New approaches to studying early brain development in Down syndrome

Abnormal Microstructural Development of the Cerebral Cortex in Neonates With Congenital Heart Disease Is Associated With Impaired Cerebral Oxygen Delivery

(2019) Christopher J. Kelly et al.   Journal of the American Heart Association

Advances in neonatal MRI of the brain: from research to practice

(2018) Christopher J Kelly et al.   Archives of Disease in Childhood-Education and Practice Edition

Trisomy of human chromosome 21 enhances amyloid-β deposition independently of an extra copy of APP

(2018) Frances K Wiseman et al.   BRAIN

Abnormal development of the inferior temporal region in fetuses with Down syndrome

(2018) Sandra Guidi et al.   BRAIN PATHOLOGY

Impact of cholinesterase inhibitors or memantine on survival in adults with Down syndrome and dementia: clinical cohort study

(2018) Nicole Eady et al.   BRITISH JOURNAL OF PSYCHIATRY

Lifespan analysis of brain development, gene expression and behavioral phenotypes in the Ts1Cje, Ts65Dn and Dp(16)1/Yey mouse models of Down syndrome

(2018) Nadine M. Aziz et al.   Disease Models & Mechanisms

Neurogenesis impairment: An early developmental defect in Down syndrome

(2018) Fiorenza Stagni et al.   FREE RADICAL BIOLOGY AND MEDICINE

Pediatric Brain Development in Down Syndrome: A Field in Its Infancy

(2018) Taralee Hamner et al.   JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY

Widespread domain-like perturbations of DNA methylation in whole blood of Down syndrome neonates

(2018) Peter Henneman et al.   PLoS One

Neuroimaging and other modalities to assess Alzheimer's disease in Down syndrome

(2018) Natalie Neale et al.   NeuroImage-Clinical

Factors Associated With Successful MRI Scanning in Unsedated Young Children

(2018) Camilia Thieba et al.   Frontiers in Pediatrics

Association of Dementia With Mortality Among Adults With Down Syndrome Older Than 35 Years

(2018) Rosalyn Hithersay et al.   JAMA Neurology

A Randomized, Double-Blind, Placebo-Controlled, Phase II Study of Oral ELND005 (scyllo-Inositol) in Young Adults with Down Syndrome without Dementia

(2017) Michael S. Rafii et al.   JOURNAL OF ALZHEIMERS DISEASE

Use of MRI in the diagnosis of fetal brain abnormalities in utero (MERIDIAN): a multicentre, prospective cohort study

(2017) Paul D Griffiths et al.   LANCET

Brain-predicted age in Down syndrome is associated with beta amyloid deposition and cognitive decline

(2017) James H. Cole et al.   NEUROBIOLOGY OF AGING

Investigating white matter fibre density and morphology using fixel-based analysis

(2017) David A. Raffelt et al.   NEUROIMAGE

Has noninvasive prenatal testing impacted termination of pregnancy and live birth rates of infants with Down syndrome?

(2017) Melissa Hill et al.   PRENATAL DIAGNOSIS

The GABAergic Hypothesis for Cognitive Disabilities in Down Syndrome

(2017) Andrea Contestabile et al.   Frontiers in Cellular Neuroscience

Impaired development of the cerebral cortex in infants with congenital heart disease is correlated to reduced cerebral oxygen delivery

(2017) Christopher J. Kelly et al.   Scientific Reports

Normative biometry of the fetal brain using magnetic resonance imaging

(2016) Vanessa Kyriakopoulou et al.   Brain Structure & Function

Epigenetic dysregulation in the developing Down syndrome cortex

(2016) Nady El Hajj et al.   Epigenetics

Structural brain alterations of Down’s syndrome in early childhood evaluation by DTI and volumetric analyses

(2016) Hediye Pınar Gunbey et al.   EUROPEAN RADIOLOGY

Absence of Prenatal Forebrain Defects in the Dp(16)1Yey/+ Mouse Model of Down Syndrome

(2016) J. W. Goodliffe et al.   JOURNAL OF NEUROSCIENCE

Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial

(2016) Rafael de la Torre et al.   LANCET NEUROLOGY

A dedicated neonatal brain imaging system

(2016) Emer J. Hughes et al.   MAGNETIC RESONANCE IN MEDICINE

Mouse models of Down syndrome: gene content and consequences

(2016) Meenal Gupta et al.   MAMMALIAN GENOME

Regional growth and atlasing of the developing human brain

(2016) Antonios Makropoulos et al.   NEUROIMAGE

Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination

(2016) Jose Luis Olmos-Serrano et al.   NEURON

Does Congenital Heart Disease Affect Neurodevelopmental Outcomes in Children with Down Syndrome?

