Article
Multidisciplinary Sciences
Jiyao Song, Liesa Steidle, Isabelle Steymans, Jasjot Singh, Anne Sanner, Lena Boettinger, Dominic Winter, Thomas Becker
Summary: Mitochondrial Hsp70 plays dual roles in the formation of ATP synthase. It cooperates with Atp11 and Atp12 to form the F-1 domain, and it transfers Atp5 to link the catalytic head with the peripheral stalk. Inactivation of mtHsp70 leads to integration of assembly-defective Atp5 variants into the mature complex, indicating its quality control function.
NATURE COMMUNICATIONS
(2023)
Article
Biology
Ayelet M. Rosenberg, Shannon Rausser, Junting Ren, Eugene Mosharov, Gabriel Sturm, R. Todd Ogden, Purvi Patel, Rajesh Kumar Soni, Clay Lacefield, Desmond J. Tobin, Ralf Paus, Martin Picard
Summary: The study introduces a method to analyze hair pigmentation patterns and demonstrates the reversibility of greying in humans, along with associated changes in protein expression. The research also suggests that greying can be reversed parallel with psychological stress.
Review
Dermatology
Joseph Michael Yardman-Frank, David E. Fisher
Summary: This review provides an overview of skin pigmentation mechanisms, including melanocytes, tanning pathways, vitiligo, follicular pigmentation, and hair greying. It highlights the importance of future research and potential intervention points in these areas.
EXPERIMENTAL DERMATOLOGY
(2021)
Article
Multidisciplinary Sciences
Hakjoo Lee, Tae Jin Lee, Chad A. Galloway, Wenbo Zhi, Wei Xiao, Karen L. de Mesy Bentley, Ashok Sharma, Yong Teng, Hiromi Sesaki, Yisang Yoon
Summary: This study reveals that OPA1 is dispensable in the liver and its deletion induces a mitohormesis response that protects the liver from drug toxicity and enhances liver resilience.
NATURE COMMUNICATIONS
(2023)
Article
Multidisciplinary Sciences
Gautam Pareek
Summary: Mitochondria play crucial roles in cellular functions but can be damaged by reactive oxygen species and misfolded proteins, leading to aging and various diseases. Cells utilize mitochondrial-resident proteases for quality control to combat mitochondrial damage.
Review
Biochemistry & Molecular Biology
Abi S. Ghifari, Monika W. Murcha
Summary: Mitochondrial function relies on the homeostasis and quality control of their proteome, which includes the components of the oxidative phosphorylation pathway. The subunits of oxidative phosphorylation are prone to oxidative damage, misfolding, and aggregation due to their exposure to reactive oxygen species. Multiple protein degradation pathways are involved in maintaining the activity and homeostasis of oxidative phosphorylation components in plant mitochondria, including proteomic turnover and modular degradation.
BIOCHEMICAL SOCIETY TRANSACTIONS
(2022)
Article
Chemistry, Applied
Raoul Vyumvuhore, Laurie Verzeaux, Sophie Gilardeau, Sylvie Bordes, Elodie Aymard, Michel Manfait, Brigitte Closs
Summary: This study used confocal Raman microspectroscopy to investigate the molecular changes occurring in greying hair shafts. Results showed the existence of 3 sub-groups within grey hair and identified a gradual modification of lipid conformation and protein secondary structure as molecular markers in greying hair. This study reports for the first time a highly specific molecular signature within grey hair shaft.
INTERNATIONAL JOURNAL OF COSMETIC SCIENCE
(2021)
Article
Biology
Shiou-Ru Tzeng, Yin-Chu Tseng, Chien-Chu Lin, Chia-Ying Hsu, Shing-Jong Huang, Yi-Ting Kuo, Chung- Chang
Summary: The N-terminal domain (NTD) of LonA selectively interacts with unfolded proteins, protein aggregates, and degron-tagged proteins through two hydrophobic patches, but not with intrinsically disordered substrates. NTD also selectively binds to protein substrates when they are thermally induced to adopt unfolded conformations, enabling LonA to perform protein quality control and selectively degrade damaged proteins.
Article
Biochemistry & Molecular Biology
Kah Ying Ng, Uwe Richter, Christopher B. Jackson, Sara Seneca, Brendan J. Battersby
Summary: Pathogenic variants disrupting human mitochondrial protein synthesis are associated with a diverse group of diseases. The underlying molecular pathogenesis is complex and goes beyond bioenergetic deficiency. This study reveals a new step in the quality control mechanism of mitochondrial protein synthesis, providing new insights into the clinical spectrum of these disorders.
