NF-κB-dependent DNA damage-signaling differentially regulates DNA double-strand break repair mechanisms in immature and mature human hematopoietic cells

Exo1 independent DNA mismatch repair involves multiple compensatory nucleases

(2014) Amar Desai et al.   DNA REPAIR

Pre-leukemic evolution of hematopoietic stem cells: the importance of early mutations in leukemogenesis

(2014) M R Corces-Zimmerman et al.   LEUKEMIA

Endonuclease G initiates DNA rearrangements at the MLL breakpoint cluster upon replication stress

(2014) B Gole et al.   ONCOGENE

Thrombopoietin promotes NHEJ DNA repair in hematopoietic stem cells through specific activation of Erk and NF- B pathways and their target, IEX-1

(2013) B. de Laval et al.   BLOOD

The DNA double-strand break response is abnormal in myeloblasts from patients with therapy-related acute myeloid leukemia

(2013) M A Jacoby et al.   LEUKEMIA

In focus: MLL-rearranged leukemia

(2013) J de Boer et al.   LEUKEMIA

The MLL recombinome of acute leukemias in 2013

(2013) C Meyer et al.   LEUKEMIA

Inhibition of NF- B Signaling Ablates the Invasive Phenotype of Glioblastoma

(2013) M.-A. Westhoff et al.   MOLECULAR CANCER RESEARCH

Double-strand break repair: 53BP1 comes into focus

(2013) Stephanie Panier et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Concise Review: Leukemia Stem Cells in Personalized Medicine

(2013) Monica L. Guzman et al.   STEM CELLS

The diverse roles and clinical relevance of PARPs in DNA damage repair: Current state of the art

(2012) Mike De Vos et al.   BIOCHEMICAL PHARMACOLOGY

Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age

(2012) J. Kenyon et al.   BLOOD

Bone Marrow Failure in Fanconi Anemia Is Triggered by an Exacerbated p53/p21 DNA Damage Response that Impairs Hematopoietic Stem and Progenitor Cells

(2012) Raphael Ceccaldi et al.   Cell Stem Cell

Exo1 plays a major role in DNA end resection in humans and influences double-strand break repair and damage signaling decisions

(2012) Nozomi Tomimatsu et al.   DNA REPAIR

The power of DNA double-strand break (DSB) repair testing to predict breast cancer susceptibility

(2012) Marlen Keimling et al.   FASEB JOURNAL

The histone variant macroH2A1.1 is recruited to DSBs through a mechanism involving PARP1

(2012) Chang Xu et al.   FEBS LETTERS

The abundance of Rad51 protein in mouse embryonic stem cells is regulated at multiple levels

(2012) Elisia D. Tichy et al.   Stem Cell Research

Identification of new Rel/NFκB regulatory networks by focused genome location analysis

(2011) Adriana De Siervi et al.   CELL CYCLE

Stem cell niches and other factors that influence the sensitivity of bone marrow to radiation-induced bone cancer and leukaemia in children and adults

(2011) Richard B. Richardson   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

NF-κB regulates DNA double-strand break repair in conjunction with BRCA1–CtIP complexes

(2011) Meta Volcic et al.   NUCLEIC ACIDS RESEARCH

Stem Cells and DNA Damage: Persist or Perish?

(2010) Andrew A. Lane et al.   CELL

Nuclear initiated NF-κB signaling: NEMO and ATM take center stage

(2010) Shigeki Miyamoto   CELL RESEARCH

A Distinctive DNA Damage Response in Human Hematopoietic Stem Cells Reveals an Apoptosis-Independent Role for p53 in Self-Renewal

(2010) Michael Milyavsky et al.   Cell Stem Cell

Hematopoietic Stem Cell Quiescence Promotes Error-Prone DNA Repair and Mutagenesis

(2010) Mary Mohrin et al.   Cell Stem Cell

Apoptosis of leukocytes triggered by acute DNA damage promotes lymphoma formation

(2010) V. Labi et al.   GENES & DEVELOPMENT

The DNA Damage Response: Making It Safe to Play with Knives

(2010) Alberto Ciccia et al.   MOLECULAR CELL

Human Replication Protein A−Rad52−Single-Stranded DNA Complex: Stoichiometry and Evidence for Strand Transfer Regulation by Phosphorylation

(2009) Xiaoyi Deng et al.   BIOCHEMISTRY

Response of human hematopoietic stem and progenitor cells to energetic carbon ions

(2009) Daniela Becker et al.   INTERNATIONAL JOURNAL OF RADIATION BIOLOGY

Cellular and molecular consequences of defective Fanconi anemia proteins in replication-coupled DNA repair: Mechanistic insights

(2009) Larry H. Thompson et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Ionizing Radiation Induces Ataxia Telangiectasia Mutated-Dependent Checkpoint Signaling and G2But Not G1Cell Cycle Arrest in Pluripotent Human Embryonic Stem Cells

(2009) Olga Momčilović et al.   STEM CELLS

Mouse but not human embryonic stem cells are deficient in rejoining of ionizing radiation-induced DNA double-strand breaks

(2008) C.A. Bañuelos et al.   DNA REPAIR

DNA repair is crucial for maintaining hematopoietic stem cell function

(2008) Laura J. Niedernhofer   DNA REPAIR

Human MutL-complexes monitor homologous recombination independently of mismatch repair

(2008) Simone Yasmin Siehler et al.   DNA REPAIR

Low-dose ionizing radiation and chromosome translocations: A review of the major considerations for human biological dosimetry

(2008) J TUCKER   MUTATION RESEARCH-REVIEWS IN MUTATION RESEARCH

Ataxia-telangiectasia: from a rare disorder to a paradigm for cell signalling and cancer

(2008) Martin F. Lavin   NATURE REVIEWS MOLECULAR CELL BIOLOGY

 -H2AX in recognition and signaling of DNA double-strand breaks in the context of chromatin

(2008) A. Kinner et al.   NUCLEIC ACIDS RESEARCH

The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage

(2008) E M Bahassi et al.   ONCOGENE

Alternative-NHEJ Is a Mechanistically Distinct Pathway of Mammalian Chromosome Break Repair

(2008) Nicole Bennardo et al.   PLoS Genetics