(2016) Tarek Alsaied et al.   Congenital Heart Disease

Genetic dissection of Down syndrome-associated congenital heart defects using a new mouse mapping panel

(2016) Eva Lana-Elola et al.   eLife

1 H-MRS metabolites in adults with Down syndrome: Effects of dementia

(2016) A.-L. Lin et al.   NeuroImage-Clinical

Perinatal Natural History of the Ts1Cje Mouse Model of Down Syndrome: Growth Restriction, Early Mortality, Heart Defects, and Delayed Development

(2016) Millie A. Ferrés et al.   PLoS One

An Integrated Human/Murine Transcriptome and Pathway Approach To Identify Prenatal Treatments For Down Syndrome

(2016) Faycal Guedj et al.   Scientific Reports

The fetal brain transcriptome and neonatal behavioral phenotype in the Ts1Cje mouse model of Down syndrome

(2015) Faycal Guedj et al.   AMERICAN JOURNAL OF MEDICAL GENETICS PART A

Influence of CHDs on psycho-social and neurodevelopmental outcomes in children with Down syndrome

(2015) Jeannie Visootsak et al.   CARDIOLOGY IN THE YOUNG

Maturation of Sensori-Motor Functional Responses in the Preterm Brain

(2015) Alessandro G. Allievi et al.   CEREBRAL CORTEX

Dissociations in Cortical Morphometry in Youth with Down Syndrome: Evidence for Reduced Surface Area but Increased Thickness

(2015) Nancy Raitano Lee et al.   CEREBRAL CORTEX

Aging in Down Syndrome and the Development of Alzheimer's Disease Neuropathology

(2015) Elizabeth Head et al.   Current Alzheimer Research

A genetic cause of Alzheimer disease: mechanistic insights from Down syndrome

(2015) Frances K. Wiseman et al.   NATURE REVIEWS NEUROSCIENCE

Construction of a fetal spatio-temporal cortical surface atlas from in utero MRI: Application of spectral surface matching

(2015) R. Wright et al.   NEUROIMAGE

Use of resting-state functional MRI to study brain development and injury in neonates

(2015) Christopher D. Smyser et al.   SEMINARS IN PERINATOLOGY

Age-related increases in long-range connectivity in fetal functional neural connectivity networks in utero

(2015) Moriah E. Thomason et al.   Developmental Cognitive Neuroscience

Timing of therapies for Down syndrome: the sooner, the better

(2015) Fiorenza Stagni et al.   Frontiers in Behavioral Neuroscience

White matter tract integrity and developmental outcome in newborn infants with hypoxic-ischemic encephalopathy treated with hypothermia

(2014) An N Massaro et al.   DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY

Automatic Whole Brain MRI Segmentation of the Developing Neonatal Brain

(2014) Antonios Makropoulos et al.   IEEE TRANSACTIONS ON MEDICAL IMAGING

Frontal white matter integrity in adults with Down syndrome with and without dementia

(2014) David Powell et al.   NEUROBIOLOGY OF AGING

Resting State fMRI in the moving fetus: A robust framework for motion, bias field and spin history correction

(2014) Giulio Ferrazzi et al.   NEUROIMAGE

Trends in maternal age distribution and the live birth prevalence of Down’s syndrome in England and Wales: 1938–2010

(2013) Jianhua Wu et al.   EUROPEAN JOURNAL OF HUMAN GENETICS

Non-neuronal cell responses differ between normal and Down syndrome developing brains

(2013) Takeshi Kanaumi et al.   INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE

Pediatric neuroimaging using magnetic resonance imaging during non-sedated sleep

(2013) Douglas C. Dean et al.   PEDIATRIC RADIOLOGY

Magnetic Resonance Imaging of the Newborn Brain: Automatic Segmentation of Brain Images into 50 Anatomical Regions

(2013) Ioannis S. Gousias et al.   PLoS One

Testing the Sensitivity of Tract-Based Spatial Statistics to Simulated Treatment Effects in Preterm Neonates

(2013) Gareth Ball et al.   PLoS One

Brain development in rodents and humans: Identifying benchmarks of maturation and vulnerability to injury across species

(2013) Bridgette D. Semple et al.   PROGRESS IN NEUROBIOLOGY

Structural and Functional Brain Networks: From Connections to Cognition

(2013) H.-J. Park et al.   SCIENCE

Abnormal brain synchrony in Down Syndrome

(2013) Jeffrey S. Anderson et al.   NeuroImage-Clinical

Motion-Compensation Techniques in Neonatal and Fetal MR Imaging

(2012) C. Malamateniou et al.   AMERICAN JOURNAL OF NEURORADIOLOGY

Pediatric neuroimaging in early childhood and infancy: challenges and practical guidelines

(2012) Nora Raschle et al.   Annals of the New York Academy of Sciences

OLIG2 over-expression impairs proliferation of human Down syndrome neural progenitors

(2012) Jie Lu et al.   HUMAN MOLECULAR GENETICS

Reconstruction of fetal brain MRI with intensity matching and complete outlier removal

(2012) Maria Kuklisova-Murgasova et al.   MEDICAL IMAGE ANALYSIS

Down syndrome: the brain in trisomic mode

(2012) Mara Dierssen   NATURE REVIEWS NEUROSCIENCE

DYRK1A: A master regulatory protein controlling brain growth

(2012) Fayçal Guedj et al.   NEUROBIOLOGY OF DISEASE

Antioxidants in Down syndrome

(2011) Ira T. Lott   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn

(2011) Laura G. Reinholdt et al.   MAMMALIAN GENOME

Identification of the translocation breakpoints in the Ts65Dn and Ts1Cje mouse lines: relevance for modeling down syndrome

(2011) Arnaud Duchon et al.   MAMMALIAN GENOME

S100B and APP Promote a Gliocentric Shift and Impaired Neurogenesis in Down Syndrome Neural Progenitors

(2011) Jie Lu et al.   PLoS One

Trisomy 21 and early brain development

(2011) Tarik F. Haydar et al.   TRENDS IN NEUROSCIENCES

Prenatally detectable congenital heart defects in fetuses with Down syndrome

(2011) R. Mogra et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Widespread Proliferation Impairment and Hypocellularity in the Cerebellum of Fetuses with Down Syndrome

(2010) Sandra Guidi et al.   BRAIN PATHOLOGY

Down's syndrome-like cardiac developmental defects in embryos of the transchromosomic Tc1 mouse

(2010) Louisa Dunlevy et al.   CARDIOVASCULAR RESEARCH

Proton magnetic resonance spectroscopy in the fetus

(2010) Lisa Story et al.   European Journal of Obstetrics & Gynecology and Reproductive Biology

A mouse model of Down syndrome trisomic for all human chromosome 21 syntenic regions

(2010) Tao Yu et al.   HUMAN MOLECULAR GENETICS

Screening for Autism Spectrum Disorders in Children With Down Syndrome

(2010) Carolyn DiGuiseppi et al.   JOURNAL OF DEVELOPMENTAL AND BEHAVIORAL PEDIATRICS

Down Syndrome: From Understanding the Neurobiology to Therapy

(2010) K. Gardiner et al.   JOURNAL OF NEUROSCIENCE

Developmental neurotoxicity of sedatives and anesthetics: A concern for neonatal and pediatric critical care medicine?*

(2010) Andreas W. Loepke   Pediatric Critical Care Medicine

Emergence of resting state networks in the preterm human brain

(2010) V. Doria et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Communication breaks-Down: From neurodevelopment defects to cognitive disabilities in Down syndrome

(2010) Andrea Contestabile et al.   PROGRESS IN NEUROBIOLOGY

Ethnicity, sex, and the incidence of congenital heart defects: a report from the National Down Syndrome Project

(2009) Sallie B Freeman et al.   GENETICS IN MEDICINE

Diffusion tensor imaging (DTI) of the brain in moving subjects: Application to in-utero fetal and ex-utero studies

(2009) Shuzhou Jiang et al.   MAGNETIC RESONANCE IN MEDICINE

The genetic architecture of Down syndrome phenotypes revealed by high-resolution analysis of human segmental trisomies

(2009) J. O. Korbel et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced cell number in the neocortical part of the human fetal brain in Down syndrome

(2008) Karen Bonde Larsen et al.   ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER

Specific relations between neurodevelopmental abilities and white matter microstructure in children born preterm

(2008) S. J. Counsell et al.   BRAIN

Genotype–phenotype correlations in Down syndrome identified by array CGH in 30 cases of partial trisomy and partial monosomy chromosome 21

(2008) Robert Lyle et al.   EUROPEAN JOURNAL OF HUMAN GENETICS