HUMAN MOLECULAR GENETICS
(2022)
Article
Biochemistry & Molecular Biology
Kwan Ting Kan, Michael G. Nelson, Chris M. Grant, Simon J. Hubbard, Hui Lu
Summary: Yme1 is a multifunctional protein that plays important roles in maintaining mitochondrial protein homeostasis and regulating biogenesis and function of mitochondrial proteins. This study shows that YME1 deletion affects yeast growth, chronological life span, mitochondrial protein homeostasis and function. It also reveals that Yme1 plays a key role in longevity and is important for maintaining the level and function of mitochondrial oxidative phosphorylation complexes.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2022)
Article
Microbiology
Stefan Pan, Aaron A. Jensen, Nicholas A. Wood, Beate Henrichfreise, Heike Broetz-Oesterhelt, Derek J. Fisher, Peter Sass, Scot P. Ouellette
Summary: Bacterial AAA+ unfoldases, such as ClpC, play crucial roles in bacterial physiology by recognizing and unfolding specific substrates for degradation. In this study, we investigated the function of chlamydial ClpC using in vitro and cell culture approaches. We found that ClpC exhibits ATPase and chaperone activities, and can form a functional protease with ClpP1P2 complexes. Depletion or overexpression of ClpC significantly affected chlamydial growth, highlighting its essentiality in Chlamydia. These findings suggest that ClpC could be a potential target for the development of antichlamydial agents.
Article
Immunology
Suzanne M. Green-Fulgham, Michael J. Lacagnina, Kendal F. Willcox, Jiahe Li, Michael E. Harland, Adriano Polican Ciena, Igor R. Correia Rocha, Jayson B. Ball, Renee A. Dreher, Younus A. Zuberi, Joseph M. Dragavon, Marucia Chacur, Steven F. Maier, Linda R. Watkins, Peter M. Grace
Summary: Regular aerobic activity, specifically voluntary wheel running, can reduce the risk of chronic pain by inhibiting MAC and preserving myelin integrity at the site of peripheral nerve injury.
BRAIN BEHAVIOR AND IMMUNITY
(2024)
Article
Multidisciplinary Sciences
Kiran Todkar, Lilia Chikhi, Veronique Desjardins, Firas El-Mortada, Genevieve Pepin, Marc Germain
Summary: Mitochondrial content in extracellular vesicles (EVs) can exacerbate inflammation, while its role in non-inflammatory conditions remains unclear. The research demonstrates that mitochondria-derived vesicles target material to EVs, while Parkinson's disease-related protein Parkin directs damaged mitochondrial content to lysosomes, shedding light on mitochondria-driven immune responses.
NATURE COMMUNICATIONS
(2021)
Review
Biochemistry & Molecular Biology
Giada Zanini, Valentina Selleri, Mara Malerba, Kateryna Solodka, Giorgia Sinigaglia, Milena Nasi, Anna Vittoria Mattioli, Marcello Pinti
Summary: Lonp1 is a multifunctional enzyme that plays a crucial role in regulating mitochondrial functions in heart and skeletal muscle. It is involved in heart development, cardioprotection, myoblast differentiation, and aging-related muscle functional decline. Lonp1 is also associated with a syndrome characterized by impaired development of multiple organs and tissues. These findings highlight the importance of Lonp1 in maintaining mitochondrial homeostasis.
Article
Multidisciplinary Sciences
Arthur Louche, Amandine Blanco, Thais Lourdes Santos Lacerda, Lison Cancade-Veyre, Claire Lionnet, Celia Berge, Monica Rolando, Frederique Lembo, Jean-Paul Borg, Carmen Buchrieser, Masami Nagahama, Francine C. A. Gerard, Jean-Pierre Gorvel, Virginie Gueguen-Chaignon, Laurent Terradot, Suzana P. P. Salcedo
Summary: The cell nucleus is a primary target for intracellular bacterial pathogens. Two Brucella abortus effectors, NyxA and NyxB, interfere with host protease SENP3, promoting intracellular replication of the pathogen.
NATURE COMMUNICATIONS
(2023)
Article
Dermatology
Franziska Peters, Frederik Tellkamp, Susanne Brodesser, Emmi Wachsmuth, Bettina Tosetti, Ulrike Karow, Wilhelm Bloch, Olaf Utermoehlen, Martin Kroenke, Carien M. Niessen
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Michele M. Nava, Yekaterina A. Miroshnikova, Leah C. Biggs, Daniel B. Whitefield, Franziska Metge, Jorge Boucas, Helena Vihinen, Eija Jokitalo, Xinping Li, Juan Manuel Garcia Arcos, Bernd Hoffmann, Rudolf Merkel, Carien M. Niessen, Kris Noel Dahl, Sara A. Wickstrom
Review
Biochemistry & Molecular Biology
Kathleen J. Green, Quinn Roth-Carter, Carien M. Niessen, Scott A. Nichols
Editorial Material
Multidisciplinary Sciences
Matthias Ruebsam, Carien M. Niessen
Editorial Material
Cell Biology
Carien M. Niessen, Nicolas A. Plachta
CURRENT OPINION IN CELL BIOLOGY
(2020)
Editorial Material
Neurosciences
Roman Praschberger, Julie Jacquemyn, Patrik Verstreken
Article
Multidisciplinary Sciences
Chen Jiang, Ahsan Javed, Laura Kaiser, Michele M. Nava, Rui Xu, Dominique T. Brandt, Dandan Zhao, Benjamin Mayer, Javier Fernandez-Baldovinos, Luping Zhou, Carsten Hoess, Kovilen Sawmynaden, Arkadiusz Oleksy, David Matthews, Lee S. Weinstein, Heidi Hahn, Hermann-Josef Groene, Peter L. Graumann, Carien M. Niessen, Stefan Offermanns, Sara A. Wickstroem, Thomas Worzfeld
Summary: The study reveals the crucial role of B-plexins in responding to mechanical forces induced by crowding, impacting cell proliferation and tissue growth in epithelial development. Plexin-B1 and Plexin-B2 sense mechanical compression of epidermal stem cells, leading to the inactivation of YAP and suppression of cell proliferation.
