Melatonin improves brain function in a model of chronic Gulf War Illness with modulation of oxidative stress, NLRP3 inflammasomes, and BDNF-ERK-CREB pathway in the hippocampus

In-vivo imaging of neuroinflammation in veterans with Gulf War illness

(2020) Zeynab Alshelh et al.   BRAIN BEHAVIOR AND IMMUNITY

Brainstem atrophy in Gulf War Illness

(2020) Yu Zhang et al.   NEUROTOXICOLOGY

Protective Effects of Melatonin on Neurogenesis Impairment in Neurological Disorders and Its Relevant Molecular Mechanisms

(2020) Joseph Wai-Hin Leung et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Gulf War Illness: Mechanisms Underlying Brain Dysfunction and Promising Therapeutic Strategies

(2020) Brandon Dickey et al.   PHARMACOLOGY & THERAPEUTICS

Targeting intracellular calcium stores alleviates neurological morbidities in a DFP-based rat model of Gulf War Illness

(2019) Kristin F Phillips et al.   TOXICOLOGICAL SCIENCES

Inflammasomes in neuroinflammatory and neurodegenerative diseases

(2019) Sofie Voet et al.   EMBO Molecular Medicine

Mitochondrial Dysfunction Leads to Cortical Under-Connectivity and Cognitive Impairment

(2019) Alejandra Fernandez et al.   NEURON

Exploring brain mechanisms underlying Gulf War Illness with group ICA based analysis of fMRI resting state networks

(2019) Kaundinya S. Gopinath et al.   NEUROSCIENCE LETTERS

A permethrin metabolite is associated with adaptive immune responses in Gulf War Illness

(2019) Utsav Joshi et al.   BRAIN BEHAVIOR AND IMMUNITY

Neuroinflammation in Gulf War Illness is linked with HMGB1 and complement activation, which can be discerned from brain-derived extracellular vesicles in the blood

(2019) Leelavathi N. Madhu et al.   BRAIN BEHAVIOR AND IMMUNITY

Depleted uranium and Gulf War Illness: Updates and comments on possible mechanisms behind the syndrome

(2019) Geir Bjørklund et al.   ENVIRONMENTAL RESEARCH

Gut DNA Virome Diversity and Its Association with Host Bacteria Regulate Inflammatory Phenotype and Neuronal Immunotoxicity in Experimental Gulf War Illness

(2019) Ratanesh K. Seth et al.   Viruses-Basel

Gut microbiota–brain axis in depression: The role of neuroinflammation

(2019) Anelise S. Carlessi et al.   EUROPEAN JOURNAL OF NEUROSCIENCE

Monosodium luminol reinstates redox homeostasis, improves cognition, mood and neurogenesis, and alleviates neuro- and systemic inflammation in a model of Gulf War Illness

(2019) Ashok K. Shetty et al.   Redox Biology

Altered function of neuronal L-type calcium channels in ageing and neuroinflammation: Implications in age-related synaptic dysfunction and cognitive decline

(2018) Sheeja Navakkode et al.   AGEING RESEARCH REVIEWS

Curcumin treatment leads to better cognitive and mood function in a model of Gulf War Illness with enhanced neurogenesis, and alleviation of inflammation and mitochondrial dysfunction in the hippocampus

(2018) M. Kodali et al.   BRAIN BEHAVIOR AND IMMUNITY

Oxidative stress and mitochondrial dysfunction contributes to postoperative cognitive dysfunction in elderly rats

(2018) Martins Back Netto et al.   BRAIN BEHAVIOR AND IMMUNITY

Immunosenescence-like state is accelerated by constant light exposure and counteracted by melatonin or turmeric administration through DJ-1/Nrf2 and P53/Bax pathways

(2018) Hanan A. El-Bakry et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

The Melatonin Signaling Pathway in a Long-Term Memory In Vitro Study

(2018) Jin-Young Sung et al.   MOLECULES

Melatonin and inflammation - story of a double-edged blade

(2018) Rüdiger Hardeland   JOURNAL OF PINEAL RESEARCH

Dynamic cerebral autoregulation is impaired in Veterans with Gulf War Illness: A case-control study

