Article
Cell Biology
Liang Wang, Huibin Yang, Liang Qiao, Jiani Liu, Xiaoxiao Liao, Huan Huang, Jianyi Dong, Jun Chen, Dapeng Chen, Jingyu Wang
Summary: This study found that Ophiopogonin D (OP-D) from Ophiopogon japonicus can inhibit the sustained activation of the NF-κB signaling pathway, and effectively treat experimental colitis. Molecular docking simulations revealed that OP-D interacts with NF-κB-p65, affecting its translocation to the nucleus. This study provides new insights into the pathogenesis and treatment options for colitis.
Article
Medicine, Research & Experimental
Xinfei Ma, Qinli Ruan, Xiaotian Ji, Ju Yang, Huiping Peng
Summary: The study demonstrated that Ligustrazine had protective effects against hepatotoxicity induced by Cyclophosphamide or its metabolite 4-hydroperoxycyclophosphamide, by improving liver structure and function, inhibiting oxidative stress and inflammation accompanied with pyroptosis, which was associated with the inhibition of the Txnip/Trx/NF-kappa B pathway.
Article
Neurosciences
Di Zhang, Bei Jing, Zhen-ni Chen, Xin Li, Hui-mei Shi, Ya-chun Zheng, Shi-quan Chang, Li Gao, Guo-ping Zhao
Summary: This study aimed to investigate the potential mechanism of ferulic acid in the treatment of sciatica. The results showed that ferulic acid can promote the repair of injured sciatic nerve by reducing neuronal cell apoptosis and inflammatory infiltration through the TLR4/NF-kappa B pathway.
CNS NEUROSCIENCE & THERAPEUTICS
(2023)
Article
Pharmacology & Pharmacy
Yongjie Chen, Linlin Zhang, Zongguang Li, Zuoxing Wu, Xixi Lin, Na Li, Rong Shen, Guojun Wei, Naichun Yu, Fengqing Gong, Gang Rui, Ren Xu, Guangrong Ji
Summary: Mogrol, an active component of Siraitia grosvenorii, exhibits anti-inflammatory, anticancer and neuroprotective effects. This study demonstrated that mogrol dose-dependently inhibited osteoclast formation and function by regulating gene expression and signaling pathway. Furthermore, mogrol reduced bone mass loss in postmenopausal mice, suggesting its promising potential for osteoporosis prevention or therapy.
FRONTIERS IN PHARMACOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Shuang Chen, Chun-Lei Zhang, Hai-Qing Shen, Xiao-Fei Zhou, Jing-He Li, Jia-Lin Yu, Qiang An, Ben-Dong Fu, Peng-Fei Yi
Summary: The study showed that sesamin has protective effects on colitis in mice induced by DSS, reducing colon damage and inflammatory responses. Sesamin alleviates colon damage by modulating the NF-kappa B and MAPK signaling pathways.
Article
Orthopedics
Peng Wang, Cuicui Yang, Jinhong Lu, Yongxin Ren, David Goltzman, Dengshun Miao
Summary: This study investigates the role and mechanism of 1,25-dihydroxyvitamin D (1,25(OH)(2)D) insufficiency in promoting intervertebral disc degeneration. The results show that 1,25(OH)(2)D insufficiency accelerates intervertebral disc degeneration, while overexpression of Sirt1 can alleviate this degeneration.
JOURNAL OF ORTHOPAEDIC TRANSLATION
(2023)
Article
Pharmacology & Pharmacy
Xi Zhang, Aie Chang, Yanqiang Zou, Heng Xu, Jikai Cui, Zhang Chen, Yuan Li, Yifan Du, Jie Wu, Jizhang Yu, Xinling Du
Summary: Aspirin inhibits the maturation of dendritic cells and the production of pro-inflammatory cytokines, attenuating acute cardiac allograft rejection and promoting regulatory T cells, leading to prolonged allograft survival.
FRONTIERS IN PHARMACOLOGY
(2021)
Article
Andrology
Shiva Rezaei, Seyed Jalal Hosseinimehr, Mehryar Zargari, Abbasali Karimpour Malekshah, Mansoureh Mirzaei, Fereshteh Talebpour Amiri
Summary: Results of the study showed that CP-induced testicular injury is characterized by atypical tissue structure, sperm parameter dysfunction, reduced testosterone levels, oxidative stress, apoptosis, and inflammation. Administration of SA protected the testis from oxidative stress, improved testosterone levels and tissue structure. Immunohistochemical findings also indicated that SA can inhibit the activity of Caspase-3 and NF-kB. Overall, the data supports that SA possesses protective effects on testicular structure and function against CP-induced injury through its antioxidant, anti-inflammatory, and anti-apoptotic activities.
Article
Food Science & Technology
Jing Mao, Shunqin Li, RongRong Fu, Yijin Wang, Jing Meng, Yan Jin, Tao Wu, Min Zhang
Summary: This study investigated the effect of sea cucumber hydrolysate (SCH) on immunosuppressed mice induced by cyclophosphamide (Cy). The results showed that SCH could enhance immunity by increasing thymus and spleen indices, reducing liver enzyme levels, increasing antibody levels, reducing gut tissue damage, and activating the NF-?B pathway. Moreover, SCH alleviated gut microbiota imbalance and identified potential bioactive peptides. These findings provide a basis for developing SCH as a nutritional supplement to alleviate immunosuppression and intestinal damage induced by Cy.
Article
Chemistry, Medicinal
Yihang Wu, Zixiu Liu, Zhenxiu He, Jumei Yi, Xingfang Qiao, Chunbin Tan, Yajing Xing, Yaobo Zeng, Dajian Yang, Junlin Yin, Baomin Fan, Guangzhi Zeng
Summary: Ulcerative colitis is a global burden due to its high incidence worldwide and chronic inflammatory nature. Cantharidin (CTD) derivatives, while showing potent cytotoxicity, have limited clinical usage as anti-cancer drugs due to organ toxicity. This study synthesized 21 CTD analogues and found that some compounds with alkynyl substitution at C5 position showed better anti-inflammatory activity than CTD and norcantharidin (NCTD), with one analogue (3i) selected for further study. Mechanism studies revealed that 3i could inhibit TNF-a induced activation of NF-?B signaling and alleviate colitis in mice. This study suggests that CTD analogues with alkynyl substitution at C5 position have potential as therapeutic agents for inflammatory diseases, with better activity and lower toxicity.
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
(2023)
Article
Biotechnology & Applied Microbiology
Qi Zhang, Yanan Li, Chunping Yin, Mingyang Gao, Jiaxu Yu, Junfei Guo, Xiaohui Xian, Zhiyong Hou, Qiujun Wang
Summary: This study investigated the role of IL-17A in sevoflurane-induced neurocognitive impairment in neonatal mice. The results showed that repeated sevoflurane exposures led to long-term cognitive impairment in wild-type mice, while IL-17A knockout mice had less severe impairment. Furthermore, IL-17A deletion protected neonatal mice from cognitive impairment by inhibiting the NF-kappa B signaling pathway and reducing neuroinflammation.
Article
Agriculture, Multidisciplinary
Zhe Xu, Shan-shan Man, Bo-yang Gong, Zhao-dong Li, Hui-fang Zhou, Yan-fei Peng, Shu-wu Zhao, Yun-long Hou, Li Wang, Yu-hong Bian
Summary: This study found that Bazi Bushen has protective effects on SAMP6 mice, improving intestinal inflammation and aging, as well as effectively rebuilding the gut microbiota ecosystem.
JOURNAL OF THE SCIENCE OF FOOD AND AGRICULTURE
(2023)
Article
Biochemistry & Molecular Biology
Zhao-Bo Luo, Liu-Hui Yang, Sheng-Zhong Han, Shuang-Yan Chang, Hongye Liu, Zhi-Yong An, Xiu-Li Zhang, Biao-Hu Quan, Xi-Jun Yin, Jin-Dan Kang
Summary: This study demonstrates that cyclophosphamide (CTX) treatment has detrimental effects on oocytes and embryos, leading to DNA damage, apoptosis, and abnormal histone modification. Supplementation with LBH589 can effectively restore the developmental potential of embryos by increasing histone modification levels and restoring protein expression of NF-kappa B, a key regulator of early embryo development.
CHEMICO-BIOLOGICAL INTERACTIONS
(2024)
Article
Environmental Sciences
Zhaoping Ou, Lijuan Zhu, Chenglong Huang, Chaoyang Ma, Li Kong, Xing Lin, Xinyu Gao, Lin Huang, Lixin Wen, Zengenni Liang, Zhihang Yuan, Jing Wu, Jine Yi
Summary: Betulinic acid (BA) has been shown to protect against cyclophosphamide-induced intestinal mucosal damage by regulating the Nrf2 and NF-kappa B/MAPK signaling pathways, suggesting new therapeutic targets for attenuating intestinal impairment and maintaining intestinal health.
ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY
(2021)
Article
Biochemistry & Molecular Biology
Xialei Wu, Liyao Lin, Haibin Wu
Summary: The study suggests that ferulic acid can ameliorate LPS-induced acute lung injury by inhibiting the inflammatory response via inactivation of the TLR4/NF-kappa B signaling pathway.
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY
(2021)