Article
Immunology
Jessica Vazquez, Melina Chavarria, Deborah A. Chasman, Rene Welch Schwartz, Chanel T. Tyler, Gladys Lopez, Rachel C. Fisher, Irene M. Ong, Aleksandar K. Stanic
Summary: MAIT cells are present in the decidua basalis with a distinct gene expression profile compared to peripheral MAIT cells. Functionally, they are skewed towards IFN gamma and TNF alpha production upon stimulation, and may be involved in tissue-repair mechanisms at the maternal-fetal interface.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Review
Immunology
Daniel Pitz Jacobsen, Heidi Elisabeth Fjeldstad, Guro Mork Johnsen, Ingrid Knutsdotter Fosheim, Kjartan Moe, Patji Alnaes-Katjavivi, Ralf Dechend, Meryam Sugulle, Anne Cathrine Staff
Summary: Decidua basalis, the endometrium of pregnancy, plays a crucial role in maternal-fetal interface with acute atherosis being a common lesion, particularly in conditions like preeclampsia. The causal factors and effects of acute atherosis are still uncertain, potentially involving various pathways such as inflammation and arterial lesions. Further research is needed to determine if the presence of acute atherosis can identify women at higher risk for premature cardiovascular disease.
FRONTIERS IN IMMUNOLOGY
(2021)
Article
Cell Biology
Manijeh Khanmohammadi, Shayanti Mukherjee, Saeedeh Darzi, Kallyanashis Paul, Jerome A. Werkmeister, Fiona L. Cousins, Caroline E. Gargett
Summary: SUSD2 marker can enrich maternal pMSCs, originating potentially from eMSCs. SUSD2(+) pMSCs exhibit higher CFU-F activity and express more perivascular markers CD146, CD140b, and SUSD2 compared to SUSD2(-) pSFs. Placental decidua basalis can serve as an alternative MSC source for clinical translation when endometrial tissue is inaccessible.
CELL AND TISSUE RESEARCH
(2021)
Article
Immunology
Derek Miller, Valeria Garcia-Flores, Roberto Romero, Jose Galaz, Roger Pique-Regi, Nardhy Gomez-Lopez
Summary: Single-cell technologies have allowed for a deeper understanding of the processes occurring at the maternal-fetal interface, leading to the discovery of new pathways and cell types. These technologies have also been applied to study cellular dynamics during pregnancy and obstetrical syndromes. Additionally, they have been used to evaluate the impact of COVID-19 infection on maternal and fetal immunity.
JOURNAL OF IMMUNOLOGY
(2022)
Article
Immunology
Xuezi Tian, Kaveri T. S. Aiyer, Johanna M. Kapsenberg, Dave L. Roelen, Marie-Louise van der Hoorn, Michael Eikmans
Summary: Uncomplicated oocyte donation (OD) pregnancies exhibit a higher proportion of CD163-positive cells in decidual macrophages compared to non-OD in vitro fertilization (IVF) pregnancies, potentially indicating a need for a local type 2 macrophage-related mechanism to compensate for higher fetal-maternal HLA mismatch load.
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2022)
Article
Biochemistry & Molecular Biology
Ana Clara B. Menezes, Carl R. Dahlen, Kacie L. McCarthy, Cierrah J. Kassetas, Friederike Baumgaertner, James D. Kirsch, Sheri T. Dorsam, Tammi L. Neville, Alison K. Ward, Pawel P. Borowicz, Lawrence P. Reynolds, Kevin K. Sedivec, J. Chris Forcherio, Ronald Scott, Joel S. Caton, Matthew S. Crouse
Summary: In this study, the hepatic lipid metabolic profiles of bovine fetuses were evaluated in response to maternal vitamin and mineral supplementation and different rates of gain. The results showed that maternal body weight gain had a greater influence on fetal lipid profiles than vitamin and mineral supplementation, with lower rates of gain resulting in increased lipid composition.
