Biomimetic Nanocarriers Guide Extracellular ATP Homeostasis to Remodel Energy Metabolism for Activating Innate and Adaptive Immunity System

Boosting anti-PD-1 therapy with metformin-loaded macrophage-derived microparticles

(2021) Zhaohan Wei et al.   Nature Communications

Our Current Understanding of Checkpoint Inhibitor Therapy in Cancer Immunotherapy

(2021) Elena Goleva et al.   ANNALS OF ALLERGY ASTHMA & IMMUNOLOGY

Smart transformable nanomedicines for cancer therapy

(2021) Yuequan Wang et al.   BIOMATERIALS

Harnessing Innate Immunity Using Biomaterials for Cancer Immunotherapy

(2021) DaeYong Lee et al.   ADVANCED MATERIALS

ATP and cancer immunosurveillance

(2021) Oliver Kepp et al.   EMBO JOURNAL

An amphiphilic dendrimer as a light-activable immunological adjuvant for in situ cancer vaccination

(2021) Yongchao Wang et al.   Nature Communications

Graphene Oxide-Grafted Magnetic Nanorings Mediated Magnetothermodynamic Therapy Favoring Reactive Oxygen Species-Related Immune Response for Enhanced Antitumor Efficacy

(2020) Xiaoli Liu et al.   ACS Nano

A review of cancer immunotherapy toxicity

(2020) Lucy Boyce Kennedy et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Context-Dependent Pharmacological Effects of Metformin on the Immune System

(2020) Fabrizio Marcucci et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

On the mechanism of anti-CD39 immune checkpoint therapy

(2020) David Allard et al.   Journal for ImmunoTherapy of Cancer

Tumor-associated macrophages

(2020) Luca Cassetta et al.   CURRENT BIOLOGY

Moving towards personalized treatments of immune-related adverse events

(2020) Khashayar Esfahani et al.   Nature Reviews Clinical Oncology

Clinical Challenges of Immune Checkpoint Inhibitors

(2020) Maria de Miguel et al.   CANCER CELL

Low-Dose Metformin Reprograms the Tumor Immune Microenvironment in Human Esophageal Cancer: Results of a Phase II Clinical Trial

(2020) Shuhong Wang et al.   CLINICAL CANCER RESEARCH

The adenosine pathway in immuno-oncology

(2020) Bertrand Allard et al.   Nature Reviews Clinical Oncology

Immunostimulation with chemotherapy in the era of immune checkpoint inhibitors

(2020) Lorenzo Galluzzi et al.   Nature Reviews Clinical Oncology

Conversion of extracellular ATP into adenosine: a master switch in renal health and disease

(2020) Karen M. Dwyer et al.   Nature Reviews Nephrology

CAR T Cell Therapy for Solid Tumors: Bright Future or Dark Reality?

(2020) Jessica Wagner et al.   MOLECULAR THERAPY

Proton-driven transformable nanovaccine for cancer immunotherapy

(2020) Ningqiang Gong et al.   Nature Nanotechnology

Targeting tumor-associated macrophages for cancer immunotherapy

(2020) Yongheng Shu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Bioinspired polydopamine/graphene oxide/collagen nanofilms as a controlled release carrier of bioactive substances

(2020) Kui Xu et al.   CHEMICAL ENGINEERING JOURNAL

Near infrared and pH dual-activated coordination polymer nanosystem for imaging-guided chemo-photothermal therapy

(2020) Mingmao Chen et al.   CHEMICAL ENGINEERING JOURNAL

Approaches to treat immune hot, altered and cold tumours with combination immunotherapies

(2019) Jérôme Galon et al.   NATURE REVIEWS DRUG DISCOVERY

The Emergence of Natural Killer Cells as a Major Target in Cancer Immunotherapy

(2019) Fernando Souza-Fonseca-Guimaraes et al.   TRENDS IN IMMUNOLOGY

Navigating metabolic pathways to enhance antitumour immunity and immunotherapy

(2019) Xiaoyun Li et al.   Nature Reviews Clinical Oncology

A Safe-by-Design Strategy towards Safer Nanomaterials in Nanomedicines

(2019) Liang Yan et al.   ADVANCED MATERIALS

Cancer Cell Membrane Camouflaged Nanoparticles to Realize Starvation Therapy Together with Checkpoint Blockades for Enhancing Cancer Therapy

