Critical Interactions between Immunogenic Cancer Cell Death, Oncolytic Viruses, and the Immune System Define the Rational Design of Combination Immunotherapies

The ectonucleotidases CD39 and CD73: Novel checkpoint inhibitor targets

(2017) Bertrand Allard et al.   IMMUNOLOGICAL REVIEWS

Relevance of necroptosis in cancer

(2017) Najoua Lalaoui et al.   IMMUNOLOGY AND CELL BIOLOGY

Mismatch repair deficiency predicts response of solid tumors to PD-1 blockade

(2017) Dung T. Le et al.   SCIENCE

Immunogenicity of oncolytic vaccinia viruses JX-GFP and TG6002 in a human melanoma in vitro model: studying immunogenic cell death, dendritic cell maturation and interaction with cytotoxic T lymphocytes

(2017) Bernd Heinrich et al.   OncoTargets and Therapy

Rational combination of oncolytic vaccinia virus and PD-L1 blockade works synergistically to enhance therapeutic efficacy

(2017) Zuqiang Liu et al.   Nature Communications

HMGB1 and Its Hyperacetylated Isoform are Sensitive and Specific Serum Biomarkers to Detect Asbestos Exposure and to Identify Mesothelioma Patients

(2016) A. Napolitano et al.   CLINICAL CANCER RESEARCH

Expansion and Activation of CD103 + Dendritic Cell Progenitors at the Tumor Site Enhances Tumor Responses to Therapeutic PD-L1 and BRAF Inhibition

(2016) Hélène Salmon et al.   IMMUNITY

Immunogenic Chemotherapy Sensitizes Tumors to Checkpoint Blockade Therapy

(2016) Christina Pfirschke et al.   IMMUNITY

The necrosome promotes pancreatic oncogenesis via CXCL1 and Mincle-induced immune suppression

(2016) Lena Seifert et al.   NATURE

The epigenetic landscape of T cell exhaustion

(2016) D. R. Sen et al.   SCIENCE

Vaccination with Necroptotic Cancer Cells Induces Efficient Anti-tumor Immunity

(2016) Tania Løve Aaes et al.   Cell Reports

Vectorization in an oncolytic vaccinia virus of an antibody, a Fab and a scFv against programmed cell death -1 (PD-1) allows their intratumoral delivery and an improved tumor-growth inhibition

(2016) Patricia Kleinpeter et al.   OncoImmunology

Reprogramming antitumor immunity against chemoresistant ovarian cancer by a CXCR4 antagonist-armed viral oncotherapy

(2016) Marcin P Komorowski et al.   Molecular Therapy-Oncolytics

Low Mutation Burden in Ovarian Cancer May Limit the Utility of Neoantigen-Targeted Vaccines

(2016) Spencer D. Martin et al.   PLoS One

The oncolytic peptide LTX-315 triggers necrotic cell death

(2015) Sabrina Forveille et al.   CELL CYCLE

The role of oncolytic virus immunotherapies to subvert cancer immune evasion

(2015) Samuel T Workenhe et al.   Future Oncology

Clonal Deletion Prunes but Does Not Eliminate Self-Specific αβ CD8+ T Lymphocytes

(2015) Wong Yu et al.   IMMUNITY

Type I IFN signaling on dendritic cells is required for NK cell-mediated anti-tumor immunity

(2015) Khalil Karimi et al.   Innate Immunity

Theoretical study of the dimerization of aqueous beryllium cations

(2015) Xiaoyan Jin et al.   JOURNAL OF MOLECULAR MODELING

Necroptosis and its role in inflammation

(2015) Manolis Pasparakis et al.   NATURE

Oncolytic viruses: a new class of immunotherapy drugs

(2015) Howard L. Kaufman et al.   NATURE REVIEWS DRUG DISCOVERY

PD-1 Blockade in Tumors with Mismatch-Repair Deficiency

(2015) Dung T. Le et al.   NEW ENGLAND JOURNAL OF MEDICINE

RIPK1 and NF- B signaling in dying cells determines cross-priming of CD8+ T cells

(2015) N. Yatim et al.   SCIENCE

Genomic correlates of response to CTLA-4 blockade in metastatic melanoma

(2015) E. M. Van Allen et al.   SCIENCE

Neoantigens in cancer immunotherapy

(2015) T. N. Schumacher et al.   SCIENCE

Mutational landscape determines sensitivity to PD-1 blockade in non-small cell lung cancer

(2015) N. A. Rizvi et al.   SCIENCE

Prognostic value of tumor-infiltrating FoxP3+ regulatory T cells in cancers: a systematic review and meta-analysis

(2015) Bin Shang et al.   Scientific Reports

Integrated transcriptional profiling and genomic analyses reveal RPN2 and HMGB1 as promising biomarkers in colorectal cancer

(2015) Jialing Zhang et al.   Cell and Bioscience

Molecular and Translational Classifications of DAMPs in Immunogenic Cell Death

(2015) Abhishek D. Garg et al.   Frontiers in Immunology

Oncolytic virotherapy with an armed vaccinia virus in an orthotopic model of renal carcinoma is associated with modification of the tumor microenvironment

(2015) Laetitia Fend et al.   OncoImmunology

First oncolytic virus approved for melanoma immunotherapy

(2015) Jonathan Pol et al.   OncoImmunology

Serum HMGB1 is a predictive and prognostic biomarker for oncolytic immunotherapy

(2015) Ilkka Liikanen et al.   OncoImmunology

The Ever-Expanding Immunomodulatory Role of Calreticulin in Cancer Immunity

(2015) Marco de Bruyn et al.   Frontiers in Oncology

Myeloid Expression of Adenosine A2A Receptor Suppresses T and NK Cell Responses in the Solid Tumor Microenvironment

(2014) C. Cekic et al.   CANCER RESEARCH

Efficient Identification of Mutated Cancer Antigens Recognized by T Cells Associated with Durable Tumor Regressions

(2014) Y.-C. Lu et al.   CLINICAL CANCER RESEARCH

High hydrostatic pressure induces immunogenic cell death in human tumor cells

(2014) Jitka Fucikova et al.   INTERNATIONAL JOURNAL OF CANCER

Chemotherapeutic Drugs Induce ATP Release via Caspase-gated Pannexin-1 Channels and a Caspase/Pannexin-1-independent Mechanism

(2014) Andrea Boyd-Tressler et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Analysis of the anti-apoptotic activity of four vaccinia virus proteins demonstrates that B13 is the most potent inhibitor in isolation and during viral infection

(2014) D. L. Veyer et al.   JOURNAL OF GENERAL VIROLOGY

HMGB1-mediated autophagy promotes docetaxel resistance in human lung adenocarcinoma

(2014) Banzhou Pan et al.   Molecular Cancer

CTLA-4 and PD-L1 Checkpoint Blockade Enhances Oncolytic Measles Virus Therapy

(2014) Christine E Engeland et al.   MOLECULAR THERAPY

Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy

(2014) Antonella Sistigu et al.   NATURE MEDICINE

ER stress, autophagy and immunogenic cell death in photodynamic therapy-induced anti-cancer immune responses

(2014) Abhishek D. Garg et al.   PHOTOCHEMICAL & PHOTOBIOLOGICAL SCIENCES

Delta-24-RGD Oncolytic Adenovirus Elicits Anti-Glioma Immunity in an Immunocompetent Mouse Model

(2014) Hong Jiang et al.   PLoS One

JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation

(2014) B. Lu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Rewiring cancer cell death to enhance oncolytic viro-immunotherapy

(2014) Samuel T Workenhe et al.   OncoImmunology

Consensus guidelines for the detection of immunogenic cell death

(2014) Oliver Kepp et al.   OncoImmunology

Oncolytic Immunotherapy: Dying the Right Way is a Key to Eliciting Potent Antitumor Immunity

(2014) Zong Sheng Guo et al.   Frontiers in Oncology

Contribution of humoral immune responses to the antitumor effects mediated by anthracyclines

(2013) D Hannani et al.   CELL DEATH AND DIFFERENTIATION

Molecular mechanisms of ATP secretion during immunogenic cell death

(2013) I Martins et al.   CELL DEATH AND DIFFERENTIATION

Immunogenic calreticulin exposure occurs through a phylogenetically conserved stress pathway involving the chemokine CXCL8

(2013) A Q Sukkurwala et al.   CELL DEATH AND DIFFERENTIATION

Anticancer Chemotherapy-Induced Intratumoral Recruitment and Differentiation of Antigen-Presenting Cells

(2013) Yuting Ma et al.   IMMUNITY

Cytokine patterns in patients with cancer: a systematic review

(2013) Bodo E Lippitz   LANCET ONCOLOGY

Oncolytic Adenovirus With Temozolomide Induces Autophagy and Antitumor Immune Responses in Cancer Patients

(2013) Ilkka Liikanen et al.   MOLECULAR THERAPY

Oncolytic Virotherapy and Immunogenic Cancer Cell Death: Sharpening the Sword for Improved Cancer Treatment Strategies

(2013) Samuel T Workenhe et al.   MOLECULAR THERAPY

Nivolumab plus Ipilimumab in Advanced Melanoma

(2013) Jedd D. Wolchok et al.   NEW ENGLAND JOURNAL OF MEDICINE

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Combining Oncolytic HSV-1 with Immunogenic Cell Death-Inducing Drug Mitoxantrone Breaks Cancer Immune Tolerance and Improves Therapeutic Efficacy

(2013) S. T. Workenhe et al.   Cancer Immunology Research

Rules of Engagement: Molecular Insights from Host-Virus Arms Races

(2012) Matthew D. Daugherty et al.   Annual Review of Genetics

Immunogenic Cell Death in Cancer Therapy

(2012) Guido Kroemer et al.   Annual Review of Immunology

Cancer Cell Secretion of the DAMP Protein HMGB1 Supports Progression in Malignant Mesothelioma

(2012) S. Jube et al.   CANCER RESEARCH

High mobility group box 1 released from necrotic cells enhances regrowth and metastasis of cancer cells that have survived chemotherapy