Article
Hematology
Arwen Stikvoort, Ahmed Gaballa, Martin Solders, Iris Nederlof, Bjorn Onfelt, Berit Sundberg, Mats Remberger, Mikael Sundin, Jonas Mattsson, Michael Uhlin
BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION
(2018)
Article
Immunology
Martin Solders, Anna-Carin Lundell, Laia Gorchs, Sebastian Gidlof, Eleonor Tiblad, Helen Kaipe
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2019)
Article
Immunology
Martin Solders, Laia Gorchs, Eleonor Tiblad, Sebastian Gidlof, Edwin Leeansyah, Joana Dias, Johan K. Sandberg, Isabelle Magalhaes, Anna-Carin Lundell, Helen Kaipe
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Immunology
Laia Gorchs, Carlos Fernandez Moro, Peter Bankhead, Katharina P. Kern, Imrul Sadeak, Qingda Meng, Elena Rangelova, Helen Kaipe
FRONTIERS IN IMMUNOLOGY
(2019)
Article
Cell & Tissue Engineering
Sandra Petrus-Reurer, Nerges Winblad, Pankaj Kumar, Laia Gorchs, Michael Chrobok, Arnika KathleenWagner, Hammurabi Bartuma, Emma Lardner, Monica Aronsson, Alvaro Plaza Reyes, Helder Andre, Evren Alici, Helen Kaipe, Anders Kvanta, Fredrik Lanner
Article
Multidisciplinary Sciences
Laia Gorchs, Sultan Ahmed, Chante Mayer, Alisa Knauf, Carlos Fernandez Moro, Mattias Svensson, Rainer Heuchel, Elena Rangelova, Peter Bergman, Helen Kaipe
SCIENTIFIC REPORTS
(2020)
Review
Immunology
Helen Kaipe, Johanna Raffetseder, Jan Ernerudh, Martin Solders, Eleonor Tiblad
FRONTIERS IN IMMUNOLOGY
(2020)
Article
Immunology
R. Lindau, S. Vondra, J. Spreckels, M. Solders, J. Svensson-Arvelund, G. Berg, J. Pollheimer, H. Kaipe, M. C. Jenmalm, J. Ernerudh
Summary: The study found that maternal decidual stromal cells can induce specific types of macrophages and Treg cells, thereby influencing the tolerogenic environment at the foetal-maternal interface during pregnancy.
JOURNAL OF REPRODUCTIVE IMMUNOLOGY
(2021)
Article
Radiology, Nuclear Medicine & Medical Imaging
Ida Friberger, Emma Jussing, Jinming Han, Jeroen A. C. M. Goos, Jonathan Siikanen, Helen Kaipe, Melanie Lambert, Robert A. Harris, Erik Samen, Mattias Carlsten, Staffan Holmin, Thuy A. Tran
Summary: This study successfully optimized the synthesis of [Zr-89]Zr-oxine and [Zr-89]Zr-DFO-NCS, demonstrating a straightforward protocol for cell labelling with high efficiency. The radiotracers were equally effective, but [Zr-89]Zr-oxine showed superiority in long-term stability, cellular retention, minimal variation between cell types, and cell labelling efficiency.
MOLECULAR IMAGING AND BIOLOGY
(2021)
Review
Oncology
Laia Gorchs, Helen Kaipe
Summary: Despite advances in therapeutic modalities, the five-year overall survival for pancreatic cancer remains less than 10%, mainly due to the immunosuppressive effects of CAFs in the fibrotic stroma of pancreatic tumors. Current therapies fail to enhance the anti-tumor activity of T cells, but targeting CAFs may offer a new approach for the development of more effective combinational treatments.
Correction
Radiology, Nuclear Medicine & Medical Imaging
Ida Friberger, Emma Jussing, Jinming Han, Jeroen A. C. M. Goos, Jonathan Siikanen, Helen Kaipe, Melanie Lambert, Robert A. Harris, Erik Samen, Mattias Carlsten, Staffan Holmin, Thuy A. Tran
MOLECULAR IMAGING AND BIOLOGY
(2022)
Review
Oncology
Elena Rangelova, Helen Kaipe
Summary: Although most trials reported limited clinical effectiveness, the immunological effects observed in almost all trials demonstrate the potential of immunotherapy. Check point inhibitors trials did not show survival advantage. Horizontal comparison indicates that careful re-evaluation of clinical premises and focus on combination and cell therapy may improve survival rates for pancreatic cancer patients through immunotherapy.
CHINESE CLINICAL ONCOLOGY
(2022)
Article
Oncology
Laia Gorchs, Marlies Oosthoek, Tulay Yucel-Lindberg, Carlos Fernandez Moro, Helen Kaipe
Summary: The infiltration of T cells in pancreatic tumors is associated with better overall survival. However, cancer-associated fibroblasts (CAFs) in the tumor microenvironment can prevent T cells from reaching the tumor nests. This study investigated how CAFs modulate chemokine receptors on T cells and the spatial distribution of T cells within tumors. It was found that CXCR3 ligands were associated with increased T cell numbers in tumor-rich areas, and CAFs downregulated the expression of CXCR3 on T cells. Understanding these mechanisms is crucial for developing targeted therapies.