Hydroxytyrosol prevents reduction in liver activity of Δ-5 and Δ-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice

Hydroxytyrosol prevents metabolic impairment reducing hepatic inflammation and restoring duodenal integrity in a rat model of NAFLD

(2016) Claudio Pirozzi et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

The effect of linoleic acid on the whole body synthesis rates of polyunsaturated fatty acids from α-linolenic acid and linoleic acid in free-living rats

(2016) Anthony F. Domenichiello et al.   JOURNAL OF NUTRITIONAL BIOCHEMISTRY

Prokineticin-2 is associated with metabolic syndrome in a middle-aged and elderly Chinese population

(2016) Yong Wang et al.   Lipids in Health and Disease

Fads1 and 2 are promoted to meet instant need for long-chain polyunsaturated fatty acids in goose fatty liver

(2016) Rashid H. Osman et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Hydroxytyrosol induces phase II detoxifying enzyme expression and effectively protects dopaminergic cells against dopamine- and 6-hydroxydopamine induced cytotoxicity

(2016) Guohua Yu et al.   NEUROCHEMISTRY INTERNATIONAL

Supplementation with antioxidant-rich extra virgin olive oil prevents hepatic oxidative stress and reduction of desaturation capacity in mice fed a high-fat diet: Effects on fatty acid composition in liver and extrahepatic tissues

(2016) Miguel Angel Rincón-Cervera et al.   NUTRITION

Arachidonic acid needed in infant formula when docosahexaenoic acid is present

(2016) J. Thomas Brenna   NUTRITION REVIEWS

Vegetable oils rich in alpha linolenic acid increment hepatic n-3 LCPUFA, modulating the fatty acid metabolism and antioxidant response in rats

(2016) Miguel Ángel Rincón-Cervera et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Dietary linoleic acid requirements in the presence of α-linolenic acid are lower than the historical 2 % of energy intake value, study in rats

(2015) Benjamin Choque et al.   BRITISH JOURNAL OF NUTRITION

Causal role of oxidative stress in unfolded protein response development in the hyperthyroid state

(2015) Luis A. Videla et al.   FREE RADICAL BIOLOGY AND MEDICINE

FADS2genotype regulates delta-6 desaturase activity and inflammation in human adipose tissue

(2015) Maija Vaittinen et al.   JOURNAL OF LIPID RESEARCH

Protective effect of hydroxytyrosol and its predominant plasmatic human metabolites against endothelial dysfunction in human aortic endothelial cells

(2015) Úrsula Catalán et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Olive oil and its phenolic compounds (hydroxytyrosol and tyrosol) ameliorated TCDD-induced heptotoxicity in rats via inhibition of oxidative stress and apoptosis

(2015) Ilavarasi Kalaiselvan et al.   PHARMACEUTICAL BIOLOGY

Is docosahexaenoic acid synthesis from α-linolenic acid sufficient to supply the adult brain?

(2015) Anthony F. Domenichiello et al.   PROGRESS IN LIPID RESEARCH

Reduction in the desaturation capacity of the liver in mice subjected to high fat diet: Relation to LCPUFA depletion in liver and extrahepatic tissues

(2015) Rodrigo Valenzuela et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

Palmitic acid induced lipotoxicity is associated with altered lipid metabolism, enhanced CYP450 2E1 and intracellular calcium mediated ER stress in human hepatoma cells

(2015) Ashraf U. Nissar et al.   Toxicology Research

Hydroxytyrosol, a natural molecule from olive oil, suppresses the growth of human hepatocellular carcinoma cells via inactivating AKT and nuclear factor-kappa B pathways

(2014) Baolei Zhao et al.   CANCER LETTERS

Genetic ablation of solute carrier family 7a3a leads to hepatic steatosis in zebrafish during fasting

(2014) Qilin Gu et al.   HEPATOLOGY

Polyunsaturated fatty acids and their metabolites in brain function and disease

(2014) Richard P. Bazinet et al.   NATURE REVIEWS NEUROSCIENCE

Alpha linolenic acid (ALA) from Rosa canina, sacha inchi and chia oils may increase ALA accretion and its conversion into n-3 LCPUFA in diverse tissues of the rat

(2014) Rodrigo Valenzuela B et al.   Food & Function

Hydroxytyrosol suppresses MMP-9 and COX-2 activity and expression in activated human monocytes via PKCα and PKCβ1 inhibition

