Dipeptidyl Peptidase Inhibition Enhances CD8 T Cell Recruitment and Activates Intrahepatic Inflammasome in a Murine Model of Hepatocellular Carcinoma

NLRP1: a jack of all trades, or a master of one?

(2021) Daniel A. Bachovchin   MOLECULAR CELL

DPP4 Inhibitor Sitagliptin Enhances Lymphocyte Recruitment and Prolongs Survival in a Syngeneic Ovarian Cancer Mouse Model

(2021) Amy L. Wilson et al.   Cancers

DPP9 sequesters the C terminus of NLRP1 to repress inflammasome activation

(2021) L. Robert Hollingsworth et al.   NATURE

Structural and biochemical mechanisms of NLRP1 inhibition by DPP9

(2021) Menghang Huang et al.   NATURE

DPP9: Comprehensive In Silico Analyses of Loss of Function Gene Variants and Associated Gene Expression Signatures in Human Hepatocellular Carcinoma

(2021) Jiali Carrie Huang et al.   Cancers

Profibrotic mechanisms of DPP8 and DPP9 highly expressed in the proximal renal tubule epithelial cells

(2021) Yuzhan Zhang et al.   PHARMACOLOGICAL RESEARCH

Autophagy promotes immune evasion of pancreatic cancer by degrading MHC-I

(2020) Keisuke Yamamoto et al.   NATURE

Atezolizumab plus Bevacizumab in Unresectable Hepatocellular Carcinoma

(2020) Richard S. Finn et al.   NEW ENGLAND JOURNAL OF MEDICINE

Human proline specific peptidases: A comprehensive analysis

(2020) Yakov E. Dunaevsky et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease

(2020) Ilaria Barchetta et al.   JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION

Overcoming stromal barriers to immuno-oncological responses via fibroblast activation protein-targeted therapy

(2020) W Nathaniel Brennen et al.   Immunotherapy

Hepatocellular Carcinoma

(2019) Augusto Villanueva   NEW ENGLAND JOURNAL OF MEDICINE

Dipeptidyl peptidase 4 inhibitors as novel agents in improving survival in diabetic patients with colorectal cancer and lung cancer: A Surveillance Epidemiology and Endpoint Research Medicare study

(2019) Rohit Bishnoi et al.   Cancer Medicine

Immune regeneration in irradiated mice is not impaired by the absence of DPP9 enzymatic activity

(2019) Margaret G. Gall et al.   Scientific Reports

DPP8/DPP9 inhibitor-induced pyroptosis for treatment of acute myeloid leukemia

(2018) Darren C. Johnson et al.   NATURE MEDICINE

Multiple liver insults synergize to accelerate experimental hepatocellular carcinoma

(2018) James M. Henderson et al.   Scientific Reports

Identification of Novel Natural Substrates of Fibroblast Activation Protein-alpha by Differential Degradomics and Proteomics

(2018) Hui Emma Zhang et al.   MOLECULAR & CELLULAR PROTEOMICS

Hepatocyte-secreted DPP4 in obesity promotes adipose inflammation and insulin resistance

(2018) Devram S. Ghorpade et al.   NATURE

Effects of a DPP4 Inhibitor on Progression of NASH-related HCC and the p62/ Keap1/Nrf2-Pentose Phosphate Pathway in a Mouse Model

(2018) Takumi Kawaguchi et al.   Liver Cancer

The trends in incidence of primary liver cancer caused by specific etiologies: Results from the Global Burden of Disease Study 2016 and implications for liver cancer prevention

(2018) Zhenqiu Liu et al.   JOURNAL OF HEPATOLOGY

A Liver Capsular Network of Monocyte-Derived Macrophages Restricts Hepatic Dissemination of Intraperitoneal Bacteria by Neutrophil Recruitment

(2017) Frederic Sierro et al.   IMMUNITY

Nivolumab in patients with advanced hepatocellular carcinoma (CheckMate 040): an open-label, non-comparative, phase 1/2 dose escalation and expansion trial

(2017) Anthony B El-Khoueiry et al.   LANCET

Circulating fibroblast activation protein activity and antigen levels correlate strongly when measured in liver disease and coronary heart disease

