Induction of pyroptotic cell death as a potential tool for cancer treatment

Ferroptosis in cancer therapy: a novel approach to reversing drug resistance

(2022) Chen Zhang et al.   Molecular Cancer

Immunogenic cell stress and death

(2022) Guido Kroemer et al.   NATURE IMMUNOLOGY

Harnessing cytokines and chemokines for cancer therapy

(2022) David J. Propper et al.   Nature Reviews Clinical Oncology

Intratumoral IL-1R1 expression delineates a distinctive molecular subset with therapeutic resistance in patients with gastric cancer

(2022) Puran Zhang et al.   Journal for ImmunoTherapy of Cancer

VB12-Sericin-PBLG-IR780 Nanomicelles for Programming Cell Pyroptosis via Photothermal (PTT)/Photodynamic (PDT) Effect-Induced Mitochondrial DNA (mitoDNA) Oxidative Damage

(2022) Weihong Guo et al.   ACS Applied Materials & Interfaces

Intravenous Delivery of Living Listeria monocytogenes Elicits Gasdmermin-Dependent Tumor Pyroptosis and Motivates Anti-Tumor Immune Response

(2022) Yao Liu et al.   ACS Nano

Biomimetic Nanocarriers Guide Extracellular ATP Homeostasis to Remodel Energy Metabolism for Activating Innate and Adaptive Immunity System

(2022) Long Wu et al.   Advanced Science

Small molecule inhibitors from organoid‐based drug screen induce concurrent apoptosis and gasdermin E‐dependent pyroptosis in colorectal cancer

(2022) Yuchen Zhang et al.   Clinical and Translational Medicine

Mitochondria-Targeting Polymer Micelle of Dichloroacetate Induced Pyroptosis to Enhance Osteosarcoma Immunotherapy

(2022) Jiakang Jin et al.   ACS Nano

Pyroptosis Remodeling Tumor Microenvironment to Enhance Pancreatic Cancer Immunotherapy Driven by Membrane Anchoring Photosensitizer

(2022) Meng Wang et al.   Advanced Science

Blockade of AIM2 inflammasome or α1-AR ameliorates IL-1β release and macrophage-mediated immunosuppression induced by CAR-T treatment

(2021) Dan Liu et al.   Journal for ImmunoTherapy of Cancer

Targeting tumor-derived NLRP3 reduces melanoma progression by limiting MDSCs expansion

(2021) Isak W. Tengesdal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasdermin E permits interleukin-1 beta release in distinct sublytic and pyroptotic phases

(2021) Bowen Zhou et al.   Cell Reports

The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation

(2021) Chuanhui Han et al.   Science Immunology

STAT3-mediated upregulation of the AIM2 DNA sensor links innate immunity with cell migration to promote epithelial tumourigenesis

(2021) Ruby E Dawson et al.   GUT

AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma

(2021) Keitaro Fukuda et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Transcriptional and epigenetic regulation of gasdermins

(2021) Emilie Bourdonnay et al.   JOURNAL OF MOLECULAR BIOLOGY

TIM-3 restrains anti-tumour immunity by regulating inflammasome activation

(2021) Karen O. Dixon et al.   NATURE

Strategies to package recombinant Adeno-Associated Virus expressing the N-terminal gasdermin domain for tumor treatment

(2021) Yuan Lu et al.   Nature Communications

ADAR1 restricts ZBP1-mediated immune response and PANoptosis to promote tumorigenesis

(2021) Rajendra Karki et al.   Cell Reports

YAP drives fate conversion and chemoresistance of small cell lung cancer

(2021) Qingzhe Wu et al.   Science Advances

DPP inhibition alters the CXCR3 axis and enhances NK and CD8+ T cell infiltration to improve anti-PD1 efficacy in murine models of pancreatic ductal adenocarcinoma

(2021) Allison A Fitzgerald et al.   Journal for ImmunoTherapy of Cancer

Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma

(2021) James M. Henderson et al.   Cancers

Tumor Cell–Derived IL1β Promotes Desmoplasia and Immune Suppression in Pancreatic Cancer

(2020) Shipra Das et al.   CANCER RESEARCH

Characterization of virus-mediated immunogenic cancer cell death and the consequences for oncolytic virus-based immunotherapy of cancer

(2020) Jing Ma et al.   Cell Death & Disease

Gasdermin E–mediated target cell pyroptosis by CAR T cells triggers cytokine release syndrome

(2020) Yuying Liu et al.   Science Immunology

mtDNA Activates cGAS Signaling and Suppresses the YAP-Mediated Endothelial Cell Proliferation Program to Promote Inflammatory Injury

(2020) Long Shuang Huang et al.   IMMUNITY

A tumor-intrinsic PD-L1/NLRP3 inflammasome signaling pathway drives resistance to anti–PD-1 immunotherapy

(2020) Balamayoora Theivanthiran et al.   JOURNAL OF CLINICAL INVESTIGATION

Gasdermin E suppresses tumour growth by activating anti-tumour immunity

(2020) Zhibin Zhang et al.   NATURE

A bioorthogonal system reveals antitumour immune function of pyroptosis

(2020) Qinyang Wang et al.   NATURE

cFLIPL protects macrophages from LPS-induced pyroptosis via inhibition of complex II formation

(2020) Hayley I. Muendlein et al.   SCIENCE

Granzyme A from cytotoxic lymphocytes cleaves GSDMB to trigger pyroptosis in target cells

(2020) Zhiwei Zhou et al.   SCIENCE

DDX3X Suppresses the Susceptibility of Hindbrain Lineages to Medulloblastoma

(2020) Deanna M. Patmore et al.   DEVELOPMENTAL CELL

A novel chimeric PD1-NKG2D-41BB receptor enhances antitumor activity of NK92 cells against human lung cancer H1299 cells by triggering pyroptosis

(2020) Chengui Lu et al.   MOLECULAR IMMUNOLOGY

Pharmacologic induction of innate immune signaling directly drives homologous recombination deficiency

(2020) Lena J. McLaughlin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Specific targeting of IL-1β activity to CD8+ T cells allows for safe use as a vaccine adjuvant

(2020) Bram Van Den Eeckhout et al.   npj Vaccines

Differential effects of PD-L1 versus PD-1 blockade on myeloid inflammation in human cancer

(2020) Noffar Bar et al.   JCI Insight

Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer

(2020) Rajendra Karki et al.   JCI Insight

Caspase-1 cleaves Bid to release mitochondrial SMAC and drive secondary necrosis in the absence of GSDMD

(2020) Rosalie Heilig et al.   Life Science Alliance

PD-L1-mediated gasdermin C expression switches apoptosis to pyroptosis in cancer cells and facilitates tumour necrosis

(2020) Junwei Hou et al.   NATURE CELL BIOLOGY

IL1β promotes immune suppression in the tumor microenvironment independent of the inflammasome and gasdermin D

(2020) Mate Kiss et al.   Cancer Immunology Research

Cell-Type-Specific Responses to Interleukin-1 Control Microbial Invasion and Tumor-Elicited Inflammation in Colorectal Cancer

(2019) Oxana Dmitrieva-Posocco et al.   IMMUNITY

Targeting TMEM176B Enhances Antitumor Immunity and Augments the Efficacy of Immune Checkpoint Blockers by Unleashing Inflammasome Activation

(2019) Mercedes Segovia et al.   CANCER CELL

Interleukin-1 and Related Cytokines in the Regulation of Inflammation and Immunity

(2019) Alberto Mantovani et al.   IMMUNITY

Gasdermin pores permeabilize mitochondria to augment caspase-3 activation during apoptosis and inflammasome activation

(2019) Corey Rogers et al.   Nature Communications

A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis

(2019) Yilong Zou et al.   Nature Communications

DDX3X acts as a live-or-die checkpoint in stressed cells by regulating NLRP3 inflammasome

(2019) Parimal Samir et al.   NATURE

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

Recent Progress in Ferroptosis Inducers for Cancer Therapy

(2019) Chen Liang et al.   ADVANCED MATERIALS

Macrophage-Derived CXCL9 and CXCL10 Are Required for Antitumor Immune Responses Following Immune Checkpoint Blockade

(2019) Imran G. House et al.   CLINICAL CANCER RESEARCH

Mitochondria as multifaceted regulators of cell death

(2019) Florian J. Bock et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Extracellular NK histones promote immune cell anti-tumor activity by inducing cell clusters through binding to CD138 receptor

(2019) B. Martín-Antonio et al.   Journal for ImmunoTherapy of Cancer

Mutant BRAF and MEK Inhibitors Regulate the Tumor Immune Microenvironment via Pyroptosis

(2019) Dan A. Erkes et al.   Cancer Discovery

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

(2018) Charles L. Evavold et al.   IMMUNITY

Next generation of immune checkpoint therapy in cancer: new developments and challenges

(2018) Julian A. Marin-Acevedo et al.   Journal of Hematology & Oncology

Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies

(2018) Jacob P. van Vloten et al.   JOURNAL OF IMMUNOLOGY

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

(2018) Darren C. Johnson et al.   NATURE MEDICINE

Immune-Related Adverse Events Associated with Immune Checkpoint Blockade

(2018) Michael A. Postow et al.   NEW ENGLAND JOURNAL OF MEDICINE

ESCRT-dependent control of membrane remodelling during cell division

(2018) Caroline Louise Stoten et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

The Role of Ferroptosis in Cancer Development and Treatment Response

(2018) Bin Lu et al.   Frontiers in Pharmacology

Immune Checkpoint Inhibition Overcomes ADCP-Induced Immunosuppression by Macrophages

