GnRH replacement rescues cognition in Down syndrome

Restoring statistical validity in group analyses of motion‐corrupted MRI data

(2022) Antoine Lutti et al.   HUMAN BRAIN MAPPING

A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAA-α5 NAM (basmisanil) on intellectual disability associated with Down syndrome

(2022) Celia Goeldner et al.   Journal of Neurodevelopmental Disorders

Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study

(2022) Pascal Benkert et al.   LANCET NEUROLOGY

FSH blockade improves cognition in mice with Alzheimer’s disease

(2022) Jing Xiong et al.   NATURE

Complexity Analysis of the Default Mode Network Using Resting-State fMRI in Down Syndrome: Relationships Highlighted by a Neuropsychological Assessment

(2021) María Dolores Figueroa-Jimenez et al.   Brain Sciences

Temporal trajectory of brain tissue property changes induced by electroconvulsive therapy

(2021) L. Gyger et al.   NEUROIMAGE

The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia

(2021) Katalin Skrapits et al.   eLife

Gonadotropin‐releasing hormone (GnRH) measurements in pituitary portal blood: A history

(2021) Suzanne M. Moenter et al.   JOURNAL OF NEUROENDOCRINOLOGY

GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation

(2021) Giuliana Pellegrino et al.   NATURE NEUROSCIENCE

Down syndrome

(2020) Stylianos E. Antonarakis et al.   Nature Reviews Disease Primers

Hypoplasia of cerebellar afferent networks in Down syndrome revealed by DTI-driven tensor based morphometry

(2020) Nancy Raitano Lee et al.   Scientific Reports

Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study

(2020) Juan Fortea et al.   LANCET

Down Syndrome

(2020) Marilyn J. Bull   NEW ENGLAND JOURNAL OF MEDICINE

GnRH stimulation testing and serum inhibin B in males: insufficient specificity for discriminating between congenital hypogonadotropic hypogonadism from constitutional delay of growth and puberty

(2020) Héléna Mosbah et al.   HUMAN REPRODUCTION

Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome

(2020) Bruno Pinto et al.   NEURON

Myelin development in cerebral gray and white matter during adolescence and late childhood

(2020) Neva M. Corrigan et al.   NEUROIMAGE

hMRI – A toolbox for quantitative MRI in neuroscience and clinical research

(2019) Karsten Tabelow et al.   NEUROIMAGE

Differential CRE expression in Lhrh-Cre and Gnrh-Cre alleles and the impact on fertility in Otx2-flox mice

(2019) Hanne M. Hoffmann et al.   NEUROENDOCRINOLOGY

Dementia in Down syndrome: unique insights for Alzheimer disease research

(2019) Ira T. Lott et al.   Nature Reviews Neurology

New approaches to studying early brain development in Down syndrome

(2019) Ana A Baburamani et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Enhanced dendritic inhibition and impaired NMDAR activation in a mouse model of Down syndrome

(2019) Jan M. Schulz et al.   JOURNAL OF NEUROSCIENCE

Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins

(2019) Sonia Chothani et al.   CIRCULATION

Promoter DNA hypermethylation – Implications for Alzheimer’s disease

(2019) Yiyuan Liu et al.   NEUROSCIENCE LETTERS

Controlling motion artefact levels in MR images by suspending data acquisition during periods of head motion

(2018) Rémi Castella et al.   MAGNETIC RESONANCE IN MEDICINE

Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome

(2018) Eleonore Bayen et al.   JAMA Neurology

Progressive Age-Related Cognitive Decline in Tau Mice

(2018) Ann Van der Jeugd et al.   JOURNAL OF ALZHEIMERS DISEASE

Up-To-Date Review About Minipuberty and Overview on Hypothalamic-Pituitary-Gonadal Axis Activation in Fetal and Neonatal Life

(2018) Lucia Lanciotti et al.   Frontiers in Endocrinology

Regional growth trajectories of cortical myelination in adolescents and young adults: longitudinal validation and functional correlates

(2018) Dongjin Kwon et al.   Brain Imaging and Behavior

Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator

(2018) Snehajyoti Chatterjee et al.   EMBO Molecular Medicine

Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice

(2018) Jennifer J. Tuscher et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains

(2016) Filippo Casoni et al.   DEVELOPMENT

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

(2016) Rafael de la Torre et al.   LANCET NEUROLOGY

Dementia in Down's syndrome

(2016) Clive Ballard et al.   LANCET NEUROLOGY

Data-driven hypothesis weighting increases detection power in genome-scale multiple testing

(2016) Nikolaos Ignatiadis et al.   NATURE METHODS

A microRNA switch regulates the rise in hypothalamic GnRH production before puberty

(2016) Andrea Messina et al.   NATURE NEUROSCIENCE

Down syndrome and the complexity of genome dosage imbalance

(2016) Stylianos E. Antonarakis   NATURE REVIEWS GENETICS

Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

(2016) Jose Luis Olmos-Serrano et al.   NEURON

Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease

(2016) Minghui Wang et al.   Genome Medicine

The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying

(2016) Shuaiyu Wang et al.   PLoS Genetics

Olfaction in People with Down Syndrome: A Comprehensive Assessment across Four Decades of Age

(2016) Maria Paola Cecchini et al.   PLoS One

Age-Related Changes in Resting-State Networks of A Large Sample Size of Healthy Elderly

(2015) Chun-Chao Huang et al.   CNS Neuroscience & Therapeutics

Anomalous brain functional connectivity contributing to poor adaptive behavior in Down syndrome

(2015) Jesus Pujol et al.   CORTEX

HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models

(2015) Eva Benito et al.   JOURNAL OF CLINICAL INVESTIGATION

Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome

(2015) Gabriele Deidda et al.   NATURE MEDICINE

European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment

(2015) Ulrich Boehm et al.   Nature Reviews Endocrinology

Translational regulation shapes the molecular landscape of complex disease phenotypes

(2015) Sebastian Schafer et al.   Nature Communications

HTSeq--a Python framework to work with high-throughput sequencing data

(2014) S. Anders et al.   BIOINFORMATICS

Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation

(2014) A. K. Kondadi et al.   EMBO JOURNAL

MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease

(2014) J. Banzhaf-Strathmann et al.   EMBO JOURNAL

Early depolarizing GABA controls critical-period plasticity in the rat visual cortex

(2014) Gabriele Deidda et al.   NATURE NEUROSCIENCE

svaseq: removing batch effects and other unwanted noise from sequencing data

(2014) Jeffrey T. Leek   NUCLEIC ACIDS RESEARCH

A Simple Method for 3D Analysis of Immunolabeled Axonal Tracts in a Transparent Nervous System

(2014) Morgane Belle et al.   Cell Reports

Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 Are Identified in Individuals with Congenital Hypogonadotropic Hypogonadism

(2013) Hichem Miraoui et al.   AMERICAN JOURNAL OF HUMAN GENETICS

The Rodent Hippocampus Is Essential for Nonspatial Object Memory

(2013) Sarah J. Cohen et al.   CURRENT BIOLOGY

Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice

(2013) F. J. Steyn et al.   ENDOCRINOLOGY

Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome

(2013) Patrizia Bianchi et al.   EXPERIMENTAL NEUROLOGY

Strengthening connections between Down syndrome and AD

(2013) The Lancet Neurology   LANCET NEUROLOGY

Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH

(2013) Guo Zhang et al.   NATURE

Object recognition test in mice

(2013) Marianne Leger et al.   Nature Protocols

Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down Syndrome

(2013) Tatjana Begenisic et al.   NEUROBIOLOGY OF DISEASE

Symmetric diffeomorphic modeling of longitudinal structural MRI

(2013) John Ashburner   Frontiers in Neuroscience

Quantitative multi-parameter mapping of R1, PD*, MT, and R2* at 3T: a multi-center validation

(2013) Nikolaus Weiskopf et al.   Frontiers in Neuroscience

RSeQC: quality control of RNA-seq experiments

(2012) Liguo Wang et al.   BIOINFORMATICS

STAR: ultrafast universal RNA-seq aligner

(2012) Alexander Dobin et al.   BIOINFORMATICS

High-resolution imaging of entire organs by 3-dimensional imaging of solvent cleared organs (3DISCO)

(2012) Ali Ertürk et al.   EXPERIMENTAL NEUROLOGY

The acute inhibition of rapid eye movement sleep by citalopram may impair spatial learning and passive avoidance in mice

(2012) A. Bridoux et al.   JOURNAL OF NEURAL TRANSMISSION

Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome

(2012) Md. Mahiuddin Ahmed et al.   JOURNAL OF PROTEOME RESEARCH

Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial

(2012) Marisa Hanney et al.   LANCET

High-resolution functional MRI at 3 T: 3D/2D echo-planar imaging with optimized physiological noise correction