(2017) Shirley Uitte de Willige et al.   PLoS One

Regulation of dipeptidyl peptidase 8 and 9 expression in activated lymphocytes and injured liver

(2017) Sumaiya Chowdhury et al.   WORLD JOURNAL OF GASTROENTEROLOGY

The pro-fibrotic role of dipeptidyl peptidase 4 in carbon tetrachloride-induced experimental liver injury

(2016) Xin M Wang et al.   IMMUNOLOGY AND CELL BIOLOGY

DPP8 and DPP9 inhibition induces pro-caspase-1-dependent monocyte and macrophage pyroptosis

(2016) Marian C Okondo et al.   Nature Chemical Biology

Histopathology of hepatocellular carcinoma

(2016) Manuel Schlageter et al.   WORLD JOURNAL OF GASTROENTEROLOGY

Dipeptidyl peptidase 9 subcellular localization and a role in cell adhesion involving focal adhesion kinase and paxillin

(2015) Hui Zhang et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Global cancer statistics, 2012

(2015) Lindsey A. Torre et al.   CA-A CANCER JOURNAL FOR CLINICIANS

Lower serum fibroblast activation protein shows promise in the exclusion of clinically significant liver fibrosis due to non-alcoholic fatty liver disease in diabetes and obesity

(2015) K.H. Williams et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

The Dipeptidyl Peptidases 4, 8, and 9 in Mouse Monocytes and Macrophages: DPP8/9 Inhibition Attenuates M1 Macrophage Activation in Mice

(2015) Yannick Waumans et al.   INFLAMMATION

Establishment of a General NAFLD Scoring System for Rodent Models and Comparison to Human Liver Pathology

(2014) Wen Liang et al.   PLoS One

Understanding fibroblast activation protein (FAP): Substrates, activities, expression and targeting for cancer therapy

(2014) Elizabeth J. Hamson et al.   Proteomics Clinical Applications

A pan inhibitor of DASH family enzymes induces immunogenic modulation and sensitizes murine and human carcinoma cells to antigen-specific cytotoxic T lymphocyte killing: implications for combination therapy with cancer vaccines

(2014) Renee N. Donahue et al.   VACCINE

Circulating dipeptidyl peptidase-4 activity correlates with measures of hepatocyte apoptosis and fibrosis in non-alcoholic fatty liver disease in type 2 diabetes mellitus and obesity: A dual cohort cross-sectional study

(2014) Kathryn H. Williams et al.   Journal of Diabetes

A Pan-Inhibitor of DASH Family Enzymes Induces Immune-mediated Regression of Murine Sarcoma and Is a Potent Adjuvant to Dendritic Cell Vaccination and Adoptive T-cell Therapy

(2013) Brynn B. Duncan et al.   JOURNAL OF IMMUNOTHERAPY

Val-BoroPro Accelerates T Cell Priming via Modulation of Dendritic Cell Trafficking Resulting in Complete Regression of Established Murine Tumors

(2013) Meghaan P. Walsh et al.   PLoS One

Targeted Inactivation of Dipeptidyl Peptidase 9 Enzymatic Activity Causes Mouse Neonate Lethality

(2013) Margaret G. Gall et al.   PLoS One

Dipeptidyl peptidase-4: A key player in chronic liver disease

(2013) Minoru Itou   WORLD JOURNAL OF GASTROENTEROLOGY

Immunity, Inflammation, and Cancer

(2010) Sergei I. Grivennikov et al.   CELL

The dipeptidyl peptidase IV family in cancer and cell biology

(2010) Denise M. T. Yu et al.   FEBS Journal

The In Vivo Expression of Dipeptidyl Peptidases 8 and 9

(2009) Denise M.T. Yu et al.   JOURNAL OF HISTOCHEMISTRY & CYTOCHEMISTRY

Pyroptosis: host cell death and inflammation

(2009) Tessa Bergsbaken et al.   NATURE REVIEWS MICROBIOLOGY

Immune Therapy for Cancer

(2008) Michael Dougan et al.   Annual Review of Immunology

Sorafenib in Advanced Hepatocellular Carcinoma

(2008) Josep M. Llovet et al.   NEW ENGLAND JOURNAL OF MEDICINE