Microglial NLRP3 inflammasome activates neurotoxic astrocytes in depression-like mice

Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression

(2022) Haixia Wang et al.   Journal of Neuroinflammation

Opposing functions of β-arrestin 1 and 2 in Parkinson’s disease via microglia inflammation and Nprl3

(2021) Yinquan Fang et al.   CELL DEATH AND DIFFERENTIATION

Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release

(2021) Hana Starobova et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reactive astrocyte nomenclature, definitions, and future directions

(2021) Carole Escartin et al.   NATURE NEUROSCIENCE

Reactive astrocytes in ALS display diminished intron retention

(2021) Oliver J Ziff et al.   NUCLEIC ACIDS RESEARCH

Tau immunotherapy is associated with glial responses in FTLD-tau

(2021) Boram Kim et al.   ACTA NEUROPATHOLOGICA

Soluble α-synuclein–antibody complexes activate the NLRP3 inflammasome in hiPSC-derived microglia

(2021) Dorit Trudler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Gasdermin D mediates the maturation and release of IL-1α downstream of inflammasomes

(2021) Kohsuke Tsuchiya et al.   Cell Reports

Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation

(2021) Marjan Gharagozloo et al.   ACTA NEUROPATHOLOGICA

Neuroinflammatory astrocyte subtypes in the mouse brain

(2021) Philip Hasel et al.   NATURE NEUROSCIENCE

RhoA drives actin compaction to restrict axon regeneration and astrocyte reactivity after CNS injury

(2021) Sina Stern et al.   NEURON

Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

(2021) Shanya Jiang et al.   Cell Reports

Quercetin hinders microglial activation to alleviate neurotoxicity via the interplay between NLRP3 inflammasome and mitophagy

(2021) Xiaojuan Han et al.   Redox Biology

Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus

(2021) Leelavathi N. Madhu et al.   Redox Biology

Neurotoxic reactive astrocytes induce cell death via saturated lipids

(2021) Kevin A. Guttenplan et al.   NATURE

Autophagy in Astrocytes and its Implications in Neurodegeneration

(2020) Katherine Sung et al.   JOURNAL OF MOLECULAR BIOLOGY

MAFG-driven astrocytes promote CNS inflammation

(2020) Michael A. Wheeler et al.   NATURE

Herpes simplex virus type 1 inflammasome activation in proinflammatory human macrophages is dependent on NLRP3, ASC, and caspase-1

(2020) Andrew H. Karaba et al.   PLoS One

Pyridoxine induces glutathione synthesis via PKM2-mediated Nrf2 transactivation and confers neuroprotection

(2020) Yao Wei et al.   Nature Communications

Non-canonical Caspase-1 Signaling Drives RIP2-Dependent and TNF-α-Mediated Inflammation In Vivo

(2020) Sören Reinke et al.   Cell Reports

Rhein Suppresses Lung Inflammatory Injury Induced by Human Respiratory Syncytial Virus Through Inhibiting NLRP3 Inflammasome Activation via NF-κB Pathway in Mice

(2020) Cunsi Shen et al.   Frontiers in Pharmacology

Single-nucleus RNA-seq identifies Huntington disease astrocyte states

(2020) Osama Al-Dalahmah et al.   Acta Neuropathologica Communications

Disease-associated astrocytes in Alzheimer’s disease and aging

(2020) Naomi Habib et al.   NATURE NEUROSCIENCE

Dysfunctional Nurr1 promotes high glucose-induced Müller cell activation by up-regulating the NF-κB/NLRP3 inflammasome axis

(2020) Wendie Li et al.   NEUROPEPTIDES

Inhibition of the NLRP3-inflammasome prevents cognitive deficits in experimental autoimmune encephalomyelitis mice via the alteration of astrocyte phenotype

(2020) Baohua Hou et al.   Cell Death & Disease

LncRNA Gm14205 induces astrocytic NLRP3 inflammasome activation via inhibiting oxytocin receptor in postpartum depression

(2020) Jialei Zhu et al.   BIOSCIENCE REPORTS

Regionally encoded functional heterogeneity of astrocytes in health and disease: A perspective

(2020) Benjamin E. Clarke et al.   GLIA

Slc6a3-dependent expression of a CAPS-associated Nlrp3 allele results in progressive behavioral abnormalities and neuroinflammation in aging mice

(2020) Katharine M. von Herrmann et al.   Journal of Neuroinflammation

Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice

(2020) Yuan Dong et al.   Journal of Neuroinflammation

Astrocyte Reactivity: Subtypes, States, and Functions in CNS Innate Immunity

(2020) Michael V. Sofroniew   TRENDS IN IMMUNOLOGY

GC1qR Cleavage by Caspase-1 Drives Aerobic Glycolysis in Tumor Cells

(2020) Annika Sünderhauf et al.   Frontiers in Oncology

Severe reactive astrocytes precipitate pathological hallmarks of Alzheimer’s disease via H2O2− production

(2020) Heejung Chun et al.   NATURE NEUROSCIENCE

Depression in the Primary Care Setting

(2019) Lawrence T. Park et al.   NEW ENGLAND JOURNAL OF MEDICINE

Author Correction: Inflammasome signalling in brain function and neurodegenerative disease

(2019) Michael T. Heneka et al.   NATURE REVIEWS NEUROSCIENCE

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

(2019) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

LncRNA H19 initiates microglial pyroptosis and neuronal death in retinal ischemia/reperfusion injury

(2019) Peixing Wan et al.   CELL DEATH AND DIFFERENTIATION

The A1 astrocyte paradigm: New avenues for pharmacological intervention in neurodegeneration

