标题
GnRH replacement rescues cognition in Down syndrome
作者
关键词
-
出版物
SCIENCE
Volume 377, Issue 6610, Pages -
出版商
American Association for the Advancement of Science (AAAS)
发表日期
2022-09-02
DOI
10.1126/science.abq4515
参考文献
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注意:仅列出部分参考文献,下载原文获取全部文献信息。- Restoring statistical validity in group analyses of motion‐corrupted MRI data
- (2022) Antoine Lutti et al. HUMAN BRAIN MAPPING
- A randomized, double-blind, placebo-controlled phase II trial to explore the effects of a GABAA-α5 NAM (basmisanil) on intellectual disability associated with Down syndrome
- (2022) Celia Goeldner et al. Journal of Neurodevelopmental Disorders
- Serum neurofilament light chain for individual prognostication of disease activity in people with multiple sclerosis: a retrospective modelling and validation study
- (2022) Pascal Benkert et al. LANCET NEUROLOGY
- FSH blockade improves cognition in mice with Alzheimer’s disease
- (2022) Jing Xiong et al. NATURE
- Complexity Analysis of the Default Mode Network Using Resting-State fMRI in Down Syndrome: Relationships Highlighted by a Neuropsychological Assessment
- (2021) María Dolores Figueroa-Jimenez et al. Brain Sciences
- Temporal trajectory of brain tissue property changes induced by electroconvulsive therapy
- (2021) L. Gyger et al. NEUROIMAGE
- The cryptic gonadotropin-releasing hormone neuronal system of human basal ganglia
- (2021) Katalin Skrapits et al. eLife
- Gonadotropin‐releasing hormone (GnRH) measurements in pituitary portal blood: A history
- (2021) Suzanne M. Moenter et al. JOURNAL OF NEUROENDOCRINOLOGY
- GnRH neurons recruit astrocytes in infancy to facilitate network integration and sexual maturation
- (2021) Giuliana Pellegrino et al. NATURE NEUROSCIENCE
- Down syndrome
- (2020) Stylianos E. Antonarakis et al. Nature Reviews Disease Primers
- Hypoplasia of cerebellar afferent networks in Down syndrome revealed by DTI-driven tensor based morphometry
- (2020) Nancy Raitano Lee et al. Scientific Reports
- Clinical and biomarker changes of Alzheimer's disease in adults with Down syndrome: a cross-sectional study
- (2020) Juan Fortea et al. LANCET
- Down Syndrome
- (2020) Marilyn J. Bull NEW ENGLAND JOURNAL OF MEDICINE
- GnRH stimulation testing and serum inhibin B in males: insufficient specificity for discriminating between congenital hypogonadotropic hypogonadism from constitutional delay of growth and puberty
- (2020) Héléna Mosbah et al. HUMAN REPRODUCTION
- Rescuing Over-activated Microglia Restores Cognitive Performance in Juvenile Animals of the Dp(16) Mouse Model of Down Syndrome
- (2020) Bruno Pinto et al. NEURON
- Myelin development in cerebral gray and white matter during adolescence and late childhood
- (2020) Neva M. Corrigan et al. NEUROIMAGE
- hMRI – A toolbox for quantitative MRI in neuroscience and clinical research
- (2019) Karsten Tabelow et al. NEUROIMAGE
- Differential CRE expression in Lhrh-Cre and Gnrh-Cre alleles and the impact on fertility in Otx2-flox mice
- (2019) Hanne M. Hoffmann et al. NEUROENDOCRINOLOGY
- Dementia in Down syndrome: unique insights for Alzheimer disease research
- (2019) Ira T. Lott et al. Nature Reviews Neurology
- New approaches to studying early brain development in Down syndrome
- (2019) Ana A Baburamani et al. DEVELOPMENTAL MEDICINE AND CHILD NEUROLOGY
- Enhanced dendritic inhibition and impaired NMDAR activation in a mouse model of Down syndrome
- (2019) Jan M. Schulz et al. JOURNAL OF NEUROSCIENCE
- Widespread Translational Control of Fibrosis in the Human Heart by RNA-Binding Proteins
- (2019) Sonia Chothani et al. CIRCULATION
- Promoter DNA hypermethylation – Implications for Alzheimer’s disease
- (2019) Yiyuan Liu et al. NEUROSCIENCE LETTERS
