Metabolic functions of FABPs—mechanisms and therapeutic implications

Serum Levels of Adipocyte Fatty Acid–Binding Protein Are Independently Associated With Left Ventricular Mass and Myocardial Performance Index in Obstructive Sleep Apnea Syndrome

(2016) Mustafa Mücahit Balci et al.   JOURNAL OF INVESTIGATIVE MEDICINE

Uncoupling Lipid Metabolism from Inflammation through Fatty Acid Binding Protein-Dependent Expression of UCP2

(2015) Hongliang Xu et al.   MOLECULAR AND CELLULAR BIOLOGY

The mAb against adipocyte fatty acid-binding protein 2E4 attenuates the inflammation in the mouse model of high-fat diet-induced obesity via toll-like receptor 4 pathway

(2015) Xiaoliang Miao et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Circulating adipocyte fatty acid-binding protein induces insulin resistance in micein vivo

(2015) Susan Kralisch et al.   Obesity

Bone marrow adipocytes promote tumor growth in bone via FABP4-dependent mechanisms

(2015) Mackenzie Herroon et al.   Oncotarget

Discovery of a Class of Endogenous Mammalian Lipids with Anti-Diabetic and Anti-inflammatory Effects

(2014) Mark M. Yore et al.   CELL

Low-Expression Variant of Fatty Acid-Binding Protein 4 Favors Reduced Manifestations of Atherosclerotic Disease and Increased Plaque Stability

(2014) J. Saksi et al.   Circulation-Cardiovascular Genetics

Interaction of epoxyeicosatrienoic acids and adipocyte fatty acid-binding protein in the modulation of cardiomyocyte contractility

(2014) V Lamounier-Zepter et al.   INTERNATIONAL JOURNAL OF OBESITY

Fatty Acid-binding Protein 5 (FABP5) Regulates Cognitive Function Both by Decreasing Anandamide Levels and by Activating the Nuclear Receptor Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ) in the Brain

(2014) Shuiliang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Fatty Acid-binding Protein 4, a Point of Convergence for Angiogenic and Metabolic Signaling Pathways in Endothelial Cells

(2014) Ulrike Harjes et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of FDA-Approved Drugs as Inhibitors of Fatty Acid Binding Protein 4 Using Molecular Docking Screening

(2014) Yan Wang et al.   Journal of Chemical Information and Modeling

Secretion of fatty acid binding protein aP2 from adipocytes through a nonclassical pathway in response to adipocyte lipase activity

(2014) Meric Erikci Ertunc et al.   JOURNAL OF LIPID RESEARCH

Sphingolipid metabolites in inflammatory disease

(2014) Michael Maceyka et al.   NATURE

Oligopeptide complex for targeted non-viral gene delivery to adipocytes

(2014) Young-Wook Won et al.   NATURE MATERIALS

Fatty Acid Binding Protein 4 Deficiency Protects against Oxygen-Induced Retinopathy in Mice

(2014) Magali Saint-Geniez et al.   PLoS One

Binding Modes of Three Inhibitors 8CA, F8A and I4A to A-FABP Studied Based on Molecular Dynamics Simulation

(2014) Jianzhong Chen et al.   PLoS One

Identification of fatty acid binding protein 4 as an adipokine that regulates insulin secretion during obesity

(2014) Lindsay E. Wu et al.   Molecular Metabolism

Benzbromarone, an old uricosuric drug, inhibits human fatty acid binding protein 4 in vitro and lowers the blood glucose level in db/db mice

(2013) Hai-yan Cai et al.   ACTA PHARMACOLOGICA SINICA

Fatty Acid Binding Protein 4 Regulates VEGF-Induced Airway Angiogenesis and Inflammation in a Transgenic Mouse Model

(2013) Elisa Ghelfi et al.   AMERICAN JOURNAL OF PATHOLOGY

Liver Fatty Acid-binding Protein Is A Diagnostic Marker to Detect Liver Injury Due to Chronic Hepatitis C Infection

(2013) Erdem Akbal et al.   ARCHIVES OF MEDICAL RESEARCH

Capillary Endothelial Fatty Acid Binding Proteins 4 and 5 Play a Critical Role in Fatty Acid Uptake in Heart and Skeletal Muscle

(2013) Tatsuya Iso et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Lipid modulation of ion channels through specific binding sites

(2013) J.A. Poveda et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Adipocyte Lipid Chaperone aP2 Is a Secreted Adipokine Regulating Hepatic Glucose Production

(2013) Haiming Cao et al.   Cell Metabolism

FABP4 Attenuates PPAR  and Adipogenesis and Is Inversely Correlated With PPAR  in Adipose Tissues

(2013) T. Garin-Shkolnik et al.   DIABETES

Adipocyte fatty acid-binding protein is released from adipocytes by a non-conventional mechanism

(2013) S Kralisch et al.   INTERNATIONAL JOURNAL OF OBESITY

Calcium-dependent release of adipocyte fatty acid binding protein from human adipocytes

(2013) I Schlottmann et al.   INTERNATIONAL JOURNAL OF OBESITY

Plasma Intestinal Fatty Acid–Binding Protein Levels Correlate With Morphologic Epithelial Intestinal Damage in a Human Translational Ischemia-reperfusion Model

(2013) Dirk H. S. M. Schellekens et al.   JOURNAL OF CLINICAL GASTROENTEROLOGY

FABP4 Induces Vascular Smooth Muscle Cell Proliferation and Migration through a MAPK-Dependent Pathway

(2013) Josefa Girona et al.   PLoS One

Circulating Levels of Fatty Acid-Binding Protein Family and Metabolic Phenotype in the General Population

(2013) Shutaro Ishimura et al.   PLoS One

Gene silencing in adipose tissue macrophages regulates whole-body metabolism in obese mice

(2013) M. Aouadi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Elevated Circulating Adipocyte‐Fatty Acid Binding Protein Levels Predict Incident Cardiovascular Events in a Community‐Based Cohort: A 12‐Year Prospective Study

(2013) Wing Sun Chow et al.   Journal of the American Heart Association

Endothelial cell-fatty acid binding protein 4 promotes angiogenesis: role of stem cell factor/c-kit pathway

(2012) Harun Elmasri et al.   ANGIOGENESIS

Circulating Adipocyte Fatty Acid-Binding Protein Levels and Cardiovascular Morbidity and Mortality in Patients With Coronary Heart Disease

(2012) Maximilian von Eynatten et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Fatty acid-binding protein 4 impairs the insulin-dependent nitric oxide pathway in vascular endothelial cells

(2012) Gemma Aragonès et al.   Cardiovascular Diabetology

Design, synthesis and biological evaluation of thiazole- and indole-based derivatives for the treatment of type II diabetes

(2012) Qinyuan Xu et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Retinoic Acid Induces Neurogenesis by Activating Both Retinoic Acid Receptors (RARs) and Peroxisome Proliferator-activated Receptor β/δ (PPARβ/δ)

(2012) Shuiliang Yu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cardiometabolic Correlates and Heritability of Fetuin-A, Retinol-Binding Protein 4, and Fatty-Acid Binding Protein 4 in the Framingham Heart Study

(2012) Bernhard M. Kaess et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover

(2012) Roger H. Unger et al.   JOURNAL OF CLINICAL INVESTIGATION

Pharmacological inhibition of adipocyte fatty acid binding protein alleviates both acute liver injury and non-alcoholic steatohepatitis in mice

(2012) Ruby L.C. Hoo et al.   JOURNAL OF HEPATOLOGY

Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human

(2012) Atsuhiko Ichimura et al.   NATURE

PPARs at the crossroads of lipid signaling and inflammation

(2012) Walter Wahli et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Macrophage Mal1 Deficiency Suppresses Atherosclerosis in Low-Density Lipoprotein Receptor–Null Mice by Activating Peroxisome Proliferator-Activated Receptor-γ–Regulated Genes

(2011) Vladimir R. Babaev et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

New aromatic substituted pyrazoles as selective inhibitors of human adipocyte fatty acid-binding protein

(2011) Xiujie Liu et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Adipose tissue remodeling and obesity

(2011) Kai Sun et al.   JOURNAL OF CLINICAL INVESTIGATION

Deficiency of the Leukotriene B4 Receptor, BLT-1, Protects against Systemic Insulin Resistance in Diet-Induced Obesity

