostøl et al.   Nature Microbiology

Recombination between phages and CRISPR−cas loci facilitates horizontal gene transfer in staphylococci

(2019) Andrew Varble et al.   Nature Microbiology

CasX enzymes comprise a distinct family of RNA-guided genome editors

(2019) Jun-Jie Liu et al.   NATURE

Deletion of cas3 gene in Streptococcus mutans affects biofilm formation and increases fluoride sensitivity

(2019) Boyu Tang et al.   ARCHIVES OF ORAL BIOLOGY

A Type III CRISPR Ancillary Ribonuclease Degrades Its Cyclic Oligoadenylate Activator

(2019) Januka S. Athukoralage et al.   JOURNAL OF MOLECULAR BIOLOGY

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

(2019) Alexander J. Meeske et al.   NATURE

Author Correction: A CRISPR/Cas system mediates bacterial innate immune evasion and virulence

(2019) Timothy R. Sampson et al.   NATURE

Origins and evolution of CRISPR-Cas systems

(2019) Eugene V. Koonin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence

(2019) Hannah K. Ratner et al.   MOLECULAR CELL

CRISPR-Cas III-A Csm6 CARF Domain Is a Ring Nuclease Triggering Stepwise cA4 Cleavage with ApA>p Formation Terminating RNase Activity

(2019) Ning Jia et al.   MOLECULAR CELL

Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration

(2019) Sanne E. Klompe et al.   NATURE

RNA-guided DNA insertion with CRISPR-associated transposases

(2019) Jonathan Strecker et al.   SCIENCE

Inhibition of CRISPR-Cas9 ribonucleoprotein complex assembly by anti-CRISPR AcrIIC2

(2019) Annoj Thavalingam et al.   Nature Communications

Functional and Proteomic Analysis of Streptococcus pyogenes Virulence Upon Loss of Its Native Cas9 Nuclease

(2019) Nina J. Gao et al.   Frontiers in Microbiology

The CRISPR‐Cas13a Gene‐Editing System Induces Collateral Cleavage of RNA in Glioma Cells

(2019) Qixue Wang et al.   Advanced Science

Cas9 regulated gene expression and pathogenicity in Riemerella anatipestifer

(2019) Ying Wang et al.   MICROBIAL PATHOGENESIS

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Type IV CRISPR–Cas systems are highly diverse and involved in competition between plasmids

(2019) Rafael Pinilla-Redondo et al.   NUCLEIC ACIDS RESEARCH

Shooting the messenger: RNA-targetting CRISPR-Cas systems

(2018) Yifan Zhu et al.   BIOSCIENCE REPORTS

CRISPR RNA-Dependent Binding and Cleavage of Endogenous RNAs by the Campylobacter jejuni Cas9

(2018) Gaurav Dugar et al.   MOLECULAR CELL

Programmable RNA Cleavage and Recognition by a Natural CRISPR-Cas9 System from Neisseria meningitidis

(2018) Beth A. Rousseau et al.   MOLECULAR CELL

Systematic discovery of antiphage defense systems in the microbial pangenome

(2018) Shany Doron et al.   SCIENCE

CRISPR-Cas-Mediated Phage Resistance Enhances Horizontal Gene Transfer by Transduction

(2018) Bridget N. J. Watson et al.   mBio

RNA-dependent RNA targeting by CRISPR-Cas9

(2018) Steven C Strutt et al.   eLife

The CRISPR-Cas system in Enterobacteriaceae

(2018) Liliana Medina-Aparicio et al.   Pathogens and Disease

RNA Guide Complementarity Prevents Self-Targeting in Type VI CRISPR Systems

(2018) Alexander J. Meeske et al.   MOLECULAR CELL

Ring nucleases deactivate type III CRISPR ribonucleases by degrading cyclic oligoadenylate

(2018) Januka S. Athukoralage et al.   NATURE

Conformational Activation Promotes CRISPR-Cas12a Catalysis and Resetting of the Endonuclease Activity

(2018) Stefano Stella et al.   CELL

Functionally diverse type V CRISPR-Cas systems

(2018) Winston X. Yan et al.   SCIENCE

Programmed DNA destruction by miniature CRISPR-Cas14 enzymes

(2018) Lucas B. Harrington et al.   SCIENCE

Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum

(2018) Ahsen Özcan et al.   Nature Microbiology

The dev Operon Regulates the Timing of Sporulation during Myxococcus xanthus Development

(2017) Ramya Rajagopalan et al.   JOURNAL OF BACTERIOLOGY

Cas13b Is a Type VI-B CRISPR-Associated RNA-Guided RNase Differentially Regulated by Accessory Proteins Csx27 and Csx28

