Chronic Circadian Rhythm Disturbance Accelerates Knee Cartilage Degeneration in Rats Accompanied by the Activation of the Canonical Wnt/β-Catenin Signaling Pathway

Communicating clocks shape circadian homeostasis

(2021) Kevin B. Koronowski et al.   SCIENCE

Circadian Rhythm Gene PER3 Negatively Regulates Stemness of Prostate Cancer Stem Cells via WNT/β-Catenin Signaling in Tumor Microenvironment

(2021) Qilin Li et al.   Frontiers in Cell and Developmental Biology

Drivers of phenotypic variation in cartilage: Circadian clock genes

(2021) Xiaopeng Song et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Circadian Rhythms in Exudative Age-Related Macular Degeneration: The Key Role of the Canonical WNT/β-Catenin Pathway

(2020) Alexandre Vallée et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective effects of Erdosteine on interleukin-1β-stimulated inflammation via inhibiting the activation of MAPK, NF-κB, and Wnt/β-catenin signaling pathways in rat osteoarthritis

(2020) Yang Xi et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Association between shift work and obesity among nurses: A systematic review and meta-analysis

(2020) Qi Zhang et al.   INTERNATIONAL JOURNAL OF NURSING STUDIES

Circadian Rhythm Protein Bmal1 Modulates Cartilage Gene Expression in Temporomandibular Joint Osteoarthritis via the MAPK/ERK Pathway

(2020) Guokun Chen et al.   Frontiers in Pharmacology

The influence of circadian rhythms and aerobic glycolysis in autism spectrum disorder

(2020) Alexandre Vallée et al.   Translational Psychiatry

Deletion of clock gene Bmal1 impaired the chondrocyte function due to disruption of the HIF1α-VEGF signaling pathway

(2019) Zhengmin Ma et al.   CELL CYCLE

Circadian Rhythm Disruption Aggravates DSS-Induced Colitis in Mice with Fecal Calprotectin as a Marker of Colitis Severity

(2019) Joseph Amara et al.   DIGESTIVE DISEASES AND SCIENCES

Off the Clock: From Circadian Disruption to Metabolic Disease

(2019) Eleonore Maury   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Disruption of circadian rhythm by alternating light‐dark cycles aggravates atherosclerosis development in APOE*3‐Leiden.CETP mice

(2019) Maaike Schilperoort et al.   JOURNAL OF PINEAL RESEARCH

Shift work and the risk of knee osteoarthritis among Chinese workers: a retrospective cohort study

(2019) Min Zhou et al.   SCANDINAVIAN JOURNAL OF WORK ENVIRONMENT & HEALTH

Conditional Controlled Light/Dark Cycle Influences Exercise-Induced Benefits in a Rat Model with Osteoarthritis: In Vitro and In Vivo Study

(2019) Hong et al.   Journal of Clinical Medicine

Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway

(2019) Xuchang Liu et al.   Journal of Orthopaedic Surgery and Research

Platelet-rich plasma inhibits Wnt/β-catenin signaling in rabbit cartilage cells activated by IL-1β

(2018) Jian Wu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Dehydroepiandrosterone: Molecular mechanisms and therapeutic implications in osteoarthritis

(2018) Kai Huang et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

BMAL1 Deficiency Contributes to Mandibular Dysplasia by Upregulating MMP3

(2018) Jiajia Zhao et al.   Stem Cell Reports

BMAL1 regulates balance of osteogenic–osteoclastic function of bone marrow mesenchymal stem cells in type 2 diabetes mellitus through the NF-κB pathway

(2018) Xiaoguang Li et al.   MOLECULAR BIOLOGY REPORTS

Rotating night shift work and adherence to unhealthy lifestyle in predicting risk of type 2 diabetes: results from two large US cohorts of female nurses

(2018) Zhilei Shan et al.   BMJ-British Medical Journal

Circadian rhythm disruption impairs tissue homeostasis and exacerbates chronic inflammation in the intestine

(2017) René Pagel et al.   FASEB JOURNAL

Brain and muscle aryl hydrocarbon receptor nuclear translocator-like protein-1 cooperates with glycogen synthase kinase-3β to regulate osteogenesis of bone-marrow mesenchymal stem cells in type 2 diabetes

(2017) Xiaoguang Li et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Osteoarthritis: Wnt inhibitor shows potential as a DMOAD

(2017) Sarah Onuora   Nature Reviews Rheumatology

Role of sleep and circadian disruption on energy expenditure and in metabolic predisposition to human obesity and metabolic disease