(2019) Jared T. Hinkle et al.   MOVEMENT DISORDERS

An update on reactive astrocytes in chronic pain

(2019) Ting Li et al.   Journal of Neuroinflammation

Fragmented mitochondria released from microglia trigger A1 astrocytic response and propagate inflammatory neurodegeneration

(2019) Amit U. Joshi et al.   NATURE NEUROSCIENCE

Evidence of decreased gap junction coupling between astrocytes and oligodendrocytes in the anterior cingulate cortex of depressed suicides

(2019) Arnaud Tanti et al.   NEUROPSYCHOPHARMACOLOGY

The effect of fluoxetine on astrocyte autophagy flux and injured mitochondria clearance in a mouse model of depression

(2019) Xiaodong Shu et al.   Cell Death & Disease

Men’s Depression and Suicide

(2019) John L. Oliffe et al.   Current Psychiatry Reports

Mechanisms and treatment of late-life depression

(2019) George S. Alexopoulos   Translational Psychiatry

Neuroinflammatory Processes, A1 Astrocyte Activation and Protein Aggregation in the Retina of Alzheimer’s Disease Patients, Possible Biomarkers for Early Diagnosis

(2019) Alfonso Grimaldi et al.   Frontiers in Neuroscience

Repeated stress induces a pro-inflammatory state, increases amygdala neuronal and microglial activation, and causes anxiety in adult male rats

(2019) Soumyabrata Munshi et al.   BRAIN BEHAVIOR AND IMMUNITY

Inflammasome signaling and regulation of interleukin-1 family cytokines

(2019) Amy H. Chan et al.   JOURNAL OF EXPERIMENTAL MEDICINE

A single-cell atlas of entorhinal cortex from individuals with Alzheimer’s disease reveals cell-type-specific gene expression regulation

(2019) Alexandra Grubman et al.   NATURE NEUROSCIENCE

Astrocyte molecular signatures in Huntington’s disease

(2019) Blanca Diaz-Castro et al.   Science Translational Medicine

Soluble Aβ oligomers and protofibrils induce NLRP3 inflammasome activation in microglia

(2019) Asta Lučiūnaitė et al.   JOURNAL OF NEUROCHEMISTRY

Curcumin inhibits LPS-induced neuroinflammation by promoting microglial M2 polarization via TREM2/ TLR4/ NF-κB pathways in BV2 cells

(2019) Jiawei Zhang et al.   MOLECULAR IMMUNOLOGY

Altered inflammasome machinery as a key player in the perpetuation of Rett syndrome oxinflammation

(2019) Alessandra Pecorelli et al.   Redox Biology

lincRNA-Cox2 regulates NLRP3 inflammasome and autophagy mediated neuroinflammation

(2018) Zhenyi Xue et al.   CELL DEATH AND DIFFERENTIATION

Dopamine D2 receptor restricts astrocytic NLRP3 inflammasome activation via enhancing the interaction of β-arrestin2 and NLRP3

(2018) Jialei Zhu et al.   CELL DEATH AND DIFFERENTIATION

The adhesion and migration of microglia to β-amyloid (Aβ) is decreased with aging and inhibited by Nogo/NgR pathway

(2018) Yinquan Fang et al.   Journal of Neuroinflammation

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Normal aging induces A1-like astrocyte reactivity

(2018) Laura E. Clarke et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Apelin-13 Administration Protects Against LPS-Induced Acute Lung Injury by Inhibiting NF-κB Pathway and NLRP3 Inflammasome Activation

(2018) Hailin Zhang et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Menin Deficiency Leads to Depressive-like Behaviors in Mice by Modulating Astrocyte-Mediated Neuroinflammation

(2018) Lige Leng et al.   NEURON

Reactive Astrocytes: Production, Function, and Therapeutic Potential

(2017) Shane A. Liddelow et al.   IMMUNITY

Function and regulation of IL-1α in inflammatory diseases and cancer

(2017) Ankit Malik et al.   IMMUNOLOGICAL REVIEWS

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Antidepressants induce autophagy dependent-NLRP3-inflammasome inhibition in Major depressive disorder

(2017) Elísabet Alcocer-Gómez et al.   PHARMACOLOGICAL RESEARCH

NLRP3 Inflammasome in Neurological Diseases, from Functions to Therapies

(2017) Limin Song et al.   Frontiers in Cellular Neuroscience

Apigenin ameliorates chronic mild stress-induced depressive behavior by inhibiting interleukin-1β production and NLRP3 inflammasome activation in the rat brain

(2016) Ruipeng Li et al.   BEHAVIOURAL BRAIN RESEARCH

Uncoupling protein 2 modulation of the NLRP3 inflammasome in astrocytes and its implications in depression

(2016) Ren-Hong Du et al.   Redox Biology

Glial fibrillary acidic protein (GFAP) and the astrocyte intermediate filament system in diseases of the central nervous system

(2015) Elly M Hol et al.   CURRENT OPINION IN CELL BIOLOGY

Stress-Induced Depressive Behaviors Require a Functional NLRP3 Inflammasome

(2015) Elísabet Alcocer-Gómez et al.   MOLECULAR NEUROBIOLOGY

Depression as a Microglial Disease

(2015) Raz Yirmiya et al.   TRENDS IN NEUROSCIENCES

Functional and molecular defects of hiPSC-derived neurons from patients with ATM deficiency

(2014) L Carlessi et al.   Cell Death & Disease

NIH Image to ImageJ: 25 years of image analysis

(2012) Caroline A Schneider et al.   NATURE METHODS