The AIM2 and NLRP3 inflammasomes trigger IL-1–mediated antitumor effects during radiation

Low-Dose Radiation Therapy Promotes Radiation Pneumonitis by Activating NLRP3 Inflammasome

(2020) Xiaoyu Li et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

Tumor cells suppress radiation-induced immunity by hijacking caspase 9 signaling

(2020) Chuanhui Han et al.   NATURE IMMUNOLOGY

Radiation causes tissue damage by dysregulating inflammasome–gasdermin D signaling in both host and transplanted cells

(2020) Jianqiu Xiao et al.   PLOS BIOLOGY

Tumor-reprogrammed resident T cells resist radiation to control tumors

(2019) Ainhoa Arina et al.   Nature Communications

5-Androstenediol prevents radiation injury in mice by promoting NF-κB signaling and inhibiting AIM2 inflammasome activation

(2019) Tiancong Wu et al.   BIOMEDICINE & PHARMACOTHERAPY

Targeting innate sensing in the tumor microenvironment to improve immunotherapy

(2019) Zhida Liu et al.   Cellular & Molecular Immunology

Protective Effects of Flagellin A N/C Against Radiation-Induced NLR Pyrin Domain Containing 3 Inflammasome-Dependent Pyroptosis in Intestinal Cells

(2018) Dongming Wu et al.   INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS

The role of macrophage phenotype in regulating the response to radiation therapy

(2018) Xiaoshan Shi et al.   Translational Research

Tumor cure by radiation therapy and checkpoint inhibitors depends on pre-existing immunity

(2018) Marka R. Crittenden et al.   Scientific Reports

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

(2018) Ishita Banerjee et al.   IMMUNITY

Inflammasome Activation Triggers Caspase-1-Mediated Cleavage of cGAS to Regulate Responses to DNA Virus Infection

(2017) Yutao Wang et al.   IMMUNITY

A noncanonical function of cGAMP in inflammasome priming and activation

(2017) Karen V. Swanson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

NLRP3 inflammasome activation mediates radiation-induced pyroptosis in bone marrow-derived macrophages

(2017) Yan-gang Liu et al.   Cell Death & Disease

DNA exonuclease Trex1 regulates radiotherapy-induced tumour immunogenicity

(2017) Claire Vanpouille-Box et al.   Nature Communications

Inflammasomes in Inflammation-Induced Cancer

(2017) Chu Lin et al.   Frontiers in Immunology

The DNA-sensing AIM2 inflammasome controls radiation-induced cell death and tissue injury

(2016) Bo Hu et al.   SCIENCE

IL-1 drives breast cancer growth and bone metastasis in vivo

(2016) Ingunn Holen et al.   Oncotarget

Targeting inflammasome/IL-1 pathways for cancer immunotherapy

(2016) Beichu Guo et al.   Scientific Reports

Innate Immune Recognition of Cancer

(2015) Seng-Ryong Woo et al.   Annual Review of Immunology

From DNA Damage to Nucleic Acid Sensing: A Strategy to Enhance Radiation Therapy

(2015) L. Deng et al.   CLINICAL CANCER RESEARCH

Proteolytic Processing of Interleukin-1 Family Cytokines: Variations on a Common Theme

(2015) Inna S. Afonina et al.   IMMUNITY

Inflammasomes: mechanism of action, role in disease and therapeutics

(2015) Haitao Guo et al.   NATURE MEDICINE

The STING pathway and the T cell-inflamed tumor microenvironment

(2015) Seng-Ryong Woo et al.   TRENDS IN IMMUNOLOGY

K+ regulates Ca2+ to drive inflammasome signaling: dynamic visualization of ion flux in live cells

(2015) J R Yaron et al.   Cell Death & Disease

Mechanisms and Functions of Inflammasomes

(2014) Mohamed Lamkanfi et al.   CELL

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Innate and adaptive immune cells in the tumor microenvironment

(2013) Thomas F Gajewski et al.   NATURE IMMUNOLOGY

NLRP3 Suppresses NK Cell-Mediated Responses to Carcinogen-Induced Tumors and Metastases

(2012) M. T. Chow et al.   CANCER RESEARCH

Inflammasome Activators Induce Interleukin-1α Secretion via Distinct Pathways with Differential Requirement for the Protease Function of Caspase-1

(2012) Olaf Groß et al.   IMMUNITY

Oxidized Mitochondrial DNA Activates the NLRP3 Inflammasome during Apoptosis

(2012) Kenichi Shimada et al.   IMMUNITY

Inflammasomes in carcinogenesis and anticancer immune responses

(2012) Laurence Zitvogel et al.   NATURE IMMUNOLOGY

Chemotherapy-triggered cathepsin B release in myeloid-derived suppressor cells activates the Nlrp3 inflammasome and promotes tumor growth

(2012) Mélanie Bruchard et al.   NATURE MEDICINE

Type I interferon response and innate immune sensing of cancer

(2012) Mercedes B. Fuertes et al.   TRENDS IN IMMUNOLOGY

The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon-Dependent Innate and Adaptive Immunity

(2011) B. C. Burnette et al.   CANCER RESEARCH

Type I Interferon Inhibits Interleukin-1 Production and Inflammasome Activation

(2011) Greta Guarda et al.   IMMUNITY

Host type I IFN signals are required for antitumor CD8+T cell responses through CD8α+dendritic cells

(2011) Mercedes B. Fuertes et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Role of extracellular DNA oxidative modification in radiation induced bystander effects in human endotheliocytes

(2011) Svetlana V. Kostyuk et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

A role for mitochondria in NLRP3 inflammasome activation

(2010) Rongbin Zhou et al.   NATURE

Therapeutic effects of ablative radiation on local tumor require CD8+ T cells: changing strategies for cancer treatment

(2009) Y. Lee et al.   BLOOD

IL-1, IL-18, and IL-33 families of cytokines

(2008) William P. Arend et al.   IMMUNOLOGICAL REVIEWS