ROR activation by Nobiletin enhances antitumor efficacy via suppression of IκB/NF-κB signaling in triple-negative breast cancer

Clocking cancer: the circadian clock as a target in cancer therapy

(2021) Francesca Battaglin et al.   ONCOGENE

Restoration of the molecular clock is tumor suppressive in neuroblastoma

(2021) Myrthala Moreno-Smith et al.   Nature Communications

NF-κB modifies the mammalian circadian clock through interaction with the core clock protein BMAL1

(2021) Yang Shen et al.   PLoS Genetics

In pancreatic islets from type 2 diabetes patients, the dampened circadian oscillators lead to reduced insulin and glucagon exocytosis

(2020) Volodymyr Petrenko et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MiR-18a-downregulated RORA inhibits the proliferation and tumorigenesis of glioma using the TNF-α-mediated NF-κB signaling pathway

(2020) Yang Jiang et al.   EBioMedicine

Cardiolipin Synthesis in Skeletal Muscle Is Rhythmic and Modifiable by Age and Diet

(2020) Kazunari Nohara et al.   Oxidative Medicine and Cellular Longevity

Nobiletin affects circadian rhythms and oncogenic characteristics in a cell-dependent manner

(2020) Sujeewa S. Lellupitiyage Don et al.   PLoS One

Nobiletin in Cancer Therapy: How This Plant Derived-Natural Compound Targets Various Oncogene and Onco-Suppressor Pathways

(2020) Milad Ashrafizadeh et al.   Biomedicines

A bicistronic vector backbone for rapid seamless cloning and chimerization of αβT-cell receptor sequences

(2020) Korbinian N. Kropp et al.   PLoS One

Circadian regulation of chemotherapy-induced peripheral neuropathic pain and the underlying transcriptomic landscape

(2020) Hee Kee Kim et al.   Scientific Reports

The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function

(2020) Marvin Wirianto et al.   Cell Reports

Nobiletin: Targeting the Circadian Network to Promote Bioenergetics and Healthy Aging

(2020) E. Mileykovskaya et al.   BIOCHEMISTRY-MOSCOW

Genome-wide correlation analysis to identify amplitude regulators of circadian transcriptome output

(2020) Evan S. Littleton et al.   Scientific Reports

Nobiletin Inhibits Cell Viability via the SRC/AKT/STAT3/YY1AP1 Pathway in Human Renal Carcinoma Cells

(2019) Di Wei et al.   Frontiers in Pharmacology

Tumor-Stroma-Inflammation Networks Promote Pro-metastatic Chemokines and Aggressiveness Characteristics in Triple-Negative Breast Cancer

(2019) Yulia Liubomirski et al.   Frontiers in Immunology

Nobiletin and Derivatives: Functional Compounds from Citrus Fruit Peel for Colon Cancer Chemoprevention

(2019) Goh et al.   Cancers

Coordinate Regulation of Cholesterol and Bile Acid Metabolism by the Clock Modifier Nobiletin in Metabolically Challenged Old Mice

(2019) Kazunari Nohara et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

RORγ is a targetable master regulator of cholesterol biosynthesis in a cancer subtype

(2019) Demin Cai et al.   Nature Communications

Nobiletin fortifies mitochondrial respiration in skeletal muscle to promote healthy aging against metabolic challenge

(2019) Kazunari Nohara et al.   Nature Communications

Circadian pathway genetic variation and cancer risk: evidence from genome-wide association studies

(2018) Simone Mocellin et al.   BMC Medicine

Acute Pharmacologic Degradation of a Stable Antigen Enhances Its Direct Presentation on MHC Class I Molecules

(2018) Sarah C. Moser et al.   Frontiers in Immunology

The Genomic Landscape and Pharmacogenomic Interactions of Clock Genes in Cancer Chronotherapy

(2018) Youqiong Ye et al.   Cell Systems

Requirement for NF-κB in maintenance of molecular and behavioral circadian rhythms in mice

(2018) Hee-Kyung Hong et al.   GENES & DEVELOPMENT

Incompatibility of the circadian protein BMAL1 and HNF4α in hepatocellular carcinoma

(2018) Baharan Fekry et al.   Nature Communications

Magnitude of Therapeutic STING Activation Determines CD8+ T Cell-Mediated Anti-tumor Immunity

(2018) Kelsey E. Sivick et al.   Cell Reports

CYCLOPS reveals human transcriptional rhythms in health and disease

(2017) Ron C. Anafi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Potent Effects of Flavonoid Nobiletin on Amplitude, Period, and Phase of the Circadian Clock Rhythm in PER2::LUCIFERASE Mouse Embryonic Fibroblasts

(2017) Ayako Shinozaki et al.   PLoS One

Citrus Flavonoids as Regulators of Lipoprotein Metabolism and Atherosclerosis

(2016) Erin E. Mulvihill et al.   Annual Review of Nutrition

Targeting Inflammation in Cancer Prevention and Therapy

(2016) J. Todoric et al.   Cancer Prevention Research

Core Circadian Clock Genes Regulate Leukemia Stem Cells in AML

(2016) Rishi V. Puram et al.   CELL

Circadian Rhythm Disruption Promotes Lung Tumorigenesis

(2016) Thales Papagiannakopoulos et al.   Cell Metabolism

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

Identification of circadian-related gene expression profiles in entrained breast cancer cell lines

(2016) Miguel A. Gutiérrez-Monreal et al.   CHRONOBIOLOGY INTERNATIONAL

Triple-negative breast cancer: challenges and opportunities of a heterogeneous disease

(2016) Giampaolo Bianchini et al.   Nature Reviews Clinical Oncology

Transcriptional architecture of the mammalian circadian clock

(2016) Joseph S. Takahashi   NATURE REVIEWS GENETICS

The Nuclear Receptor, RORγ, Regulates Pathways Necessary for Breast Cancer Metastasis

(2016) Tae Gyu Oh et al.   EBioMedicine

MYC Disrupts the Circadian Clock and Metabolism in Cancer Cells

(2015) Brian J. Altman et al.   Cell Metabolism

limma powers differential expression analyses for RNA-sequencing and microarray studies

(2015) Matthew E. Ritchie et al.   NUCLEIC ACIDS RESEARCH

Ammonia-lowering activities and carbamoyl phosphate synthetase 1 (Cps1) induction mechanism of a natural flavonoid

(2015) Kazunari Nohara et al.   Nutrition & Metabolism

Nobiletin enhances the efficacy of chemotherapeutic agents in ABCB1 overexpression cancer cells

(2015) Wenzhe Ma et al.   Scientific Reports

PRMT2 and RORγ Expression Are Associated With Breast Cancer Survival Outcomes

(2014) Tae Gyu Oh et al.   MOLECULAR ENDOCRINOLOGY

REV-ERB and ROR nuclear receptors as drug targets

(2014) Douglas J. Kojetin et al.   NATURE REVIEWS DRUG DISCOVERY

NF- B, an Active Player in Human Cancers

(2014) Y. Xia et al.   Cancer Immunology Research

Triple-Negative Breast Cancer and the Need for New Therapeutic Targets

(2013) Olav Engebraaten et al.   AMERICAN JOURNAL OF PATHOLOGY

Overexpression of p65 attenuates celecoxib-induced cell death in MDA-MB-231 human breast cancer cell line

(2013) Ling Wang et al.   Cancer Cell International

The Omics of Triple-Negative Breast Cancers

(2013) H. Xu et al.   CLINICAL CHEMISTRY

Research Resource: Nuclear Receptors as Transcriptome: Discriminant and Prognostic Value in Breast Cancer

(2013) George E. O. Muscat et al.   MOLECULAR ENDOCRINOLOGY

Combination of GHRH antagonists and docetaxel shows experimental effectiveness for the treatment of triple-negative breast cancers

(2013) S. SEITZ et al.   ONCOLOGY REPORTS

Retinoic acid-related orphan receptors α and γ: key regulators of lipid/glucose metabolism, inflammation, and insulin sensitivity

(2013) Anton M. Jetten et al.   Frontiers in Endocrinology

DAVID-WS: a stateful web service to facilitate gene/protein list analysis

(2012) X. Jiao et al.   BIOINFORMATICS

ROR  Suppresses Breast Tumor Invasion by Inducing SEMA3F Expression

(2012) G. Xiong et al.   CANCER RESEARCH

RORα, a Potential Tumor Suppressor and Therapeutic Target of Breast Cancer

(2012) Jun Du et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Antimetastatic effect of nobiletin through the down-regulation of CXC chemokine receptor type 4 and matrix metallopeptidase-9

(2012) Seung Ho Baek et al.   PHARMACEUTICAL BIOLOGY

Core circadian protein CLOCK is a positive regulator of NF- B-mediated transcription

(2012) M. L. Spengler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Circadian clock protein cryptochrome regulates the expression of proinflammatory cytokines

(2012) R. Narasimamurthy et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Hallmarks of Cancer: The Next Generation

(2011) Douglas Hanahan et al.   CELL

DNA Damage-Induced RORα Is Crucial for p53 Stabilization and Increased Apoptosis

(2011) Hyunkyung Kim et al.   MOLECULAR CELL

Identification of SR1078, a Synthetic Agonist for the Orphan Nuclear Receptors RORα and RORγ

(2010) Yongjun Wang et al.   ACS Chemical Biology

Regulation of the RelA (p65) transactivation domain

(2008) John M. O'shea et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Orphan Nuclear Receptor, RORα, Regulates Gene Expression That Controls Lipid Metabolism

(2008) Patrick Lau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Redundant Function of REV-ERBα and β and Non-Essential Role for Bmal1 Cycling in Transcriptional Regulation of Intracellular Circadian Rhythms

(2008) Andrew C. Liu et al.   PLoS Genetics