(2013) Egeria Scoditti et al.   ATHEROSCLEROSIS

Diet, cognition, and Alzheimer’s disease: food for thought

(2013) Ane Otaegui-Arrazola et al.   EUROPEAN JOURNAL OF NUTRITION

Hydroxytyrosol prevents diet-induced metabolic syndrome and attenuates mitochondrial abnormalities in obese mice

(2013) Ke Cao et al.   FREE RADICAL BIOLOGY AND MEDICINE

Whole body synthesis rates of DHA from α-linolenic acid are greater than brain DHA accretion and uptake rates in adult rats

(2013) Anthony F. Domenichiello et al.   JOURNAL OF LIPID RESEARCH

Protective effects of hydroxytyrosol on liver ischemia/reperfusion injury in mice

(2013) Shangha Pan et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Hydroxytyrosol attenuates tunicamycin-induced endoplasmic reticulum stress in human hepatocarcinoma cells

(2013) Elena Giordano et al.   MOLECULAR NUTRITION & FOOD RESEARCH

(n-3) Fatty Acids and Cardiovascular Health: Are Effects of EPA and DHA Shared or Complementary?

(2012) Dariush Mozaffarian et al.   JOURNAL OF NUTRITION

Antimicrobial, antioxidant and anti-inflammatory phenolic activities in extra virgin olive oil

(2011) S Cicerale et al.   CURRENT OPINION IN BIOTECHNOLOGY

A maternal erythrocyte DHA content of approximately 6 g% is the DHA status at which intrauterine DHA biomagnifications turns into bioattenuation and postnatal infant DHA equilibrium is reached

(2011) Martine F. Luxwolda et al.   EUROPEAN JOURNAL OF NUTRITION

Ubiquitin–proteasome pathway and cellular responses to oxidative stress

(2011) Fu Shang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hydroxytyrosol Induces Proliferation and Cytoprotection against Oxidative Injury in Vascular Endothelial Cells: Role of Nrf2 Activation and HO-1 Induction

(2011) Houda Zrelli et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Omega-3 Fatty Acids and Cardiovascular Disease

(2011) Dariush Mozaffarian et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

The Front-end Desaturase: Structure, Function, Evolution and Biotechnological Use

(2011) Dauenpen Meesapyodsuk et al.   LIPIDS

Genetic variants of the fatty acid desaturase gene cluster predict amounts of red blood cell docosahexaenoic and other polyunsaturated fatty acids in pregnant women: findings from the Avon Longitudinal Study of Parents and Children

(2010) Berthold Koletzko et al.   AMERICAN JOURNAL OF CLINICAL NUTRITION

Effect of omega-3 polyunsaturated fatty acid supplementation on semen profile and enzymatic anti-oxidant capacity of seminal plasma in infertile men with idiopathic oligoasthenoteratospermia: a double-blind, placebo-controlled, randomised study

(2010) M. R. Safarinejad   ANDROLOGIA

Role of FADS1 and FADS2 polymorphisms in polyunsaturated fatty acid metabolism

(2010) Claudia Glaser et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Hydroxytyrosol induces antioxidant/detoxificant enzymes and Nrf2 translocation via extracellular regulated kinases and phosphatidylinositol-3-kinase/protein kinase B pathways in HepG2 cells

(2010) María Angeles Martín et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Relationship of omega-3 and omega-6 fatty acids with semen characteristics, and anti-oxidant status of seminal plasma: A comparison between fertile and infertile men

(2009) Mohammad Reza Safarinejad et al.   CLINICAL NUTRITION

Antidiabetic and Antioxidant Effects of Hydroxytyrosol and Oleuropein from Olive Leaves in Alloxan-Diabetic Rats

(2009) Hedya Jemai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Decreased Liver Fatty Acid Δ-6 and Δ-5 Desaturase Activity in Obese Patients

(2009) Julia Araya et al.   Obesity

Alpha-linolenic acid and its conversion to longer chain n−3 fatty acids: Benefits for human health and a role in maintaining tissue n−3 fatty acid levels

(2009) Gwendolyn Barceló-Coblijn et al.   PROGRESS IN LIPID RESEARCH

Lipid-Lowering and Antioxidant Effects of Hydroxytyrosol and Its Triacetylated Derivative Recovered from Olive Tree Leaves in Cholesterol-Fed Rats

(2008) Hedya Jemai et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY