Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 22, Issue 14, Pages -Publisher
MDPI
DOI: 10.3390/ijms22147696
Keywords
decidualization; mouse; single-cell RNA-seq; transcriptional changes
Funding
- National Natural Science Foundation of China [32070845, 31771665, 2021B1515020079]
- Innovation Team Project of Guangdong University [2019KCXTD001]
- Guangdong Special Support Program [2019BT02Y276]
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This study utilized a mouse model to generate a single-cell transcriptomic atlas of a mouse uterus during decidualization, revealing global gene expression changes in each cell type during this process. Additionally, it identified intercellular crosstalk between decidual cells and niche cells, including immune cells, endothelial cells, and trophoblast cells. The data provide a valuable resource for deciphering the molecular mechanism underlying decidualization.
Decidualization is a crucial step for human reproduction, which is a prerequisite for embryo implantation, placentation and pregnancy maintenance. Despite rapid advances over recent years, the molecular mechanism underlying decidualization remains poorly understood. Here, we used the mouse as an animal model and generated a single-cell transcriptomic atlas of a mouse uterus during decidualization. By analyzing the undecidualized inter-implantation site of the uterus as a control, we were able to identify global gene expression changes associated with decidualization in each cell type. Additionally, we identified intercellular crosstalk between decidual cells and niche cells, including immune cells, endothelial cells and trophoblast cells. Our data provide a valuable resource for deciphering the molecular mechanism underlying decidualization.
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