- Controlling motion artefact levels in MR images by suspending data acquisition during periods of head motion
- (2018) Rémi Castella et al. MAGNETIC RESONANCE IN MEDICINE
- Prevalence of Aging, Dementia, and Multimorbidity in Older Adults With Down Syndrome
- (2018) Eleonore Bayen et al. JAMA Neurology
- Progressive Age-Related Cognitive Decline in Tau Mice
- (2018) Ann Van der Jeugd et al. JOURNAL OF ALZHEIMERS DISEASE
- Up-To-Date Review About Minipuberty and Overview on Hypothalamic-Pituitary-Gonadal Axis Activation in Fetal and Neonatal Life
- (2018) Lucia Lanciotti et al. Frontiers in Endocrinology
- Regional growth trajectories of cortical myelination in adolescents and young adults: longitudinal validation and functional correlates
- (2018) Dongjin Kwon et al. Brain Imaging and Behavior
- Reinstating plasticity and memory in a tauopathy mouse model with an acetyltransferase activator
- (2018) Snehajyoti Chatterjee et al. EMBO Molecular Medicine
- Chemogenetic inactivation of the dorsal hippocampus and medial prefrontal cortex, individually and concurrently, impairs object recognition and spatial memory consolidation in female mice
- (2018) Jennifer J. Tuscher et al. NEUROBIOLOGY OF LEARNING AND MEMORY
- Development of the neurons controlling fertility in humans: new insights from 3D imaging and transparent fetal brains
- (2016) Filippo Casoni et al. DEVELOPMENT
- Safety and efficacy of cognitive training plus epigallocatechin-3-gallate in young adults with Down's syndrome (TESDAD): a double-blind, randomised, placebo-controlled, phase 2 trial
- (2016) Rafael de la Torre et al. LANCET NEUROLOGY
- Dementia in Down's syndrome
- (2016) Clive Ballard et al. LANCET NEUROLOGY
- Data-driven hypothesis weighting increases detection power in genome-scale multiple testing
- (2016) Nikolaos Ignatiadis et al. NATURE METHODS
- A microRNA switch regulates the rise in hypothalamic GnRH production before puberty
- (2016) Andrea Messina et al. NATURE NEUROSCIENCE
- Down syndrome and the complexity of genome dosage imbalance
- (2016) Stylianos E. Antonarakis NATURE REVIEWS GENETICS
- Down Syndrome Developmental Brain Transcriptome Reveals Defective Oligodendrocyte Differentiation and Myelination
- (2016) Jose Luis Olmos-Serrano et al. NEURON
- Integrative network analysis of nineteen brain regions identifies molecular signatures and networks underlying selective regional vulnerability to Alzheimer’s disease
- (2016) Minghui Wang et al. Genome Medicine
- The Mitochondrial m-AAA Protease Prevents Demyelination and Hair Greying
- (2016) Shuaiyu Wang et al. PLoS Genetics
- Olfaction in People with Down Syndrome: A Comprehensive Assessment across Four Decades of Age
- (2016) Maria Paola Cecchini et al. PLoS One
- Age-Related Changes in Resting-State Networks of A Large Sample Size of Healthy Elderly
- (2015) Chun-Chao Huang et al. CNS Neuroscience & Therapeutics
- Anomalous brain functional connectivity contributing to poor adaptive behavior in Down syndrome
- (2015) Jesus Pujol et al. CORTEX
- HDAC inhibitor–dependent transcriptome and memory reinstatement in cognitive decline models
- (2015) Eva Benito et al. JOURNAL OF CLINICAL INVESTIGATION
- Reversing excitatory GABAAR signaling restores synaptic plasticity and memory in a mouse model of Down syndrome
- (2015) Gabriele Deidda et al. NATURE MEDICINE
- European Consensus Statement on congenital hypogonadotropic hypogonadism—pathogenesis, diagnosis and treatment
- (2015) Ulrich Boehm et al. Nature Reviews Endocrinology
- Translational regulation shapes the molecular landscape of complex disease phenotypes
- (2015) Sebastian Schafer et al. Nature Communications
- HTSeq--a Python framework to work with high-throughput sequencing data