(2018) Michael J. Falvo et al.   PLoS One

Fatigue in Gulf War Illness is associated with tonically high activation in the executive control network

(2018) G.R. Wylie et al.   NeuroImage-Clinical

Corticosterone primes the neuroinflammatory response to Gulf War Illness-relevant organophosphates independently of acetylcholinesterase inhibition

(2017) Alicia R. Locker et al.   JOURNAL OF NEUROCHEMISTRY

Melatonin alleviates cadmium-induced liver injury by inhibiting the TXNIP-NLRP3 inflammasome

(2017) Zhengwang Cao et al.   JOURNAL OF PINEAL RESEARCH

Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis

(2017) Ibtissem Rahim et al.   JOURNAL OF PINEAL RESEARCH

Targeting Adult Neurogenesis to Optimize Hippocampal Circuits in Aging

(2017) Kathleen M. McAvoy et al.   Neurotherapeutics

Screening for novel central nervous system biomarkers in veterans with Gulf War Illness

(2017) Mohamed B. Abou-Donia et al.   NEUROTOXICOLOGY AND TERATOLOGY

Neuropsychological characteristics of Gulf War illness: A meta-analysis

(2017) Patricia A. Janulewicz et al.   PLoS One

Subcortical brain atrophy in Gulf War Illness

(2017) Peka Christova et al.   EXPERIMENTAL BRAIN RESEARCH

Chronic Oxidative Stress, Mitochondrial Dysfunction, Nrf2 Activation and Inflammation in the Hippocampus Accompany Heightened Systemic Inflammation and Oxidative Stress in an Animal Model of Gulf War Illness

(2017) Geetha A. Shetty et al.   Frontiers in Molecular Neuroscience

Altered gut microbiome in a mouse model of Gulf War Illness causes neuroinflammation and intestinal injury via leaky gut and TLR4 activation

(2017) Firas Alhasson et al.   PLoS One

Recent research on Gulf War illness and other health problems in veterans of the 1991 Gulf War: Effects of toxicant exposures during deployment

(2016) Roberta F. White et al.   CORTEX

Voluntary Running Exercise-Mediated Enhanced Neurogenesis Does Not Obliterate Retrograde Spatial Memory

(2016) M. Kodali et al.   JOURNAL OF NEUROSCIENCE

Melatonin attenuated early brain injury induced by subarachnoid hemorrhage via regulating NLRP3 inflammasome and apoptosis signaling

(2016) Yushu Dong et al.   JOURNAL OF PINEAL RESEARCH

Same molecule but different expression: aging and sepsis trigger NLRP3 inflammasome activation, a target of melatonin

(2016) Huayqui Volt et al.   JOURNAL OF PINEAL RESEARCH

Melatonin as an antioxidant: under promises but over delivers

(2016) Russel J. Reiter et al.   JOURNAL OF PINEAL RESEARCH

Repeated low-dose organophosphate DFP exposure leads to the development of depression and cognitive impairment in a rat model of Gulf War Illness

(2016) Kristin F. Phillips et al.   NEUROTOXICOLOGY

Memory and functional brain differences in a national sample of U.S. veterans with Gulf War Illness

(2016) Crystal M. Cooper et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

Translational potential of long-term decreases in mitochondrial lipids in a mouse model of Gulf War Illness

(2016) Laila Abdullah et al.   TOXICOLOGY

Astroglial NF-kB contributes to white matter damage and cognitive impairment in a mouse model of vascular dementia

(2016) Raman Saggu et al.   Acta Neuropathologica Communications

The Cognitive Neuroscience of Working Memory

(2015) Mark D'Esposito et al.   Annual Review of Psychology

Oxidative stress and redox regulation on hippocampal-dependent cognitive functions

(2015) Ting-Ting Huang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Corticosterone primes the neuroinflammatory response to DFP in mice: potential animal model of Gulf War Illness

(2015) James P. O'Callaghan et al.   JOURNAL OF NEUROCHEMISTRY

Melatonin and brain inflammaging

(2015) Rüdiger Hardeland et al.   PROGRESS IN NEUROBIOLOGY

NF-KappaB in Long-Term Memory and Structural Plasticity in the Adult Mammalian Brain

