Importance of Bmal1 in Alzheimer's disease and associated aging‐related diseases: Mechanisms and interventions

BMAL1 drives muscle repair through control of hypoxic NAD+ regeneration in satellite cells

(2022) Pei Zhu et al.   GENES & DEVELOPMENT

Alzheimer’s Disease-Associated SNP rs708727 in SLC41A1 May Increase Risk for Parkinson’s Disease: Report from Enlarged Slovak Study

(2022) Michal Cibulka et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Growing Link between Circadian Rhythms, Type 2 Diabetes Mellitus and Alzheimer’s Disease

(2022) Xuemin Peng et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Special Issue “Oxidative Stress in Aging and Associated Chronic Diseases”

(2022) Cristina Mas-Bargues et al.   Antioxidants

Curcumin Nanoformulations to Combat Aging-related Diseases

(2021) Maryam Mahjoob et al.   AGEING RESEARCH REVIEWS

Bioactive Compounds Effective Against Type 2 Diabetes Mellitus: A Systematic Review

(2021) Chukwuebuka Egbuna et al.   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Impact of Comorbidity Burden on Cognitive Decline: A Prospective Cohort Study of Older Adults with Dementia

(2021) Sheng-Lun Kao et al.   DEMENTIA AND GERIATRIC COGNITIVE DISORDERS

New insights on association between circadian rhythm and lipid metabolism in spontaneously hypertensive rats

(2021) Qingqing Hou et al.   LIFE SCIENCES

Increased risk of Alzheimer’s disease among patients with age-related macular degeneration: A nationwide population-based study

(2021) Li-Yen Wen et al.   PLoS One

Metformin attenuates atherosclerosis and plaque vulnerability by upregulating KLF2-mediated autophagy in apoE−/- mice

(2021) Han Wu et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Adiponectin improves amyloid‐β 31‐35‐induced circadian rhythm disorder in mice

(2021) Yuan Yuan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Bmal1 Regulates the Redox Rhythm of HSPB1, and Homooxidized HSPB1 Attenuates the Oxidative Stress Injury of Cardiomyocytes

(2021) Xiehong Liu et al.   Oxidative Medicine and Cellular Longevity

NAD+ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING

(2021) Yujun Hou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

L-3,4-Dihydroxyphenylalanine Recovers Circadian Rhythm Disturbances in the Rat Models of Parkinson's Disease by Regulating the D1R-ERK1/2-mTOR Pathway

(2021) Shuyuan Yang et al.   Frontiers in Aging Neuroscience

Effects of the Clock Modulator Nobiletin on Circadian Rhythms and Pathophysiology in Female Mice of an Alzheimer’s Disease Model

(2021) Eunju Kim et al.   Biomolecules

The circadian clock gene, Bmal1, regulates intestinal stem cell signaling and represses tumor initiation.

(2021) Kyle Stokes et al.   Cellular and Molecular Gastroenterology and Hepatology

Bmal1 Downregulation Worsens Critical Limb Ischemia by Promoting Inflammation and Impairing Angiogenesis

(2021) Lirong Xu et al.   Frontiers in Cardiovascular Medicine

Chronic sleep deprivation altered the expression of circadian clock genes and aggravated Alzheimer's disease neuropathology

(2021) Long Niu et al.   BRAIN PATHOLOGY

Loss of myeloid Bmal1 exacerbates hypertensive vascular remodelling through interaction with STAT6 in mice

(2021) Mingyu Huo et al.   CARDIOVASCULAR RESEARCH

Tea polyphenols ameliorates memory decline in aging model rats by inhibiting brain TLR4/NF-κB inflammatory signaling pathway caused by intestinal flora dysbiosis

(2021) Chenmeng Song et al.   EXPERIMENTAL GERONTOLOGY

Melatonin ameliorates cerebral ischemia‐reperfusion injury in diabetic mice by enhancing autophagy via the SIRT1‐BMAL1 pathway

(2021) Lian Liu et al.   FASEB JOURNAL

Circadian Clock Component BMAL1 in the Paraventricular Nucleus Regulates Glucose Metabolism

(2021) Masanori Nakata et al.   Nutrients

Peripheral Clock System Abnormalities in Patients With Parkinson’s Disease

(2021) Tianbai Li et al.   Frontiers in Aging Neuroscience

Chronic Circadian Rhythm Disturbance Accelerates Knee Cartilage Degeneration in Rats Accompanied by the Activation of the Canonical Wnt/β-Catenin Signaling Pathway

(2021) Xiaopeng Song et al.   Frontiers in Pharmacology

Metformin attenuates cartilage degeneration in an experimental osteoarthritis model by regulating AMPK/mTOR

(2020) Xiaofeng Feng et al.   Aging-US

BMAL1-Downregulation Aggravates Porphyromonas Gingivalis-Induced Atherosclerosis by Encouraging Oxidative Stress

(2020) Mengru Xie et al.   CIRCULATION RESEARCH

Nobiletin exerts anti-diabetic and anti-inflammatory effects in an in vitro human model and in vivo murine model of gestational diabetes.