(2011) M. Spite et al.   JOURNAL OF IMMUNOLOGY

Adipocytes promote ovarian cancer metastasis and provide energy for rapid tumor growth

(2011) Kristin M Nieman et al.   NATURE MEDICINE

Serum adipocyte fatty acid-binding protein associated with ischemic stroke and early death

(2011) A. W. K. Tso et al.   NEUROLOGY

Fatty acid binding protein 4 is expressed in distinct endothelial and non-endothelial cell populations in glioblastoma

(2011) O. Cataltepe et al.   NEUROPATHOLOGY AND APPLIED NEUROBIOLOGY

Deep Sequencing the Transcriptome Reveals Seasonal Adaptive Mechanisms in a Hibernating Mammal

(2011) Marshall Hampton et al.   PLoS One

Fatty Acids Identified in the Burmese Python Promote Beneficial Cardiac Growth

(2011) C. A. Riquelme et al.   SCIENCE

Fatty-acid binding protein 4 gene polymorphisms and plasma levels in children with obstructive sleep apnea

(2011) Bharat Bhushan et al.   SLEEP MEDICINE

Chronic administration of BMS309403 improves endothelial function in apolipoprotein E-deficient mice and in cultured human endothelial cells

(2010) Mary YK Lee et al.   BRITISH JOURNAL OF PHARMACOLOGY

GPR120 Is an Omega-3 Fatty Acid Receptor Mediating Potent Anti-inflammatory and Insulin-Sensitizing Effects

(2010) Da Young Oh et al.   CELL

Tissue-specific Functions in the Fatty Acid-binding Protein Family

(2010) Judith Storch et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Serum Adipocyte Fatty Acid-Binding Protein Is Associated Independently with Vascular Inflammation: Analysis with18F-Fluorodeoxyglucose Positron Emission Tomography

(2010) Hye Jin Yoo et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Membrane Fatty Acid Transporters as Regulators of Lipid Metabolism: Implications for Metabolic Disease

(2010) Jan F. C. Glatz et al.   PHYSIOLOGICAL REVIEWS

X-ray crystallographic analysis of adipocyte fatty acid binding protein (aP2) modified with 4-hydroxy-2-nonenal

(2010) Kristina Hellberg et al.   PROTEIN SCIENCE

Acyl-CoA synthesis, lipid metabolism and lipotoxicity

(2009) Lei O. Li et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

N-Benzyl-indolo carboxylic acids: Design and synthesis of potent and selective adipocyte fatty-acid binding protein (A-FABP) inhibitors

(2009) Tjeerd Barf et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Adipocyte fatty acid-binding protein as a novel prognostic factor in obese breast cancer patients

(2009) K. Hancke et al.   BREAST CANCER RESEARCH AND TREATMENT

Adipocyte Fatty Acid–Binding Protein Suppresses Cardiomyocyte Contraction

(2009) Valéria Lamounier-Zepter et al.   CIRCULATION RESEARCH

Fatty acid binding protein 4 is a target of VEGF and a regulator of cell proliferation in endothelial cells

(2009) Harun Elmasri et al.   FASEB JOURNAL

Interaction of Adipocyte Fatty Acid-binding Protein (AFABP) and JAK2

(2009) Brian R. Thompson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Orally delivered siRNA targeting macrophage Map4k4 suppresses systemic inflammation

(2009) Myriam Aouadi et al.   NATURE

Reducing endoplasmic reticulum stress through a macrophage lipid chaperone alleviates atherosclerosis

(2009) Ebru Erbay et al.   NATURE MEDICINE

Lipid Mediators in Health and Disease: Enzymes and Receptors as Therapeutic Targets for the Regulation of Immunity and Inflammation

(2008) Takao Shimizu   Annual Review of Pharmacology and Toxicology

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

Serum adipocyte-fatty acid binding protein discriminates patients with permanent and temporary body weight loss

(2008) D. Stejskal et al.   JOURNAL OF CLINICAL LABORATORY ANALYSIS

Fatty acid-binding proteins: role in metabolic diseases and potential as drug targets

(2008) Masato Furuhashi et al.   NATURE REVIEWS DRUG DISCOVERY