(2012) Antoine Lutti et al.   MAGNETIC RESONANCE IN MEDICINE

Three-dimensional imaging of solvent-cleared organs using 3DISCO

(2012) Ali Ertürk et al.   Nature Protocols

Olfactory dysfunction in Parkinson disease

(2012) Richard L. Doty   Nature Reviews Neurology

Down syndrome: the brain in trisomic mode

(2012) Mara Dierssen   NATURE REVIEWS NEUROSCIENCE

Relevance of Exocytotic Glutamate Release from Retinal Glia

(2012) Michal Slezak et al.   NEURON

Robust and Fast Whole Brain Mapping of the RF Transmit Field B1 at 7T

(2012) Antoine Lutti et al.   PLoS One

DynPeak: An Algorithm for Pulse Detection and Frequency Analysis in Hormonal Time Series

(2012) Alexandre Vidal et al.   PLoS One

Measurement and Correction of Microscopic Head Motion during Magnetic Resonance Imaging of the Brain

(2012) Julian Maclaren et al.   PLoS One

SEMA3A, a Gene Involved in Axonal Pathfinding, Is Mutated in Patients with Kallmann Syndrome

(2012) Naresh Kumar Hanchate et al.   PLoS Genetics

From Abnormal Hippocampal Synaptic Plasticity in Down Syndrome Mouse Models to Cognitive Disability in Down Syndrome

(2012) Nathan Cramer et al.   NEURAL PLASTICITY

Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial

(2012) R Boada et al.   Translational Psychiatry

Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility

(2011) Andrea Messina et al.   HUMAN MOLECULAR GENETICS

Early onset of primary hypogonadism revealed by serum anti-Müllerian hormone determination during infancy and childhood in trisomy 21

(2011) R. P. Grinspon et al.   INTERNATIONAL JOURNAL OF ANDROLOGY

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

(2011) Laura G. Reinholdt et al.   MAMMALIAN GENOME

Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)

(2011) B. Draganski et al.   NEUROIMAGE

Sexual dimorphism of kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women

(2011) Erik Hrabovszky   Frontiers in Endocrinology

Widespread Proliferation Impairment and Hypocellularity in the Cerebellum of Fetuses with Down Syndrome

(2010) Sandra Guidi et al.   BRAIN PATHOLOGY

GnRH Receptor Gene Expression in the Developing Rat Hippocampus: Transcriptional Regulation and Potential Roles in Neuronal Plasticity

(2010) Anne-Laure Schang et al.   ENDOCRINOLOGY

Optimization and validation of methods for mapping of the radiofrequency transmit field at 3T

(2010) Antoine Lutti et al.   MAGNETIC RESONANCE IN MEDICINE

Increased male reproductive success in Ts65Dn “Down syndrome” mice

(2010) Clara S. Moore et al.   MAMMALIAN GENOME

Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis

(2010) S. Wen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Embryonic Preoptic Area Is a Novel Source of Cortical GABAergic Interneurons

(2009) D. M. Gelman et al.   JOURNAL OF NEUROSCIENCE

Interneurons Produced in Adulthood Are Required for the Normal Functioning of the Olfactory Bulb Network and for the Execution of Selected Olfactory Behaviors

(2009) V. Breton-Provencher et al.   JOURNAL OF NEUROSCIENCE

DYRK1A, a Novel Determinant of the Methionine-Homocysteine Cycle in Different Mouse Models Overexpressing this Down-Syndrome-Associated Kinase

(2009) Christophe Noll et al.   PLoS One

The Relative Role of Gonadal Sex Steroids and Gonadotropin-Releasing Hormone Pulse Frequency in the Regulation of Follicle-Stimulating Hormone Secretion in Men

(2008) Nelly Pitteloud et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

High-resolution maps of magnetization transfer with inherent correction for RF inhomogeneity andT1relaxation obtained from 3D FLASH MRI

(2008) Gunther Helms et al.   MAGNETIC RESONANCE IN MEDICINE

Quantitative FLASH MRI at 3T using a rational approximation of the Ernst equation

(2008) Gunther Helms et al.   MAGNETIC RESONANCE IN MEDICINE

Unusual Repertoire of Vocalizations in the BTBR T+tf/J Mouse Model of Autism

(2008) Maria Luisa Scattoni et al.   PLoS One