(2015) Barbara Kaltschmidt et al.   Frontiers in Molecular Neuroscience

Gulf War Agent Exposure Causes Impairment of Long-Term Memory Formation and Neuropathological Changes in a Mouse Model of Gulf War Illness

(2015) Zuchra Zakirova et al.   PLoS One

Melatonin blunts the mitochondrial/NLRP3 connection and protects against radiation-induced oral mucositis

(2014) Francisco Ortiz et al.   JOURNAL OF PINEAL RESEARCH

Melatonin reduced microglial activation and alleviated neuroinflammation induced neuron degeneration in experimental traumatic brain injury: Possible involvement of mTOR pathway

(2014) Ke Ding et al.   NEUROCHEMISTRY INTERNATIONAL

Object location and object recognition memory impairments, motivation deficits and depression in a model of Gulf War illness

(2014) Bharathi Hattiangady et al.   Frontiers in Behavioral Neuroscience

Object-in-Place Associative Recognition Memory Depends on Glutamate Receptor Neurotransmission Within Two Defined Hippocampal-Cortical Circuits: A Critical Role for AMPA and NMDA Receptors in the Hippocampus, Perirhinal, and Prefrontal Cortices

(2013) Gareth Robert Issac Barker et al.   CEREBRAL CORTEX

Mood and Memory Deficits in a Model of Gulf War Illness Are Linked with Reduced Neurogenesis, Partial Neuron Loss and Mild Inflammation in the Hippocampus

(2013) Vipan K Parihar et al.   NEUROPSYCHOPHARMACOLOGY

Chronic elevation of phosphocholine containing lipids in mice exposed to Gulf War agents pyridostigmine bromide and permethrin

(2013) Laila Abdullah et al.   NEUROTOXICOLOGY AND TERATOLOGY

Inflammasomes and Their Roles in Health and Disease

(2012) Mohamed Lamkanfi et al.   Annual Review of Cell and Developmental Biology

Depression: an inflammatory illness?: Figure 1

(2012) Rajeev Krishnadas et al.   JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY

Gulf War Illness

(2012) Brian N. Smith et al.   JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Melatonin modulates TLR4-mediated inflammatory genes through MyD88- and TRIF-dependent signaling pathways in lipopolysaccharide-stimulated RAW264.7 cells

(2012) Mi-Zhen Xia et al.   JOURNAL OF PINEAL RESEARCH

Memory impairment exhibited by veterans with Gulf War Illness

(2012) Timothy N. Odegard et al.   NEUROCASE

Adult hippocampal neurogenesis buffers stress responses and depressive behaviour

(2011) Jason S. Snyder et al.   NATURE

Proteomic CNS Profile of Delayed Cognitive Impairment in Mice Exposed to Gulf War Agents

(2011) Laila Abdullah et al.   NEUROMOLECULAR MEDICINE

Hippocampal Dysfunction in Gulf War Veterans: Investigation with ASL Perfusion MR Imaging and Physostigmine Challenge

(2011) Xiufeng Li et al.   RADIOLOGY

The role of CREB signaling in Alzheimer’s disease and other cognitive disorders

(2011) Carlos A. Saura et al.   REVIEWS IN THE NEUROSCIENCES

New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?

(2010) Wei Deng et al.   NATURE REVIEWS NEUROSCIENCE

TrkB signalling pathways in LTP and learning

(2009) Liliana Minichiello   NATURE REVIEWS NEUROSCIENCE

Abnormal brain response to cholinergic challenge in chronic encephalopathy from the 1991 Gulf War

(2009) Robert W. Haley et al.   PSYCHIATRY RESEARCH-NEUROIMAGING

The Nuclear Factor NF- B Pathway in Inflammation

(2009) T. Lawrence   Cold Spring Harbor Perspectives in Biology

Status epilepticus during old age is not associated with enhanced hippocampal neurogenesis

(2008) Muddanna S. Rao et al.   HIPPOCAMPUS

Acetylcholinesterase inhibitors and Gulf War illnesses

(2008) B. A. Golomb   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA