Exhausted and Senescent T Cells at the Maternal-Fetal Interface in Preterm and Term Labor

Effector and Activated T Cells Induce Preterm Labor and Birth That Is Prevented by Treatment with Progesterone

(2019) Marcia Arenas-Hernandez et al.   JOURNAL OF IMMUNOLOGY

Are B Cells Altered in the Decidua of Women with Preterm or Term Labor?

(2019) Yaozhu Leng et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Innate lymphoid cells at the human maternal-fetal interface in spontaneous preterm labor

(2018) Yi Xu et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Oxidative stress-induced TGF-beta/TAB1-mediated p38MAPK activation in human amnion epithelial cells†

(2018) Lauren Richardson et al.   BIOLOGY OF REPRODUCTION

Intrauterine inflammatory activation, functional progesterone withdrawal, and the timing of term and preterm birth

(2018) Jeffrey A. Keelan   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Alloreactive fetal T cells promote uterine contractility in preterm labor via IFN-γ and TNF-α

(2018) Michela Frascoli et al.   Science Translational Medicine

Inflammasome activation during spontaneous preterm labor with intra-amniotic infection or sterile intra-amniotic inflammation

(2018) Nardhy Gomez-Lopez et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

The frequency and type of placental histologic lesions in term pregnancies with normal outcome

(2018) Roberto Romero et al.   JOURNAL OF PERINATAL MEDICINE

Single-cell reconstruction of the early maternal–fetal interface in humans

(2018) Roser Vento-Tormo et al.   NATURE

Innate Lymphoid Cells in the Maternal and Fetal Compartments

(2018) Derek Miller et al.   Frontiers in Immunology

T-Cell Exhaustion in Chronic Infections: Reversing the State of Exhaustion and Reinvigorating Optimal Protective Immune Responses

(2018) Alireza Saeidi et al.   Frontiers in Immunology

Markers of T Cell Senescence in Humans

(2017) Weili Xu et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Decidual T Cells Exhibit a Highly Differentiated Phenotype and Demonstrate Potential Fetal Specificity and a Strong Transcriptional Response to IFN

(2017) Richard M. Powell et al.   JOURNAL OF IMMUNOLOGY

Tim-3 and PD-1 regulate CD8+ T cell function to maintain early pregnancy in mice

(2017) Yuan-Yuan XU et al.   JOURNAL OF REPRODUCTION AND DEVELOPMENT

Alternative theories: Pregnancy and immune tolerance

(2017) Elizabeth A. Bonney   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Mixed signature of activation and dysfunction allows human decidual CD8+T cells to provide both tolerance and immunity

(2017) Anita van der Zwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Maternal Adaptive Immune Cells in Decidua Parietalis Display a More Activated and Coinhibitory Phenotype Compared to Decidua Basalis

(2017) Martin Solders et al.   Stem Cells International

Onset of human preterm and term birth is related to unique inflammatory transcriptome profiles at the maternal fetal interface

(2017) Radek Bukowski et al.   PeerJ

Uterine Natural Killer Cells: Functional Distinctions and Influence on Pregnancy in Humans and Mice

(2017) Louise M. Gaynor et al.   Frontiers in Immunology

Preterm neonatal morbidity and mortality by gestational age: a contemporary cohort

(2016) Tracy A. Manuck et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

In vivo T-cell activation by a monoclonal αCD3ε antibody induces preterm labor and birth

(2016) Nardhy Gomez-Lopez et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Reversing T-cell Dysfunction and Exhaustion in Cancer

(2016) H. M. Zarour   CLINICAL CANCER RESEARCH

Programmed cell death-1 (PD-1) and T-cell immunoglobulin mucin-3 (Tim-3) regulate CD4+T cells to induce Type 2 helper T cell (Th2) bias at the maternal–fetal interface

(2016) SongCun Wang et al.   HUMAN REPRODUCTION

Lag-3, Tim-3, and TIGIT: Co-inhibitory Receptors with Specialized Functions in Immune Regulation

(2016) Ana C. Anderson et al.   IMMUNITY

p53 coordinates decidual sestrin 2/AMPK/mTORC1 signaling to govern parturition timing

(2016) Wenbo Deng et al.   JOURNAL OF CLINICAL INVESTIGATION

An M1-like Macrophage Polarization in Decidual Tissue during Spontaneous Preterm Labor That Is Attenuated by Rosiglitazone Treatment

(2016) Yi Xu et al.   JOURNAL OF IMMUNOLOGY

Tim-3: Expression on immune cells and roles at the maternal-fetal interface

(2016) Xiao-Hui Hu et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Group 3 innate lymphoid cells regulate neutrophil migration and function in human decidua

(2016) D Croxatto et al.   Mucosal Immunology

Immune Regulation in Pregnancy

(2016) Elizabeth A. Bonney   OBSTETRICS AND GYNECOLOGY CLINICS OF NORTH AMERICA

Neutrophils induce proangiogenic T cells with a regulatory phenotype in pregnancy

(2016) Suchita Nadkarni et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The decidua—the maternal bed embracing the embryo—maintains the pregnancy

(2016) Mayumi Mori et al.   Seminars in Immunopathology

Senescence of T Lymphocytes: Implications for Enhancing Human Immunity

(2016) Arne N. Akbar et al.   TRENDS IN IMMUNOLOGY

TGFβ-dependent expression of PD-1 and PD-L1 controls CD8+ T cell anergy in transplant tolerance

(2016) Marije Baas et al.   eLife

Effector, Memory, and Dysfunctional CD8+T Cell Fates in the Antitumor Immune Response

(2016) John Reiser et al.   Journal of Immunology Research

Unique Eomes+ NK Cell Subsets Are Present in Uterus and Decidua During Early Pregnancy

(2016) Elisa Montaldo et al.   Frontiers in Immunology

Acute chorioamnionitis and funisitis: definition, pathologic features, and clinical significance

(2015) Chong Jai Kim et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Classification of placental lesions

(2015) Raymond W. Redline   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Immune Checkpoint Blockade: A Common Denominator Approach to Cancer Therapy

(2015) Suzanne L. Topalian et al.   CANCER CELL

An imbalance between innate and adaptive immune cells at the maternal–fetal interface occurs prior to endotoxin-induced preterm birth

(2015) Marcia Arenas-Hernandez et al.   Cellular & Molecular Immunology

Manipulating IL-10 signalling blockade for better immunotherapy

(2015) Guoying Ni et al.   CELLULAR IMMUNOLOGY

T-cell exhaustion in allograft rejection and tolerance

(2015) Edward B. Thorp et al.   Current Opinion in Organ Transplantation

Interleukin-6 controls uterine Th9 cells and CD8+ T regulatory cells to accelerate parturition in mice

(2015) Nardhy Gomez-Lopez et al.   IMMUNOLOGY AND CELL BIOLOGY

Composition, Development, and Function of Uterine Innate Lymphoid Cells

(2015) Jean-Marc Doisne et al.   JOURNAL OF IMMUNOLOGY

The Human Fetal Placenta Promotes Tolerance against the Semiallogeneic Fetus by Inducing Regulatory T Cells and Homeostatic M2 Macrophages

(2015) Judit Svensson-Arvelund et al.   JOURNAL OF IMMUNOLOGY

Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis

(2015) Li Liu et al.   LANCET

Immune mechanisms at the maternal-fetal interface: perspectives and challenges

(2015) Mercy PrabhuDas et al.   NATURE IMMUNOLOGY

Cell-Free Fetal DNA, Telomeres, and the Spontaneous Onset of Parturition

(2015) Mark Phillippe   Reproductive Sciences

PD-1 and Tim-3 pathways are associated with regulatory CD8+ T-cell function in decidua and maintenance of normal pregnancy

(2015) S-C Wang et al.   Cell Death & Disease

T-cell exhaustion in the tumor microenvironment

(2015) Y Jiang et al.   Cell Death & Disease

Isolation of Leukocytes from the Human Maternal-fetal Interface

(2015) Yi Xu et al.   Jove-Journal of Visualized Experiments

Prevalence and Clinical Significance of Sterile Intra-amniotic Inflammation in Patients with Preterm Labor and Intact Membranes

(2014) Roberto Romero et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Immune cells in term and preterm labor

(2014) Nardhy Gomez-Lopez et al.   Cellular & Molecular Immunology

p38 signaling inhibits mTORC1-independent autophagy in senescent human CD8+ T cells

(2014) Sian M. Henson et al.   JOURNAL OF CLINICAL INVESTIGATION

Interplay between regulatory T cells and PD-1 in modulating T cell exhaustion and viral control during chronic LCMV infection

(2014) Pablo Penaloza-MacMaster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Telomerase-Based Pharmacologic Enhancement of Antiviral Function of Human CD8+ T Lymphocytes

(2014) S. R. Fauce et al.   JOURNAL OF IMMUNOLOGY

Identification of a Novel Neutrophil Population: Proangiogenic Granulocytes in Second-Trimester Human Decidua

(2014) Hagai Amsalem et al.   JOURNAL OF IMMUNOLOGY

Tissue-Resident Exhausted Effector Memory CD8+ T Cells Accumulate in the Retina during Chronic Experimental Autoimmune Uveoretinitis

(2014) J. Boldison et al.   JOURNAL OF IMMUNOLOGY

Sterile and microbial-associated intra-amniotic inflammation in preterm prelabor rupture of membranes

(2014) Roberto Romero et al.   Journal of Maternal-Fetal & Neonatal Medicine

Identification of diverse innate lymphoid cells in human decidua

(2014) P Vacca et al.   Mucosal Immunology

The kinase p38 activated by the metabolic regulator AMPK and scaffold TAB1 drives the senescence of human T cells

(2014) Alessio Lanna et al.   NATURE IMMUNOLOGY

Impaired selectin-dependent leukocyte recruitment induces T-cell exhaustion and prevents chronic allograft vasculopathy and rejection

(2014) B. Sarraj et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Preterm labor: One syndrome, many causes

(2014) R. Romero et al.   SCIENCE

B Cells: The Old New Players in Reproductive Immunology

(2014) Franziska Fettke et al.   Frontiers in Immunology

Preterm Birth, Intrauterine Infection, and Fetal Inflammation

(2014) Matthew W. Kemp   Frontiers in Immunology

Adaptive Immune Responses During Pregnancy

(2013) Ana Claudia Zenclussen   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Evidence for a Role for the Adaptive Immune Response in Human Term Parturition

(2013) Nardhy Gomez-Lopez et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Immunology of the Maternal-Fetal Interface

(2013) Adrian Erlebacher   Annual Review of Immunology

Regulatory B10 Cells Restore Pregnancy Tolerance in a Mouse Model1

(2013) Federico Jensen et al.   BIOLOGY OF REPRODUCTION

PD-1 Regulates T Cell Proliferation in a Tissue and Subset-Specific Manner During Normal Mouse Pregnancy

(2013) Michelle T. Shepard et al.   IMMUNOLOGICAL INVESTIGATIONS

Human decidual macrophages suppress IFN-γ production by T cells through costimulatory B7-H1:PD-1 signaling in early pregnancy

(2013) Seisuke Sayama et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Identification of Chemokines Associated with the Recruitment of Decidual Leukocytes in Human Labour: Potential Novel Targets for Preterm Labour

(2013) Sarah A. Hamilton et al.   PLoS One

Tolerance and exhaustion: defining mechanisms of T cell dysfunction

(2013) Andrea Schietinger et al.   TRENDS IN IMMUNOLOGY

Methylome of Fetal and Maternal Monocytes and Macrophages at the Feto-Maternal Interface

(2012) Sun Young Kim et al.   AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY

T regulatory cells: regulating both term and preterm labor?

(2012) Nardhy Gomez-Lopez et al.   IMMUNOLOGY AND CELL BIOLOGY

National, regional, and worldwide estimates of preterm birth rates in the year 2010 with time trends since 1990 for selected countries: a systematic analysis and implications

(2012) Hannah Blencowe et al.   LANCET

Specific inflammatory microenvironments in the zones of the fetal membranes at term delivery

(2011) Nardhy Gomez-Lopez et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

Macrophages Infiltrate the Human and Rat Decidua During Term and Preterm Labor: Evidence That Decidual Inflammation Precedes Labor1

(2011) Sarah Hamilton et al.   BIOLOGY OF REPRODUCTION

The Molecular Mechanisms of Cervical Ripening Differ between Term and Preterm Birth

(2011) Roxane Holt et al.   ENDOCRINOLOGY

The effect of pregnancy on the uterine NK cell KIR repertoire

(2011) Victoria Male et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Two Unique Human Decidual Macrophage Populations

(2011) B. L. Houser et al.   JOURNAL OF IMMUNOLOGY

Reversible Senescence in Human CD4+CD45RA+CD27- Memory T Cells

(2011) D. Di Mitri et al.   JOURNAL OF IMMUNOLOGY

Macrophages at the Fetal-Maternal Interface Express Markers of Alternative Activation and Are Induced by M-CSF and IL-10

(2011) J. Svensson et al.   JOURNAL OF IMMUNOLOGY

T cell exhaustion

(2011) E John Wherry   NATURE IMMUNOLOGY

Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice

(2011) Y. Hirota et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the transcriptome of chorioamniotic membranes at the site of rupture in spontaneous labor at term

(2010) Chia-Ling Nhan-Chang et al.   AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY

The PD-1 pathway in tolerance and autoimmunity

(2010) Loise M. Francisco et al.   IMMUNOLOGICAL REVIEWS

Evidence that CD8 T-cell homeostasis and function remain intact during murine pregnancy

(2010) Michelle T. Norton et al.   IMMUNOLOGY

T-cell exhaustion: characteristics, causes and conversion

(2010) John S. Yi et al.   IMMUNOLOGY

Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice

(2010) Yasushi Hirota et al.   JOURNAL OF CLINICAL INVESTIGATION

Human Decidual Tissue Contains Differentiated CD8+ Effector-Memory T Cells with Unique Properties

(2010) T. Tilburgs et al.   JOURNAL OF IMMUNOLOGY

Invasion of the leukocytes into the fetal-maternal interface during pregnancy

(2010) Nardhy Gomez-Lopez et al.   JOURNAL OF LEUKOCYTE BIOLOGY

Preterm and Term Cervical Ripening in CD1 Mice (Mus musculus): Similar or Divergent Molecular Mechanisms?1

(2009) Juan M. Gonzalez et al.   BIOLOGY OF REPRODUCTION

Decidual CD8+CD28− T cells express CD103 but not perforin

(2009) Tamara Tilburgs et al.   HUMAN IMMUNOLOGY

Human decidual stromal cells suppress cytokine secretion by allogenic CD4+ T cells via PD-1 ligand interactions

(2009) T. Nagamatsu et al.   HUMAN REPRODUCTION

Expression of NK cell receptors on decidual T cells in human pregnancy

(2009) Tamara Tilburgs et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Fetal membranes exhibit selective leukocyte chemotaxic activity during human labor

(2009) N. Gomez-Lopez et al.   JOURNAL OF REPRODUCTIVE IMMUNOLOGY

Screening for Partial Conjunction Hypotheses

(2008) Yoav Benjamini et al.   BIOMETRICS

Coregulation of CD8+ T cell exhaustion by multiple inhibitory receptors during chronic viral infection

(2008) Shawn D Blackburn et al.   NATURE IMMUNOLOGY

Inflammation in Pregnancy: Its Roles in Reproductive Physiology, Obstetrical Complications, and Fetal Injury

(2008) Roberto Romero et al.   NUTRITION REVIEWS

Comparison of Macrophage Phenotype Between Decidua Basalis and Decidua Parietalis by Flow Cytometry

(2008) U. Repnik et al.   PLACENTA

Gene Expression Profiling of Human Decidual Macrophages: Evidence for Immunosuppressive Phenotype

(2008) Charlotte Gustafsson et al.   PLoS One

Exhaustive Differentiation of Alloreactive CD8+ T Cells: Critical for Determination of Graft Acceptance or Rejection

(2008) Ulrich Steger et al.   TRANSPLANTATION