- (2014) S. Anders et al. BIOINFORMATICS
- Loss of the m-AAA protease subunit AFG3L2 causes mitochondrial transport defects and tau hyperphosphorylation
- (2014) A. K. Kondadi et al. EMBO JOURNAL
- MicroRNA-125b induces tau hyperphosphorylation and cognitive deficits in Alzheimer's disease
- (2014) J. Banzhaf-Strathmann et al. EMBO JOURNAL
- Early depolarizing GABA controls critical-period plasticity in the rat visual cortex
- (2014) Gabriele Deidda et al. NATURE NEUROSCIENCE
- svaseq: removing batch effects and other unwanted noise from sequencing data
- (2014) Jeffrey T. Leek NUCLEIC ACIDS RESEARCH
- A Simple Method for 3D Analysis of Immunolabeled Axonal Tracts in a Transparent Nervous System
- (2014) Morgane Belle et al. Cell Reports
- Mutations in FGF17, IL17RD, DUSP6, SPRY4, and FLRT3 Are Identified in Individuals with Congenital Hypogonadotropic Hypogonadism
- (2013) Hichem Miraoui et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The Rodent Hippocampus Is Essential for Nonspatial Object Memory
- (2013) Sarah J. Cohen et al. CURRENT BIOLOGY
- Development of a Methodology for and Assessment of Pulsatile Luteinizing Hormone Secretion in Juvenile and Adult Male Mice
- (2013) F. J. Steyn et al. ENDOCRINOLOGY
- Age-related impairment of olfactory bulb neurogenesis in the Ts65Dn mouse model of Down syndrome
- (2013) Patrizia Bianchi et al. EXPERIMENTAL NEUROLOGY
- Strengthening connections between Down syndrome and AD
- (2013) The Lancet Neurology LANCET NEUROLOGY
- Hypothalamic programming of systemic ageing involving IKK-β, NF-κB and GnRH
- (2013) Guo Zhang et al. NATURE
- Object recognition test in mice
- (2013) Marianne Leger et al. Nature Protocols
- Fluoxetine in adulthood normalizes GABA release and rescues hippocampal synaptic plasticity and spatial memory in a mouse model of Down Syndrome
- (2013) Tatjana Begenisic et al. NEUROBIOLOGY OF DISEASE
- Symmetric diffeomorphic modeling of longitudinal structural MRI
- (2013) John Ashburner Frontiers in Neuroscience
- Quantitative multi-parameter mapping of R1, PD*, MT, and R2* at 3T: a multi-center validation
- (2013) Nikolaus Weiskopf et al. Frontiers in Neuroscience
- RSeQC: quality control of RNA-seq experiments
- (2012) Liguo Wang et al. BIOINFORMATICS
- STAR: ultrafast universal RNA-seq aligner
- (2012) Alexander Dobin et al. BIOINFORMATICS
- High-resolution imaging of entire organs by 3-dimensional imaging of solvent cleared organs (3DISCO)
- (2012) Ali Ertürk et al. EXPERIMENTAL NEUROLOGY
- The acute inhibition of rapid eye movement sleep by citalopram may impair spatial learning and passive avoidance in mice
- (2012) A. Bridoux et al. JOURNAL OF NEURAL TRANSMISSION
- Loss of Correlations among Proteins in Brains of the Ts65Dn Mouse Model of Down Syndrome
- (2012) Md. Mahiuddin Ahmed et al. JOURNAL OF PROTEOME RESEARCH
- Memantine for dementia in adults older than 40 years with Down's syndrome (MEADOWS): a randomised, double-blind, placebo-controlled trial
- (2012) Marisa Hanney et al. LANCET
- High-resolution functional MRI at 3 T: 3D/2D echo-planar imaging with optimized physiological noise correction
- (2012) Antoine Lutti et al. MAGNETIC RESONANCE IN MEDICINE
- Three-dimensional imaging of solvent-cleared organs using 3DISCO
- (2012) Ali Ertürk et al. Nature Protocols
- Olfactory dysfunction in Parkinson disease
- (2012) Richard L. Doty Nature Reviews Neurology
- Down syndrome: the brain in trisomic mode
- (2012) Mara Dierssen NATURE REVIEWS NEUROSCIENCE
- Relevance of Exocytotic Glutamate Release from Retinal Glia
- (2012) Michal Slezak et al. NEURON
- Robust and Fast Whole Brain Mapping of the RF Transmit Field B1 at 7T
- (2012) Antoine Lutti et al. PLoS One
