NF-κB inhibitors gifted by nature: The anticancer promise of polyphenol compounds

Helicobacter pylori-induced RASAL2 through activation of NF-kB promotes gastric tumorigenesis via β-catenin signaling axis

(2022) Longlong Cao et al.   GASTROENTEROLOGY

Involvement of microRNA modifications in anticancer effects of major polyphenols from green tea, coffee, wine, and curry

(2022) Tomokazu Ohishi et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

NF‐κB as a regulator of cancer metastasis and therapy response: A focus on epithelial–mesenchymal transition

(2022) Sepideh Mirzaei et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Medicinal Plants in Cancer Treatment: Contribution of Nuclear Factor-Kappa B (NF-kB) Inhibitors

(2022) Rina Das et al.   MINI-REVIEWS IN MEDICINAL CHEMISTRY

ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer

(2022) Eunju Kim et al.   Cell Death & Disease

Examination of Combined Treatment of Ginsenoside Rg3 and 5-Fluorouracil in Lung Adenocarcinoma Cells

(2022) Kuizhong Shan et al.   Computational and Mathematical Methods in Medicine

Regulation of temozolomide resistance in glioma cells via the RIP2/NF‐κB/MGMT pathway

(2021) Yu‐Hua Hu et al.   CNS Neuroscience & Therapeutics

Plant Natural Products: Promising Resources for Cancer Chemoprevention

(2021) Li Ma et al.   MOLECULES

NF-κB in Cancer Immunity: Friend or Foe?

(2021) Guilhem Lalle et al.   Cells

Inhibition of cell-intrinsic NF-κB activity and metastatic abilities of breast cancer by aloe-emodin and emodic-acid isolated from Asphodelus microcarpus

(2021) Amira A. Abdellatef et al.   Journal of Natural Medicines

Chlorogenic acid inhibits proliferation in human hepatoma cells by suppressing noncanonical NF-κB signaling pathway and triggering mitochondrial apoptosis

(2021) Yanfei Jiang et al.   MOLECULAR BIOLOGY REPORTS

Trilobatin Induces Apoptosis and Attenuates Stemness Phenotype of Acquired Gefitinib Resistant Lung Cancer Cells via Suppression of NF-κB Pathway

(2021) Wang Li et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Inhibition of Cell Proliferation and Metastasis by Scutellarein Regulating PI3K/Akt/NF-κB Signaling through PTEN Activation in Hepatocellular Carcinoma

(2021) Sang Eun Ha et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Targeting hypoxia-inducible factor 1 (HIF-1) signaling with natural products toward cancer chemotherapy

(2021) Hiroaki Ikeda et al.   JOURNAL OF ANTIBIOTICS

Synthetic curcumin analog: inhibiting the invasion, angiogenesis, and metastasis in human laryngeal carcinoma cells via NF-kB pathway

(2021) Kumaravel Mohankumar et al.   MOLECULAR BIOLOGY REPORTS

Research progress of phenolic compounds regulating IL ‐6 to exert antitumor effects

(2021) Tingting Xia et al.   PHYTOTHERAPY RESEARCH

Linear Ubiquitination Mediates EGFR-Induced NF-κB Pathway and Tumor Development

(2021) Fang Hua et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Presurgical Study of Curcumin Combined with Anthocyanin Supplements in Patients with Colorectal Adenomatous Polyps

(2021) Irene Maria Briata et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Chronic and Cycling Hypoxia: Drivers of Cancer Chronic Inflammation through HIF-1 and NF-κB Activation: A Review of the Molecular Mechanisms

(2021) Jan Korbecki et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Curcumin and its derivatives in cancer therapy: Potentiating antitumor activity of cisplatin and reducing side effects

(2021) Asal Jalal Abadi et al.   PHYTOTHERAPY RESEARCH

Curcumin Delivery Mediated by Bio-Based Nanoparticles: A Review

(2020) Mahshid Moballegh Nasery et al.   MOLECULES

The dual role of curcumin and ferulic acid in counteracting chemoresistance and cisplatin-induced ototoxicity

(2020) Fabiola Paciello et al.   Scientific Reports

Myeloid-Derived Suppressor Cells as a Therapeutic Target for Cancer

(2020) Andrew M. K. Law et al.   Cells

Bladder neoplasms and NF-κB: an unfathomed association

(2020) Charles Emmanuel Jebaraj Walter et al.   EXPERT REVIEW OF MOLECULAR DIAGNOSTICS

Curcumin and Colorectal Cancer: From Basic to Clinical Evidences

(2020) Maria Pricci et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Looking down on NF-κB

(2020) Leah M. Williams et al.   MOLECULAR AND CELLULAR BIOLOGY

Pretreatment of Anthocyanin from the Fruit of Vitis coignetiae Pulliat Acts as a Potent Inhibitor of TNF-α Effect by Inhibiting NF-κB-Regulated Genes in Human Breast Cancer Cells

(2020) Anjugam Paramanantham et al.   MOLECULES

Natural products as promising targets in glioblastoma multiforme: a focus on NF-κB signaling pathway

(2020) Mohammad Soukhtanloo et al.   Pharmacological Reports

Curcumin suppressed proliferation and migration of human retinoblastoma cells through modulating NF-κB pathway

(2020) Ying-Tao Mu et al.   INTERNATIONAL OPHTHALMOLOGY

Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin

(2020) Kazuo Umezawa et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Potential implications of polyphenols on aging considering oxidative stress, inflammation, autophagy, and gut microbiota

(2020) Min Wu et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

Targeting Cancer using Curcumin Encapsulated Vesicular Drug Delivery Systems

(2020) Joel Hardwick et al.   CURRENT PHARMACEUTICAL DESIGN

Natural products and their derivatives: Promising modulators of tumor immunotherapy

(2020) Li‐Juan Deng et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Chlorogenic acid attenuates cyclophosphamide-induced rat interstitial cystitis

(2020) Jing Luo et al.   LIFE SCIENCES

Anthocyanins Isolated from Vitis coignetiae Pulliat Enhances Cisplatin Sensitivity in MCF-7 Human Breast Cancer Cells through Inhibition of Akt and NF-κB Activation

(2020) Anjugam Paramanantham et al.   MOLECULES

Target Analysis and Mechanism of Podophyllotoxin in the Treatment of Triple-Negative Breast Cancer

(2020) Wenfeng Zhang et al.   Frontiers in Pharmacology

Chemopreventive Effect of Dietary Anthocyanins against Gastrointestinal Cancers: A Review of Recent Advances and Perspectives

(2020) K.V. Surangi Dharmawansa et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Resveratrol prevents TNF-α-induced VCAM-1 and ICAM-1 upregulation in endothelial progenitor cells via reduction of NF-κB activation

(2020) Yefei Zhang et al.   JOURNAL OF INTERNATIONAL MEDICAL RESEARCH

The Effect of Resveratrol or Curcumin on Head and Neck Cancer Cells Sensitivity to the Cytotoxic Effects of Cisplatin

(2020) Marinela Bostan et al.   Nutrients

Pharmacological significance of the non-canonical NF-κB pathway in tumorigenesis

(2020) Dhakshayini Morgan et al.   BIOCHIMICA ET BIOPHYSICA ACTA-REVIEWS ON CANCER

Anthocyanins Derived from Vitis coignetiae Pulliat Contributes Anti-Cancer Effects by Suppressing NF-κB Pathways in Hep3B Human Hepatocellular Carcinoma Cells and In Vivo

(2020) Min Jeong Kim et al.   MOLECULES

Chlorogenic acid induces apoptosis, inhibits metastasis and improves antitumor immunity in breast cancer via the NF‑κB signaling pathway

(2020) Anqi Zeng et al.   ONCOLOGY REPORTS

Phosphorylation of the Regulators, a Complex Facet of NF-κB Signaling in Cancer

(2020) Aishat Motolani et al.   Biomolecules

NF‐κB targeting for overcoming tumor resistance and normal tissues toxicity

(2019) Keywan Mortezaee et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Cirsiliol Suppressed Epithelial to Mesenchymal Transition in B16F10 Malignant Melanoma Cells through Alteration of the PI3K/Akt/NF-κB Signaling Pathway

(2019) Priyanka Prasad et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Apigenin inhibits epithelial-mesenchymal transition of human colon cancer cells through NF-κB/Snail signaling pathway

(2019) Jiafeng Tong et al.   BIOSCIENCE REPORTS

Anti-cancer effects of polyphenols via targeting p53 signaling pathway: updates and future directions

