Single-Cell Immunobiology of the Maternal–Fetal Interface

MAX deficiency impairs human endometrial decidualization through down-regulating OSR2 in women with recurrent spontaneous abortion

(2022) Weixu Ma et al.   CELL AND TISSUE RESEARCH

Cellular and molecular atlas of the placenta from a COVID‐19 pregnant woman infected at midgestation highlights the defective impacts on foetal health

(2022) Jingsi Chen et al.   CELL PROLIFERATION

Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment

(2022) Matthew J. Shannon et al.   DEVELOPMENT

Immune landscape of human placental villi using single-cell analysis

(2022) Jessica M. Toothaker et al.   DEVELOPMENT

Maternal-fetal immune responses in pregnant women infected with SARS-CoV-2

(2022) Valeria Garcia-Flores et al.   Nature Communications

Integrated Analysis Reveals the Characteristics and Effects of SARS-CoV-2 Maternal–Fetal Transmission

(2022) Ziliang Huang et al.   Frontiers in Microbiology

The etiology of preeclampsia

(2022) Eunjung Jung et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Spatial transcriptomic profiles of mouse uterine microenvironments at pregnancy day 7.5

(2022) Rong Li et al.   BIOLOGY OF REPRODUCTION

A single-cell atlas of the myometrium in human parturition

(2022) Roger Pique-Regi et al.   JCI Insight

Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Mesenchymal Stem/Stromal Cells Derived from Human Placenta

(2022) Jinlu Li et al.   Frontiers in Cell and Developmental Biology

Regionally distinct trophoblast regulate barrier function and invasion in the human placenta

(2022) Bryan Marsh et al.   eLife

Imaging mass cytometry reveals the prominent role of myeloid cells at the maternal-fetal interface

(2022) Juliette Krop et al.   iScience

Single-cell Immune Landscape of Human Recurrent Miscarriage

(2021) Feiyang Wang et al.   GENOMICS PROTEOMICS & BIOINFORMATICS

Single-cell profiling of the human decidual immune microenvironment in patients with recurrent pregnancy loss

(2021) Chuang Guo et al.   Cell Discovery

Inference and analysis of cell-cell communication using CellChat

(2021) Suoqin Jin et al.   Nature Communications

Cellular immune responses in the pathophysiology of preeclampsia

(2021) Derek Miller et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Multiomic analysis reveals decidual‐specific transcriptional programing of MAIT cells

(2021) Jessica Vazquez et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Single-cell RNA-seq profiling of mouse endothelial cells in response to pulmonary arterial hypertension

(2021) Julie Rodor et al.   CARDIOVASCULAR RESEARCH

Single‐cell transcriptome analysis reveals defective decidua stromal niche attributes to recurrent spontaneous abortion

(2021) Lili Du et al.   CELL PROLIFERATION

De novo generation of macrophage from placenta-derived hemogenic endothelium

(2021) Guixian Liang et al.   DEVELOPMENTAL CELL

Single-cell RNA-seq revealed diverse cell types in the mouse placenta at mid-gestation

(2021) Xiaobo Zhou et al.   EXPERIMENTAL CELL RESEARCH

Identification of Intercellular Crosstalk between Decidual Cells and Niche Cells in Mice

(2021) Jia-Peng He et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The triumphs and limitations of computational methods for scRNA-seq

(2021) Peter V. Kharchenko   NATURE METHODS

The Immune Atlas of Human Deciduas With Unexplained Recurrent Pregnancy Loss

(2021) Pengfei Chen et al.   Frontiers in Immunology

Dissecting human trophoblast cell transcriptional heterogeneity in preeclampsia using single‐cell RNA sequencing

(2021) Tao Zhang et al.   Molecular Genetics & Genomic Medicine

COVID‐19 and vertical transmission: assessing the expression of ACE2/TMPRSS2 in the human fetus and placenta to assess the risk of SARS‐CoV‐2 infection

(2021) MA Beesley et al.   BJOG-AN INTERNATIONAL JOURNAL OF OBSTETRICS AND GYNAECOLOGY

Transcription factor SOX4 facilitates BMP2‐regulated gene expression during invasive trophoblast differentiation

(2021) Yuyin Yi et al.   FASEB JOURNAL

Maternal Monocytes Respond to Cell-Free Fetal DNA and Initiate Key Processes of Human Parturition

(2021) Nazanin Yeganeh Kazemi et al.   JOURNAL OF IMMUNOLOGY

‘Fetal side’ of the placenta: anatomical mis-annotation of carbon particle ‘transfer’ across the human placenta

(2021) Beth Holder et al.   Nature Communications

Macrophages exert homeostatic actions in pregnancy to protect against preterm birth and fetal inflammatory injury

(2021) Nardhy Gomez-Lopez et al.   JCI Insight

Deciphering the Intercellular Communication Network of Peripartum Decidua that Orchestrates Delivery

(2021) Jingrui Huang et al.   Frontiers in Cell and Developmental Biology

Prediction of Non-canonical Routes for SARS-CoV-2 Infection in Human Placenta Cells

(2021) Flávia Bessi Constantino et al.   Frontiers in Molecular Biosciences

MAIT Cells in Health and Disease

(2020) Nicholas M. Provine et al.   Annual Review of Immunology

Amniotic fluid cell-free transcriptome: a glimpse into fetal development and placental cellular dynamics during normal pregnancy

(2020) Adi L. Tarca et al.   BMC Medical Genomics

CellPhoneDB: inferring cell–cell communication from combined expression of multi-subunit ligand–receptor complexes

(2020) Mirjana Efremova et al.   Nature Protocols

Structural basis for RNA replication by the SARS-CoV-2 polymerase

(2020) Quan Wang et al.   CELL

SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor

(2020) Markus Hoffmann et al.   CELL

Maternal and fetal T cells in term pregnancy and preterm labor

(2020) Derek Miller et al.   Cellular & Molecular Immunology

Structural basis of receptor recognition by SARS-CoV-2

(2020) Jian Shang et al.   NATURE

SingleCellSignalR: inference of intercellular networks from single-cell transcriptomics

(2020) Simon Cabello-Aguilar et al.   NUCLEIC ACIDS RESEARCH

The SARS-CoV-2 receptor ACE2 expression of maternal-fetal interface and fetal organs by single-cell transcriptome study

(2020) Mengmeng Li et al.   PLoS One

Sexually dimorphic crosstalk at the maternal-fetal interface

(2020) Tianyanxin Sun et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Regulation of Uterine Spiral Artery Remodeling: a Review

(2020) Eugene D. Albrecht et al.   Reproductive Sciences

Regulatory T Cells Play a Role in a Subset of Idiopathic Preterm Labor/Birth and Adverse Neonatal Outcomes

(2020) Nardhy Gomez-Lopez et al.   Cell Reports

Does the human placenta express the canonical cell entry mediators for SARS-CoV-2?

(2020) Roger Pique-Regi et al.   eLife

Failure of physiological transformation and spiral artery atherosis: their roles in preeclampsia

(2020) Anne Cathrine Staff et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Single-cell transcriptomic atlas of the human endometrium during the menstrual cycle

(2020) Wanxin Wang et al.   NATURE MEDICINE

Single Cell Transcriptome Research in Human Placenta

(2020) Hui Li et al.   REPRODUCTION

Single‐cell RNA expression profiling of ACE2 and TMPRSS2 in the human trophectoderm and placenta

(2020) D. Cui et al.   ULTRASOUND IN OBSTETRICS & GYNECOLOGY

Single cell transcriptomics comes of age

(2020) Sarah Aldridge et al.   Nature Communications

Visualizing Dynamic Changes at the Maternal-Fetal Interface Throughout Human Pregnancy by Mass Cytometry

(2020) Anita van der Zwan et al.   Frontiers in Immunology

Human Tregs at the materno-fetal interface show site-specific adaptation reminiscent of tumor Tregs

(2020) Judith Wienke et al.   JCI Insight

Single-Cell RNA-seq Identifies Cell Subsets in Human Placenta That Highly Expresses Factors Driving Pathogenesis of SARS-CoV-2

(2020) Nancy Ashary et al.   Frontiers in Cell and Developmental Biology

Systemic transcriptome comparison between early‐ And late‐onset pre‐eclampsia shows distinct pathology and novel biomarkers

(2020) Fang Guo et al.   CELL PROLIFERATION

Single‐cell RNA sequencing reveals heterogeneity and differential expression of decidual tissues during the peripartum period

(2020) Jingrui Huang et al.   CELL PROLIFERATION

Reproductive medicine, as seen through single-cell glasses

(2020) Felipe Vilella et al.   FERTILITY AND STERILITY

Targeted expression profiling by RNA-Seq improves detection of cellular dynamics during pregnancy and identifies a role for T cells in term parturition

(2019) Adi L. Tarca et al.   Scientific Reports

Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone

(2019) Marcia Arenas-Hernandez et al.   JOURNAL OF IMMUNOLOGY

Are B Cells Altered in the Decidua of Women with Preterm or Term Labor?

(2019) Yaozhu Leng et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

A comparison of single-cell trajectory inference methods

(2019) Wouter Saelens et al.   NATURE BIOTECHNOLOGY

Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor

(2019) Rebecca Slutsky et al.   Journal of Immunology Research

Single-Cell RNA-Seq Technologies and Related Computational Data Analysis

(2019) Geng Chen et al.   Frontiers in Genetics

Placental Bed Research: 1. The Placental Bed. From Spiral Arteries Remodeling to the Great Obstetrical Syndromes

(2019) Ivo Brosens et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Single-cell technologies in reproductive immunology

(2019) Jessica Vazquez et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Comprehensive Integration of Single-Cell Data

(2019) Tim Stuart et al.   CELL

Pre-eclampsia: pathophysiology and clinical implications

(2019) Graham J Burton et al.   BMJ-British Medical Journal

Recruitment of MAIT Cells to the Intervillous Space of the Placenta by Placenta-Derived Chemokines

(2019) Martin Solders et al.   Frontiers in Immunology

Dynamic Function and Composition Changes of Immune Cells During Normal and Pathological Pregnancy at the Maternal-Fetal Interface

(2019) Fenglian Yang et al.   Frontiers in Immunology

Endovascular trophoblast and spiral artery remodeling

(2019) Yukiyasu Sato   MOLECULAR AND CELLULAR ENDOCRINOLOGY

NicheNet: modeling intercellular communication by linking ligands to target genes

(2019) Robin Browaeys et al.   NATURE METHODS

Single cell transcriptional signatures of the human placenta in term and preterm parturition

(2019) Roger Pique-Regi et al.   eLife

Human Chorionic Gonadotropin-Mediated Immune Responses That Facilitate Embryo Implantation and Placentation

(2019) Anne Schumacher et al.   Frontiers in Immunology

The Cellular Transcriptome in the Maternal Circulation During Normal Pregnancy: A Longitudinal Study

(2019) Nardhy Gomez-Lopez et al.   Frontiers in Immunology

Slingshot: cell lineage and pseudotime inference for single-cell transcriptomics

(2018) Kelly Street et al.   BMC GENOMICS

Choriodecidual leukocytes display a unique gene expression signature in spontaneous labor at term

(2018) Marcia Arenas-Hernandez et al.   GENES AND IMMUNITY

HLA-DR is aberrantly expressed at feto-maternal interface in pre-eclampsia

(2018) C. Tersigni et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Exploring the single-cell RNA-seq analysis landscape with the scRNA-tools database

(2018) Luke Zappia et al.   PLoS Computational Biology

Single-cell RNA-seq reveals the diversity of trophoblast subtypes and patterns of differentiation in the human placenta 

(2018) Yawei Liu et al.   CELL RESEARCH

High-Resolution Genetic and Phenotypic Analysis of KIR2DL1 Alleles and Their Association with Pre-Eclampsia

(2018) Oisín Huhn et al.   JOURNAL OF IMMUNOLOGY

The combination of maternal KIR-B and fetal HLA-C2 is associated with decidua basalis acute atherosis in pregnancies with preeclampsia

(2018) Guro M. Johnsen et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Regulatory T cells in embryo implantation and the immune response to pregnancy

(2018) Sarah A. Robertson et al.   JOURNAL OF CLINICAL INVESTIGATION

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Innate Lymphoid Cells in the Maternal and Fetal Compartments

(2018) Derek Miller et al.   Frontiers in Immunology

A Single-Cell Sequencing Guide for Immunologists

(2018) Peter See et al.   Frontiers in Immunology

A single-cell survey of the human first-trimester placenta and decidua

(2018) Hemant Suryawanshi et al.   Science Advances

Single-cell transcriptomics of the human placenta: inferring the cell communication network of the maternal-fetal interface

(2017) Mihaela Pavličev et al.   GENOME RESEARCH

The role of KIR and HLA interactions in pregnancy complications

(2017) Francesco Colucci   IMMUNOGENETICS

Multiplexed droplet single-cell RNA-sequencing using natural genetic variation

(2017) Hyun Min Kang et al.   NATURE BIOTECHNOLOGY

Embryo implantation evolved from an ancestral inflammatory attachment reaction

(2017) Oliver W. Griffith et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Integrative single-cell and cell-free plasma RNA transcriptomics elucidates placental cellular dynamics

(2017) Jason C. H. Tsang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Massively parallel digital transcriptional profiling of single cells

(2017) Grace X. Y. Zheng et al.   Nature Communications

MAIT cells accumulate in placental intervillous space and display a highly cytotoxic phenotype upon bacterial stimulation

(2017) Martin Solders et al.   Scientific Reports

Fine-Tuned and Cell-Cycle-Restricted Expression of Fusogenic Protein Syncytin-2 Maintains Functional Placental Syncytia

(2017) Xiaoyin Lu et al.   Cell Reports

Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis

(2017) Martin Solders et al.   Stem Cells International

Changes in T Cell and Dendritic Cell Phenotype from Mid to Late Pregnancy Are Indicative of a Shift from Immune Tolerance to Immune Activation

(2017) Nishel Mohan Shah et al.   Frontiers in Immunology

Single-cell transcriptome analysis of endometrial tissue

(2016) K. Krjutškov et al.   HUMAN REPRODUCTION

Invariant NKT Cell Activation Induces Late Preterm Birth That Is Attenuated by Rosiglitazone

(2016) Derek St. Louis et al.   JOURNAL OF IMMUNOLOGY

An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment

(2016) Yi Xu et al.   JOURNAL OF IMMUNOLOGY

Immune Regulation in Pregnancy

(2016) Elizabeth A. Bonney   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Notch1 controls development of the extravillous trophoblast lineage in the human placenta

(2016) Sandra Haider et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The decidua—the maternal bed embracing the embryo—maintains the pregnancy

(2016) Mayumi Mori et al.   Seminars in Immunopathology

Single-cell RNA-seq reveals cell type-specific transcriptional signatures at the maternal–foetal interface during pregnancy

(2016) Andrew C. Nelson et al.   Nature Communications

The placenta is the center of the chronic disease universe

(2015) Kent L. Thornburg et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

What is the placenta?

(2015) Graham J. Burton et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Droplet Barcoding for Single-Cell Transcriptomics Applied to Embryonic Stem Cells

(2015) Allon M. Klein et al.   CELL

Highly Parallel Genome-wide Expression Profiling of Individual Cells Using Nanoliter Droplets

(2015) Evan Z. Macosko et al.   CELL

The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages

(2015) Judit Svensson-Arvelund et al.   JOURNAL OF IMMUNOLOGY

Paternal antigen-specific proliferating regulatory T cells are increased in uterine-draining lymph nodes just before implantation and in pregnant uterus just after implantation by seminal plasma-priming in allogeneic mouse pregnancy

(2015) Tomoko Shima et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Molecular Cross-Talk at the Feto–Maternal Interface

(2015) Gendie E. Lash   Cold Spring Harbor Perspectives in Medicine

Immune cells in term and preterm labor

(2014) Nardhy Gomez-Lopez et al.   Cellular & Molecular Immunology

Regulatory T Cells: New Keys for Further Unlocking the Enigma of Fetal Tolerance and Pregnancy Complications

(2014) T. T. Jiang et al.   JOURNAL OF IMMUNOLOGY

Pre-eclampsia part 1: current understanding of its pathophysiology

(2014) Tinnakorn Chaiworapongsa et al.   Nature Reviews Nephrology

Dynamic changes in maternal decidual leukocyte populations from first to second trimester gestation

(2014) M. Kwan et al.   PLACENTA

Preterm labor: One syndrome, many causes

(2014) R. Romero et al.   SCIENCE

Massively Parallel Single-Cell RNA-Seq for Marker-Free Decomposition of Tissues into Cell Types

(2014) D. A. Jaitin et al.   SCIENCE

OMICtools: an informative directory for multi-omic data analysis

(2014) V. J. Henry et al.   Database-The Journal of Biological Databases and Curation

Evidence for a Role for the Adaptive Immune Response in Human Term Parturition

(2013) Nardhy Gomez-Lopez et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Pathways of Antigen Processing

(2013) Janice S. Blum et al.   Annual Review of Immunology

Immunology of the Maternal-Fetal Interface

(2013) Adrian Erlebacher   Annual Review of Immunology

Infiltration of myeloid cells into decidua is a critical early event in the labour cascade and post-partum uterine remodelling

(2013) Oksana Shynlova et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Macrophages regulate corpus luteum development during embryo implantation in mice

(2013) Alison S. Care et al.   JOURNAL OF CLINICAL INVESTIGATION

Self-Specific Memory Regulatory T Cells Protect Embryos at Implantation in Mice

(2013) T. Chen et al.   JOURNAL OF IMMUNOLOGY

Uterine natural killer cells pace early development of mouse decidua basalis

(2013) A. P. Hofmann et al.   MOLECULAR HUMAN REPRODUCTION

Fetomaternal immune cross-talk and its consequences for maternal and offspring's health

(2013) Petra C Arck et al.   NATURE MEDICINE

Review: Cell-free fetal DNA in the maternal circulation as an indication of placental health and disease

(2013) E.S. Taglauer et al.   PLACENTA

Identification of Chemokines Associated with the Recruitment of Decidual Leukocytes in Human Labour: Potential Novel Targets for Preterm Labour

(2013) Sarah A. Hamilton et al.   PLoS One

Extrathymic Generation of Regulatory T Cells in Placental Mammals Mitigates Maternal-Fetal Conflict

(2012) Robert M. Samstein et al.   CELL

Pregnancy imprints regulatory memory that sustains anergy to fetal antigen

(2012) Jared H. Rowe et al.   NATURE

Full-length mRNA-Seq from single-cell levels of RNA and individual circulating tumor cells

(2012) Daniel Ramsköld et al.   NATURE BIOTECHNOLOGY

Mechanisms of implantation: strategies for successful pregnancy

(2012) Jeeyeon Cha et al.   NATURE MEDICINE

clusterProfiler: an R Package for Comparing Biological Themes Among Gene Clusters

(2012) Guangchuang Yu et al.   OMICS-A JOURNAL OF INTEGRATIVE BIOLOGY

Villous trophoblast apoptosis is elevated and restricted to cytotrophoblasts in pregnancies complicated by preeclampsia, IUGR, or preeclampsia with IUGR

(2012) M.S. Longtine et al.   PLACENTA

CEL-Seq: Single-Cell RNA-Seq by Multiplexed Linear Amplification

(2012) Tamar Hashimshony et al.   Cell Reports

The definition of severe and early-onset preeclampsia. Statements from the International Society for the Study of Hypertension in Pregnancy (ISSHP)

(2012) Andrea L. Tranquilli et al.   Pregnancy Hypertension-An International Journal of Womens Cardiovascular Health

Choriodecidua and amnion exhibit selective leukocyte chemotaxis during term human labor

(2011) Nardhy Gomez-Lopez et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Specific inflammatory microenvironments in the zones of the fetal membranes at term delivery

(2011) Nardhy Gomez-Lopez et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Deep placentation

(2011) R. Pijnenborg et al.   BEST PRACTICE & RESEARCH CLINICAL OBSTETRICS & GYNAECOLOGY

Macrophages Infiltrate the Human and Rat Decidua During Term and Preterm Labor: Evidence That Decidual Inflammation Precedes Labor1

(2011) Sarah Hamilton et al.   BIOLOGY OF REPRODUCTION

Maternal activating KIRs protect against human reproductive failure mediated by fetal HLA-C2

(2010) Susan E. Hiby et al.   JOURNAL OF CLINICAL INVESTIGATION

Invasion of the leukocytes into the fetal-maternal interface during pregnancy

(2010) Nardhy Gomez-Lopez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Regulatory T cells are necessary for implantation and maintenance of early pregnancy but not late pregnancy in allogeneic mice

(2010) Tomoko Shima et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Pregnancy induces a fetal antigen-specific maternal T regulatory cell response that contributes to tolerance

(2010) D. A. Kahn et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Fetal membranes exhibit selective leukocyte chemotaxic activity during human labor

(2009) N. Gomez-Lopez et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Activating T regulatory cells for tolerance in early pregnancy — the contribution of seminal fluid

(2009) Sarah A. Robertson et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

mRNA-Seq whole-transcriptome analysis of a single cell

(2009) Fuchou Tang et al.   NATURE METHODS

Comparison of Macrophage Phenotype Between Decidua Basalis and Decidua Parietalis by Flow Cytometry

(2008) U. Repnik et al.   PLACENTA