NATURE COMMUNICATIONS
(2021)
Article
Dermatology
Raneem Tayem, Catherin Niemann, Monika Pesch, Jessica Morgner, Carien M. Niessen, Sara A. Wickstrom, Monique Aumailley
Summary: Research indicates that loss of Lm332 leads to epidermolysis bullosa junctionalis. The absence of Lm332 promotes skin thickening and desquamation, resulting in modifications to the keratinocyte genetic program.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Dermatology
Oana D. Persa, Janis Koester, Carien M. Niessen
Summary: The mammalian skin plays a crucial role in protecting the organism and facilitating communication with the environment. However, aging and external influences like UVR can compromise skin function and regeneration, potentially leading to skin cancer. More research is needed to understand how aging impacts tissue architecture and cell dynamics in skin homeostasis and regeneration, and whether these changes contribute to the development of skin cancer.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Jorg Hoehfeld, Thomas Benzing, Wilhelm Bloch, Dieter O. Fuerst, Sebastian Gehlert, Michael Hesse, Bernd Hoffmann, Thorsten Hoppe, Pitter F. Huesgen, Maja Koehn, Waldemar Kolanus, Rudolf Merkel, Carien M. Niessen, Wojciech Pokrzywa, Markus M. Rinschen, Dagmar Wachten, Bettina Warscheid
Summary: Mechanical stress can threaten protein structure and proteome integrity, but cells have folding and degradation systems to combat this stress. These systems play crucial roles in cell differentiation, adhesion, and migration, and are essential for maintaining the integrity of various tissues.
Article
Cell Biology
Janis Koester, Yekaterina A. Miroshnikova, Sushmita Ghatak, Carlos Andres Chacon-Martinez, Jessica Morgner, Xinping Li, Ilian Atanassov, Janine Altmueller, David E. Birk, Manuel Koch, Wilhelm Bloch, Michaela Bartusel, Carien M. Niessen, Alvaro Rada-Iglesias, Sara A. Wickstroem
Summary: The research reveals that as hair follicle stem cells age, their ability to activate bivalent genes for self-renewal and differentiation is reduced due to increased niche stiffness and subsequent epigenetic effects.
NATURE CELL BIOLOGY
(2021)
Article
Urology & Nephrology
Sybille Koehler, Johanna Odenthal, Vivian Ludwig, David Unnersjo Jess, Martin Hoehne, Christian Juengst, Ferdi Grawe, Martin Helmstaedter, Johanna L. Janku, Carsten Bergmann, Peter F. Hoyer, H. Henning Hagmann, Gerd Walz, Wilhelm Bloch, Carien Niessen, Bernhard Schermer, Andreas Wodarz, Barry Denholm, Thomas Benzing, Sandra Iden, Paul T. Brinkkoetter
Summary: Podocyte injury is a major cause of glomerular diseases. The Par3 polarity complex is linked to actin regulators that maintain podocyte architecture. Par3A and Par3B have distinct functions in regulating cytoskeleton and synaptopodin localization.
KIDNEY INTERNATIONAL
(2022)
Article
Dermatology
Katrin Rietscher, Heinz-Georg Jahnke, Matthias Ruebsam, Eric W. Lin, Cristina Has, M. Bishr Omary, Carien M. Niessen, Thomas M. Magin
Summary: This study demonstrates that the multikinase inhibitor PKC412 can reduce keratin aggregation in patient-derived EBS keratinocytes and restore intercellular adhesion. The findings provide a proof of concept for the repurposing of existing drugs for the targeted treatment of EBS and pave the way for clinical trials using PKC412 in EBS patients.
JOURNAL OF INVESTIGATIVE DERMATOLOGY
(2022)
Editorial Material
Cell Biology
Gladiola Goranci-Buzhala, Carien M. M. Niessen
Summary: The question of how adult stem cells coordinate their fate and behavior over time in vivo remains challenging. In this study, Moore et al. combine high-resolution live imaging in mice with machine learning tools to uncover temporally regulated tissue-scale patterns of Ca2+ signaling orchestrated by cycling basal stem cells of the skin epidermis.
JOURNAL OF CELL BIOLOGY
(2023)
Article
Chemistry, Physical
Preeti Sahu, Daniel M. Sussman, Matthias Ruebsam, Aaron F. Mertz, Valerie Horsley, Eric R. Dufresne, Carien M. Niessen, M. Cristina Marchetti, M. Lisa Manning, J. M. Schwarz