(2019) Haroon Khan et al.   BIOTECHNOLOGY ADVANCES

Identifying the Antiproliferative Effect of Astragalus Polysaccharides on Breast Cancer: Coupling Network Pharmacology With Targetable Screening From the Cancer Genome Atlas

(2019) Cun Liu et al.   Frontiers in Oncology

USP13 functions as a tumor suppressor by blocking the NF-kB-mediated PTEN downregulation in human bladder cancer

(2019) Xiaojun Man et al.   JOURNAL OF EXPERIMENTAL & CLINICAL CANCER RESEARCH

Targeting NF-κB-Mediated Inflammatory Pathways in Cisplatin-Resistant NSCLC

(2019) Sarah-Louise Ryan et al.   LUNG CANCER

NF-κB and mitochondria cross paths in cancer: mitochondrial metabolism and beyond

(2019) Daria Capece et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting NF-κB signaling pathway in cancer by dietary polyphenols

(2019) Haroon Khan et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

MALT1 is a critical mediator of PAR1-driven NF-κB activation and metastasis in multiple tumor types

(2019) J. Randall McAuley et al.   ONCOGENE

The Modulatory Properties of Astragalus membranaceus Treatment on Triple-Negative Breast Cancer: An Integrated Pharmacological Method

(2019) Cun Liu et al.   Frontiers in Pharmacology

Curcumin inhibits autocrine growth hormone-mediated invasion and metastasis by targeting NF-κB signaling and polyamine metabolism in breast cancer cells

(2018) Ajda Coker-Gurkan et al.   AMINO ACIDS

Apigenin Suppresses the IL-1β-Induced Expression of the Urokinase-Type Plasminogen Activator Receptor by Inhibiting MAPK-Mediated AP-1 and NF-κB Signaling in Human Bladder Cancer T24 Cells

(2018) Yong Xia et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Curcumin prevents the bile reflux-induced NF-κB-related mRNA oncogenic phenotype, in human hypopharyngeal cells

(2018) Dimitra P. Vageli et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Resveratrol sensitizes lung cancer cell to TRAIL by p53 independent and suppression of Akt/NF-κB signaling

(2018) Mohammad Rasheduzzaman et al.   LIFE SCIENCES

CCL2/CCL5 secreted by the stroma induce IL-6/PYK2 dependent chemoresistance in ovarian cancer

(2018) Jennifer Pasquier et al.   Molecular Cancer

NF-κB pathways in the development and progression of colorectal cancer

(2018) Meera Patel et al.   Translational Research

Quercetin inhibits prostate cancer by attenuating cell survival and inhibiting anti-apoptotic pathways

(2018) Ashley B. Ward et al.   World Journal of Surgical Oncology

Nobiletin Inhibits CD36-Dependent Tumor Angiogenesis, Migration, Invasion, and Sphere Formation Through the Cd36/Stat3/Nf-Κb Signaling Axis

(2018) Nipin Sp et al.   Nutrients

TRIM52 plays an oncogenic role in ovarian cancer associated with NF-kB pathway

(2018) Weihong Yang et al.   Cell Death & Disease

Hydroxytyrosol supplementation ameliorates the metabolic disturbances in white adipose tissue from mice fed a high-fat diet through recovery of transcription factors Nrf2, SREBP-1c, PPAR-γ and NF-κB

(2018) Paola Illesca et al.   BIOMEDICINE & PHARMACOTHERAPY

The role of microRNAs regulating the expression of matrix metalloproteinases (MMPs) in breast cancer development, progression, and metastasis

(2018) Mahsa Javadian et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Ferulic acid reverses P-glycoprotein-mediated multidrug resistance via inhibition of PI3K/Akt/NF-κB signaling pathway

(2018) Ganesan Muthusamy et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Recent advances in understanding the roles of matrix metalloproteinases in tumour invasion and metastasis

(2018) Guy A Conlon et al.   JOURNAL OF PATHOLOGY

Curcumin prevented human autocrine growth hormone (GH) signaling mediated NF-κB activation and miR-183-96-182 cluster stimulated epithelial mesenchymal transition in T47D breast cancer cells

(2018) Ajda Coker-Gurkan et al.   MOLECULAR BIOLOGY REPORTS

miR-191 suppresses angiogenesis by activation of NF-κB signaling

(2017) Yuan Gu et al.   FASEB JOURNAL

Liposomal curcumin and its application in cancer

(2017) Ting Feng et al.   International Journal of Nanomedicine

Curcumin induces G2/M arrest, apoptosis, NF-κB inhibition, and expression of differentiation genes in thyroid carcinoma cells