(2020) Caitlyn Nguyen-Ngo et al.   CLINICAL SCIENCE

Alzheimer’s Disease and Vascular Aging

(2020) Marta Cortes-Canteli et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Circadian rhythms in the absence of the clock gene Bmal1

(2020) Sandipan Ray et al.   SCIENCE

Benzodiazepines and Related Drugs as a Risk Factor in Alzheimer's Disease Dementia

(2020) Miren Ettcheto et al.   Frontiers in Aging Neuroscience

BMAL1 regulation of microglia‐mediated neuroinflammation in MPTP‐induced Parkinson's disease mouse model

(2020) Wen‐Wen Liu et al.   FASEB JOURNAL

SIRT1 and aging related signaling pathways

(2020) Cui Chen et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Exercise Training Impacts Skeletal Muscle Clock in Adults with Prediabetes

(2020) Melissa L. Erickson et al.   MEDICINE AND SCIENCE IN SPORTS AND EXERCISE

Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

(2020) Habib Yaribeygi et al.   Oxidative Medicine and Cellular Longevity

Association between atherosclerosis and Alzheimer's disease: A systematic review and meta‐analysis

(2020) Beijia Xie et al.   Brain and Behavior

Modeling Parkinson’s Disease With the Alpha-Synuclein Protein

(2020) Mónica Gómez-Benito et al.   Frontiers in Pharmacology

Nicotinamide Mononucleotide: A Promising Molecule for Therapy of Diverse Diseases by Targeting NAD+ Metabolism

(2020) Weiqi Hong et al.   Frontiers in Cell and Developmental Biology

The diagnosis and treatment of age-related macular degeneration

(2020) Andreas Stahl   Deutsches Arzteblatt International

The biological function of BMAL1 in skeleton development and disorders

(2020) Guangjin Chen et al.   LIFE SCIENCES

Clock Protein Bmal1 and Nrf2 Cooperatively Control Aging or Oxidative Response and Redox Homeostasis by Regulating Rhythmic Expression of Prdx6

(2020) Bhavana Chhunchha et al.   Cells

Effect of melatonin administration on the PER1 and BMAL1 clock genes in patients with Parkinson’s disease

(2020) D.L. Delgado-Lara et al.   BIOMEDICINE & PHARMACOTHERAPY

Elevated CLOCK and BMAL1 Contribute to the Impairment of Aerobic Glycolysis from Astrocytes in Alzheimer’s Disease

(2020) Ik Dong Yoo et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Metformin rescues Parkinson’s disease phenotypes caused by hyperactive mitochondria

(2020) Danielle E. Mor et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Deletion of Bmal1 Impairs Pancreatic β-Cell Function via Mitochondrial Signaling Pathway

(2020) Lu Ye et al.   Biomed Research International

Circadian Rhythm Protein Bmal1 Modulates Cartilage Gene Expression in Temporomandibular Joint Osteoarthritis via the MAPK/ERK Pathway

(2020) Guokun Chen et al.   Frontiers in Pharmacology

Melatonin regulates Aβ production/clearance balance and Aβ neurotoxicity: A potential therapeutic molecule for Alzheimer’s disease

(2020) Yuanming Li et al.   BIOMEDICINE & PHARMACOTHERAPY

The core circadian component, Bmal1, is maintained in the pineal gland of old killifish brain

(2020) Seongsin Lee et al.   iScience

Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model

(2019) Nicole Reichenbach et al.   EMBO Molecular Medicine

BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders

(2019) Peiyuan Qiu et al.   National Science Review

Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathway

(2019) Zhengmin Ma et al.   CELL CYCLE

BMAL1-Driven Tissue Clocks Respond Independently to Light to Maintain Homeostasis

(2019) Patrick-Simon Welz et al.   CELL

Potential Benefits of Nobiletin, A Citrus Flavonoid, against Alzheimer’s Disease and Parkinson’s Disease

(2019) Akira Nakajima et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

D‐Ser2‐oxyntomodulin ameliorated Aβ31‐35‐induced circadian rhythm disorder in mice

(2019) Li Wang et al.   CNS Neuroscience & Therapeutics

Clock-Bmal1 mediates MMP9 induction in acrolein-promoted atherosclerosis associated with gut microbiota regulation

