AIM2 regulates anti-tumor immunity and is a viable therapeutic target for melanoma

IL1α Antagonizes IL1β and Promotes Adaptive Immune Rejection of Malignant Tumors

(2020) Tian Tian et al.   Cancer Immunology Research

Vaccine efficacy against primary and metastatic cancer with in vitro-generated CD103+conventional dendritic cells

(2020) Yifan Zhou et al.   Journal for ImmunoTherapy of Cancer

Effective cancer immunotherapy by natural mouse conventional type-1 dendritic cells bearing dead tumor antigen

(2019) Stefanie K. Wculek et al.   Journal for ImmunoTherapy of Cancer

Pembrolizumab versus ipilimumab in advanced melanoma (KEYNOTE-006): post-hoc 5-year results from an open-label, multicentre, randomised, controlled, phase 3 study

(2019) Caroline Robert et al.   LANCET ONCOLOGY

Human CD141+ dendritic cells generated from adult peripheral blood monocytes

(2019) SOO JI kim et al.   CYTOTHERAPY

Host conditioning with IL-1β improves the antitumor function of adoptively transferred T cells

(2019) Ping-Hsien Lee et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Engineering dendritic cell vaccines to improve cancer immunotherapy

(2019) Caleb R. Perez et al.   Nature Communications

Dendritic cell trafficking in tumor-bearing mice

(2018) Sarah C. Krzastek et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

Comparison of partially and fully chemically-modified siRNA in conjugate-mediated delivery in vivo

(2018) Matthew R Hassler et al.   NUCLEIC ACIDS RESEARCH

Inhibition of AIM2 inflammasome activation by a novel transcript isoform of IFI16

(2018) Pei‐Hui Wang et al.   EMBO REPORTS

Non-canonical NF-κB Antagonizes STING Sensor-Mediated DNA Sensing in Radiotherapy

(2018) Yuzhu Hou et al.   IMMUNITY

Gasdermin D Restrains Type I Interferon Response to Cytosolic DNA by Disrupting Ionic Homeostasis

(2018) Ishita Banerjee et al.   IMMUNITY

Intron-containing RNA from the HIV-1 provirus activates type I interferon and inflammatory cytokines

(2018) Sean Matthew McCauley et al.   Nature Communications

The DNA Methylcytosine Dioxygenase Tet2 Sustains Immunosuppressive Function of Tumor-Infiltrating Myeloid Cells to Promote Melanoma Progression

(2017) Wen Pan et al.   IMMUNITY

High-Dimensional Phenotypic Mapping of Human Dendritic Cells Reveals Interindividual Variation and Tissue Specialization

(2017) Marcela Alcántara-Hernández et al.   IMMUNITY

Interleukin-18: Biological properties and role in disease pathogenesis

(2017) Gilles Kaplanski   IMMUNOLOGICAL REVIEWS

Promising Targets for Cancer Immunotherapy: TLRs, RLRs, and STING-Mediated Innate Immune Pathways

(2017) Kai Li et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Combining Type I Interferons and 5-Aza-2′-Deoxycitidine to Improve Anti-Tumor Response against Melanoma

(2017) Valeria Lucarini et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Single-cell RNA-seq reveals new types of human blood dendritic cells, monocytes, and progenitors

(2017) Alexandra-Chloé Villani et al.   SCIENCE

Integrating Next-Generation Dendritic Cell Vaccines into the Current Cancer Immunotherapy Landscape

(2017) Abhishek D. Garg et al.   TRENDS IN IMMUNOLOGY

Innate immune signaling and regulation in cancer immunotherapy

(2016) Leticia Corrales et al.   CELL RESEARCH

Augmentation of Immune Checkpoint Cancer Immunotherapy with IL18

(2016) Z. Ma et al.   CLINICAL CANCER RESEARCH

The Vaccine Adjuvant Chitosan Promotes Cellular Immunity via DNA Sensor cGAS-STING-Dependent Induction of Type I Interferons

(2016) Elizabeth. C. Carroll et al.   IMMUNITY

Randomized, Prospective Evaluation Comparing Intensity of Lymphodepletion Before Adoptive Transfer of Tumor-Infiltrating Lymphocytes for Patients With Metastatic Melanoma

(2016) Stephanie L. Goff et al.   JOURNAL OF CLINICAL ONCOLOGY

Antagonism of the STING Pathway via Activation of the AIM2 Inflammasome by Intracellular DNA

(2016) Leticia Corrales et al.   JOURNAL OF IMMUNOLOGY

Response to Programmed Cell Death-1 Blockade in a Murine Melanoma Syngeneic Model Requires Costimulation, CD4, and CD8 T Cells

(2016) B. Homet Moreno et al.   Cancer Immunology Research

Cytosolic DNA Sensor Upregulation Accompanies DNA Electrotransfer in B16.F10 Melanoma Cells

(2016) Katarina Znidar et al.   Molecular Therapy-Nucleic Acids

Suppression of Intratumoral CCL22 by Type I Interferon Inhibits Migration of Regulatory T Cells and Blocks Cancer Progression

(2015) David Anz et al.   CANCER RESEARCH

AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

(2015) Si Ming Man et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

GM-CSF Mouse Bone Marrow Cultures Comprise a Heterogeneous Population of CD11c+MHCII+ Macrophages and Dendritic Cells

(2015) Julie Helft et al.   IMMUNITY

Immunomodulatory effect of peritumorally administered interferon-beta on melanoma through tumor-associated macrophages

(2015) Aya Kakizaki et al.   OncoImmunology

Selective and efficient generation of functional Batf3-dependent CD103+ dendritic cells from mouse bone marrow

(2014) C. T. Mayer et al.   BLOOD

STING-Dependent Cytosolic DNA Sensing Mediates Innate Immune Recognition of Immunogenic Tumors

(2014) Seng-Ryong Woo et al.   IMMUNITY

STING-Dependent Cytosolic DNA Sensing Promotes Radiation-Induced Type I Interferon-Dependent Antitumor Immunity in Immunogenic Tumors

(2014) Liufu Deng et al.   IMMUNITY

Metastatic melanoma cell lines do not secrete IL-1β but promote IL-1β production from macrophages

(2014) Samuel Gehrke et al.   JOURNAL OF DERMATOLOGICAL SCIENCE

Type I interferons directly inhibit regulatory T cells to allow optimal antiviral T cell responses during acute LCMV infection

(2014) Shivani Srivastava et al.   JOURNAL OF EXPERIMENTAL MEDICINE

IL-18 Enhances Immunosuppressive Responses by Promoting Differentiation into Monocytic Myeloid-Derived Suppressor Cells

(2014) Hui Xuan Lim et al.   JOURNAL OF IMMUNOLOGY

Context-dependent role of IL-18 in cancer biology and counter-regulation by IL-18BP

(2014) Marina Fabbi et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Clinical use of dendritic cells for cancer therapy

(2014) Sébastien Anguille et al.   LANCET ONCOLOGY

PD-1 blockade induces responses by inhibiting adaptive immune resistance

(2014) Paul C. Tumeh et al.   NATURE

CXCL10 Is Critical for the Progression and Maintenance of Depigmentation in a Mouse Model of Vitiligo

(2014) M. Rashighi et al.   Science Translational Medicine

DC-derived IL-18 drives Treg differentiation, murine Helicobacter pylori–specific immune tolerance, and asthma protection

(2012) Mathias Oertli et al.   JOURNAL OF CLINICAL INVESTIGATION

Extensive evolutionary and functional diversity among mammalian AIM2-like receptors

(2012) Rebecca L. Brunette et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Constitutive Aberrant Endogenous Interleukin-1 Facilitates Inflammation and Growth in Human Melanoma

(2011) Y. Qin et al.   MOLECULAR CANCER RESEARCH

APC Activation by IFN-  Decreases Regulatory T Cell and Enhances Th Cell Functions

(2010) L. Pace et al.   JOURNAL OF IMMUNOLOGY

The AIM2 inflammasome is essential for host defense against cytosolic bacteria and DNA viruses

(2010) Vijay A K Rathinam et al.   NATURE IMMUNOLOGY

Absent in melanoma 2 is required for innate immune recognition of Francisella tularensis

(2010) J. W. Jones et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

RIG-I-dependent sensing of poly(dA:dT) through the induction of an RNA polymerase III–transcribed RNA intermediate

(2009) Andrea Ablasser et al.   NATURE IMMUNOLOGY

Costimulatory effects of IL-1 on the expansion/differentiation of CD4+ CD25+ Foxp3+ and CD4+ CD25+ Foxp3- T cells

(2008) Carine Brinster et al.   JOURNAL OF LEUKOCYTE BIOLOGY

STING is an endoplasmic reticulum adaptor that facilitates innate immune signalling

(2008) Hiroki Ishikawa et al.   NATURE

Antigens for cancer immunotherapy

(2008) Michelle A. Neller et al.   SEMINARS IN IMMUNOLOGY