Atherosclerosis: current pathogenesis and therapeutic options

Effect of CC Chemokine Receptor 2 CCR2 Blockade on Serum C-Reactive Protein in Individuals at Atherosclerotic Risk and With a Single Nucleotide Polymorphism of the Monocyte Chemoattractant Protein-1 Promoter Region

(2011) Jim Gilbert et al.   AMERICAN JOURNAL OF CARDIOLOGY

Macrophages in the Pathogenesis of Atherosclerosis

(2011) Kathryn J. Moore et al.   CELL

Lipoprotein-Derived Lysophosphatidic Acid Promotes Atherosclerosis by Releasing CXCL1 from the Endothelium

(2011) Zhe Zhou et al.   Cell Metabolism

Immunotherapy With Tolerogenic Apolipoprotein B-100–Loaded Dendritic Cells Attenuates Atherosclerosis in Hypercholesterolemic Mice

(2011) Andreas Hermansson et al.   CIRCULATION

The novel atherosclerosis locus at 10q11 regulates plasma CXCL12 levels

(2011) Nehal N. Mehta et al.   EUROPEAN HEART JOURNAL

CCL17-expressing dendritic cells drive atherosclerosis by restraining regulatory T cell homeostasis in mice

(2011) Christian Weber et al.   JOURNAL OF CLINICAL INVESTIGATION

Nicotinic acid inhibits progression of atherosclerosis in mice through its receptor GPR109A expressed by immune cells

(2011) Martina Lukasova et al.   JOURNAL OF CLINICAL INVESTIGATION

Suppressed monocyte recruitment drives macrophage removal from atherosclerotic plaques of Apoe–/– mice during disease regression

(2011) Stephane Potteaux et al.   JOURNAL OF CLINICAL INVESTIGATION

9p21 DNA variants associated with coronary artery disease impair interferon-γ signalling response

(2011) Olivier Harismendy et al.   NATURE

Gut flora metabolism of phosphatidylcholine promotes cardiovascular disease

(2011) Zeneng Wang et al.   NATURE

Large-scale association analysis identifies 13 new susceptibility loci for coronary artery disease

(2011) Heribert Schunkert et al.   NATURE GENETICS

A genome-wide association study in Europeans and South Asians identifies five new loci for coronary artery disease

(2011) John F Peden et al.   NATURE GENETICS

The immune system in atherosclerosis

(2011) Göran K Hansson et al.   NATURE IMMUNOLOGY

Unexpected protective role for Toll-like receptor 3 in the arterial wall

(2011) J. E. Cole et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Stabilisation of atherosclerotic plaques

(2011) Jacob Fog Bentzon et al.   THROMBOSIS AND HAEMOSTASIS

Atherosclerosis in ApoE-deficient mice progresses independently of the NLRP3 inflammasome

(2011) P Menu et al.   Cell Death & Disease

Distinct Infiltration of Neutrophils in Lesion Shoulders in ApoE−/− Mice

(2010) Pierre Rotzius et al.   AMERICAN JOURNAL OF PATHOLOGY

Rosiglitazone Revisited

(2010) Steven E. Nissen et al.   ARCHIVES OF INTERNAL MEDICINE

Intranasal Immunization With an Apolipoprotein B-100 Fusion Protein Induces Antigen-Specific Regulatory T Cells and Reduces Atherosclerosis

(2010) Roland Klingenberg et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Coronary Artery Disease–Related Genetic Variant on Chromosome 10q11 Is Associated With Carotid Intima-Media Thickness and Atherosclerosis

(2010) Stefan Kiechl et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

High-Mobility Group Box Protein 1 Neutralization Reduces Development of Diet-Induced Atherosclerosis in Apolipoprotein E–Deficient Mice

(2010) Peter Kanellakis et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Platelet CD40L mediates thrombotic and inflammatory processes in atherosclerosis

(2010) D. Lievens et al.   BLOOD

Myeloid Type I Interferon Signaling Promotes Atherosclerosis by Stimulating Macrophage Recruitment to Lesions

(2010) Pieter Goossens et al.   Cell Metabolism

Atherogenic Lipids and Lipoproteins Trigger CD36-TLR2-Dependent Apoptosis in Macrophages Undergoing Endoplasmic Reticulum Stress

(2010) Tracie A. Seimon et al.   Cell Metabolism

Chemokine Receptor 7 Knockout Attenuates Atherosclerotic Plaque Development

(2010) Maren Luchtefeld et al.   CIRCULATION

Hyperlipidemia-Triggered Neutrophilia Promotes Early Atherosclerosis

(2010) Maik Drechsler et al.   CIRCULATION

Circulating MicroRNAs in Patients With Coronary Artery Disease

(2010) Stephan Fichtlscherer et al.   CIRCULATION RESEARCH

Circulating Platelet-Activating Factor Is Primarily Cleared by Transport, Not Intravascular Hydrolysis by Lipoprotein-Associated Phospholipase A 2 / PAF Acetylhydrolase

(2010) Jinbo Liu et al.   CIRCULATION RESEARCH

Genetics of myocardial infarction: a progress report

(2010) H. Schunkert et al.   EUROPEAN HEART JOURNAL

MIF-chemokine receptor interactions in atherogenesis are dependent on an N-loop-based 2-site binding mechanism

(2010) Sandra Kraemer et al.   FASEB JOURNAL

Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice

(2010) Fei Wang et al.   JOURNAL OF CLINICAL INVESTIGATION

LXR promotes the maximal egress of monocyte-derived cells from mouse aortic plaques during atherosclerosis regression

(2010) Jonathan E. Feig et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficient CD40-TRAF6 signaling in leukocytes prevents atherosclerosis by skewing the immune response toward an antiinflammatory profile

(2010) Esther Lutgens et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of T cell response to native low-density lipoprotein reduces atherosclerosis

(2010) Andreas Hermansson et al.   JOURNAL OF EXPERIMENTAL MEDICINE

B cell depletion reduces the development of atherosclerosis in mice

(2010) Hafid Ait-Oufella et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Conventional B2 B Cell Depletion Ameliorates whereas Its Adoptive Transfer Aggravates Atherosclerosis

(2010) T. Kyaw et al.   JOURNAL OF IMMUNOLOGY

Lp-PLA2- a novel risk factor for high-risk coronary and carotid artery disease

(2010) K. C. Epps et al.   JOURNAL OF INTERNAL MEDICINE

A New Monocyte Chemotactic Protein-1/Chemokine CC Motif Ligand-2 Competitor Limiting Neointima Formation and Myocardial Ischemia/Reperfusion Injury in Mice

(2010) Elisa A. Liehn et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

A multilocus genetic risk score for coronary heart disease: case-control and prospective cohort analyses

(2010) Samuli Ripatti et al.   LANCET

NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals

(2010) Peter Duewell et al.   NATURE

Biological, clinical and population relevance of 95 loci for blood lipids

(2010) Tanya M. Teslovich et al.   NATURE

Endoplasmic reticulum stress and atherosclerosis

(2010) Gökhan S Hotamisligil   NATURE MEDICINE

Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases

(2010) Steffen Massberg et al.   NATURE MEDICINE

Monocytes in atherosclerosis: subsets and functions

(2010) Kevin J. Woollard et al.   Nature Reviews Cardiology

Therapeutic targeting of chemokine interactions in atherosclerosis

(2010) Rory R. Koenen et al.   NATURE REVIEWS DRUG DISCOVERY

Cholesterol Crystals Activate the NLRP3 Inflammasome in Human Macrophages: A Novel Link between Cholesterol Metabolism and Inflammation

(2010) Kristiina Rajamäki et al.   PLoS One

ATP-Binding Cassette Transporters and HDL Suppress Hematopoietic Stem Cell Proliferation

