Complement component 3 from astrocytes mediates retinal ganglion cell loss during neuroinflammation

Complement-associated loss of CA2 inhibitory synapses in the demyelinated hippocampus impairs memory

(2021) Valeria Ramaglia et al.   ACTA NEUROPATHOLOGICA

Complement-dependent synapse loss and microgliosis in a mouse model of multiple sclerosis

(2020) Jennetta W. Hammond et al.   BRAIN BEHAVIOR AND IMMUNITY

Microglia, Lifestyle Stress, and Neurodegeneration

(2020) Charlotte Madore et al.   IMMUNITY

Glial Cells as Regulators of Neuroimmune Interactions in the Central Nervous System

(2020) Jack P. Antel et al.   JOURNAL OF IMMUNOLOGY

Perturbation of gut microbiota decreases susceptibility but does not modulate ongoing autoimmune neurological disease

(2020) Clemens Gödel et al.   Journal of Neuroinflammation

Systemic factors as mediators of brain homeostasis, ageing and neurodegeneration

(2020) John V. Pluvinage et al.   NATURE REVIEWS NEUROSCIENCE

Diapedesis-Induced Integrin Signaling via LFA-1 Facilitates Tissue Immunity by Inducing Intrinsic Complement C3 Expression in Immune Cells

(2020) Martin Kolev et al.   IMMUNITY

Glia in neurodegeneration: Drivers of disease or along for the ride?

(2020) Amy J. Gleichman et al.   NEUROBIOLOGY OF DISEASE

CD49f Is a Novel Marker of Functional and Reactive Human iPSC-Derived Astrocytes

(2020) Lilianne Barbar et al.   NEURON

Neurotoxic Reactive Astrocytes Drive Neuronal Death after Retinal Injury

(2020) Kevin A. Guttenplan et al.   Cell Reports

Complement inhibition as a therapeutic strategy in retinal disorders

(2019) Enoch Kassa et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis

(2019) Roberta Brambilla   ACTA NEUROPATHOLOGICA

Early complement genes are associated with visual system degeneration in multiple sclerosis

(2019) Kathryn C Fitzgerald et al.   BRAIN

C3- and CR3-dependent microglial clearance protects photoreceptors in retinitis pigmentosa

(2019) Sean M. Silverman et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The astrocyte transcriptome in EAE optic neuritis shows complement activation and reveals a sex difference in astrocytic C3 expression

(2019) Alessia Tassoni et al.   Scientific Reports

Glial pathology and retinal neurotoxicity in the anterior visual pathway in experimental autoimmune encephalomyelitis

(2019) Jing Jin et al.   Acta Neuropathologica Communications

Complement C3 Is Activated in Human AD Brain and Is Required for Neurodegeneration in Mouse Models of Amyloidosis and Tauopathy

(2019) Tiffany Wu et al.   Cell Reports

Cell-Type-Specific Complement Expression in the Healthy and Diseased Retina

(2019) Diana Pauly et al.   Cell Reports

Targeted Complement Inhibition at Synapses Prevents Microglial Synaptic Engulfment and Synapse Loss in Demyelinating Disease

(2019) Sebastian Werneburg et al.   IMMUNITY

New tricks for an ancient system: Physiological and pathological roles of complement in the CNS

(2018) Andrea J. Tenner et al.   MOLECULAR IMMUNOLOGY

Block of A1 astrocyte conversion by microglia is neuroprotective in models of Parkinson’s disease

(2018) Seung Pil Yun et al.   NATURE MEDICINE

Classical and alternative complement activation on photoreceptor outer segments drives monocyte-dependent retinal atrophy

(2018) Kenneth J. Katschke et al.   Scientific Reports

Modeling month-season of birth as a risk factor in mouse models of chronic disease: from multiple sclerosis to autoimmune encephalomyelitis

(2017) Jacob D. Reynolds et al.   FASEB JOURNAL

Retinal layer segmentation in multiple sclerosis: a systematic review and meta-analysis

(2017) Axel Petzold et al.   LANCET NEUROLOGY

Neurotoxic reactive astrocytes are induced by activated microglia

(2017) Shane A. Liddelow et al.   NATURE

Cell-specific and region-specific transcriptomics in the multiple sclerosis model: Focus on astrocytes

(2017) Noriko Itoh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Complement C3 on microglial clusters in multiple sclerosis occur in chronic but not acute disease: Implication for disease pathogenesis

(2016) Iliana Michailidou et al.   GLIA

Complement-Mediated Regulation of Metabolism and Basic Cellular Processes

(2016) Christoph Hess et al.   IMMUNITY

Microglia response in retina and optic nerve in chronic experimental autoimmune encephalomyelitis

(2016) Lioba Horstmann et al.   JOURNAL OF NEUROIMMUNOLOGY

Complement is activated in progressive multiple sclerosis cortical grey matter lesions

(2016) Lewis M. Watkins et al.   Journal of Neuroinflammation

Complement and microglia mediate early synapse loss in Alzheimer mouse models

(2016) S. Hong et al.   SCIENCE

Complement C1q-C3-associated synaptic changes in multiple sclerosis hippocampus

(2015) Iliana Michailidou et al.   ANNALS OF NEUROLOGY

Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline

(2015) Q. Shi et al.   JOURNAL OF NEUROSCIENCE

Complement activation in patients with neuromyelitis optica

(2014) Petra Nytrova et al.   JOURNAL OF NEUROIMMUNOLOGY

Complement activation in multiple sclerosis plaques: an immunohistochemical analysis

(2014) Gillian Ingram et al.   Acta Neuropathologica Communications

C3-dependent mechanism of microglial priming relevant to multiple sclerosis

(2012) V. Ramaglia et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ocular pathology in multiple sclerosis: retinal atrophy and inflammation irrespective of disease duration

(2010) A. J. Green et al.   BRAIN

Pten Deletion in Adult Neural Stem/Progenitor Cells Enhances Constitutive Neurogenesis

(2009) C. Gregorian et al.   JOURNAL OF NEUROSCIENCE

Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?

(2009) Kurt M. Lucin et al.   NEURON

Treatment with selective estrogen receptor modulators regulates myelin specific T-cells and suppresses experimental autoimmune encephalomyelitis

(2008) Bruce F. Bebo et al.   GLIA