(2019) Xiaoyue Wu et al.   ENVIRONMENTAL POLLUTION

NAD+ in Brain Aging and Neurodegenerative Disorders

(2019) Sofie Lautrup et al.   Cell Metabolism

Correlation between inflammatory markers and impaired circadian clock gene expression in type 2 diabetes mellitus

(2019) Rongguo Yu et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Bmal1‐deficiency affects glial synaptic coverage of the hippocampal mossy fiber synapse and the actin cytoskeleton in astrocytes

(2019) Amira A. H. Ali et al.   GLIA

Inhibition of REV‐ERBs stimulates microglial amyloid‐beta clearance and reduces amyloid plaque deposition in the 5XFAD mouse model of Alzheimer’s disease

(2019) Jiyeon Lee et al.   AGING CELL

A dual GLP-1 and Gcg receptor agonist rescues spatial memory and synaptic plasticity in APP/PS1 transgenic mice

(2019) Zhao-Jun Wang et al.   HORMONES AND BEHAVIOR

Bmal1 knockdown suppresses wake and increases immobility without altering orexin A, corticotrophin-releasing hormone, or glutamate decarboxylase

(2018) Afaf Akladious et al.   CNS Neuroscience & Therapeutics

Melatonin and Oxidative Stress in the Diabetic State: Clinical Implications and Potential Therapeutic Applications

(2018) Javier Espino et al.   CURRENT MEDICINAL CHEMISTRY

Untimely oxidative stress in β-cells leads to diabetes – Role of circadian clock in β-cell function

(2018) J. Lee et al.   FREE RADICAL BIOLOGY AND MEDICINE

Regulation of amyloid-β dynamics and pathology by the circadian clock

(2018) Geraldine J. Kress et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Bone marrow lesions in osteoarthritis: What lies beneath

(2018) Tamara Alliston et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Alzheimer’s disease susceptibility genes modify the risk of Parkinson disease and Parkinson’s disease-associated cognitive impairment

(2018) Lu Fang et al.   NEUROSCIENCE LETTERS

Disruption of the Circadian Clock Alters Antioxidative Defense via the SIRT1-BMAL1 Pathway in 6-OHDA-Induced Models of Parkinson’s Disease

(2018) Yali Wang et al.   Oxidative Medicine and Cellular Longevity

Hypertension Accelerates Alzheimer’s Disease-Related Pathologies in Pigs and 3xTg Mice

(2018) Yao-Hsiang Shih et al.   Frontiers in Aging Neuroscience

Time-Restricted Feeding Prevents Obesity and Metabolic Syndrome in Mice Lacking a Circadian Clock

(2018) Amandine Chaix et al.   Cell Metabolism

Circadian clock protein BMAL1 regulates IL-1β in macrophages via NRF2

(2018) James O. Early et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Racial and ethnic estimates of Alzheimer's disease and related dementias in the United States (2015–2060) in adults aged ≥65 years

(2018) Kevin A. Matthews et al.   Alzheimers & Dementia

Neuroprotective Mechanisms of Resveratrol in Alzheimer’s Disease: Role of SIRT1

(2018) Bruno Alexandre Quadros Gomes et al.   Oxidative Medicine and Cellular Longevity

Cell-Autonomous Regulation of Astrocyte Activation by the Circadian Clock Protein BMAL1

(2018) Brian V. Lananna et al.   Cell Reports

Treadmill exercise decreases amyloid-β burden possibly via activation of SIRT-1 signaling in a mouse model of Alzheimer's disease

(2017) Jung-Hoon Koo et al.   EXPERIMENTAL NEUROLOGY

Myeloid Bmal1 deletion increases monocyte recruitment and worsens atherosclerosis

(2017) Mingyu Huo et al.   FASEB JOURNAL

Tea polyphenols ameliorates neural redox imbalance and mitochondrial dysfunction via mechanisms linking the key circadian regular Bmal1

(2017) Guoyuan Qi et al.   FOOD AND CHEMICAL TOXICOLOGY

Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 cooperates with glycogen synthase kinase-3β to regulate osteogenesis of bone-marrow mesenchymal stem cells in type 2 diabetes

(2017) Xiaoguang Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes

(2017) R. Akagi et al.   OSTEOARTHRITIS AND CARTILAGE

Islet amyloid polypeptide: Another key molecule in Alzheimer’s pathogenesis?

(2017) Yun Zhang et al.   PROGRESS IN NEUROBIOLOGY

Astrocyte deletion of Bmal1 alters daily locomotor activity and cognitive functions via GABA signalling

(2017) Olga Barca-Mayo et al.   Nature Communications

Nicotinamide mononucleotide supplementation reverses vascular dysfunction and oxidative stress with aging in mice

(2016) Natalie E. de Picciotto et al.   AGING CELL

The Small Molecule Nobiletin Targets the Molecular Oscillator to Enhance Circadian Rhythms and Protect against Metabolic Syndrome

(2016) Baokun He et al.   Cell Metabolism

Circadian transcription factor BMAL1 regulates innate immunity against select RNA viruses

(2016) Tanmay Majumdar et al.   Innate Immunity

Apoptosis signaling pathways in osteoarthritis and possible protective role of melatonin

(2016) Azam Hosseinzadeh et al.   JOURNAL OF PINEAL RESEARCH

Slowing ageing by design: the rise of NAD+ and sirtuin-activating compounds

(2016) Michael S. Bonkowski et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Mechanisms linking circadian clocks, sleep, and neurodegeneration

(2016) Erik S. Musiek et al.   SCIENCE

Circadian Rhythms, Sleep, and Disorders of Aging

(2016) Joanna Mattis et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis

(2016) Xiaoyue Pan et al.   Nature Communications

Antioxidant N-acetyl-L-cysteine ameliorates symptoms of premature aging associated with the deficiency of the circadian protein BMAL1

(2016) Roman V. Kondratov et al.   Aging-US

Association between ARNTL (BMAL1) rs2278749 polymorphism T >C and susceptibility to Alzheimer disease in a Chinese population

(2015) Q. Chen et al.   GENETICS AND MOLECULAR RESEARCH

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

Melatonin as a Potent and Inducible Endogenous Antioxidant: Synthesis and Metabolism

(2015) Dun-Xian Tan et al.   MOLECULES

Acute melatonin treatment alters dendritic morphology and circadian clock gene expression in the hippocampus of Siberian Hamsters

(2014) Tomoko Ikeno et al.   HIPPOCAMPUS

Effects of Chronic Sleep Deprivation on the Extracellular Signal-Regulated Kinase Pathway in the Temporomandibular Joint of Rats

(2014) Chuan Ma et al.   PLoS One

SIRT1 and other sirtuins in metabolism

(2014) Hung-Chun Chang et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Sleep and Circadian Rhythm Regulation in Early Parkinson Disease

(2014) David P. Breen et al.   JAMA Neurology

Mechanism of the circadian clock in physiology

(2013) Jacob Richards et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

SIRT1 Mediates Central Circadian Control in the SCN by a Mechanism that Decays with Aging

(2013) Hung-Chun Chang et al.   CELL

Circadian Disruption Leads to Insulin Resistance and Obesity

(2013) Shu-qun Shi et al.   CURRENT BIOLOGY

Circadian clock proteins regulate neuronal redox homeostasis and neurodegeneration

(2013) Erik S. Musiek et al.   JOURNAL OF CLINICAL INVESTIGATION

Hypoxia-based strategies for angiogenic induction

(2013) Ektoras Hadjipanayi et al.   Organogenesis

Development of dilated cardiomyopathy in Bmal1-deficient mice

(2012) Mellani Lefta et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Influence of aging on Bmal1 and Per2 expression in extra-SCN oscillators in hamster brain

(2012) Marilyn J. Duncan et al.   BRAIN RESEARCH

Increased Superoxide and Endothelial NO Synthase Uncoupling in Blood Vessels of Bmal1-Knockout Mice

(2012) Ciprian B. Anea et al.   CIRCULATION RESEARCH

The major circadian pacemaker ARNT-like protein-1 (BMAL1) is associated with susceptibility to gestational diabetes mellitus

(2012) Kalliopi I. Pappa et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Dysregulation of Glutathione Homeostasis in Neurodegenerative Diseases

(2012) William M. Johnson et al.   Nutrients

Circadian Clock Gene Expression in Brain Regions of Alzheimer ’s Disease Patients and Control Subjects

(2011) Nicolas Cermakian et al.   JOURNAL OF BIOLOGICAL RHYTHMS

Disruption of the clock components CLOCK and BMAL1 leads to hypoinsulinaemia and diabetes

(2010) Biliana Marcheva et al.   NATURE

Circadian Clock Feedback Cycle Through NAMPT-Mediated NAD+ Biosynthesis

(2009) K. M. Ramsey et al.   SCIENCE

Hypertension and disrupted blood pressure circadian rhythm in Type 2 diabetic db/db mice

(2008) Wen Su et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Sirtuin 1 Reduction Parallels the Accumulation of Tau in Alzheimer Disease

(2008) Carl Julien et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY