Interferon regulatory factor 1 regulates PANoptosis to prevent colorectal cancer

Caspase-6 Is a Key Regulator of Innate Immunity, Inflammasome Activation, and Host Defense

(2020) Min Zheng et al.   CELL

IRF2 transcriptionally induces GSDMD expression for pyroptosis

(2019) Nobuhiko Kayagaki et al.   Science Signaling

Activation of Pyroptotic Cell Death Pathways in Cancer: An Alternative Therapeutic Approach

(2019) Kanipandian Nagarajan et al.   Translational Oncology

IRF 1 and IRF 2 regulate the non‐canonical inflammasome

(2019) Sara J Thygesen et al.   EMBO REPORTS

The role of pyroptosis in cancer: pro-cancer or pro-“host”?

(2019) Xiaojing Xia et al.   Cell Death & Disease

ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis)

(2019) R. K. Subbarao Malireddi et al.   Frontiers in Cellular and Infection Microbiology

TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

(2018) R.K. Subbarao Malireddi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Innate immune adaptor MyD88 deficiency prevents skin inflammation in SHARPIN-deficient mice

(2018) Bhesh Raj Sharma et al.   CELL DEATH AND DIFFERENTIATION

Fungal ligands released by innate immune effectors promote inflammasome activation during Aspergillus fumigatus infection

(2018) Benoit Briard et al.   Nature Microbiology

Mesenchymal Cells in Colon Cancer

(2017) Vasiliki Koliaraki et al.   GASTROENTEROLOGY

Regression of apoptosis-resistant colorectal tumors by induction of necroptosis in mice

(2017) Gui-Wei He et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A pathology atlas of the human cancer transcriptome

(2017) Mathias Uhlen et al.   SCIENCE

Inflammasomes and Cancer

(2017) Rajendra Karki et al.   Cancer Immunology Research

Cancer therapy in the necroptosis era

(2016) Z Su et al.   CELL DEATH AND DIFFERENTIATION

Targeting Programmed Cell Death Using Small-Molecule Compounds to Improve Potential Cancer Therapy

(2016) Bowen Ke et al.   MEDICINAL RESEARCH REVIEWS

NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

(2016) Rajendra Karki et al.   NATURE

Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

(2015) Si Ming Man et al.   CELL

Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling

(2015) Nobuhiko Kayagaki et al.   NATURE

The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

(2015) Si Ming Man et al.   NATURE IMMUNOLOGY

Tissue-based map of the human proteome

(2015) M. Uhlen et al.   SCIENCE

Broad targeting of resistance to apoptosis in cancer

(2015) Ramzi M. Mohammad et al.   SEMINARS IN CANCER BIOLOGY

How cell death shapes cancer

(2015) V Labi et al.   Cell Death & Disease

FADD and Caspase-8 Mediate Priming and Activation of the Canonical and Noncanonical Nlrp3 Inflammasomes

(2014) P. Gurung et al.   JOURNAL OF IMMUNOLOGY

Dietary modulation of the microbiome affects autoinflammatory disease

(2014) John R. Lukens et al.   NATURE

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

Translocation of mixed lineage kinase domain-like protein to plasma membrane leads to necrotic cell death

(2013) Xin Chen et al.   CELL RESEARCH

Function and mechanism by which interferon regulatory factor-1 inhibits oncogenesis

(2012) FEI-FEI CHEN et al.   Oncology Letters

IL-18 Production Downstream of the Nlrp3 Inflammasome Confers Protection against Colorectal Tumor Formation

(2010) M. H. Zaki et al.   JOURNAL OF IMMUNOLOGY

Molecular mechanisms of necroptosis: an ordered cellular explosion

(2010) Peter Vandenabeele et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

IRF-1 transcriptionally upregulates PUMA, which mediates the mitochondrial apoptotic pathway in IRF-1-induced apoptosis in cancer cells

(2009) J Gao et al.   CELL DEATH AND DIFFERENTIATION

Dysregulation of apoptotic signaling in cancer: Molecular mechanisms and therapeutic opportunities

(2008) Jessica Plati et al.   JOURNAL OF CELLULAR BIOCHEMISTRY