(2017) A. W. McHill et al.   Obesity Reviews

Meta-analysis on shift work and risks of specific obesity types

(2017) M. Sun et al.   Obesity Reviews

Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes

(2017) R. Akagi et al.   OSTEOARTHRITIS AND CARTILAGE

Deficiency of circadian clock protein BMAL1 in mice results in a low bone mass phenotype

(2016) William E. Samsa et al.   BONE

CLOCK-BMAL1 regulate the cardiac L-type calcium channel subunit CACNA1C through PI3K-Akt signaling pathway

(2016) Yanhong Chen et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Circadian Influence on Metabolism and Inflammation in Atherosclerosis

(2016) Cameron S. McAlpine et al.   CIRCULATION RESEARCH

Influence of sleep deprivation and circadian misalignment on cortisol, inflammatory markers, and cytokine balance

(2015) Kenneth P. Wright et al.   BRAIN BEHAVIOR AND IMMUNITY

Environmental Disruption of Circadian Rhythm Predisposes Mice to Osteoarthritis-Like Changes in Knee Joint

(2015) Ranjan Kc et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The chondrocyte clock gene Bmal1 controls cartilage homeostasis and integrity

(2015) Michal Dudek et al.   JOURNAL OF CLINICAL INVESTIGATION

Osteoarthritis-like pathologic changes in the knee joint induced by environmental disruption of circadian rhythms is potentiated by a high-fat diet

(2015) Ranjan Kc et al.   Scientific Reports

The Effects of Light at Night on Circadian Clocks and Metabolism

(2014) Laura K. Fonken et al.   ENDOCRINE REVIEWS

Hinokitiol reduces matrix metalloproteinase expression by inhibiting Wnt/β-Catenin signaling in vitro and in vivo

(2014) Jin Li et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Clock genes: Their role in colorectal cancer

(2014) Theodoros Karantanos   WORLD JOURNAL OF GASTROENTEROLOGY

Animal Models of Osteoarthritis: Challenges of Model Selection and Analysis

(2013) Erin Teeple et al.   AAPS Journal

Roles of brain and muscle ARNT-like 1 and Wnt antagonist Dkk1 during osteogenesis of bone marrow stromal cells

(2013) Y. He et al.   CELL PROLIFERATION

Entrainment of the Human Circadian Clock to the Natural Light-Dark Cycle

(2013) Kenneth P. Wright et al.   CURRENT BIOLOGY

Tetrandrine Inhibits the Wnt/β-Catenin Signalling Pathway and Alleviates Osteoarthritis: An In Vitro and In Vivo Study

(2013) Xindie Zhou et al.   Evidence-based Complementary and Alternative Medicine

Over-expression of circadian clock geneBmal1affects proliferation and the canonical Wnt pathway in NIH-3T3 cells

(2012) Fuwei Lin et al.   CELL BIOCHEMISTRY AND FUNCTION

The clock gene, brain and muscle Arnt-like 1, regulates adipogenesis via Wnt signaling pathway

(2012) Bingyan Guo et al.   FASEB JOURNAL

Dual function of β-catenin in articular cartilage growth and degeneration at different stages of postnatal cartilage development

(2011) Bo Ning et al.   INTERNATIONAL ORTHOPAEDICS

The circadian molecular clock creates epidermal stem cell heterogeneity

(2011) Peggy Janich et al.   NATURE

Shift-work and cardiovascular disease: a population-based 22-year follow-up study

(2010) Christer Hublin et al.   EUROPEAN JOURNAL OF EPIDEMIOLOGY

Dysregulation of Inflammatory Responses by Chronic Circadian Disruption

(2010) O. Castanon-Cervantes et al.   JOURNAL OF IMMUNOLOGY

Retrospective cohort study of the risk of obesity among shift workers: findings from the Industry-based Shift Workers' Health study, Japan

(2010) T. Kubo et al.   OCCUPATIONAL AND ENVIRONMENTAL MEDICINE

Circadian Integration of Metabolism and Energetics

(2010) J. Bass et al.   SCIENCE

Adverse effects of chronic circadian desynchronization in animals in a “challenging” environment

(2008) Fabian Preuss et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

 -Catenin Induces  -TrCP-Mediated PER2 Degradation Altering Circadian Clock Gene Expression in Intestinal Mucosa of ApcMin/+ Mice

(2008) X. Yang et al.   JOURNAL OF BIOCHEMISTRY

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH