Antiviral activity of bacterial TIR domains via immune signalling molecules

HORMA Domain Proteins and a Trip13-like ATPase Regulate Bacterial cGAS-like Enzymes to Mediate Bacteriophage Immunity

(2020) Qiaozhen Ye et al.   MOLECULAR CELL

Toll-like Receptors and the Control of Immunity

(2020) Katherine A. Fitzgerald et al.   CELL

Quantifying the heterogeneity of macromolecular machines by mass photometry

(2020) Adar Sonn-Segev et al.   Nature Communications

The TIR-domain containing effectors BtpA and BtpB from Brucella abortus impact NAD metabolism

(2020) Julia María Coronas-Serna et al.   PLoS Pathogens

Enzymatic Functions for Toll/Interleukin-1 Receptor Domain Proteins in the Plant Immune System

(2020) Adam M. Bayless et al.   Frontiers in Genetics

Induced proximity of a TIR signaling domain on a plant-mammalian NLR chimera activates defense in plants

(2020) Zane Duxbury et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural and functional evidence of bacterial antiphage protection by Thoeris defense system via NAD+ degradation

(2020) Donghyun Ka et al.   Nature Communications

Abortive Infection: Bacterial Suicide as an Antiviral Immune Strategy

(2020) Anna Lopatina et al.   Annual Review of Virology

Identification of uncharacterized components of prokaryotic immune systems and their diverse eukaryotic reformulations

(2020) A. Maxwell Burroughs et al.   JOURNAL OF BACTERIOLOGY

STING cyclic dinucleotide sensing originated in bacteria

(2020) Benjamin R. Morehouse et al.   NATURE

Prokaryotic viperins produce diverse antiviral molecules

(2020) Aude Bernheim et al.   NATURE

Cyclic GMP–AMP signalling protects bacteria against viral infection

(2019) Daniel Cohen et al.   NATURE

TIR domains of plant immune receptors are NAD+-cleaving enzymes that promote cell death

(2019) Li Wan et al.   SCIENCE

NAD+ cleavage activity by animal and plant TIR domains in cell death pathways

(2019) Shane Horsefield et al.   SCIENCE

Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

(2019) Yihe Huang et al.   eLife

A structural overview of the ion channels of the TRPM family

(2019) Yihe Huang et al.   CELL CALCIUM

TIR Domain Proteins Are an Ancient Family of NAD + -Consuming Enzymes

(2018) Kow Essuman et al.   CURRENT BIOLOGY

Systematic discovery of antiphage defense systems in the microbial pangenome

(2018) Shany Doron et al.   SCIENCE

The SARM1 Toll/Interleukin-1 Receptor Domain Possesses Intrinsic NAD + Cleavage Activity that Promotes Pathological Axonal Degeneration

(2017) Kow Essuman et al.   NEURON

Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling

(2015) A. Maxwell Burroughs et al.   NUCLEIC ACIDS RESEARCH

Fumarate induces redox-dependent senescence by modifying glutathione metabolism

(2015) Liang Zheng et al.   Nature Communications

Complete Sequence of the First Chimera Genome Constructed by Cloning the Whole Genome of Synechocystis Strain PCC6803 into the Bacillus subtilis 168 Genome

(2012) S. Watanabe et al.   JOURNAL OF BACTERIOLOGY

MZmine 2: Modular framework for processing, visualizing, and analyzing mass spectrometry-based molecular profile data

(2010) Tomáš Pluskal et al.   BMC BIOINFORMATICS