S-Nitrosylation links obesity-associated inflammation to endoplasmic reticulum dysfunction

Multiple autophosphorylations significantly enhance the endoribonuclease activity of human inositol requiring enzyme 1α

(2014) Daniel Itzhak et al.   BMC BIOCHEMISTRY

Allosteric Inhibition of the IRE1α RNase Preserves Cell Viability and Function during Endoplasmic Reticulum Stress

(2014) Rajarshi Ghosh et al.   CELL

Structure of Human RNase L Reveals the Basis for Regulated RNA Decay in the IFN Response

(2014) Y. Han et al.   SCIENCE

Getting RIDD of RNA: IRE1 in cell fate regulation

(2014) M. Maurel et al.   TRENDS IN BIOCHEMICAL SCIENCES

Protein Control of S-Nitrosothiol Reactivity: Interplay of Antagonistic Resonance Structures

(2013) Marat R. Talipov et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Restoration of the Unfolded Protein Response in Pancreatic   Cells Protects Mice Against Type 1 Diabetes

(2013) F. Engin et al.   Science Translational Medicine

Guidelines for the use and interpretation of assays for monitoring autophagy

(2012) Daniel J. Klionsky et al.   Autophagy

Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors

(2012) Likun Wang et al.   Nature Chemical Biology

The unfolded protein response: controlling cell fate decisions under ER stress and beyond

(2012) Claudio Hetz   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Inflammatory Mechanisms in Obesity

(2011) Margaret F. Gregor et al.   Annual Review of Immunology

Structural and functional basis for RNA cleavage by Ire1

(2011) Alexei V Korennykh et al.   BMC BIOLOGY

Inflammatory links between obesity and metabolic disease

(2011) Carey N. Lumeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Identification and Quantification of S-Nitrosylation by Cysteine Reactive Tandem Mass Tag Switch Assay

(2011) Christopher I. Murray et al.   MOLECULAR & CELLULAR PROTEOMICS

PKA phosphorylation couples hepatic inositol-requiring enzyme 1  to glucagon signaling in glucose metabolism

(2011) T. Mao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Double-Stranded RNA-Dependent Protein Kinase Links Pathogen Sensing with Stress and Metabolic Homeostasis

(2010) Takahisa Nakamura et al.   CELL

Endoplasmic Reticulum Stress and the Inflammatory Basis of Metabolic Disease

(2010) Gökhan S. Hotamisligil   CELL

Flavonol Activation Defines an Unanticipated Ligand-Binding Site in the Kinase-RNase Domain of IRE1

(2010) R. Luke Wiseman et al.   MOLECULAR CELL

A regulatory subunit of phosphoinositide 3-kinase increases the nuclear accumulation of X-box–binding protein-1 to modulate the unfolded protein response

(2010) Jonathon N Winnay et al.   NATURE MEDICINE

The regulatory subunits of PI3K, p85α and p85β, interact with XBP-1 and increase its nuclear translocation

(2010) Sang Won Park et al.   NATURE MEDICINE

IRE1α Disruption Causes Histological Abnormality of Exocrine Tissues, Increase of Blood Glucose Level, and Decrease of Serum Immunoglobulin Level

(2010) Takao Iwawaki et al.   PLoS One

Quantitative approaches to monitor protein-nucleic acid interactions using fluorescent probes

(2010) J. M. Pagano et al.   RNA

IRE1α Kinase Activation Modes Control Alternate Endoribonuclease Outputs to Determine Divergent Cell Fates

(2009) Dan Han et al.   CELL

Regulated Ire1-dependent decay of messenger RNAs in mammalian cells

(2009) Julie Hollien et al.   JOURNAL OF CELL BIOLOGY

CLIP: Construction of cDNA libraries for high-throughput sequencing from RNAs cross-linked to proteins in vivo

(2009) Zhen Wang et al.   METHODS

BAX Inhibitor-1 Is a Negative Regulator of the ER Stress Sensor IRE1α

(2009) Fernanda Lisbona et al.   MOLECULAR CELL

The CREB coactivator CRTC2 links hepatic ER stress and fasting gluconeogenesis

(2009) Yiguo Wang et al.   NATURE

Hypothalamic IKKβ/NF-κB and ER Stress Link Overnutrition to Energy Imbalance and Obesity

(2008) Xiaoqing Zhang et al.   CELL

Structure of the Dual Enzyme Ire1 Reveals the Basis for Catalysis and Regulation in Nonconventional RNA Splicing

(2008) Kenneth P.K. Lee et al.   CELL

Identification of a Lipokine, a Lipid Hormone Linking Adipose Tissue to Systemic Metabolism

(2008) Haiming Cao et al.   CELL

A Strategy for Direct Identification of Protein S-Nitrosylation Sites by Quadrupole Time-of-Flight Mass Spectrometry

(2008) Y WANG et al.   JOURNAL OF THE AMERICAN SOCIETY FOR MASS SPECTROMETRY

The unfolded protein response signals through high-order assembly of Ire1

(2008) Alexei V. Korennykh et al.   NATURE

Chromium Alleviates Glucose Intolerance, Insulin Resistance, and Hepatic ER Stress in Obese Mice

(2008) Nair Sreejayan et al.   Obesity