Evolutionary plasticity and functional versatility of CRISPR systems

A natural single-guide RNA repurposes Cas9 to autoregulate CRISPR-Cas expression

(2021) Rachael E. Workman et al.   CELL

The Card1 nuclease provides defence during type-III CRISPR immunity

(2021) Jakob T. Rostøl et al.   NATURE

The CRISPR ancillary effector Can2 is a dual-specificity nuclease potentiating type III CRISPR defence

(2021) Wenlong Zhu et al.   NUCLEIC ACIDS RESEARCH

Structure of a type IV CRISPR-Cas ribonucleoprotein complex

(2021) Yi Zhou et al.   iScience

Dual modes of CRISPR-associated transposon homing

(2021) Makoto Saito et al.   CELL

CRISPR transposons on the move

(2021) Ioannis Mougiakos et al.   Cell Host & Microbe

crRNA complementarity shifts endogenous CRISPR-Cas systems between transcriptional repression and DNA defense

(2021) Hannah K. Ratner et al.   RNA Biology

Cyclic oligoadenylate signalling and regulation by ring nucleases during type III CRISPR defence

(2021) Januka S Athukoralage et al.   RNA

Toxin-antitoxin RNA pairs safeguard CRISPR-Cas systems

(2021) Ming Li et al.   SCIENCE

Programmable RNA targeting with the single-protein CRISPR effector Cas7-11

(2021) Ahsen Özcan et al.   NATURE

The gRAMP CRISPR-Cas effector is an RNA endonuclease complexed with a caspase-like peptidase

(2021) Sam P. B. van Beljouw et al.   SCIENCE

The widespread IS200/605 transposon family encodes diverse programmable RNA-guided endonucleases

(2021) Han Altae-Tran et al.   SCIENCE

Positioning Diverse Type IV Structures and Functions Within Class 1 CRISPR-Cas Systems

(2021) Hannah N. Taylor et al.   Frontiers in Microbiology

Bacteriophage ICP1: A Persistent Predator of Vibrio cholerae

(2021) Caroline M. Boyd et al.   Annual Review of Virology

Evolution of Type IV CRISPR-Cas Systems: Insights from CRISPR Loci in Integrative Conjugative Elements of Acidithiobacillia

(2021) Ana Moya-Beltrán et al.   CRISPR Journal

Structure and mechanism of a Type III CRISPR defence DNA nuclease activated by cyclic oligoadenylate

(2020) Stephen A. McMahon et al.   Nature Communications

Evolutionary and functional classification of the CARF domain superfamily, key sensors in prokaryotic antivirus defense

(2020) Kira S Makarova et al.   NUCLEIC ACIDS RESEARCH

Unprecedented Diversity of Unique CRISPR-Cas-Related Systems and Cas1 Homologs in Asgard Archaea

(2020) Kira S. Makarova et al.   CRISPR Journal

Molecular Mechanisms of CRISPR-Cas Immunity in Bacteria

(2020) Philip M. Nussenzweig et al.   Annual Review of Genetics

Publisher Correction: Structural basis of DNA targeting by a transposon-encoded CRISPR–Cas system

(2020) Tyler S. Halpin-Healy et al.   NATURE

Guide RNA Categorization Enables Target Site Choice in Tn7-CRISPR-Cas Transposons

(2020) Michael T. Petassi et al.   CELL

Cell death signalling in virus infection

(2020) Gergely Imre   CELLULAR SIGNALLING

CRISPR: a new principle of genome engineering linked to conceptual shifts in evolutionary biology

(2019) Eugene V. Koonin   BIOLOGY & PHILOSOPHY

Megaphages infect Prevotella and variants are widespread in gut microbiomes

(2019) Audra E. Devoto et al.   Nature Microbiology

Cas13-induced cellular dormancy prevents the rise of CRISPR-resistant bacteriophage

(2019) Alexander J. Meeske et al.   NATURE

Origins and evolution of CRISPR-Cas systems

(2019) Eugene V. Koonin et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Catalytically Active Cas9 Mediates Transcriptional Interference to Facilitate Bacterial Virulence

(2019) Hannah K. Ratner et al.   MOLECULAR CELL

Transposon-encoded CRISPR–Cas systems direct RNA-guided DNA integration

(2019) Sanne E. Klompe et al.   NATURE

CRISPR–Cas in mobile genetic elements: counter-defence and beyond

(2019) Guilhem Faure et al.   NATURE REVIEWS MICROBIOLOGY

RNA-guided DNA insertion with CRISPR-associated transposases

(2019) Jonathan Strecker et al.   SCIENCE

Targeted transposition with Tn7 elements: safe sites, mobile plasmids, CRISPR/Cas and beyond

(2019) Joseph E. Peters   MOLECULAR MICROBIOLOGY

Evolutionary entanglement of mobile genetic elements and host defence systems: guns for hire

(2019) Eugene V. Koonin et al.   NATURE REVIEWS GENETICS

Virus-borne mini-CRISPR arrays are involved in interviral conflicts

(2019) Sofia Medvedeva et al.   Nature Communications

Evolutionary classification of CRISPR–Cas systems: a burst of class 2 and derived variants

(2019) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Type IV CRISPR–Cas systems are highly diverse and involved in competition between plasmids

(2019) Rafael Pinilla-Redondo et al.   NUCLEIC ACIDS RESEARCH

Systematic prediction of genes functionally linked to CRISPR-Cas systems by gene neighborhood analysis