(2019) Wei Xie et al.   ACS Nano

Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

(2019) Ladan Mashouri et al.   Molecular Cancer

Exosomes

(2019) D. Michiel Pegtel et al.   Annual Review of Biochemistry

Exosomes and Nanoengineering: A Match Made for Precision Therapeutics

(2019) Phuong H. L. Tran et al.   ADVANCED MATERIALS

Amino acid metabolism in hematologic malignancies and the era of targeted therapy

(2019) Yoko Tabe et al.   BLOOD

Targeting Glycolysis through Inhibition of Lactate Dehydrogenase Impairs Tumor Growth in Preclinical Models of Ewing Sarcoma

(2019) Choh Yeung et al.   CANCER RESEARCH

Dendritic Cell Metabolism and Function in Tumors

(2019) Paolo Giovanelli et al.   TRENDS IN IMMUNOLOGY

Harnessing innate immunity in cancer therapy

(2019) Olivier Demaria et al.   NATURE

4-Octyl itaconate inhibits aerobic glycolysis by targeting GAPDH to exert anti-inflammatory effects

(2019) Shan-Ting Liao et al.   Nature Communications

Targeting CD39 in Cancer Reveals an Extracellular ATP- and Inflammasome-Driven Tumor Immunity

(2019) Xian-Yang Li et al.   Cancer Discovery

CAR-T cell therapy: a potential new strategy against prostate cancer

(2019) Giuseppe Schepisi et al.   Journal for ImmunoTherapy of Cancer

Responsive Exosome Nano-bioconjugates for Synergistic Cancer Therapy

(2019) Weidong Nie et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Harnessing tumor-associated macrophages as aids for cancer immunotherapy

(2019) Xiaolei Li et al.   Molecular Cancer

Metformin-Induced Reduction of CD39 and CD73 Blocks Myeloid-Derived Suppressor Cell Activity in Patients with Ovarian Cancer

(2018) Lifeng Li et al.   CANCER RESEARCH

Metformin Inhibits Prostate Cancer Progression by Targeting Tumor-Associated Inflammatory Infiltration

(2018) Qiuli Liu et al.   CLINICAL CANCER RESEARCH

Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway

(2018) Xu Chen et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Pharmacology of Adenosine Receptors: The State of the Art

(2018) Pier Andrea Borea et al.   PHYSIOLOGICAL REVIEWS

Dimethyl fumarate targets GAPDH and aerobic glycolysis to modulate immunity

(2018) Michael D. Kornberg et al.   SCIENCE

Cancer immunotherapy using checkpoint blockade

(2018) Antoni Ribas et al.   SCIENCE

Prevalence of PDL1 Amplification and Preliminary Response to Immune Checkpoint Blockade in Solid Tumors

(2018) Aaron M. Goodman et al.   JAMA Oncology

Targeting adenosine for cancer immunotherapy

(2018) Robert D. Leone et al.   Journal for ImmunoTherapy of Cancer

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Drug-induced amino acid deprivation as strategy for cancer therapy

(2017) Marcus Kwong Lam Fung et al.   Journal of Hematology & Oncology

CD39 limits P2X7 receptor inflammatory signaling and attenuates sepsis-induced liver injury

(2017) Luiz Eduardo Baggio Savio et al.   JOURNAL OF HEPATOLOGY

AMPK: Mechanisms of Cellular Energy Sensing and Restoration of Metabolic Balance

(2017) Daniel Garcia et al.   MOLECULAR CELL

AMPK: guardian of metabolism and mitochondrial homeostasis

(2017) Sébastien Herzig et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

CD39/CD73 upregulation on myeloid-derived suppressor cells via TGF-β-mTOR-HIF-1 signaling in patients with non-small cell lung cancer

(2017) Jieyao Li et al.   OncoImmunology

Efficacy of PD-1 Blockade Is Potentiated by Metformin-Induced Reduction of Tumor Hypoxia

(2016) Nicole E. Scharping et al.   Cancer Immunology Research

Metabolic Pathways in Immune Cell Activation and Quiescence

(2013) Erika L. Pearce et al.   IMMUNITY