(2010) L. Yvan-Charvet et al.   SCIENCE

Structure and Function of HDL Mimetics

(2009) Mohamad Navab et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Dendritic cells pulsed with malondialdehyde modified low density lipoprotein aggravate atherosclerosis in Apoe−/− mice

(2009) Charlotta Hjerpe et al.   ATHEROSCLEROSIS

Vaccination using oxidized low-density lipoprotein-pulsed dendritic cells reduces atherosclerosis in LDL receptor-deficient mice

(2009) Kim L.L. Habets et al.   CARDIOVASCULAR RESEARCH

Chemokines in the vascular inflammatory response of atherosclerosis

(2009) A. Zernecke et al.   CARDIOVASCULAR RESEARCH

Reduced Apoptosis and Plaque Necrosis in Advanced Atherosclerotic Lesions of Apoe−/− and Ldlr−/− Mice Lacking CHOP

(2009) Edward Thorp et al.   Cell Metabolism

Conventional Dendritic Cells at the Crossroads Between Immunity and Cholesterol Homeostasis in Atherosclerosis

(2009) Emmanuel L. Gautier et al.   CIRCULATION

Oral Anti-CD3 Antibody Treatment Induces Regulatory T Cells and Inhibits the Development of Atherosclerosis in Mice

(2009) Naoto Sasaki et al.   CIRCULATION

Functional Role of CD11c + Monocytes in Atherogenesis Associated With Hypercholesterolemia

(2009) Huaizhu Wu et al.   CIRCULATION

Resident Intimal Dendritic Cells Accumulate Lipid and Contribute to the Initiation of Atherosclerosis

(2009) Kim E. Paulson et al.   CIRCULATION RESEARCH

Treating inflammation in atherosclerotic cardiovascular disease: emerging therapies

(2009) Roland Klingenberg et al.   EUROPEAN HEART JOURNAL

Evidence that cathelicidin peptide LL-37 may act as a functional ligand for CXCR2 on human neutrophils

(2009) Zhifang Zhang et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Identification of antigen-presenting dendritic cells in mouse aorta and cardiac valves

(2009) Jae-Hoon Choi et al.   JOURNAL OF EXPERIMENTAL MEDICINE

GM-CSF regulates intimal cell proliferation in nascent atherosclerotic lesions

(2009) Su-Ning Zhu et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Reduction in C-reactive protein and LDL cholesterol and cardiovascular event rates after initiation of rosuvastatin: a prospective study of the JUPITER trial

(2009) Paul M Ridker et al.   LANCET

Rosiglitazone evaluated for cardiovascular outcomes in oral agent combination therapy for type 2 diabetes (RECORD): a multicentre, randomised, open-label trial

(2009) Philip D Home et al.   LANCET

Genome-wide association of early-onset myocardial infarction with single nucleotide polymorphisms and copy number variants

(2009) Sekar Kathiresan et al.   NATURE GENETICS

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

Disrupting functional interactions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice

(2009) Rory R Koenen et al.   NATURE MEDICINE

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Ticagrelor versus Clopidogrel in Patients with Acute Coronary Syndromes

(2009) Lars Wallentin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Extended-Release Niacin or Ezetimibe and Carotid Intima–Media Thickness

(2009) Allen J. Taylor et al.   NEW ENGLAND JOURNAL OF MEDICINE

Delivery of MicroRNA-126 by Apoptotic Bodies Induces CXCL12-Dependent Vascular Protection

(2009) A. Zernecke et al.   Science Signaling

Macrophage Migration Inhibitory Factor: A Noncanonical Chemokine Important in Atherosclerosis

(2009) Heidi Noels et al.   TRENDS IN CARDIOVASCULAR MEDICINE

NETs: a new strategy for using old weapons

(2009) Venizelos Papayannopoulos et al.   TRENDS IN IMMUNOLOGY

A Novel RANTES Antagonist Prevents Progression of Established Atherosclerotic Lesions in Mice