(2018) Sergey A. Shmakov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Comprehensive search for accessory proteins encoded with archaeal and bacterial type III CRISPR-cas gene cassettes reveals 39 new cas gene families

(2018) Shiraz A. Shah et al.   RNA Biology

CRISPR–Cas: Complex Functional Networks and Multiple Roles beyond Adaptive Immunity

(2018) Guilhem Faure et al.   JOURNAL OF MOLECULAR BIOLOGY

A Reverse Transcriptase-Cas1 Fusion Protein Contains a Cas6 Domain Required for Both CRISPR RNA Biogenesis and RNA Spacer Acquisition

(2018) Georg Mohr et al.   MOLECULAR CELL

Functionally diverse type V CRISPR-Cas systems

(2018) Winston X. Yan et al.   SCIENCE

In silico Analysis Suggests Common Appearance of scaRNAs in Type II Systems and Their Association With Bacterial Virulence

(2018) Jelena Guzina et al.   Frontiers in Genetics

Type IV CRISPR RNA processing and effector complex formation in Aromatoleum aromaticum

(2018) Ahsen Özcan et al.   Nature Microbiology

The dev Operon Regulates the Timing of Sporulation during Myxococcus xanthus Development

(2017) Ramya Rajagopalan et al.   JOURNAL OF BACTERIOLOGY

Type III CRISPR–Cas systems produce cyclic oligoadenylate second messengers

(2017) Ole Niewoehner et al.   NATURE

Diversity and evolution of class 2 CRISPR–Cas systems

(2017) Sergey Shmakov et al.   NATURE REVIEWS MICROBIOLOGY

Recruitment of CRISPR-Cas systems by Tn7-like transposons

(2017) Joseph E. Peters et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A cyclic oligonucleotide signaling pathway in type III CRISPR-Cas systems

(2017) Migle Kazlauskiene et al.   SCIENCE

On the Origin of Reverse Transcriptase-Using CRISPR-Cas Systems and Their Hyperdiverse, Enigmatic Spacer Repertoires

(2017) Sukrit Silas et al.   mBio

A decade of discovery: CRISPR functions and applications

(2017) Rodolphe Barrangou et al.   Nature Microbiology

Coupling immunity and programmed cell suicide in prokaryotes: Life-or-death choices

(2016) Eugene V. Koonin et al.   BIOESSAYS

Applications of CRISPR technologies in research and beyond

(2016) Rodolphe Barrangou et al.   NATURE BIOTECHNOLOGY

Direct CRISPR spacer acquisition from RNA by a natural reverse transcriptase-Cas1 fusion protein

(2016) S. Silas et al.   SCIENCE

Diverse evolutionary roots and mechanistic variations of the CRISPR-Cas systems

(2016) Prarthana Mohanraju et al.   SCIENCE

C2c2 is a single-component programmable RNA-guided RNA-targeting CRISPR effector

(2016) Omar O. Abudayyeh et al.   SCIENCE

ISC, a Novel Group of Bacterial and Archaeal DNA Transposons That Encode Cas9 Homologs

(2015) Vladimir V. Kapitonov et al.   JOURNAL OF BACTERIOLOGY

devIIs an Evolutionarily Young Negative Regulator of Myxococcus xanthus Development

(2015) Ramya Rajagopalan et al.   JOURNAL OF BACTERIOLOGY

A Conserved Structural Chassis for Mounting Versatile CRISPR RNA-Guided Immune Responses

(2015) Ryan N. Jackson et al.   MOLECULAR CELL

Discovery and Functional Characterization of Diverse Class 2 CRISPR-Cas Systems

(2015) Sergey Shmakov et al.   MOLECULAR CELL

An updated evolutionary classification of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   NATURE REVIEWS MICROBIOLOGY

Comparative genomic analyses reveal a vast, novel network of nucleotide-centric systems in biological conflicts, immunity and signaling

(2015) A. Maxwell Burroughs et al.   NUCLEIC ACIDS RESEARCH

The basic building blocks and evolution of CRISPR–Cas systems

(2015) Kira S. Makarova et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Casposons: a new superfamily of self-synthesizing DNA transposons at the origin of prokaryotic CRISPR-Cas immunity

(2014) Mart Krupovic et al.   BMC BIOLOGY

CRISPR-Cas Systems: Prokaryotes Upgrade to Adaptive Immunity

(2014) Rodolphe Barrangou et al.   MOLECULAR CELL

CRISPR–Cas systems: beyond adaptive immunity

(2014) Edze R. Westra et al.   NATURE REVIEWS MICROBIOLOGY

The new frontier of genome engineering with CRISPR-Cas9

(2014) J. A. Doudna et al.   SCIENCE

A bacteriophage encodes its own CRISPR/Cas adaptive response to evade host innate immunity

(2013) Kimberley D. Seed et al.   NATURE

A CRISPR/Cas system mediates bacterial innate immune evasion and virulence

(2013) Timothy R. Sampson et al.   NATURE

The tracrRNA and Cas9 families of type II CRISPR-Cas immunity systems

(2013) Krzysztof Chylinski et al.   RNA Biology

Nature and Intensity of Selection Pressure on CRISPR-Associated Genes

(2011) N. Takeuchi et al.   JOURNAL OF BACTERIOLOGY

CRISPR RNA maturation by trans-encoded small RNA and host factor RNase III

(2011) Elitza Deltcheva et al.   NATURE