- DynPeak: An Algorithm for Pulse Detection and Frequency Analysis in Hormonal Time Series
- (2012) Alexandre Vidal et al. PLoS One
- Measurement and Correction of Microscopic Head Motion during Magnetic Resonance Imaging of the Brain
- (2012) Julian Maclaren et al. PLoS One
- SEMA3A, a Gene Involved in Axonal Pathfinding, Is Mutated in Patients with Kallmann Syndrome
- (2012) Naresh Kumar Hanchate et al. PLoS Genetics
- From Abnormal Hippocampal Synaptic Plasticity in Down Syndrome Mouse Models to Cognitive Disability in Down Syndrome
- (2012) Nathan Cramer et al. NEURAL PLASTICITY
- Antagonism of NMDA receptors as a potential treatment for Down syndrome: a pilot randomized controlled trial
- (2012) R Boada et al. Translational Psychiatry
- Dysregulation of Semaphorin7A/β1-integrin signaling leads to defective GnRH-1 cell migration, abnormal gonadal development and altered fertility
- (2011) Andrea Messina et al. HUMAN MOLECULAR GENETICS
- Early onset of primary hypogonadism revealed by serum anti-Müllerian hormone determination during infancy and childhood in trisomy 21
- (2011) R. P. Grinspon et al. INTERNATIONAL JOURNAL OF ANDROLOGY
- Molecular characterization of the translocation breakpoints in the Down syndrome mouse model Ts65Dn
- (2011) Laura G. Reinholdt et al. MAMMALIAN GENOME
- Regional specificity of MRI contrast parameter changes in normal ageing revealed by voxel-based quantification (VBQ)
- (2011) B. Draganski et al. NEUROIMAGE
- Sexual dimorphism of kisspeptin and neurokinin B immunoreactive neurons in the infundibular nucleus of aged men and women
- (2011) Erik Hrabovszky Frontiers in Endocrinology
- Widespread Proliferation Impairment and Hypocellularity in the Cerebellum of Fetuses with Down Syndrome
- (2010) Sandra Guidi et al. BRAIN PATHOLOGY
- GnRH Receptor Gene Expression in the Developing Rat Hippocampus: Transcriptional Regulation and Potential Roles in Neuronal Plasticity
- (2010) Anne-Laure Schang et al. ENDOCRINOLOGY
- Optimization and validation of methods for mapping of the radiofrequency transmit field at 3T
- (2010) Antoine Lutti et al. MAGNETIC RESONANCE IN MEDICINE
- Increased male reproductive success in Ts65Dn “Down syndrome” mice
- (2010) Clara S. Moore et al. MAMMALIAN GENOME
- Embryonic gonadotropin-releasing hormone signaling is necessary for maturation of the male reproductive axis
- (2010) S. Wen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The Embryonic Preoptic Area Is a Novel Source of Cortical GABAergic Interneurons
- (2009) D. M. Gelman et al. JOURNAL OF NEUROSCIENCE
- Interneurons Produced in Adulthood Are Required for the Normal Functioning of the Olfactory Bulb Network and for the Execution of Selected Olfactory Behaviors
- (2009) V. Breton-Provencher et al. JOURNAL OF NEUROSCIENCE
- DYRK1A, a Novel Determinant of the Methionine-Homocysteine Cycle in Different Mouse Models Overexpressing this Down-Syndrome-Associated Kinase
- (2009) Christophe Noll et al. PLoS One
- The Relative Role of Gonadal Sex Steroids and Gonadotropin-Releasing Hormone Pulse Frequency in the Regulation of Follicle-Stimulating Hormone Secretion in Men
- (2008) Nelly Pitteloud et al. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM
- High-resolution maps of magnetization transfer with inherent correction for RF inhomogeneity andT1relaxation obtained from 3D FLASH MRI
- (2008) Gunther Helms et al. MAGNETIC RESONANCE IN MEDICINE
- Quantitative FLASH MRI at 3T using a rational approximation of the Ernst equation
- (2008) Gunther Helms et al. MAGNETIC RESONANCE IN MEDICINE
- Unusual Repertoire of Vocalizations in the BTBR T+tf/J Mouse Model of Autism
- (2008) Maria Luisa Scattoni et al. PLoS One
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