Proteopathic tau primes and activates interleukin-1β via myeloid-cell-specific MyD88- and NLRP3-ASC-inflammasome pathway

Plasma p-tau231: a new biomarker for incipient Alzheimer’s disease pathology

(2021) Nicholas J. Ashton et al.   ACTA NEUROPATHOLOGICA

In vivo PET imaging of mitochondrial abnormalities in a mouse model of tauopathy

(2020) Anna M. Barron et al.   NEUROBIOLOGY OF AGING

Aggregated Tau activates NLRP3–ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo

(2019) Ilie-Cosmin Stancu et al.   ACTA NEUROPATHOLOGICA

Qß Virus-like particle-based vaccine induces robust immunity and protects against tauopathy

(2019) Nicole M. Maphis et al.   npj Vaccines

Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts

(2019) Shuo Xu et al.   ARCHIVES OF ORAL BIOLOGY

NLRP3 inflammasome activation drives tau pathology

(2019) Christina Ising et al.   NATURE

Toll-Like Receptor 2 Signaling and Current Approaches for Therapeutic Modulation in Synucleinopathies

(2018) Ian F. Caplan et al.   Frontiers in Pharmacology

Tau and neuroinflammation: What impact for Alzheimer's Disease and Tauopathies?

(2018) Cyril Laurent et al.   Biomedical Journal

Structures of filaments from Pick’s disease reveal a novel tau protein fold

(2018) Benjamin Falcon et al.   NATURE

Differential effects of partial and complete loss of TREM2 on microglial injury response and tauopathy

(2018) Faten A. Sayed et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Co-Localization of Glia Maturation Factor with NLRP3 Inflammasome and Autophagosome Markers in Human Alzheimer’s Disease Brain

(2017) Mohammad Ejaz Ahmed et al.   JOURNAL OF ALZHEIMERS DISEASE

Microglia-derived ASC specks cross-seed amyloid-β in Alzheimer’s disease

(2017) Carmen Venegas et al.   NATURE

Whole Genome Expression Analysis in a Mouse Model of Tauopathy Identifies MECP2 as a Possible Regulator of Tau Pathology

(2017) Nicole M. Maphis et al.   Frontiers in Molecular Neuroscience

18F-AV-1451 tau PET imaging correlates strongly with tau neuropathology inMAPTmutation carriers

(2016) Ruben Smith et al.   BRAIN

VCP/p97 cooperates with YOD1, UBXD1 and PLAA to drive clearance of ruptured lysosomes by autophagy

(2016) Chrisovalantis Papadopoulos et al.   EMBO JOURNAL

Tau Oligomers Associate with Inflammation in the Brain and Retina of Tauopathy Mice and in Neurodegenerative Diseases

(2016) Ashley N. Nilson et al.   JOURNAL OF ALZHEIMERS DISEASE

Activation of phagocytic activity in astrocytes by reduced expression of the inflammasome component ASC and its implication in a mouse model of Alzheimer disease

(2016) Julien Couturier et al.   Journal of Neuroinflammation

PET Imaging of Tau Deposition in the Aging Human Brain

(2016) Michael Schöll et al.   NEURON

The suitability of BV2 cells as alternative model system for primary microglia cultures or for animal experiments examining brain inflammation

(2016) Anja Henn   ALTEX-Alternatives to Animal Experimentation

Reactive microglia drive tau pathology and contribute to the spreading of pathological tau in the brain

(2015) Nicole Maphis et al.   BRAIN

α-TLR2 antibody attenuates the Aβ-mediated inflammatory response in microglia through enhanced expression of SIGIRR

(2015) Derek A. Costello et al.   BRAIN BEHAVIOR AND IMMUNITY

Depletion of microglia and inhibition of exosome synthesis halt tau propagation

(2015) Hirohide Asai et al.   NATURE NEUROSCIENCE

A mechanistic model of tau amyloid aggregation based on direct observation of oligomers

(2015) Sarah L. Shammas et al.   Nature Communications

Pharmaceutical screen identifies novel target processes for activation of autophagy with a broad translational potential

(2015) Santosh Chauhan et al.   Nature Communications

Loss of tau rescues inflammation-mediated neurodegeneration

(2015) Nicole Maphis et al.   Frontiers in Neuroscience

Toll-Like Receptors in Alzheimer’s Disease: A Therapeutic Perspective

(2014) Maria Gambuzza et al.   CNS & Neurological Disorders-Drug Targets

MyD88-dependent interplay between myeloid and endothelial cells in the initiation and progression of obesity-associated inflammatory diseases

(2014) Minjia Yu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis

(2014) Maj-Linda B Selenica et al.   Journal of Neuroinflammation

Tau Overexpression Impacts a Neuroinflammation Gene Expression Network Perturbed in Alzheimer’s Disease

(2014) Paul D. Wes et al.   PLoS One

Causal analysis approaches in Ingenuity Pathway Analysis

(2013) Andreas Krämer et al.   BIOINFORMATICS

Nod-Like Receptor Protein 1 Inflammasome Mediates Neuron Injury under High Glucose

(2013) Xian-Fang Meng et al.   MOLECULAR NEUROBIOLOGY

Heparan sulfate proteoglycans mediate internalization and propagation of specific proteopathic seeds

(2013) B. B. Holmes et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fate Mapping Reveals Origins and Dynamics of Monocytes and Tissue Macrophages under Homeostasis

(2012) Simon Yona et al.   IMMUNITY

Small Misfolded Tau Species Are Internalized via Bulk Endocytosis and Anterogradely and Retrogradely Transported in Neurons

(2012) Jessica W. Wu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Trans-cellular Propagation of Tau Aggregation by Fibrillar Species

(2012) Najla Kfoury et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

MyD88: A Critical Adaptor Protein in Innate Immunity Signal Transduction

(2012) N. Warner et al.   JOURNAL OF IMMUNOLOGY

Who fans the flames of Alzheimer's disease brains? Misfolded tau on the crossroad of neurodegenerative and inflammatory pathways

(2012) Norbert Zilka et al.   Journal of Neuroinflammation

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

NLRP3 is activated in Alzheimer’s disease and contributes to pathology in APP/PS1 mice

(2012) Michael T. Heneka et al.   NATURE

Fiji: an open-source platform for biological-image analysis

(2012) Johannes Schindelin et al.   NATURE METHODS

Clinical and Biomarker Changes in Dominantly Inherited Alzheimer's Disease

(2012) Randall J. Bateman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tissue-specific opposing functions of the inflammasome adaptor ASC in the regulation of epithelial skin carcinogenesis

(2012) S. K. Drexler et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exosomes: Vehicles for the Transfer of Toxic Proteins Associated with Neurodegenerative Diseases?

(2012) Shayne A. Bellingham et al.   Frontiers in Physiology

RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome

(2011) Bo Li et al.   BMC BIOINFORMATICS

Autophagy-based unconventional secretory pathway for extracellular delivery of IL-1β

(2011) Nicolas Dupont et al.   EMBO JOURNAL

Exosome-associated Tau Is Secreted in Tauopathy Models and Is Selectively Phosphorylated in Cerebrospinal Fluid in Early Alzheimer Disease

(2011) Sudad Saman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Misfolded Truncated Protein   Induces Innate Immune Response via MAPK Pathway

(2011) A. Kovac et al.   JOURNAL OF IMMUNOLOGY

TLR4 dependent heparan sulphate-induced pancreatic inflammatory response is IRF3-mediated

(2011) Hamid Akbarshahi et al.   Journal of Translational Medicine

Presence of Reactive Microglia and Neuroinflammatory Mediators in a Case of Frontotemporal Dementia with P301S Mutation

(2011) Arianna Bellucci et al.   Neurodegenerative Diseases

Astrocyte-Restricted Ablation of Interleukin-17-Induced Act1-Mediated Signaling Ameliorates Autoimmune Encephalomyelitis

(2010) Zizhen Kang et al.   IMMUNITY

Tau Potentiates Nerve Growth Factor-induced Mitogen-activated Protein Kinase Signaling and Neurite Initiation without a Requirement for Microtubule Binding

(2010) Chad J. Leugers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Regulation of Tau Pathology by the Microglial Fractalkine Receptor

(2010) Kiran Bhaskar et al.   NEURON

Human misfolded truncated tau protein promotes activation of microglia and leukocyte infiltration in the transgenic rat model of tauopathy

(2009) Norbert Zilka et al.   JOURNAL OF NEUROIMMUNOLOGY

The Inflammasomes

(2009) Mohamed Lamkanfi et al.   PLoS Pathogens

The Potential for -Structure in the Repeat Domain of Tau Protein Determines Aggregation, Synaptic Decay, Neuronal Loss, and Coassembly with Endogenous Tau in Inducible Mouse Models of Tauopathy

(2008) M.-M. Mocanu et al.   JOURNAL OF NEUROSCIENCE