(2017) Suzan Schwertheim et al.   JOURNAL OF CANCER RESEARCH AND CLINICAL ONCOLOGY

Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice

(2017) Rodrigo Valenzuela et al.   Lipids in Health and Disease

Exposure to TNF-α combined with TGF-β induces carcinogenesis in vitro via NF-κB/Twist axis

(2017) Weilei Dong et al.   ONCOLOGY REPORTS

Ginsenoside 20(S)-Rg3 suppresses ovarian cancer migration via hypoxia-inducible factor 1 alpha and nuclear factor-kappa B signals

(2017) Ting Liu et al.   TUMOR BIOLOGY

Molecular adaptations underlying the beneficial effects of hydroxytyrosol in the pathogenic alterations induced by a high-fat diet in mouse liver: PPAR-α and Nrf2 activation, and NF-κB down-regulation

(2017) Rodrigo Valenzuela et al.   Food & Function

Induction of sirtuin-1 signaling by resveratrol induces human chondrosarcoma cell apoptosis and exhibits antitumor activity

(2017) Sung-Chuan Chao et al.   Scientific Reports

NF-kappaB Is Involved in the Regulation of EMT Genes in Breast Cancer Cells

(2017) Bruno R. B. Pires et al.   PLoS One

Polyphenols in Food: Cancer Prevention and Apoptosis Induction

(2017) Ashita Sharma et al.   CURRENT MEDICINAL CHEMISTRY

Quercetin derivative induces cell death in glioma cells by modulating NF-κB nuclear translocation and caspase-3 activation

(2016) Cíntia J. Kiekow et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Ferulic Acid against Cyclophosphamide-Induced Heart Toxicity in Mice by Inhibiting NF-κB Pathway

(2016) Yafan Song et al.   Evidence-based Complementary and Alternative Medicine

The flavonoid apigenin reduces prostate cancer CD44 + stem cell survival and migration through PI3K/Akt/NF-κB signaling

(2016) Suat Erdogan et al.   LIFE SCIENCES

Curcumin inhibits H2O2-induced invasion and migration of human pancreatic cancer via suppression of the ERK/NF-κB pathway

(2016) Lei Cao et al.   ONCOLOGY REPORTS

Polyphenols as Modulator of Oxidative Stress in Cancer Disease: New Therapeutic Strategies

(2016) Anna Maria Mileo et al.   Oxidative Medicine and Cellular Longevity

Dietary Natural Products for Prevention and Treatment of Liver Cancer

(2016) Yue Zhou et al.   Nutrients

Natural Polyphenols for Prevention and Treatment of Cancer

(2016) Yue Zhou et al.   Nutrients

Resveratrol induces chemosensitization to 5-fluorouracil through up-regulation of intercellular junctions, Epithelial-to-mesenchymal transition and apoptosis in colorectal cancer

(2015) Constanze Buhrmann et al.   BIOCHEMICAL PHARMACOLOGY

Mutations of p53 and KRAS activate NF-κB to promote chemoresistance and tumorigenesis via dysregulation of cell cycle and suppression of apoptosis in lung cancer cells

(2015) Lina Yang et al.   CANCER LETTERS

Nephroprotective effect of vanillic acid against cisplatin induced nephrotoxicity in wistar rats: A biochemical and molecular study

(2015) Ganapathy Sindhu et al.   ENVIRONMENTAL TOXICOLOGY AND PHARMACOLOGY

Inhibition of pancreatic cancer cell migration by plasma anthocyanins isolated from healthy volunteers receiving an anthocyanin-rich berry juice

(2015) Sabine Kuntz et al.   EUROPEAN JOURNAL OF NUTRITION

Curcumin effectively inhibits oncogenic NF-κB signaling and restrains stemness features in liver cancer

(2015) Jens U. Marquardt et al.   JOURNAL OF HEPATOLOGY

NF-κB-dependent DNA damage-signaling differentially regulates DNA double-strand break repair mechanisms in immature and mature human hematopoietic cells

(2015) D Kraft et al.   LEUKEMIA

Anthocyanins from Black Rice (Oryza sativaL.) Demonstrate Antimetastatic Properties by Reducing MMPs and NF-κB Expressions in Human Oral Cancer CAL 27 Cells

(2015) Ming-Jen Fan et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Discovery of lesser known flavones as inhibitors of NF-κB signaling in MDA-MB-231 breast cancer cells—A SAR study

(2014) K. Amrutha et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Separation and Characterization of Soluble Esterified and Glycoside-Bound Phenolic Compounds in Dry-Blanched Peanut Skins by Liquid Chromatography–Electrospray Ionization Mass Spectrometry

(2014) Yuanyuan Ma et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Th17-type cytokines, IL-6 and TNF-α synergistically activate STAT3 and NF-kB to promote colorectal cancer cell growth

(2014) V De Simone et al.   ONCOGENE

Diabetes and the Brain: Oxidative Stress, Inflammation, and Autophagy

(2014) María Muriach et al.   Oxidative Medicine and Cellular Longevity

Gastro-intestinal toxicity of chemotherapeutics in colorectal cancer: The role of inflammation

(2014) Chun Seng Lee   WORLD JOURNAL OF GASTROENTEROLOGY

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Molecular Mechanisms That Influence the Macrophage M1–M2 Polarization Balance

(2014) Nan Wang et al.   Frontiers in Immunology

Inhibition of ErbB receptors, Hedgehog and NF-kappaB signaling by polyphenols in cancer

(2013) Roberto Bei   Frontiers in Bioscience-Landmark

Overexpression of Integrin-linked Kinase Promotes Lung Cancer Cell Migration and Invasion via NF-κB-mediated Upregulation of Matrix Metalloproteinase-9

(2013) Mingjing Zhao et al.   International Journal of Medical Sciences

Acacetin (5,7-dihydroxy-4′-methoxyflavone) exhibits in vitro and in vivo anticancer activity through the suppression of NF-κB/Akt signaling in prostate cancer cells

(2013) HYE RI KIM et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Luteolin attenuates TGF-β1-induced epithelial–mesenchymal transition of lung cancer cells by interfering in the PI3K/Akt–NF-κB–Snail pathway

(2013) Kun-Chieh Chen et al.   LIFE SCIENCES

The complexity of NF-κB signaling in inflammation and cancer

(2013) Bastian Hoesel et al.   Molecular Cancer

Flavonoid apigenin modified gene expression associated with inflammation and cancer and induced apoptosis in human pancreatic cancer cells through inhibition of GSK-3β/NF-κB signaling cascade

(2013) Jodee L. Johnson et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Chemopreventive Effect of Quercetin in MNU and Testosterone Induced Prostate Cancer of Sprague-Dawley Rats

(2013) Govindaraj Sharmila et al.   NUTRITION AND CANCER-AN INTERNATIONAL JOURNAL

Apigenin potentiates the growth inhibitory effects by IKK-β-mediated NF-κB activation in pancreatic cancer cells

(2013) Ding-Guo Wu et al.   TOXICOLOGY LETTERS

NF-κB and the link between inflammation and cancer

(2012) Joseph A. DiDonato et al.   IMMUNOLOGICAL REVIEWS

Chemosensitization of tumors by resveratrol

(2011) Subash C. Gupta et al.   Annals of the New York Academy of Sciences

Chemopreventive effects of dietary phytochemicals against cancer invasion and metastasis: Phenolic acids, monophenol, polyphenol, and their derivatives

(2011) Chia-Jui Weng et al.   CANCER TREATMENT REVIEWS

A hypoxia-dependent upregulation of hypoxia-inducible factor-1 by nuclear factor-κB promotes gastric tumour growth and angiogenesis

(2010) S Y Nam et al.   BRITISH JOURNAL OF CANCER

NF-kappaB in lung cancer, a carcinogenesis mediator and a prevention and therapy target

(2010) Wenshu Chen   Frontiers in Bioscience-Landmark

Mechanisms of Cisplatin Nephrotoxicity

(2010) Ronald P. Miller et al.   Toxins

Fighting Cancer with Red Wine? Molecular Mechanisms of Resveratrol

(2009) Thomas E. Kraft et al.   CRITICAL REVIEWS IN FOOD SCIENCE AND NUTRITION

NF-κB and cancer: how intimate is this relationship

(2009) Sahdeo Prasad et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY