Review
Immunology
Hong Liu, Jie Zheng, Aihua Liao
Summary: The immune microenvironment at the maternal-fetal interface, regulated by the trophoblast and maternal-derived cells, plays a crucial role in early pregnancy. Dysfunctions in these cells can lead to pregnancy complications. RNA methylation, particularly N6-methyladenosine (m6A), appears to be an important factor in embryogenesis and immune response. However, the function of m6A modifications at the maternal-fetal interface is still poorly understood. Therefore, exploring the potential value of m6A modifications in early pregnancy is essential for identifying novel therapeutic targets.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Jinli Ding, Yan Zhang, Xiaopeng Cai, Lianghui Diao, Chaogang Yang, Jing Yang
Summary: The immune tolerance microenvironment at the maternal-fetal interface is crucial for pregnancy establishment and maintenance. Macrophages and trophoblasts play essential roles in this process and their interaction influences trophoblast behaviors and the state of the maternal-fetal immune microenvironment.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Immunology
Baimei Zhuang, Jin Shang, Yuanqing Yao
Summary: HLA-G plays a crucial role in maternal-fetal immune tolerance, maintaining immune homeostasis and considered a key factor for successful pregnancies. Understanding the characteristics of HLA-G is important for treating pathological pregnancies and other immune-related diseases.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Reproductive Biology
Jisoo Han, Inkyu Yoo, Soohyung Lee, Yugyeong Cheon, Cheol-Heui Yun, Hakhyun Ka
Summary: The expression of IL10 and IL12 in the endometrium of pigs shows a specific pattern during pregnancy. IL10 may provide anti-inflammatory conditions for maternal immune tolerance.
BIOLOGY OF REPRODUCTION
(2022)
Review
Immunology
Bo Pang, Cong Hu, Huimin Li, Xinyu Nie, Keqi Wang, Chen Zhou, Huanfa Yi
Summary: Myeloid-derived suppressor cells (MDSCs) are immunosuppressive cells derived from myeloid progenitors, with well-known roles in tumors and autoimmune diseases. Their role in reproduction has gained increasing attention, particularly their association with recurrent implantation failure, pathological pregnancy, and neonatal health. This review focuses on the interaction between MDSCs and other cell types during the reproductive process, and discusses molecular mechanisms that could be targeted for therapeutic purposes. It aims to encourage further research in maternal-fetal interface immunity to identify pathways driving MDSCs accumulation and effectively target their role in promoting embryo implantation, reducing pathological pregnancy, and improving neonatal health.
FRONTIERS IN IMMUNOLOGY
(2023)
Review
Immunology
Dongyong Yang, Fangfang Dai, Mengqin Yuan, Yajing Zheng, Shiyi Liu, Zhimin Deng, Wei Tan, Liping Chen, Qianjie Zhang, Xiaomiao Zhao, Yanxiang Cheng
Summary: TGF-beta 1 plays a crucial role in regulating fetal-maternal immune tolerance during pregnancy by inducing regulatory T cells and balancing macrophages, but dysregulation of TGF-beta 1 may be associated with recurrent spontaneous abortion and preeclampsia.
FRONTIERS IN IMMUNOLOGY
(2021)
Review
Biochemistry & Molecular Biology
Caitlyn E. Bowman, Zoltan Arany, Michael J. Wolfgang
Summary: Pregnancy is a nutritionally sensitive stage, and communication between mother and fetus through metabolites is crucial. Studies on humans and animals provide insights into the metabolic adaptations of the fetus, placenta, and mother during pregnancy. Understanding the dynamic nature of maternal-fetal metabolic communication may lead to the discovery of new biomarkers and therapeutic targets for metabolic disorders in pregnancy.
CELLULAR AND MOLECULAR LIFE SCIENCES
(2021)
Review
Immunology
Yiran Yang, Wanning Wang, Jing Weng, Huifang Li, Yanmin Ma, Lingyan Liu, Wei Ma
Summary: HLA class Ib molecules play an important role in maternal-fetal immune tolerance. While early studies focused on the mechanism of HLA-G, recent research has delved into the mechanisms of HLA-E and HLA-F as well. Trophoblast cells express HLA class Ib molecules to protect the fetus from maternal immune cell attack and shift the Th1/Th2 balance towards a Th2 bias.
FRONTIERS IN IMMUNOLOGY
(2022)
Review
Immunology
Wu Zhu, Yue-qiu Tan, Fu-yan Wang
Summary: The establishment and maintenance of pregnancy involve maternal-fetal immune tolerance, and immune aberrations may lead to recurrent spontaneous abortion (RSA). Studies have shown that the inhibitory checkpoint protein Tim-3 plays a critical role in maintaining immune tolerance, and its abnormal expression may be associated with RSA.
CLINICAL IMMUNOLOGY
(2022)
Article
Immunology
Gry Persson, Christophe Picard, Gregory Marin, Cecilie Isgaard, Christina Seefeldt Staehr, Nicolas Molinari, Jacques Chiaroni, Morten Lebech, Thomas Vauvert F. Hviid, Julie Di Cristofaro
Summary: This study identified maternal HLA class Ib genetic factors associated with anti-HLA allo-immunization during pregnancy, with HLA-E*01:06, HLA-F*01:03, and HLA-G UTR4 being significant factors. These findings highlight the importance of certain HLA class Ib alleles in reducing the risk for allo-immunization in pregnancy and suggest the need for further research on their roles.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Immunology
Xiaoming Zhang, Laura Kracht, Antonio M. Lerario, Marissa L. Dubbelaar, Nieske Brouwer, Evelyn M. Wesseling, Erik W. G. M. Boddeke, Bart J. L. Eggen, Susanne M. Kooistra
Summary: This study provides insight into epigenetic profiles and transcription factor networks associated with transcriptional signatures of tolerized and trained microglia in vivo, leading to a better understanding of innate immune memory of microglia.
JOURNAL OF NEUROINFLAMMATION
(2022)
Review
Cell Biology
Mojgan Esparvarinha, Sahar Madadi, Lida Aslanian-Kalkhoran, Hamid Nickho, Sanam Dolati, Helen Pia, Shahla Danaii, Simin Taghavi, Mehdi Yousefi
Summary: Pregnancy problems such as recurrent pregnancy loss, repeated implantation failure, and pre-eclampsia are common in reproductive ages and can be caused by genetic, immunological, and environmental factors, as well as infections. By identifying and eliminating the causes of abortion, the chances of successful pregnancy can be increased, but for cases with unknown causes, an imbalance in immune cell pattern may be present, leading to failed pregnancy. Therefore, treatment focuses on increasing tolerance rather than suppressing the maternal immune system.
CELL BIOLOGY INTERNATIONAL
(2023)
Article
Cell Biology
Marcia Arenas-Hernandez, Roberto Romero, Meyer Gershater, Li Tao, Yi Xu, Valeria Garcia-Flores, Errile Pusod, Derek Miller, Jose Galaz, Kenichiro Motomura, George Schwenkel, Robert Para, Nardhy Gomez-Lopez
Summary: The study reveals novel interactions between specific maternal circulating innate immune cells and fetal antigens, shedding light on the systemic mechanisms of maternal-fetal crosstalk.
JOURNAL OF LEUKOCYTE BIOLOGY
(2022)
Article
Immunology
Di Zhang, Yikong Lin, Yunyun Li, Dong Zhao, Meirong Du
Summary: The study revealed that umbilical MSCs can induce expansion of decidual Foxp3( )(+)CD4(+) T cells with increased production of IL-10 and TGF-beta, reinforcing the immune suppressive functions of decidual Tregs. MSCs also enhanced the capacity of dTregs to suppress inflammatory responses, resulting in improved outcomes in mouse abortion models. This suggests a potential new therapeutic approach for recurrent miscarriage using MSCs and Tregs.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Public, Environmental & Occupational Health
Mercy PrabhuDas, Jeanna M. Piper, Patrick Jean-Philippe, Marrah Lachowicz-Scroggins
Summary: Approximately 12.5% of maternal deaths in the United States are caused by infectious diseases. The delicate immunological balance achieved during healthy pregnancies, where the mother's immune system tolerates the fetus but remains competent against infectious agents, can lead to increased susceptibility to infections during pregnancy. The disruption of this immunological homeostasis by infectious pathogens can result in detrimental health outcomes for both the mother and fetus.
JOURNAL OF WOMENS HEALTH
(2021)