(2008) Vincent Braunersreuther et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Loss of SR-A and CD36 Activity Reduces Atherosclerotic Lesion Complexity Without Abrogating Foam Cell Formation in Hyperlipidemic Mice

(2008) Jennifer J. Manning-Tobin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CX3CR1 is required for monocyte homeostasis and atherogenesis by promoting cell survival

(2008) L. Landsman et al.   BLOOD

Neutrophil secretion products pave the way for inflammatory monocytes

(2008) O. Soehnlein et al.   BLOOD

Increased Inflammatory Gene Expression in ABC Transporter–Deficient Macrophages

(2008) Laurent Yvan-Charvet et al.   CIRCULATION

Cholesteryl Ester Transfer Protein Inhibition, High-Density Lipoprotein Raising, and Progression of Coronary Atherosclerosis

(2008) Stephen J. Nicholls et al.   CIRCULATION

Effects of the Direct Lipoprotein-Associated Phospholipase A 2 Inhibitor Darapladib on Human Coronary Atherosclerotic Plaque

(2008) Patrick W. Serruys et al.   CIRCULATION

Combined Inhibition of CCL2, CX3CR1, and CCR5 Abrogates Ly6C hi and Ly6C lo Monocytosis and Almost Abolishes Atherosclerosis in Hypercholesterolemic Mice

(2008) Christophe Combadière et al.   CIRCULATION

Contribution of Macromolecular Structure to the Retention of Low-Density Lipoprotein at Arterial Branch Points

(2008) Gina P. Kwon et al.   CIRCULATION

Vessel Wall–Embedded Dendritic Cells Induce T-Cell Autoreactivity and Initiate Vascular Inflammation

(2008) Ji W. Han et al.   CIRCULATION RESEARCH

T-Cell Costimulation and Coinhibition in Atherosclerosis

(2008) Israel Gotsman et al.   CIRCULATION RESEARCH

Direct antiatherosclerotic effects of PPAR agonists

(2008) Karin AM Jandeleit-Dahm et al.   CURRENT OPINION IN LIPIDOLOGY

Effect of Rimonabant on Progression of Atherosclerosis in Patients With Abdominal Obesity and Coronary Artery Disease

(2008) Steven E. Nissen et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Emerging role of Toll-like receptors in atherosclerosis

(2008) Linda K. Curtiss et al.   JOURNAL OF LIPID RESEARCH

The macrophage scavenger receptor at 30 years of age: current knowledge and future challenges: TABLE 1.

(2008) David R. Greaves et al.   JOURNAL OF LIPID RESEARCH

Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development

(2008) Robert L Wilensky et al.   NATURE MEDICINE

Telmisartan, Ramipril, or Both in Patients at High Risk for Vascular Events

(2008)   NEW ENGLAND JOURNAL OF MEDICINE

Structural determinants of MIF functions in CXCR2-mediated inflammatory and atherogenic leukocyte recruitment

(2008) C. Weber et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1

(2008) T. A. Harris et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CXCR3 Antagonist NBI-74330 Attenuates Atherosclerotic Plaque Formation in LDL Receptor–Deficient Mice

(2007) Eva J.A. van Wanrooij et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

CX 3 CR1 Deficiency Impairs Dendritic Cell Accumulation in Arterial Intima and Reduces Atherosclerotic Burden

(2007) Peng Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fractalkine Deficiency Markedly Reduces Macrophage Accumulation and Atherosclerotic Lesion Formation in CCR2 −/− Mice

(2007) Noah Saederup et al.   CIRCULATION

Protective Role of CXC Receptor 4/CXC Ligand 12 Unveils the Importance of Neutrophils in Atherosclerosis

(2007) Alma Zernecke et al.   CIRCULATION RESEARCH