(2018) Shicheng Su et al.   CELL

Blocking IL-1β reverses the immunosuppression in mouse breast cancer and synergizes with anti–PD-1 for tumor abrogation

(2018) Irena Kaplanov et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

NLRP3 inflammasomes in macrophages drive colorectal cancer metastasis to the liver

(2018) Qiaoting Deng et al.   CANCER LETTERS

The AIM2 inflammasome: Sensor of pathogens and cellular perturbations

(2017) Jérôme Lugrin et al.   IMMUNOLOGICAL REVIEWS

Inflammasome activation and assembly at a glance

(2017) Ankit Malik et al.   JOURNAL OF CELL SCIENCE

NLRP3 signaling drives macrophage-induced adaptive immune suppression in pancreatic carcinoma

(2017) Donnele Daley et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Recent Insights into the Molecular Mechanisms Underlying Pyroptosis and Gasdermin Family Functions

(2017) Robin A. Aglietti et al.   TRENDS IN IMMUNOLOGY

Antigen-specific CD8+ T cell feedback activates NLRP3 inflammasome in antigen-presenting cells through perforin

(2017) Yikun Yao et al.   Nature Communications

NLRP3 inflammasome activation plays a carcinogenic role through effector cytokine IL-18 in lymphoma

(2017) Xia Zhao et al.   Oncotarget

Inflammasomes and Cancer

(2017) Rajendra Karki et al.   Cancer Immunology Research

GSDMD membrane pore formation constitutes the mechanism of pyroptotic cell death

(2016) Lorenzo Sborgi et al.   EMBO JOURNAL

The cell biology of inflammasomes: Mechanisms of inflammasome activation and regulation

(2016) Deepika Sharma et al.   JOURNAL OF CELL BIOLOGY

Pore-forming activity and structural autoinhibition of the gasdermin family

(2016) Jingjin Ding et al.   NATURE

Inflammasome-activated gasdermin D causes pyroptosis by forming membrane pores

(2016) Xing Liu et al.   NATURE

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

(2016) Marian C Okondo et al.   Nature Chemical Biology

GsdmD p30 elicited by caspase-11 during pyroptosis forms pores in membranes

(2016) Robin A. Aglietti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting inflammasome/IL-1 pathways for cancer immunotherapy

(2016) Beichu Guo et al.   Scientific Reports

Innate Immune Pattern Recognition: A Cell Biological Perspective

(2015) Sky W. Brubaker et al.   Annual Review of Immunology

Caspase-11 Requires the Pannexin-1 Channel and the Purinergic P2X7 Pore to Mediate Pyroptosis and Endotoxic Shock

(2015) Dahai Yang et al.   IMMUNITY

Regulation of inflammasome activation

(2015) Si Ming Man et al.   IMMUNOLOGICAL REVIEWS

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

Ferroptosis as a p53-mediated activity during tumour suppression

(2015) Le Jiang et al.   NATURE

Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy

(2015) Rosa Barreira da Silva et al.   NATURE IMMUNOLOGY

Regulation of Ferroptotic Cancer Cell Death by GPX4

(2014) Wan Seok Yang et al.   CELL

Inflammatory caspases are innate immune receptors for intracellular LPS

(2014) Jianjin Shi et al.   NATURE

A high-throughput, multiplexed assay for superfamily-wide profiling of enzyme activity

(2014) Daniel A Bachovchin et al.   Nature Chemical Biology

Of inflammasomes and pathogens - sensing of microbes by the inflammasome

(2013) Franz Bauernfeind et al.   EMBO Molecular Medicine

Caspase-11 Protects Against Bacteria That Escape the Vacuole

(2013) Y. Aachoui et al.   SCIENCE

Caspase-11 increases susceptibility to Salmonella infection in the absence of caspase-1

(2012) Petr Broz et al.   NATURE

Dissecting the genomic complexity underlying medulloblastoma

(2012) David T. W. Jones et al.   NATURE

IFI16 Acts as a Nuclear Pathogen Sensor to Induce the Inflammasome in Response to Kaposi Sarcoma-Associated Herpesvirus Infection

(2011) Nagaraj Kerur et al.   Cell Host & Microbe

Non-canonical inflammasome activation targets caspase-11

(2011) Nobuhiko Kayagaki et al.   NATURE

The Inflammasomes

(2010) Kate Schroder et al.   CELL

Pattern Recognition Receptors and Inflammation

(2010) Osamu Takeuchi et al.   CELL

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: NF- B Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

(2009) F. G. Bauernfeind et al.   JOURNAL OF IMMUNOLOGY

AIM2 activates the inflammasome and cell death in response to cytoplasmic DNA

(2009) Teresa Fernandes-Alnemri et al.   NATURE

Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors

(2009) François Ghiringhelli et al.   NATURE MEDICINE