(2012) Yi Luo et al.   EUROPEAN JOURNAL OF CANCER

Mutually exclusive redox forms of HMGB1 promote cell recruitment or proinflammatory cytokine release

(2012) Emilie Venereau et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Chemotherapy response of spontaneous mammary tumors is independent of the adaptive immune system

(2012) Metamia Ciampricotti et al.   NATURE MEDICINE

Cardiac Glycosides Exert Anticancer Effects by Inducing Immunogenic Cell Death

(2012) L. Menger et al.   Science Translational Medicine

The three main stumbling blocks for anticancer T cells

(2012) Lukas Baitsch et al.   TRENDS IN IMMUNOLOGY

Subversion of the chemotherapy-induced anticancer immune response by the ecto-ATPase CD39

(2012) Mickaël Michaud et al.   OncoImmunology

Ectonucleotidases CD39 and CD73 on OvCA cells are potent adenosine-generating enzymes responsible for adenosine receptor 2A-dependent suppression of T cell function and NK cell cytotoxicity

(2011) Sebastian F. M. Häusler et al.   CANCER IMMUNOLOGY IMMUNOTHERAPY

IL-15 and Type I Interferon Are Required for Activation of Tumoricidal NK Cells by Virus-Infected Dendritic Cells

(2011) J. E. Boudreau et al.   CANCER RESEARCH

HMGB1 Promotes Drug Resistance in Osteosarcoma

(2011) J. Huang et al.   CANCER RESEARCH

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

Adenosinergic Regulation of the Expansion and Immunosuppressive Activity of CD11b+Gr1+ Cells

(2011) S. Ryzhov et al.   JOURNAL OF IMMUNOLOGY

In situ immune response after neoadjuvant chemotherapy for breast cancer predicts survival

(2011) Sylvain Ladoire et al.   JOURNAL OF PATHOLOGY

Human Adenovirus Type 5 Induces Cell Lysis through Autophagy and Autophagy-Triggered Caspase Activity

(2011) H. Jiang et al.   JOURNAL OF VIROLOGY

Autophagy-Dependent Anticancer Immune Responses Induced by Chemotherapeutic Agents in Mice

(2011) M. Michaud et al.   SCIENCE

Immunomodulatory effects of cyclophosphamide and implementations for vaccine design

(2011) Antonella Sistigu et al.   Seminars in Immunopathology

CD73 on Tumor Cells Impairs Antitumor T-Cell Responses: A Novel Mechanism of Tumor-Induced Immune Suppression

(2010) D. Jin et al.   CANCER RESEARCH

Improved Clinical Outcome in Indolent B-Cell Lymphoma Patients Vaccinated with Autologous Tumor Cells Experiencing Immunogenic Death

(2010) R. Zappasodi et al.   CANCER RESEARCH

Cyclophosphamide Synergizes with Type I Interferons through Systemic Dendritic Cell Reactivation and Induction of Immunogenic Tumor Apoptosis

(2010) G. Schiavoni et al.   CANCER RESEARCH

Immunogenic Tumor Cell Death for Optimal Anticancer Therapy: The Calreticulin Exposure Pathway

(2010) L. Zitvogel et al.   CLINICAL CANCER RESEARCH

Viral strategies for the evasion of immunogenic cell death

(2010) L. Galluzzi et al.   JOURNAL OF INTERNAL MEDICINE

Potentiating Cancer Immunotherapy Using an Oncolytic Virus

(2010) Byram W Bridle et al.   MOLECULAR THERAPY

A critical cysteine is required for HMGB1 binding to Toll-like receptor 4 and activation of macrophage cytokine release

(2010) H. Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Calreticulin Is the Dominant Pro-Phagocytic Signal on Multiple Human Cancers and Is Counterbalanced by CD47

(2010) M. P. Chao et al.   Science Translational Medicine

NK cell-mediated killing of target cells triggers robust antigen-specific T cell-mediated and humoral responses

(2009) P. Krebs et al.   BLOOD

Mechanisms of pre-apoptotic calreticulin exposure in immunogenic cell death

(2009) Theocharis Panaretakis et al.   EMBO JOURNAL

Serum high mobility group box-1 (HMGB1) is closely associated with the clinical and pathologic features of gastric cancer

(2009) Hye Chung et al.   Journal of Translational Medicine

Complete but curtailed T-cell response to very low-affinity antigen

(2009) Dietmar Zehn et al.   NATURE

ATM-ATR-dependent up-regulation of DNAM-1 and NKG2D ligands on multiple myeloma cells by therapeutic agents results in enhanced NK-cell susceptibility and is associated with a senescent phenotype

(2008) A. Soriani et al.   BLOOD

The co-translocation of ERp57 and calreticulin determines the immunogenicity of cell death

(2008) T Panaretakis et al.   CELL DEATH AND DIFFERENTIATION

Immunosuppression Enhances Oncolytic Adenovirus Replication and Antitumor Efficacy in the Syrian Hamster Model

(2008) Maria A Thomas et al.   MOLECULAR THERAPY