(2017) Aaron A. Smargon et al.   MOLECULAR CELL

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

(2017) Ole Niewoehner et al.   NATURE

RNA targeting with CRISPR–Cas13

(2017) Omar O. Abudayyeh et al.   NATURE

Recruitment of CRISPR-Cas systems by Tn7-like transposons

(2017) Joseph E. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems

(2017) Migle Kazlauskiene et al.   SCIENCE

Nucleic acid detection with CRISPR-Cas13a/C2c2

(2017) Jonathan S. Gootenberg et al.   SCIENCE

RNA-Independent DNA Cleavage Activities of Cas9 and Cas12a

(2017) Ramya Sundaresan et al.   Cell Reports

A highly specific phage defense system is a conserved feature of the Vibrio cholerae mobilome

(2017) Brendan J. O’Hara et al.   PLoS Genetics

Commentary: Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity

(2017) Hanna Müller-Esparza et al.   Frontiers in Microbiology

Degradation of Phage Transcripts by CRISPR-Associated RNases Enables Type III CRISPR-Cas Immunity

(2016) Wenyan Jiang et al.   CELL

Type I CRISPR-Cas targets endogenous genes and regulates virulence to evade mammalian host immunity

(2016) Rongpeng Li et al.   CELL RESEARCH

RNA-activated DNA cleavage by the Type III-B CRISPR–Cas effector complex

(2016) Michael A. Estrella et al.   GENES & DEVELOPMENT

Bipartite recognition of target RNAs activates DNA cleavage by the Type III-B CRISPR–Cas system

(2016) Joshua R. Elmore et al.   GENES & DEVELOPMENT

Spatiotemporal Control of Type III-A CRISPR-Cas Immunity: Coupling DNA Degradation with the Target RNA Recognition

(2016) Migle Kazlauskiene et al.   MOLECULAR CELL

Regulatory gene mutation: a driving force behind group aStreptococcusstrain- and serotype-specific variation

(2016) Poulomee Sarkar et al.   MOLECULAR MICROBIOLOGY

Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

(2016) Prarthana Mohanraju et al.   SCIENCE

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

Viruses Infecting a Freshwater Filamentous Cyanobacterium ( Nostoc sp.) Encode a Functional CRISPR Array and a Proteobacterial DNA Polymerase B

(2016) Caroline Chénard et al.   mBio

The Bacteriophage Carrier State of Campylobacter jejuni Features Changes in Host Non-coding RNAs and the Acquisition of New Host-derived CRISPR Spacer Sequences

(2016) Steven P. T. Hooton et al.   Frontiers in Microbiology

Co-transcriptional DNA and RNA Cleavage during Type III CRISPR-Cas Immunity

(2015) Poulami Samai et al.   CELL

Cpf1 Is a Single RNA-Guided Endonuclease of a Class 2 CRISPR-Cas System

(2015) Bernd Zetsche et al.   CELL

devIIs an Evolutionarily Young Negative Regulator of Myxococcus xanthus Development

(2015) Ramya Rajagopalan et al.   JOURNAL OF BACTERIOLOGY

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

(2015) Sergey Shmakov et al.   MOLECULAR CELL

Integrase-mediated spacer acquisition during CRISPR–Cas adaptive immunity

(2015) James K. Nuñez et al.   NATURE

CRISPR-Cas immunity in prokaryotes

(2015) Luciano A. Marraffini   NATURE

CRISPR adaptation biases explain preference for acquisition of foreign DNA

(2015) Asaf Levy et al.   NATURE

Multiple mechanisms for CRISPR–Cas inhibition by anti-CRISPR proteins

(2015) Joseph Bondy-Denomy et al.   NATURE

Clustered Regularly Interspaced Short Palindromic Repeat-Dependent, Biofilm-Specific Death of Pseudomonas aeruginosa Mediated by Increased Expression of Phage-Related Genes

(2015) Gary E. Heussler et al.   mBio

Analysis of virus genomes from glacial environments reveals novel virus groups with unusual host interactions

(2015) Christopher M. Bellas et al.   Frontiers in Microbiology

Target RNA capture and cleavage by the Cmr type III-B CRISPR–Cas effector complex

(2014) Caryn R. Hale et al.   GENES & DEVELOPMENT

A CRISPR with Roles in Myxococcus xanthus Development and Exopolysaccharide Production

(2014) R. A. Wallace et al.   JOURNAL OF BACTERIOLOGY

Combinatorial Regulation of thedevOperon by MrpC2 and FruA during Myxococcus xanthus Development

(2014) Ashleigh Campbell et al.   JOURNAL OF BACTERIOLOGY

Nutrient-Regulated Proteolysis of MrpC Halts Expression of Genes Important for Commitment to Sporulation during Myxococcus xanthus Development

(2014) R. Rajagopalan et al.   JOURNAL OF BACTERIOLOGY

Structural Model of a CRISPR RNA-Silencing Complex Reveals the RNA-Target Cleavage Activity in Cmr4

(2014) Christian Benda et al.   MOLECULAR CELL

Programmable RNA Shredding by the Type III-A CRISPR-Cas System of Streptococcus thermophilus

(2014) Gintautas Tamulaitis et al.   MOLECULAR CELL

Conditional tolerance of temperate phages via transcription-dependent CRISPR-Cas targeting

(2014) Gregory W. Goldberg et al.   NATURE

Programmable RNA recognition and cleavage by CRISPR/Cas9

(2014) Mitchell R. O’Connell et al.   NATURE

DNA interrogation by the CRISPR RNA-guided endonuclease Cas9

(2014) Samuel H. Sternberg et al.   NATURE

Unravelling the structural and mechanistic basis of CRISPR–Cas systems

(2014) John van der Oost et al.   NATURE REVIEWS MICROBIOLOGY

Cmr4 is the slicer in the RNA-targeting Cmr CRISPR complex

(2014) Xing Zhu et al.   NUCLEIC ACIDS RESEARCH

Detection and characterization of spacer integration intermediates in type I-E CRISPR–Cas system

(2014) Zihni Arslan et al.   NUCLEIC ACIDS RESEARCH

A New Group of Phage Anti-CRISPR Genes Inhibits the Type I-E CRISPR-Cas System of Pseudomonas aeruginosa

(2014) A. Pawluk et al.   mBio

CRISPR-Cas systems: new players in gene regulation and bacterial physiology

(2014) Timothy R. Sampson et al.   Frontiers in Cellular and Infection Microbiology

Massive Activation of Archaeal Defense Genes during Viral Infection

(2013) T. E. F. Quax et al.   JOURNAL OF VIROLOGY

A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity

(2013) Kimberley D. Seed et al.   NATURE

A CRISPR/Cas system mediates bacterial innate immune evasion and virulence

(2013) Timothy R. Sampson et al.   NATURE

Rapid evolution of the human gut virome

(2013) S. Minot et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR-Cas

(2013) Eugene V. Koonin et al.   RNA Biology

The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems

(2013) Krzysztof Chylinski et al.   RNA Biology

CRISPR-Cas and restriction–modification systems are compatible and increase phage resistance

(2013) Marie-Ève Dupuis et al.   Nature Communications

Repression of bacterial lipoprotein production byFrancisella novicidafacilitates evasion of innate immune recognition

(2012) Crystal L. Jones et al.   CELLULAR MICROBIOLOGY

A novel link between Campylobacter jejuni bacteriophage defence, virulence and Guillain–Barré syndrome

(2012) R. Louwen et al.   EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES

Bacteriophage genes that inactivate the CRISPR/Cas bacterial immune system

(2012) Joe Bondy-Denomy et al.   NATURE

Staphylococcal pathogenicity island interference with helper phage reproduction is a paradigm of molecular parasitism

(2012) G. Ram et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Programmable Dual-RNA-Guided DNA Endonuclease in Adaptive Bacterial Immunity

(2012) M. Jinek et al.   SCIENCE

The advantages and disadvantages of horizontal gene transfer and the emergence of the first species

(2011) Aaron A Vogan et al.   Biology Direct

The human gut virome: Inter-individual variation and dynamic response to diet

(2011) S. Minot et al.   GENOME RESEARCH

Within-host competition determines reproductive success of temperate bacteriophages

(2011) Dominik Refardt   ISME Journal

Non-Identity-Mediated CRISPR-Bacteriophage Interaction Mediated via the Csy and Cas3 Proteins

(2011) K. C. Cady et al.   JOURNAL OF BACTERIOLOGY

Evolution and classification of the CRISPR–Cas systems

(2011) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

RNA-guided complex from a bacterial immune system enhances target recognition through seed sequence interactions

(2011) B. Wiedenheft et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Interference by clustered regularly interspaced short palindromic repeat (CRISPR) RNA is governed by a seed sequence

(2011) E. Semenova et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CRISPR/Cas System and Its Role in Phage-Bacteria Interactions

(2010) Hélène Deveau et al.   Annual Review of Microbiology

The phage-host arms race: Shaping the evolution of microbes

(2010) Adi Stern et al.   BIOESSAYS

The CRISPR/Cas bacterial immune system cleaves bacteriophage and plasmid DNA

(2010) Josiane E. Garneau et al.   NATURE

Bacteriophage resistance mechanisms

(2010) Simon J. Labrie et al.   NATURE REVIEWS MICROBIOLOGY

Self-targeting by CRISPR: gene regulation or autoimmunity?

(2010) Adi Stern et al.   TRENDS IN GENETICS

Myxobacteria, Polarity, and Multicellular Morphogenesis

(2010) D. Kaiser et al.   Cold Spring Harbor Perspectives in Biology

Interaction between Bacteriophage DMS3 and Host CRISPR Region Inhibits Group Behaviors of Pseudomonas aeruginosa

(2008) M. E. Zegans et al.   JOURNAL OF BACTERIOLOGY

Small CRISPR RNAs Guide Antiviral Defense in Prokaryotes

(2008) S. J. J. Brouns et al.   SCIENCE